Corrado Campochiaro, Yossra A Suliman, Michael Hughes, Jan W Schoones, Dilia Giuggioli, Pia Moinzadeh, Murray Baron, Lorinda Chung, Laura Ross, Nancy Maltez, Yannick Allanore, Christopher P Denton, Oliver Distler, Tracy Frech, Daniel E Furst, Dinesh Khanna, Thomas Krieg, Masataka Kuwana, Marco Matucci-Cerinic, Janet Pope, Alessia Alunno
INTRODUCTION: Digital ulcers (DUs) are difficult to treat in patients with systemic sclerosis (SSc) and systemic (i.e., pharmacological) therapy is currently considered the 'standard of care'. Our aim was to examine the safety and efficacy of local, non-surgical treatment for SSc-DUs. METHODS: A systematic literature review (SLR) of original research articles up to August, 29 2022 was performed according to the PICO framework. References were independently screened by two reviewers and risk of bias was assed using validated tools...
December 2023: Seminars in Arthritis and Rheumatism