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Peripheral blood gene expression to predict recurrent stroke

Tzu-Hsien Tsai, Yung-Lung Chen, Hung-Sheng Lin, Chu-Feng Liu, Hsuen-Wen Chang, Cheng-Hsien Lu, Wen-Neng Chang, Shu-Feng Chen, Chiung-Jen Wu, Steve Leu, Sheung-Fat Ko, Hon-Kan Yip
AIM: To evaluate the potential of the lipoprotein-associated phospholipase A(2) (Lp-PLA(2) level as a biomarker in the prediction of prognostic outcome in patients with acute ischemic stroke (IS). METHODS: From October 2008 to March 2010, 130 patients with acute IS were prospectively enrolled in the study and their medical records were reviewed. A blood sample was collected from each patient 48 hours after acute IS, as well as from 20 healthy volunteers as controls...
2012: Journal of Atherosclerosis and Thrombosis
Alison E Baird
Identifying blood biomarkers may be of particular value in neurologic disorders such as stroke because of the difficulty in directly studying the brain and its blood vessels. Markers of brain injury, inflammation, excitotoxicity, and oxidative damage have been evaluated for their value in stroke diagnosis, treatment, and management, but none have proved to be sensitive or specific enough for routine clinical use. However, new cellular and molecular profiling approaches using the peripheral blood offer the potential for identifying panels of genes and proteins by increasing specificity while maintaining sensitivity...
July 2006: Current Atherosclerosis Reports
Alison E Baird, Violet L Wright
Our understanding of the mechanisms underlying cerebrovascular atherosclerosis has improved in recent years, but significant gaps remain. New insights into the vascular biological processes that result in ischemic stroke may come from cellular and molecular profiling studies of the peripheral blood. In recent cellular profiling studies, increased levels of a proinflammatory T-cell subset (CD4 (+)CD28 (-)) have been associated with stroke recurrence and death. Expansion of this T-cell subset may occur after ischemic stroke and be a pathogenic mechanism leading to recurrent stroke and death...
February 2006: Seminars in Neurology
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