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https://www.readbyqxmd.com/read/27906062/severe-thrombocytopenia-in-a-child-with-typhoid-fever-a-case-report
#1
Mohammed Al Reesi, Glenn Stephens, Brendan McMullan
BACKGROUND: Although thrombocytopenia is common in typhoid fever, its course, response to treatment, and need for specific therapies such as platelet transfusion are not well characterized. CASE PRESENTATION: We report a case of typhoid fever in a 4-year-old Asian male returned traveler, admitted with prolonged fever and found to have severe thrombocytopenia (platelets 16 × 10(9)/L). Despite appropriate antibiotic therapy, his platelet recovery was slow, but did not lead to complications and he did not require platelet transfusion...
November 30, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27887651/studies-on-the-therapeutic-effect-of-propolis-along-with-standard-antibacterial-drug-in-salmonella-enterica-serovar-typhimurium-infected-balb-c-mice
#2
Preeti Kalia, Neelima R Kumar, Kusum Harjai
BACKGROUND: Antibiotic resistance is an emerging public health problem. Centers for Disease Control and Prevention (CDC) has described antibiotic resistance as one of the world's most pressing health problems in 21(st) century. WHO rated antibiotic resistance as "one of the three greatest threats to human health". One important strategy employed to overcome this resistance is the use of combination of drugs. Many plants, natural extracts have been shown to exhibit synergistic response with standard drugs against microorganisms...
November 25, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27825318/prevalence-of-malaria-typhoid-toxoplasmosis-and-rubella-among-febrile-children-in-cameroon
#3
Olivia A Achonduh-Atijegbe, Kenji O Mfuh, Aristid H E Mbange, Jean P Chedjou, Diane W Taylor, Vivek R Nerurkar, Wilfred F Mbacham, Rose Leke
BACKGROUND: The current roll-out of rapid diagnostic tests (RDTs) in many endemic countries has resulted in the reporting of fewer cases of malaria-attributed illnesses. However, lack of knowledge of the prevalence of other febrile illnesses and affordable diagnostic tests means that febrile patients are not managed optimally. This study assessed the prevalence of commonly treatable or preventable febrile illnesses in children between 6 months and 15 years using rapid diagnostic tests at the point-of-care...
November 8, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27802388/identification-of-mhc-bound-peptides-from-dendritic-cells-infected-with-salmonella-enterica-strain-sl1344-implications-for-a-non-typhoidal-salmonella-vaccine
#4
Karuna P Karunakaran, Hong Yu, Xiaozhou Jiang, Queenie Chan, Michael F Goldberg, Marc K Jenkins, Leonard J Foster, Robert C Brunham
Worldwide Salmonella enterica infections result in substantial morbidity and mortality and is the major cause of infant bacteremia in sub Saharan Africa. Diseases caused by Salmonella are treatable with antibiotics but successful antibiotic treatment has become difficult due to antimicrobial resistance and collateral effects on the microbiome. An effective vaccine together with public health efforts may be a better strategy to control these infections. Protective immunity against Salmonella depends primarily on CD4 T cell-mediated immune responses and therefore identifying relevant T cell antigens is necessary for Salmonella vaccine development...
November 1, 2016: Journal of Proteome Research
https://www.readbyqxmd.com/read/27796818/enteric-fever
#5
REVIEW
Praveen Kumar, Ruchika Kumar
Enteric fever is an important public-health problem in India. The clinical presentation of typhoid fever is very variable, ranging from fever with little other morbidities to marked toxemia and associated multisystem complications. Fever is present in majority of patients (>90 %) irrespective of their age group. Mortality is higher in younger children. Blood culture remains gold standard for diagnosis. Widal test has low sensitivity and specificity but may be used in second week to support the diagnosis...
October 29, 2016: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/27765795/disseminated-infections-with-antibiotic-resistant-non-typhoidal-salmonella-strains-contributions-of-host-and-pathogen-factors
#6
Kristen L Lokken, Gregory T Walker, Renée M Tsolis
Non-typhoidal Salmonella enterica serovars (NTS) are generally associated with gastroenteritis; however, the very young and elderly, as well as individuals with compromised immunity, are at risk of developing disseminated infection that can manifest as bacteremia or focal infections at systemic sites. Disseminated NTS infections can be fatal and are responsible for over 600,000 deaths annually. Most of these deaths are in sub-Saharan Africa, where multi-drug resistant NTS clones are currently circulating in a population with a high proportion of individuals that are susceptible to disseminated disease...
October 8, 2016: Pathogens and Disease
https://www.readbyqxmd.com/read/27738915/history-of-antibiotics-research
#7
Kathrin I Mohr
For thousands of years people were delivered helplessly to various kinds of infections, which often reached epidemic proportions and have cost the lives of millions of people. This is precisely the age since mankind has been thinking of infectious diseases and the question of their causes. However, due to a lack of knowledge, the search for strategies to fight, heal, and prevent the spread of communicable diseases was unsuccessful for a long time. It was not until the discovery of the healing effects of (antibiotic producing) molds, the first microscopic observations of microorganisms in the seventeenth century, the refutation of the abiogenesis theory, and the dissolution of the question "What is the nature of infectious diseases?" that the first milestones within the history of antibiotics research were set...
October 15, 2016: Current Topics in Microbiology and Immunology
https://www.readbyqxmd.com/read/27730778/antibiotic-lock-therapy-in-the-era-of-gram-negative-resistance
#8
Rajeev Soman, Neha Gupta, Mitesh Suthar, Jatin Kothari, Alan Almeida, Anjali Shetty, Camilla Rodrigues
BACKGROUND: Central-line-associated blood-stream infection (CLABSI) is a highly consequential nosocomial infection. The most effective management includes the removal of the infected catheter. Retention of the catheter and antibiotic lock therapy (ALT) along with systemic antibiotics may be attempted only if there are unusual extenuating circumstances. CLABSIs due to Gram-negative bacteria (GNB) is more common in our setting and the organisms are often highly resistant. Hence, there is a need to explore the use of novel antimicrobials for catheter lock solutions along with antibiofilm agents...
February 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27673328/development-of-an-acid-resistant-salmonella-typhi-ty21a-attenuated-vector-for-improved-oral-vaccine-delivery
#9
Madushini N Dharmasena, Catherine M Feuille, Carly Elizabeth C Starke, Arvind A Bhagwat, Scott Stibitz, Dennis J Kopecko
The licensed oral, live-attenuated bacterial vaccine for typhoid fever, Salmonella enterica serovar Typhi strain Ty21a, has also been utilized as a vaccine delivery platform for expression of diverse foreign antigens that stimulate protection against shigellosis, anthrax, plague, or human papilloma virus. However, Ty21a is acid-labile and, for effective oral immunization, stomach acidity has to be either neutralized with buffer or by-passed with Ty21a in an enteric-coated capsule (ECC). Several studies have shown that efficacy is reduced when Ty21a is administered in an ECC versus as a buffered liquid formulation, the former limiting exposure to GI tract lymphoid tissues...
2016: PloS One
https://www.readbyqxmd.com/read/27668899/report-of-data-on-children-with-non-typhi-salmonella-gastroenteritis-in-a-three-year-period
#10
Öznur Küçük, Suat Biçer, Meltem Ugraş, Defne Çöl, Tuba Giray, Gülay Çiler Erdag, Yeşim Gürol, Gülden Yilmaz, Zerrin Yalvaç, Ayça Vitrinel, Çigdem Kaspar
The purpose of this study was to evaluate the clinical and laboratory data of children with acute gastroenteritis caused by non-typhoid Salmonella spp. infections. Clinical (demographic data, symptoms and findings) and laboratory data (stool microscopy, rapid antigen tests, culture, multiplex polymerase chain reaction and blood test results) of children with acute gastroenteritis caused by non-typhoid Salmonella spp. between January 2010 and October 2012 were evaluated. Differences between the groups for categorical variables were estimated with a chi-square or Fisher exact test; for continuous variables with two independent samples a t test was used...
September 1, 2016: Le Infezioni in Medicina
https://www.readbyqxmd.com/read/27602884/effects-of-antimicrobial-use-in-agricultural-animals-on-drug-resistant-foodborne-salmonellosis-in-humans-a-systematic-literature-review
#11
Kristi L Helke, M A McCrackin, Ashley M Galloway, Ann Z Poole, Cassandra D Salgado, Bernadette P Marriott
Controversy continues concerning antimicrobial use in food animals and its relationship to drug-resistant infections in humans. We systematically reviewed published literature for evidence of a relationship between antimicrobial use in agricultural animals and drug-resistant meat or dairy-borne non-typhoidal salmonellosis in humans. Based on publications from the United States (U.S.), Canada, and Denmark from January 2010 to July 2014, 858 articles received title and abstract review, 104 met study criteria for full article review with 68 retained for which data are presented...
September 7, 2016: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/27524545/extended-spectrum-beta-lactamase-producing-cephalosporin-resistant-salmonella-typhi-reported-from-rawalpindi-pakistan
#12
Tehmina Munir, Munir Lodhi, Jawad Khaliq Ansari, Saadia Andleeb, Mushtaq Ahmed
Typhoid is endemic in many parts of southeast Asia. Due to the resistance of the organism to first line of antibiotics (ampicillin, chloramphenicol, cotrimoxazole) as well as to fluoroquinolones, third generation cephalosporins have been in use for the empiric treatment of typhoid for years. However an increasing incidence of Salmonella Typhi is being reported sporadically from various regions. We report a case of typhoid due to Salmonella Typhi which was non-responsive to treatment with a cephalosporin, was found to be multidrug resistant and resistant to ciprofloxacin and third generation cephalosporin as well...
August 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27479027/advances-in-diagnosis-treatment-and-prevention-of-invasive-salmonella-infections
#13
Derek R MacFadden, Isaac I Bogoch, Jason R Andrews
PURPOSE OF REVIEW: Typhoidal and nontyphoidal Salmonella enterica serotypes are among the most common bacterial causes of acute febrile illnesses in the developing world. In this review, we discuss new advances in understanding of the burden, diagnostic approaches, treatment and vaccines for invasive Salmonella infections. RECENT FINDINGS: Recent estimates of the global burden of typhoidal and nontyphoidal Salmonella not only affirm the importance of these infections but also highlight the paucity of systematic incidence data from many regions...
October 2016: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/27448659/breast-abscess-due-to-salmonella-typhimurium-in-a-patient-with-rheumatoid-arthritis-a-case-report
#14
Irmak Baran, Neriman Aksu, Altan Aksoy
BACKGROUND: This is the first report of breast abscess due to Salmonella enterica serotype Typhimurium. Staphylococcus aureus is known as the most common cause of breast abscess. Salmonella spp. may occasionally form localized abscesses after dissemination to various organ systems following a bacteraemia. But breast abscess related to Salmonella spp is a very rare complication. CASE PRESENTATION: A 43-year-old female patient referred to our hospital with a lump, fever and mild pain in her breast...
2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27413069/salmonella-serogroup-c-current-status-of-vaccines-and-why-they-are-needed
#15
REVIEW
Fabien J Fuche, Ousmane Sow, Raphael Simon, Sharon M Tennant
Nontyphoidal Salmonella (NTS; i.e., Salmonella enterica organisms that do not cause typhoid or paratyphoid) are responsible for 94 million infections and 155,000 deaths worldwide annually, 86% of which are estimated to be foodborne. Although more than 50 serogroups and 2,600 serovars have been described, not all Salmonella serovars cause disease in humans and animals. Efforts are being made to develop NTS vaccines, with most approaches eliciting protection against serovars Typhimurium and Enteritidis (serogroups B [O:4] and D [O:9], respectively), as they are widely considered the most prevalent...
September 2016: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/27387824/salmonella-enterica-serovar-enteritidis-brain-abscess-mimicking-meningitis-after-surgery-for-glioblastoma-multiforme-a-case-report-and-review-of-the-literature
#16
Léa Luciani, Grégory Dubourg, Thomas Graillon, Estelle Honnorat, Hubert Lepidi, Michel Drancourt, Piseth Seng, Andreas Stein
BACKGROUND: Salmonella brain abscess associated with brain tumor is rare. Only 11 cases have been reported to date. Here we report a case of brain abscess caused by Salmonella enterica serovar Enteritidis mimicking post-surgical meningitis in a patient with glioblastoma multiforme. CASE PRESENTATION: A 60-year-old Algerian woman was admitted through an emergency department for a 4-day history of headache, nausea and vomiting, and behavioral disorders. Surgery for cerebral tumor excision was performed and histopathological analysis revealed glioblastoma multiforme...
2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27372155/plga-microencapsulation-protects-salmonella-typhi-outer-membrane-proteins-from-acidic-degradation-and-increases-their-mucosal-immunogenicity
#17
Juan Manuel Carreño, Christian Perez-Shibayama, Cristina Gil-Cruz, Andrea Printz, Rodolfo Pastelin, Armando Isibasi, Dominic Chariatte, Yutaka Tanoue, Constantino Lopez-Macias, Bruno Gander, Burkhard Ludewig
Salmonella (S.) enterica infections are an important global health problem with more than 20 million individuals suffering from enteric fever annually and more than 200,000 lethal cases per year. Although enteric fever can be treated appropriately with antibiotics, an increasing number of antibiotic resistant Salmonella strains is detected. While two vaccines against typhoid fever are currently on the market, their availability in subtropical endemic areas is limited because these products need to be kept in uninterrupted cold chains...
July 29, 2016: Vaccine
https://www.readbyqxmd.com/read/27357537/diverse-distribution-of-toxin-antitoxin-ii-systems-in-salmonella-enterica-serovars
#18
Andrea Di Cesare, Carmen Losasso, Lisa Barco, Ester M Eckert, Daniele Conficoni, Giulia Sarasini, Gianluca Corno, Antonia Ricci
Type II Toxin-Antitoxin systems (TAs), known for their presence in virulent and antibiotic resistant bacterial strains, were recently identified in Salmonella enterica isolates. However, the relationships between the presence of TAs (ccdAB and vapBC) and the epidemiological and genetic features of different non-typhoidal Salmonella serovars are largely unknown, reducing our understanding of the ecological success of different serovars. Salmonella enterica isolates from different sources, belonging to different serovars and epidemiologically unrelated according to ERIC profiles, were investigated for the presence of type II TAs, plasmid content, and antibiotic resistance...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27300440/emergence-and-serovar-profiling-of-non-typhoidal-salmonellae-nts-isolated-from-gastroenteritis-cases-a-study-from-south-india
#19
Mamatha Ballal, Suganthi Martena Devadas, Vignesh Shetty, Sohan Rodney Bangera, Thandavarayan Ramamurthy, Anirban Sarkar
Human infection with non-typhoidal Salmonella (NTS) serovars is often a neglected and undiagnosed infection in the developing world. Invasive NTS is now being established as having a new and emerging pathogenic role. There is not sufficient data on the prevalence of NTS serovars and their antibiotic susceptibility pattern from India. Faecal specimens collected from patients with acute gastroenteritis were processed to isolate Salmonella according to the standard protocol for a period from January 2011-December 2014...
November 2016: Infectious Diseases
https://www.readbyqxmd.com/read/27296619/evaluation-of-flic-d-based-direct-blood-pcr-assays-for-typhoid-diagnosis
#20
Surojit Das, Ujjwayini Ray, Irfaan Akhter, Arka Chattopadhyay, Dilip Kumar Paul, Shanta Dutta
BACKGROUND: Typhoid cases need to be diagnosed accurately for early antibiotic therapy and reducing mortality. Identification of Salmonella Typhi (S. Typhi) in blood culture is conclusive, but has poor sensitivity. Detection of S. Typhi by PCR from blood sample has shown promise. Real-time quantitative PCR (Q-PCR) has been widely used in diagnostics for its rapidity and reliability. In the present study, the performance of molecular methods like conventional PCR (C-PCR), nested PCR (N-PCR) and Q-PCR were investigated and compared by targeting S...
2016: BMC Microbiology
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