Paula Paccielli Freire, Geysson Javier Fernandez, Diogo de Moraes, Sarah Santiloni Cury, Maeli Dal Pai-Silva, Patrícia Pintor Dos Reis, Silvia Regina Rogatto, Robson Francisco Carvalho
BACKGROUND: Cachexia is a multifactorial syndrome highly associated with specific tumour types, but the causes of variation in cachexia prevalence and severity are unknown. While circulating plasma mediators (soluble cachectic factors) derived from tumours have been implicated with the pathogenesis of the syndrome, these associations were generally based on plasma concentration rather than tissue-specific gene expression levels. Here, we hypothesized that tumour gene expression profiling of cachexia-inducing factors (CIFs) in human cancers with different prevalence of cachexia could reveal potential cancer-specific cachexia mediators and biomarkers of clinical outcome...
March 3, 2020: Journal of Cachexia, Sarcopenia and Muscle