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https://www.readbyqxmd.com/read/29900092/infection-associated-hemophagocytic-lymphohistiocytosis-an-unusual-clinical-masquerader
#1
Awais Abbas, Mohammad Raza, Aamina Majid, Yumna Khalid, Syed Hamza Bin Waqar
Hemophagocytic lymphohistiocytosis (HLH) secondary to an infection is a great impersonator. It is caused by hyperimmune activation, which leads to a wide array of hematological abnormalities. If the disease is untreated, it is usually fatal. We report the case of a four-year-old girl who presented to our tertiary care hospital with high-grade fever, frequent loose stools, and bleeding from the lips and gums. Investigations showed pancytopenia, hyperferritinemia, hypofibrinogenemia, and hypertriglyceridemia whereas the bone marrow biopsy revealed hemophagocytosis with trilineage suppression...
April 12, 2018: Curēus
https://www.readbyqxmd.com/read/29887216/typhoid-fever-causing-haemophagocytic-lymphohistiocytosis-in-a-non-endemic-country-first-case-report-and-review-of-the-current-literature
#2
Paula Sánchez-Moreno, Peter Olbrich, Lola Falcón-Neyra, Jose Manuel Lucena, Javier Aznar, Olaf Neth
INTRODUCTION: Development of secondary haemophagocytic lymphohistiocytosis (sHLH) in the context of typhoid fever (TF) is a very rare but serious complication. METHODS: Description of the first pediatric case of typhoid fever acquired in a non-endemic area complicated by sHLH. A systematic literature review of sHLH in the context of TF was performed with extraction of epidemiological, clinical and laboratory data. RESULTS: The literature search revealed 17 articles (22 patients)...
June 7, 2018: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/29875968/-a-rare-and-atypical-cause-of-scrotal-ulcerations
#3
Mohamed El Amraoui, Naoufal Hjira
Salmonelloses are bacterial infections of the faecal peril; they are endemic in some regions of the world. They can colonize almost any organ hematogenously, hence, severe forms may be observed. We report a case of typhoid fever in a 16-year old young adolescent with no medical history, sexually transmitted diseases or sexual intercourses, presenting with necrotic scrotal ulcerations evolving over the past 3 weeks in a context of fever, diarrhoea, weight loss and alteration of the general state. Paraclinical assessment showed 7g/dl hypochromic microcyticanemia with target cells in blood smear and normal hemoglobin electrophoresis, biologic inflammatory syndrome, malabsorption syndrome, cytolysis and hepatic cholestasis 20 times above the normal, hepatosplenomegaly, normal viral serologic testing (HBV, HCV, HIV, EBV and CMV) and positive testing for salmonella...
2018: Pan African Medical Journal
https://www.readbyqxmd.com/read/29875924/-antibiotic-resistance-of-salmonella-spp-strains-isolated-from-blood-cultures-in-bukavu-democratic-republic-of-the-congo
#4
Théophile Mitima Kashosi, Archippe Birindwa Muhandule, David Lupande Mwenebitu, Nicolas Mihuhi, John Kivukuto Mutendela, Kanigula Mubagwa
Introduction: Typhoid fever is a major public health problem in developing countries because of the obsolescence of health infrastructure and of an almost non-existent water distribution network. In the Democratic Republic of the Congo, in general, and in Bukavu, in particular, blood culture is inaccessible to the majority of patients. This study aimed to assess the sensitivity of Salmonella spp to antibiotics commonly used for the tratment of typhoid fever in Bukavu. Methods: We conducted a cross-sectional study over a period of 6 months...
2018: Pan African Medical Journal
https://www.readbyqxmd.com/read/29861180/multi-epitope-dnak-peptide-vaccine-against-s-typhi-an-in-silico-approach
#5
Shivani Verma, Ragumani Sugadev, Ashish Kumar, Sudhir Chandna, Lilly Ganju, Anju Bansal
Salmonella is one of the key global causes of food and water borne enteric infections, responsible for significant morbidity and mortality worldwide especially in developing countries. Currently available vaccines against typhoid are moderately effective with several side effects and not efficacious against all Salmonella serovars. Due to limitations of these vaccines and emerging threats of multidrug resistance, developing an effective vaccine against these infections has increasingly become a priority. Heat shock proteins (Hsps), being evolutionarily conserved, represent dominant antigens in the host immune response...
May 31, 2018: Vaccine
https://www.readbyqxmd.com/read/29804358/-clinical-features-of-community-acquired-bloodstream-infection-due-to-gram-negative-bacilli-in-patients-with-liver-cirrhosis
#6
B Tu, S X Liu, D Wu, X Zhang, L Shi, Y X Xie, P Zhao, E Q Qin
Objective: o investigate the features of pathogenic bacteria for community-acquired bloodstream infection due to Gram-negative bacilli in patients with liver cirrhosis and optimal therapeutic strategy. Methods: A retrospective analysis was performed for the clinical data of patients with liver cirrhosis who were admitted to 302 Hospital of PLA due to community-acquired bloodstream infection from January 2010 to December 2015, and a statistical analysis was performed for their clinical features, pathogenic bacteria, and results of drug sensitivity test...
January 20, 2018: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/29792233/antibiotic-resistance-and-molecular-characterization-of-diarrheagenic-escherichia-coli-and-non-typhoidal-salmonella-strains-isolated-from-infections-in-southwest-china
#7
Shun-Xian Zhang, Yong-Ming Zhou, Li-Guang Tian, Jia-Xu Chen, Rita Tinoco-Torres, Emmanuel Serrano, Shi-Zhu Li, Shao-Hong Chen, Lin Ai, Jun-Hu Chen, Shang Xia, Yan Lu, Shan Lv, Xue-Jiao Teng, Wen Xu, Wen-Peng Gu, Si-Tang Gong, Xiao-Nong Zhou, Lan-Lan Geng, Wei Hu
BACKGROUND: Bacterial diarrhea is one of the most common causes for medical consultations, mortality and morbidity in the world. Diarrheagenic Escherichia coli (DEC) and non-typhoidal Salmonella (NTS) are major intestinal pathogens in developing countries, and the indiscriminate use of antibiotics has greatly contributed to resistant strains. Hence, the aim of the present study is to identify the antimicrobial resistance patterns and the molecular characteristics of DEC and NTS in southwest, China...
May 7, 2018: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/29777131/activity-of-acetyltransferase-toxins-involved-in-salmonella-persister-formation-during-macrophage-infection
#8
Julian A Rycroft, Bridget Gollan, Grzegorz J Grabe, Alexander Hall, Angela M Cheverton, Gerald Larrouy-Maumus, Stephen A Hare, Sophie Helaine
Non-typhoidal Salmonella strains are responsible for invasive infections associated with high mortality and recurrence in sub-Saharan Africa, and there is strong evidence for clonal relapse following antibiotic treatment. Persisters are non-growing bacteria that are thought to be responsible for the recalcitrance of many infections to antibiotics. Toxin-antitoxin systems are stress-responsive elements that are important for Salmonella persister formation, specifically during infection. Here, we report the analysis of persister formation of clinical invasive strains of Salmonella Typhimurium and Enteritidis in human primary macrophages...
May 18, 2018: Nature Communications
https://www.readbyqxmd.com/read/29735830/changing-trends-of-culture-positive-typhoid-fever-and-antimicrobial-susceptibility-in-a-tertiary-care-north-indian-hospital-over-the-last-decade
#9
Priyanka Sharma, Sushila Dahiya, Neelam Manral, Bhavana Kumari, Sambuddha Kumar, Sangeeta Pandey, Seema Sood, Bimal Kumar Das, Arti Kapil
Purpose: The present study was undertaken to analyse the trend in prevalence of culture-positive typhoid fever during the last decade and to determine antimicrobial susceptibility profile of Salmonella Typhi and Salmonella Paratyphi A isolated from patients of enteric fever presenting to our hospital. Methods: All the culture-positive enteric fever cases during 2005-2016 presenting to our Hospital were included in the study. Antimicrobial susceptibility was done against chloramphenicol, amoxicillin, co-trimoxazole, ciprofloxacin, ofloxacin, levofloxacin, pefloxacin, ceftriaxone and azithromycin as per corresponding CLSI guidelines for each year...
January 2018: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29732321/characterization-of-non-typhoidal-salmonella-enterica-strains-of-human-origin-in-central-and-southern-italy
#10
Yolande T R Proroga, Federico Capuano, Rosanna Capparelli, Stefano Bilei, Mariano Bernardo, Maria Pia Cocco, Rosalba Campagnuolo, Vincenzo Pasquale
Non-typhoidal Salmonella enterica infection is a significant public health problem worldwide. The aim of this study was to characterize Salmonella enterica strains isolated from human specimens in central and southern Italy, for epidemiological studies. One hundred and fifty S. enterica strains were serotyped. Isolates were tested for their antimicrobial susceptibility, by disk diffusion method. The molecular characterizations, based on PCR, were carried out for the detection of invA gene and other virulence elements and phage marker genes...
March 31, 2018: Italian Journal of Food Safety
https://www.readbyqxmd.com/read/29708083/phenotypical-resistance-correlation-networks-for-10-non-typhoidal-salmonella-subpopulations-in-an-active-antimicrobial-surveillance-programme
#11
W J Love, K A Zawack, J G Booth, Y T Gröhn, C Lanzas
Antimicrobials play a critical role in treating cases of invasive non-typhoidal salmonellosis (iNTS) and other diseases, but efficacy is hindered by resistant pathogens. Selection for phenotypical resistance may occur via several mechanisms. The current study aims to identify correlations that would allow indirect selection of increased resistance to ceftriaxone, ciprofloxacin and azithromycin to improve antimicrobial stewardship. These are medically important antibiotics for treating iNTS, but these resistances persist in non-Typhi Salmonella serotypes even though they are not licensed for use in US food animals...
April 30, 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29684022/open-label-comparative-trial-of-mono-versus-dual-antibiotic-therapy-for-typhoid-fever-in-adults
#12
Niv Zmora, Sudeep Shrestha, Ami Neuberger, Yael Paran, Rajendra Tamrakar, Ashish Shrestha, Surendra K Madhup, T R S Bedi, Rajendra Koju, Eli Schwartz
BACKGROUND: Emerging resistance to antibiotics renders therapy of Typhoid Fever (TF) increasingly challenging. The current single-drug regimens exhibit prolonged fever clearance time (FCT), imposing a great burden on both patients and health systems, and potentially contributing to the development of antibiotic resistance and the chronic carriage of the pathogens. The aim of our study was to assess the efficacy of combining third-generation cephalosporin therapy with azithromycin on the outcomes of TF in patients living in an endemic region...
April 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29680695/microbiological-quality-and-antimicrobial-resistance-characterization-of-salmonella-spp-in-fresh-milk-value-chains-in-ghana
#13
Angela Parry-Hanson Kunadu, Mark Holmes, Eric L Miller, Andrew J Grant
Consumer perception of poor hygiene of fresh milk products is a major barrier to promotion of milk consumption as an intervention to alleviate the burden of malnutrition in Ghana. Fresh milk is retailed raw, boiled, or processed into unfermented cheese and spontaneously fermented products in unlicensed outlets. In this study, we have determined microbiological quality of informally retailed fresh milk products and characterized the genomic diversity and antimicrobial resistance (AMR) patterns of non-typhoidal Salmonella (NTS) in implicated products...
July 20, 2018: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29642473/resistance-to-carbapenems-in-non-typhoidal-salmonella-enterica-serovars-from-humans-animals-and-food
#14
REVIEW
Javier Fernández, Beatriz Guerra, M Rosario Rodicio
Non-typhoidal serovars of Salmonella enterica (NTS) are a leading cause of food-borne disease in animals and humans worldwide. Like other zoonotic bacteria, NTS have the potential to act as reservoirs and vehicles for the transmission of antimicrobial drug resistance in different settings. Of particular concern is the resistance to critical "last resort" antimicrobials, such as carbapenems. In contrast to other Enterobacteriaceae (e.g., Klebsiella pneumoniae , Escherichia coli , and Enterobacter , which are major nosocomial pathogens affecting debilitated and immunocompromised patients), carbapenem resistance is still very rare in NTS...
April 8, 2018: Veterinary Sciences
https://www.readbyqxmd.com/read/29623212/first-report-of-lyme-disease-in-nepal
#15
Sher Bahadur Pun, Sumit Agrawal, Santoshananda Jha, Lila Nath Bhandari, Bimal Sharma Chalise, Abadhesh Mishra, Rajesh Shah
Introduction: Lyme disease is a tick-borne illness caused by the spirochete Borrelia burgdorferi and is widely reported in the USA, Central Europe, South East Asia and Latin America. Until recently, no scientific report regarding Lyme disease in Nepal had been published. Case presentation: A 32-year-old, previously healthy female visited the hospital with a history of joint pains, fatigue, neck stiffness, tingling sensation and headache. She was initially treated for typhoid fever, brucellosis and malaria, but did not show significant improvement...
March 2018: JMM Case Reports
https://www.readbyqxmd.com/read/29616644/etiological-therapeutic-and-prognostic-particularities-of-primary-biliary-peritonitis-in-tropical-environments
#16
S Ouedraogo, M Windsouri, J T Sawadogo, M Zida, E Ouangre, S S Traore
To describe the etiological, therapeutic, and prognostic aspects of primary biliary peritonitis in Burkina Faso. This retrospective study reviewed records of all patients admitted for primary biliary peritonitis at Tenkodogo Regional Hospital (Burkina Faso) from 2010 through 2016. Cases of secondary biliary peritonitis have been excluded. Thirty patients were identified. Their average age was 26.5 years. Fourteen patients were under 12 years of age. The reasons for consultation were dominated by abdominal pain (in all cases) and bile-induced vomiting (in 22 cases)...
February 1, 2018: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/29609250/-epidemiological-characteristics-and-molecular-typing-of-typhoid-and-paratyphoid-in-china-2009-2013
#17
Y Cao, Y Y Han, F F Liu, Q H Liao, J Li, B W Diao, F X Fan, B Kan, M Y Yan
Objective: To understand the epidemiological and molecular characteristics of typhoid and paratyphoid in China from 2009 to 2013, and provide evidence for the prevention and control of typhoid and paratyphoid, the development and improvement of surveillance strategies. Methods: Epidemiological analysis was conducted on the incidence data of typhoid and paratyphoid, and related public health emergencies in China during 2009-2013. Pathogen isolation and culture, serologic test were conducted for the typhoid and paratyphoid cases from 13 national surveillance sites...
March 10, 2018: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/29559573/the-gathering-storm-is-untreatable-typhoid-fever-on-the-way
#18
Myron M Levine, Raphael Simon
Klemm et al. (mBio 9:e00105-18, 2018, https://doi.org/10.1128/mBio.00105-18) present comprehensive antibiotic sensitivity patterns and genomic sequence data on Salmonella enterica serovar Typhi blood culture isolates from typhoid fever cases during an epidemic in Pakistan. Microbiologic and genomic data pinpoint the identities and locations of the antimicrobial resistance genes and the outbreak strain's lineage. They propose that Salmonella enterica serovar Typhi be added to the list of bacterial pathogens of public health importance that have become extensively drug resistant (XDR)...
March 20, 2018: MBio
https://www.readbyqxmd.com/read/29556880/critical-care-management-of-peritonitis-in-a-low-resource-setting
#19
Jennifer Rickard, Christian Ngarambe, Leonard Ndayizeye, Blair Smart, Robert Riviello, Jean Paul Majyambere
BACKGROUND: Management of critically ill patients is challenging in a low-resource setting. In Rwanda, peritonitis is a common surgical condition where patients often present late, with advanced disease. We aim to describe critical care management of patients with peritonitis in Rwanda. METHODS: Data were collected at a tertiary referral hospital in Rwanda on patients undergoing operation for peritonitis over a 6-month period. Data included epidemiology, hospital course and outcomes...
March 19, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29463654/emergence-of-an-extensively-drug-resistant-salmonella-enterica-serovar-typhi-clone-harboring-a-promiscuous-plasmid-encoding-resistance-to-fluoroquinolones-and-third-generation-cephalosporins
#20
Elizabeth J Klemm, Sadia Shakoor, Andrew J Page, Farah Naz Qamar, Kim Judge, Dania K Saeed, Vanessa K Wong, Timothy J Dallman, Satheesh Nair, Stephen Baker, Ghazala Shaheen, Shahida Qureshi, Mohammad Tahir Yousafzai, Muhammad Khalid Saleem, Zahra Hasan, Gordon Dougan, Rumina Hasan
Antibiotic resistance is a major problem in Salmonella enterica serovar Typhi, the causative agent of typhoid. Multidrug-resistant (MDR) isolates are prevalent in parts of Asia and Africa and are often associated with the dominant H58 haplotype. Reduced susceptibility to fluoroquinolones is also widespread, and sporadic cases of resistance to third-generation cephalosporins or azithromycin have also been reported. Here, we report the first large-scale emergence and spread of a novel S  Typhi clone harboring resistance to three first-line drugs (chloramphenicol, ampicillin, and trimethoprim-sulfamethoxazole) as well as fluoroquinolones and third-generation cephalosporins in Sindh, Pakistan, which we classify as extensively drug resistant (XDR)...
February 20, 2018: MBio
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