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https://www.readbyqxmd.com/read/29684022/open-label-comparative-trial-of-mono-versus-dual-antibiotic-therapy-for-typhoid-fever-in-adults
#1
Niv Zmora, Sudeep Shrestha, Ami Neuberger, Yael Paran, Rajendra Tamrakar, Ashish Shrestha, Surendra K Madhup, T R S Bedi, Rajendra Koju, Eli Schwartz
BACKGROUND: Emerging resistance to antibiotics renders therapy of Typhoid Fever (TF) increasingly challenging. The current single-drug regimens exhibit prolonged fever clearance time (FCT), imposing a great burden on both patients and health systems, and potentially contributing to the development of antibiotic resistance and the chronic carriage of the pathogens. The aim of our study was to assess the efficacy of combining third-generation cephalosporin therapy with azithromycin on the outcomes of TF in patients living in an endemic region...
April 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29680695/microbiological-quality-and-antimicrobial-resistance-characterization-of-salmonella-spp-in-fresh-milk-value-chains-in-ghana
#2
Angela Parry-Hanson Kunadu, Mark Holmes, Eric L Miller, Andrew J Grant
Consumer perception of poor hygiene of fresh milk products is a major barrier to promotion of milk consumption as an intervention to alleviate the burden of malnutrition in Ghana. Fresh milk is retailed raw, boiled, or processed into unfermented cheese and spontaneously fermented products in unlicensed outlets. In this study, we have determined microbiological quality of informally retailed fresh milk products and characterized the genomic diversity and antimicrobial resistance (AMR) patterns of non-typhoidal Salmonella (NTS) in implicated products...
April 14, 2018: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29642473/resistance-to-carbapenems-in-non-typhoidal-salmonella-enterica-serovars-from-humans-animals-and-food
#3
REVIEW
Javier Fernández, Beatriz Guerra, M Rosario Rodicio
Non-typhoidal serovars of Salmonella enterica (NTS) are a leading cause of food-borne disease in animals and humans worldwide. Like other zoonotic bacteria, NTS have the potential to act as reservoirs and vehicles for the transmission of antimicrobial drug resistance in different settings. Of particular concern is the resistance to critical "last resort" antimicrobials, such as carbapenems. In contrast to other Enterobacteriaceae (e.g., Klebsiella pneumoniae , Escherichia coli , and Enterobacter , which are major nosocomial pathogens affecting debilitated and immunocompromised patients), carbapenem resistance is still very rare in NTS...
April 8, 2018: Veterinary Sciences
https://www.readbyqxmd.com/read/29623212/first-report-of-lyme-disease-in-nepal
#4
Sher Bahadur Pun, Sumit Agrawal, Santoshananda Jha, Lila Nath Bhandari, Bimal Sharma Chalise, Abadhesh Mishra, Rajesh Shah
Introduction: Lyme disease is a tick-borne illness caused by the spirochete Borrelia burgdorferi and is widely reported in the USA, Central Europe, South East Asia and Latin America. Until recently, no scientific report regarding Lyme disease in Nepal had been published. Case presentation: A 32-year-old, previously healthy female visited the hospital with a history of joint pains, fatigue, neck stiffness, tingling sensation and headache. She was initially treated for typhoid fever, brucellosis and malaria, but did not show significant improvement...
March 2018: JMM Case Reports
https://www.readbyqxmd.com/read/29616644/etiological-therapeutic-and-prognostic-particularities-of-primary-biliary-peritonitis-in-tropical-environments
#5
S Ouedraogo, M Windsouri, J T Sawadogo, M Zida, E Ouangre, S S Traore
To describe the etiological, therapeutic, and prognostic aspects of primary biliary peritonitis in Burkina Faso. This retrospective study reviewed records of all patients admitted for primary biliary peritonitis at Tenkodogo Regional Hospital (Burkina Faso) from 2010 through 2016. Cases of secondary biliary peritonitis have been excluded. Thirty patients were identified. Their average age was 26.5 years. Fourteen patients were under 12 years of age. The reasons for consultation were dominated by abdominal pain (in all cases) and bile-induced vomiting (in 22 cases)...
February 1, 2018: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/29609250/-epidemiological-characteristics-and-molecular-typing-of-typhoid-and-paratyphoid-in-china-2009-2013
#6
Y Cao, Y Y Han, F F Liu, Q H Liao, J Li, B W Diao, F X Fan, B Kan, M Y Yan
Objective: To understand the epidemiological and molecular characteristics of typhoid and paratyphoid in China from 2009 to 2013, and provide evidence for the prevention and control of typhoid and paratyphoid, the development and improvement of surveillance strategies. Methods: Epidemiological analysis was conducted on the incidence data of typhoid and paratyphoid, and related public health emergencies in China during 2009-2013. Pathogen isolation and culture, serologic test were conducted for the typhoid and paratyphoid cases from 13 national surveillance sites...
March 10, 2018: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/29559573/the-gathering-storm-is-untreatable-typhoid-fever-on-the-way
#7
Myron M Levine, Raphael Simon
Klemm et al. (mBio 9:e00105-18, 2018, https://doi.org/10.1128/mBio.00105-18) present comprehensive antibiotic sensitivity patterns and genomic sequence data on Salmonella enterica serovar Typhi blood culture isolates from typhoid fever cases during an epidemic in Pakistan. Microbiologic and genomic data pinpoint the identities and locations of the antimicrobial resistance genes and the outbreak strain's lineage. They propose that Salmonella enterica serovar Typhi be added to the list of bacterial pathogens of public health importance that have become extensively drug resistant (XDR)...
March 20, 2018: MBio
https://www.readbyqxmd.com/read/29556880/critical-care-management-of-peritonitis-in-a-low-resource-setting
#8
Jennifer Rickard, Christian Ngarambe, Leonard Ndayizeye, Blair Smart, Robert Riviello, Jean Paul Majyambere
BACKGROUND: Management of critically ill patients is challenging in a low-resource setting. In Rwanda, peritonitis is a common surgical condition where patients often present late, with advanced disease. We aim to describe critical care management of patients with peritonitis in Rwanda. METHODS: Data were collected at a tertiary referral hospital in Rwanda on patients undergoing operation for peritonitis over a 6-month period. Data included epidemiology, hospital course and outcomes...
March 19, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29463654/emergence-of-an-extensively-drug-resistant-salmonella-enterica-serovar-typhi-clone-harboring-a-promiscuous-plasmid-encoding-resistance-to-fluoroquinolones-and-third-generation-cephalosporins
#9
Elizabeth J Klemm, Sadia Shakoor, Andrew J Page, Farah Naz Qamar, Kim Judge, Dania K Saeed, Vanessa K Wong, Timothy J Dallman, Satheesh Nair, Stephen Baker, Ghazala Shaheen, Shahida Qureshi, Mohammad Tahir Yousafzai, Muhammad Khalid Saleem, Zahra Hasan, Gordon Dougan, Rumina Hasan
Antibiotic resistance is a major problem in Salmonella enterica serovar Typhi, the causative agent of typhoid. Multidrug-resistant (MDR) isolates are prevalent in parts of Asia and Africa and are often associated with the dominant H58 haplotype. Reduced susceptibility to fluoroquinolones is also widespread, and sporadic cases of resistance to third-generation cephalosporins or azithromycin have also been reported. Here, we report the first large-scale emergence and spread of a novel S  Typhi clone harboring resistance to three first-line drugs (chloramphenicol, ampicillin, and trimethoprim-sulfamethoxazole) as well as fluoroquinolones and third-generation cephalosporins in Sindh, Pakistan, which we classify as extensively drug resistant (XDR)...
February 20, 2018: MBio
https://www.readbyqxmd.com/read/29449781/whole-genome-sequencing-of-multidrug-resistant-salmonella-enterica-serovar-typhimurium-isolated-from-humans-and-poultry-in-burkina-faso
#10
Assèta Kagambèga, Taru Lienemann, Jonathan G Frye, Nicolas Barro, Kaisa Haukka
Background: Multidrug-resistant Salmonella is an important cause of morbidity and mortality in developing countries. The aim of this study was to characterize and compare multidrug-resistant Salmonella enterica serovar Typhimurium isolates from patients and poultry feces. Methods: Salmonella strains were isolated from poultry and patients using standard bacteriological methods described in previous studies. The strains were serotype according to Kaufmann-White scheme and tested for antibiotic susceptibility to 12 different antimicrobial agents using the disk diffusion method...
2018: Tropical Medicine and Health
https://www.readbyqxmd.com/read/29432938/first-report-on-antimicrobial-resistance-and-molecular-characterization-of-salmonella-enterica-serotype-typhi-isolated-from-human-specimens-in-luanda-angola
#11
Moisés Francisco, Sofia Santos Costa, Adriana Belas, Jorge Ramos, Isabel Couto, Constança Pomba, Miguel Viveiros
OBJECTIVES: Typhoid fever is a common infection in Africa and in spite of scarce surveillance reports, its incidence is commonly considered high by the Angolan Health system. Drug-resistant Salmonella enterica serotype Typhi has emerged, turning antimicrobial susceptibility testing essential to provide clinical guidance. This is the first report analyzing antimicrobial resistance patterns and population structure of the few S. enterica ser. Typhi isolated from patients with Typhoid fever in Luanda, Angola...
February 9, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29432657/clinical-profile-antibiotic-susceptibility-pattern-of-bacterial-isolates-and-factors-associated-with-complications-in-culture-proven-typhoid-patients-admitted-to-an-urban-hospital-in-bangladesh
#12
Halima Khatun, Shoeb Bin Islam, Nurun Nahar Naila, Syed Aminul Islam, Baitun Nahar, Md Nur Haque Alam, Tahmeed Ahmed
OBJECTIVES: Typhoid fever is one of the major causes of morbidity and mortality in typhoid endemic countries like Bangladesh. However, data on the clinical and microbiological profile as well as factors associated with complications of typhoid in Bangladesh are scarce. We intended to characterize the clinical and microbiological profile of culture-proven typhoid fever and to identify factors associated with complications. METHODOLOGY: Retrospective analysis of clinical data from 431 patients with culture-confirmed typhoid fever admitted to Dhaka hospital of International Centre for Diarrhoeal Disease Research, Bangladesh, between January 2010 and December 2014...
February 12, 2018: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29394238/plasmodium-salmonella-co-infection-induces-intense-inflammatory-responsanirban-pal-phd-cisr-central-institute-of-medicinal-and-aromatic-plants-lucknow-uttar-pradesh-indiae-oxidative-stress-and-liver-damage-a-mice-model-study-for-therapeutic-strategy
#13
Dinesh Kumar Patel, Sandeep Mittal, Nimisha Tiwari, Anil Kumar Maurya, Dhirendra Singh, Alok Kumar Pandey, Anirban Pal
Impairment of host immune response in malaria favours bacteraemia caused by typhoidal or non-typhoidal serovars of Salmonella enterica. Ofloxacin and Artesunate are the drugs that are clinically proven for treating typhoid and malaria respectively. The study evaluates the host responses upon treatment with antibiotic (Ofloxacin) and anti-malarial (Artesunate) in a standardized mice model harbouring co-infection. BALB/c mice (18-22 gm) were simultaneously co-infected with Plasmodium yoelii nigeriensis (Pyn) and Salmonella enterica Serovar Typhimurium (STm) and then treated with Ofloxacin or/and Artesunate from day 4 to day 7...
February 1, 2018: Shock
https://www.readbyqxmd.com/read/29365208/salmonella-isolated-from-chicken-carcasses-from-a-slaughterhouse-in-the-state-of-mato-grosso-brazil-antibiotic-resistance-profile-serotyping-and-characterization-by-repetitive-sequence-based-pcr-system
#14
Adelino da Cunha-Neto, Larrayane Albuês Carvalho, Ricardo César Tavares Carvalho, Dália Dos Prazeres Rodrigues, Sergio Borges Mano, Eduardo Eustáquio de Souza Figueiredo, Carlos Adam Conte-Junior
Salmonella is one of the major causative agents of foodborne infections. Salmonellosis becomes more dangerous when strains resistant to several antibiotics are found in food, especially in chicken, one of the primary transmission vehicles of this pathogen for humans. The present study aimed to estimate the occurrence of Salmonella in chicken carcasses from the state of Mato Grosso, Brazil, as well as determine the antibiotic resistance profile and genotypic characteristic of multi-drug resistant (MDR) isolates...
April 1, 2018: Poultry Science
https://www.readbyqxmd.com/read/29351771/characterization-of-salmonella-enterica-from-invasive-bloodstream-infections-and-water-sources-in-rural-ghana
#15
Denise Dekker, Ralf Krumkamp, Daniel Eibach, Nimako Sarpong, Kennedy Gyau Boahen, Michael Frimpong, Elina Fechtner, Sven Poppert, Ralf Matthias Hagen, Norbert Georg Schwarz, Yaw Adu-Sarkodie, Ellis Owusu-Dabo, Justin Im, Florian Marks, Hagen Frickmann, Jürgen May
BACKGROUND: Non-typhoidal Salmonella (NTS) cause the majority of bloodstream infections in Ghana, however the mode of transmission and source of invasive NTS in Africa are poorly understood. This study compares NTS from water sources and invasive bloodstream infections in rural Ghana. METHODS: Blood from hospitalised, febrile children and samples from drinking water sources were analysed for Salmonella spp. Strains were serotyped to trace possible epidemiological links between human and water-derived isolates...
January 19, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29327530/splenic-abscess-caused-by-salmonella-typhi-and-co-infection-with-leptospira
#16
Monalisa Sahu, Arvind Kumar, Neeraj Nischal, B G Bharath, Smita Manchanda, Naveet Wig
Splenic abscesses caused by Salmonella typhi are a very rare complication of typhoid fever in this era of use of specific antibiotics. Co-infection with Leptospira in such a patient is even rarer. Clinical diagnosis of splenic abscess caused by Salmonella is difficult owing to its rarity, being insidious in onset and having nonspecific clinical presentation. Splenic abscesses are potentially fatal complication of typhoid fever. In most of these patients, hemoglobinopathies or some other underlying immunocompromised state is usually present...
December 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29317704/biofilm-formation-protects-salmonella-from-the-antibiotic-ciprofloxacin-in-vitro-and-in-vivo-in-the-mouse-model-of-chronic-carriage
#17
Juan F González, Halley Alberts, Joel Lee, Lauren Doolittle, John S Gunn
Typhoid fever is caused by the human-restricted pathogen Salmonella enterica sv. Typhi. Approximately 5% of people that resolve the disease become chronic carriers, with the gallbladder as the main reservoir of the bacteria. Of these, about 90% present with gallstones, on which Salmonella form biofilms. Because S. Typhi is a human-restricted pathogen, these carriers are the main source of dissemination of the disease; unfortunately, antibiotic treatment has shown to be an ineffective therapy. This is believed to be caused by the inherent antibiotic resistance conferred by Salmonella biofilms growing on gallstones...
January 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29201803/massive-lower-gastrointestinal-bleed-caused-by-typhoid-ulcer-conservative-management
#18
Apoorv Goel, Roli Bansal
Typhoid fever is caused by gram-negative organism Salmonella typhi. The usual presentation is high-grade fever, but complications like gastrointestinal (GI) hemorrhage and perforation are also seen frequently. With the advent of antibiotics, these complications are rarely seen now. We present a case of a young female who was admitted with a diagnosis of typhoid fever presented with a massive GI bleed from ulcers in the terminal ileum and was managed conservatively without endotherapy and surgery. How to cite this article: Goel A, Bansal R...
July 2017: Euroasian Journal of Hepato-Gastroenterology
https://www.readbyqxmd.com/read/29201148/whole-genome-sequencing-based-detection-of-antimicrobial-resistance-and-virulence-in-non-typhoidal-salmonella-enterica-isolated-from-wildlife
#19
Milton Thomas, Gavin John Fenske, Linto Antony, Sudeep Ghimire, Ronald Welsh, Akhilesh Ramachandran, Joy Scaria
The aim of this study was to generate a reference set of Salmonella enterica genomes isolated from wildlife from the United States and to determine the antimicrobial resistance and virulence gene profile of the isolates from the genome sequence data. We sequenced the whole genomes of 103 Salmonella isolates sampled between 1988 and 2003 from wildlife and exotic pet cases that were submitted to the Oklahoma Animal Disease Diagnostic Laboratory, Stillwater, Oklahoma. Among 103 isolates, 50.48% were from wild birds, 0...
2017: Gut Pathogens
https://www.readbyqxmd.com/read/29163400/prevalence-and-antibiotic-resistance-of-non-typhoidal-salmonella-isolated-from-raw-chicken-carcasses-of-commercial-broilers-and-spent-hens-in-tai-an-china
#20
Song Li, Yufa Zhou, Zengmin Miao
The present study was aimed to determine the prevalence and characteristics of Salmonella isolated from meat samples of commercial broilers (CB) and spent hens (SH). Between March and June 2016, 200 retail raw chicken carcasses (100 from CB and 100 from SH) were obtained from local supermarkets in Tai'an city of China, and Salmonella isolates were then analyzed for antibiotic resistance, serotype, β-lactamase genes, and the presence of class 1 integron. Forty Salmonella strains were obtained in this study (CB: 21/100, 21%; SH: 19/100, 19%)...
2017: Frontiers in Microbiology
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