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Angiopoetin

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https://www.readbyqxmd.com/read/27648638/lysophosphatidic-acids-and-autotaxin-in-retinal-vein-occlusion
#1
Ivanka Dacheva, Christoph Ullmer, Karolina Ceglowska, Everson Nogoceke, Guido Hartmann, Stephan Müller, Robert Rejdak, Katarzyna Nowomiejska, Michael Reich, Matthias Nobl, Tamer Tandogan, Florian T A Kretz, Gerd U Auffarth, Michael J Koss
PURPOSE: To analyze the levels of lysophosphatidic acids (LPAs) and autotaxin (ATX) in undiluted vitreous of untreated patients with retinal vein occlusion (RVO). METHODS: Sixty-four vitreous samples (40 RVO, 24 controls with idiopathic floaters) were analyzed in this retrospective case series using LC/MS for LPAs 16:0, 18:0, 18:1, 20:4, and ELISA kits or Luminex technology for ATX, angiopoetin-1 (ANG-1), interleukin-6 (IL-6), interleukin-7 (IL-7), interleukin-8 (IL-8), monocyte chemoattractant protein-1 (MCP-1), pigment epithelium-derived factor (PEDF), and vascular endothelial growth factor (VEGF)...
December 2016: Retina
https://www.readbyqxmd.com/read/27617571/expression-of-serum-vascular-endothelial-growth-factor-and-angiopoietin-receptor-tie-2-in-essential-hypertension
#2
A K Filiz, E Ozdemir, H Gunes, H Gunes, M B Yılmaz
Objective: Hypertension is a common but incompletely understood disease. Emerging evidence supports a novel view of hypertension as a disease of inadequate or aberrant responses to angiogenic factors. In the present study we aimed to investigate the serum levels of vascular endothelial growth factor (VEGF), an angiogenic factor and soluble angiopoetin receptor Tie-2 (sTie-2) in patient with essential hypertension. Methods: In the present study 90 individuals (mean age 48 ± 7 years, 56 males and 34 females) have been divided in to three groups as 30 patients with hypertension, 30 healthy individuals (with a family history of hypertension) and 30 healthy individuals (no family history of hypertension)...
December 18, 2015: West Indian Medical Journal
https://www.readbyqxmd.com/read/27617438/angiopoetin-2-signals-do-not-mediate-the-hypervascularization-of-islets-in-type-2-diabetes
#3
Payal Shah, Navina Lueschen, Amin Ardestani, Jose Oberholzer, Johan Olerud, Per-Ola Carlsson, Kathrin Maedler
AIMS: Changes in the islet vasculature have been implicated in the regulation of β-cell survival and function during the progression to type 2 diabetes (T2D). Failure of the β-cell to compensate for the increased insulin demand in obesity eventually leads to diabetes; as a result of the complex interplay of genetic and environmental factors (e.g. ongoing inflammation within the islets) and impaired vascular function. The Angiopoietin/Tie (Ang/Tie) angiogenic system maintains vasculature and is closely related to organ inflammation and angiogenesis...
2016: PloS One
https://www.readbyqxmd.com/read/26638794/vascular-endothelium-and-hypovolemic-shock
#4
Anil Gulati
Endothelium is a site of metabolic activity and has a major reservoir of multipotent stem cells. It plays a vital role in the vascular physiological, pathophysiological and reparative processes. Endothelial functions are significantly altered following hypovolemic shock due to ischemia of the endothelial cells and by reperfusion due to resuscitation with fluids. Activation of endothelial cells leads to release of vasoactive substances (nitric oxide, endothelin, platelet activating factor, prostacyclin, mitochondrial N-formyl peptide), mediators of inflammation (tumor necrosis factor α, interleukins, interferons) and thrombosis...
2016: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/26519876/human-breast-cancer-cell-death-induced-by-bnsp-6-a-lys-49-pla%C3%A2-homologue-from-bothrops-pauloensis-venom
#5
Fernanda Van Petten Vasconcelos Azevedo, Daiana Silva Lopes, Sarah Natalie Cirilo Gimenes, David Collares Achê, Lara Vecchi, Patrícia Terra Alves, Denise de Oliveira Guimarães, Renata Santos Rodrigues, Luiz Ricardo Goulart, Veridiana de Melo Rodrigues, Kelly Aparecida Geraldo Yoneyama
This work shows the antitumoral effects of BnSP-6, a Lys 49 PLA2 isolated from Bothrops pauloensis venom, on human breast cancer MDA-MB-231 cells. BnSP-6 caused a dose-dependent cytotoxicity and inhibited cell adhesion. Interestingly, cytotoxic activity of BnSP-6 was significantly lower against MCF10A, a non-tumorigenic breast cell line, suggesting that this PLA2 presented a possible preference for targets in cancer cells. Analysis of cell death on MDA-MB-231 cells showed that BnSP-6 stimulated the autophagy process, as evidenced by labeling of autophagic vacuoles...
January 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/26477824/mir-92a-regulates-angiogenic-activity-of-adipose-derived-mesenchymal-stromal-cells
#6
Natalia Kalinina, Galina Klink, Eugeniy Glukhanyuk, Tatiana Lopatina, Anastassia Efimenko, Zhanna Akopyan, Vsevolod Tkachuk
Mesenchymal stromal cells including those from adipose tissue (MSCs) regulate angiogenesis in adult tissues. MicroRNAs (miRs), small noncoding RNAs that control gene expression by binding to target mRNAs, reducing their stability and/or inhibiting translation, appear to be important regulators of blood vessel growth. In this study, we examined the impact of angio-miRs on paracrine activities of MSCs. Using Illumina microarrays we found that miR-92a is one of the most abundant angio-miRs in human MSCs. We transfected MSC with pre-miR-92a or anti-miR-92a which led to the coordinated changes of known miR-92a target mRNA levels...
November 15, 2015: Experimental Cell Research
https://www.readbyqxmd.com/read/25982018/effect-of-different-enamel-matrix-derivative-proteins-on-behavior-and-differentiation-of-endothelial-cells
#7
Oleh Andrukhov, Anja C Gemperli, Yan Tang, Nadia Howald, Michel Dard, Frank Falkensammer, Andreas Moritz, Xiaohui Rausch-Fan
OBJECTIVES: Enamel matrix derivative (EMD) is an effective biomaterial for periodontal tissue regeneration and might stimulate angiogenesis. In order to clarify mechanisms underlying its biological activity, we separated two EMD fractions with different molecular weight protein components and investigated their effects on human umbilical vein endothelial cells (HUVECs) in vitro. METHODS: Fraction Low-Molecular Weight (LMW) included proteins with a molecular weight (M...
July 2015: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/25909285/foretinib-inhibits-angiogenesis-lymphangiogenesis-and-tumor-growth-of-pancreatic-cancer-in-vivo-by-decreasing-vegfr-2-3-and-tie-2-signaling
#8
Hsiu-Mei Chen, Chia-Hua Tsai, Wen-Chun Hung
Foretinib, a multiple kinase inhibitor undergoing clinical trials, could suppress the activity of hepatocyte growth factor (HGF) receptor c-MET and vascular endothelial growth factor receptor-2 (VEGFR-2). In addition, Foretinib may inhibit two critical lymphangiogenic signaling receptors VEGFR-3 and TIE-2. However, the effect of Foretinib on lymphatic endothelial cells (LECs) in vitro and lymphangiogenesis in vivo is still unknown. We found Foretinib decreased basal- and HGF-induced c-MET activity at low concentrations...
June 20, 2015: Oncotarget
https://www.readbyqxmd.com/read/25562438/dual-targeting-of-angiopoetin-2-and-vegf-potentiates-effective-vascular-normalisation-without-inducing-empty-basement-membrane-sleeves-in-xenograft-tumours
#9
O Coutelle, L M Schiffmann, M Liwschitz, M Brunold, V Goede, M Hallek, H Kashkar, U T Hacker
BACKGROUND: Effective vascular normalisation following vascular endothelial growth factor (VEGF) inhibition is associated with endothelial cell regression leaving empty basement membrane sleeves (BMS). These long-lived BMS permit the rapid regrowth of tumour vasculature upon treatment cessation and promote resistance to VEGF-targeting drugs. Previous attempts at removing BMS have failed. Angiopoietin-2 (Ang2) is a vascular destabilizing factor that antagonises normalisation. We hypothesised that Ang2 inhibition could permit vascular normalisation at significantly reduced doses of VEGF inhibition, avoiding excessive vessel regression and the formation of empty BMS...
February 3, 2015: British Journal of Cancer
https://www.readbyqxmd.com/read/25172169/impaired-cerebral-angiogenesis-in-the-fetal-lamb-model-of-persistent-pulmonary-hypertension
#10
Susan S Cohen, Bethany R Powers, Alexandra Lerch-Gaggl, Ru-Jeng Teng, Girija Ganesh Konduri
BACKGROUND: Persistent pulmonary hypertension of the newborn (PPHN) is associated with increased risk of neuro-developmental impairments. Whether relative fetal hypoxia during evolution of PPHN renders the fetal brain vulnerable to perinatal brain injury remains unclear. We hypothesized that in utero ductal constriction, which induces PPHN also impairs cerebral angiogenesis. METHODS: Fetal lambs with PPHN induced by prenatal ligation of the ductus arteriosus were compared to gestation matched twin controls...
November 2014: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/25159192/vasculotide-an-angiopoietin-1-mimetic-reduces-acute-skin-ionizing-radiation-damage-in-a-preclinical-mouse-model
#11
Elina Korpela, Darren Yohan, Lee Cl Chin, Anthony Kim, Xiaoyong Huang, Shachar Sade, Paul Van Slyke, Daniel J Dumont, Stanley K Liu
BACKGROUND: Most cancer patients are treated with radiotherapy, but the treatment can also damage the surrounding normal tissue. Acute skin damage from cancer radiotherapy diminishes patients' quality of life, yet effective biological interventions for this damage are lacking. Protecting microvascular endothelial cells from irradiation-induced perturbations is emerging as a targeted damage-reduction strategy. Since Angiopoetin-1 signaling through the Tie2 receptor on endothelial cells opposes microvascular perturbations in other disease contexts, we used a preclinical Angiopoietin-1 mimic called Vasculotide to investigate its effect on skin radiation toxicity using a preclinical model...
2014: BMC Cancer
https://www.readbyqxmd.com/read/24857153/for-the-next-trick-new-discoveries-in-radiobiology-applied-to-glioblastoma
#12
REVIEW
Juergen Debus, Amir Abdollahi
Glioblastoma (GBM) is the most common malignant brain tumor. Radiotherapy post surgical resection remained the mainstay of the management of GBM for decades until the addition of temozolomide was shown to prolong the median overall survival (OS) by 2.5 months to 14.6 months in 2005. Infiltrative growth to surrounding normal brain tissue and cooption of vascular niches, peripheral microvasuclar hyperplasia, and central hypoxic regions with pseudopalisading necrosis are characteristics of GBM and are causally linked to their exceptional radio- and chemo-resistant phenotype...
2014: American Society of Clinical Oncology Educational Book
https://www.readbyqxmd.com/read/24836679/angiogenic-factors-as-potential-drug-target-efficacy-and-limitations-of-anti-angiogenic-therapy
#13
REVIEW
Rajesh N Gacche, Rohan J Meshram
Formation of new blood vessels (angiogenesis) has been demonstrated to be a basic prerequisite for sustainable growth and proliferation of tumor. Several growth factors, cytokines, small peptides and enzymes support tumor growth either independently or in synergy. Decoding the crucial mechanisms of angiogenesis in physiological and pathological state has remained a subject of intense interest during the past three decades. Currently, the most widely preferred approach for arresting tumor angiogenesis is the blockade of vascular endothelial growth factor (VEGF) pathway; however, the clinical usage of this modality is still limited by several factors such as adverse effects, toxicity, acquired drug resistance, and non-availability of valid biomarkers...
August 2014: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/24807599/minimally-invasive-colorectal-resection-for-benign-pathology-is-associated-with-persistent-proangiogenic-plasma-compositional-changes
#14
H M C Shantha Kumara, Elizabeth A Myers, Sonali A C Herath, Linda Njoh, Xiaohong Yan, Daniel Kirchoff, Nadav Dujovny, Richard L Whelan
BACKGROUND: Minimally invasive colorectal resection for cancer is associated with increased plasma levels of numerous proangiogenic proteins for 3 to 4 weeks postoperatively, and plasma from postoperative weeks 2 and 3 stimulates proangiogenic endothelial cell behavior in vitro. It is unknown if similar plasma changes occur after minimally invasive colorectal resection for benign pathology. OBJECTIVE: The aim of this study is to assess 1) plasma levels of angiopoetin-2, placental growth factor, and soluble vascular cell adhesion molecule-1 after minimally invasive colorectal resection for benign pathology and 2) postoperative plasma's effects on in vitro endothelial cell proliferation (branch point formation), migration, and invasion...
June 2014: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/24353175/adipose-derived-mesenchymal-stromal-cells-from-aged-patients-with-coronary-artery-disease-keep-mesenchymal-stromal-cell-properties-but-exhibit-characteristics-of-aging-and-have-impaired-angiogenic-potential
#15
Anastasia Efimenko, Nina Dzhoyashvili, Natalia Kalinina, Tatiana Kochegura, Renat Akchurin, Vsevolod Tkachuk, Yelena Parfyonova
Tissue regeneration is impaired in aged individuals. Adipose-derived mesenchymal stromal cells (ADSCs), a promising source for cell therapy, were shown to secrete various angiogenic factors and improve vascularization of ischemic tissues. We analyzed how patient age affected the angiogenic properties of ADSCs. ADSCs were isolated from subcutaneous fat tissue of patients with coronary artery disease (CAD; n = 64, 43-77 years old) and without CAD (n = 31, 2-82 years old). ADSC phenotype characterized by flow cytometry was CD90(+)/CD73(+)/CD105(+)/CD45(-)/CD31(-) for all samples, and these cells were capable of adipogenic and osteogenic differentiation...
January 2014: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/24048963/persistent-endothelial-activation-and-inflammation-after-plasmodium-falciparum-infection-in-malawian-children
#16
Christopher A Moxon, Ngawina V Chisala, Samuel C Wassmer, Terrie E Taylor, Karl B Seydel, Malcolm E Molyneux, Brian Faragher, Neil Kennedy, Cheng-Hock Toh, Alister G Craig, Robert S Heyderman
Endothelial dysregulation is central to the pathogenesis of acute Plasmodium falciparum infection. It has been assumed that this dysregulation resolves rapidly after treatment, but this return to normality has been neither demonstrated nor quantified. We therefore measured a panel of plasma endothelial markers acutely and in convalescence in Malawian children with uncomplicated or cerebral malaria. Evidence of persistent endothelial activation and inflammation, indicated by increased plasma levels of soluble intracellular adhesion molecule 1, angiopoetin 2, and C-reactive protein, were observed at 1 month follow-up visits...
February 15, 2014: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/23984546/-the-concentration-of-growth-factors-in-patients-with-inherent-and-acquired-shortenings-of-limbs-bones
#17
M V Strogov, S N Luneva, K I Novikov
The article deals with the results of study of level of growth factors in blood serum of patients with inherent and post-traumatic shortenings of limbs' bones. The detection in blood serum the level of epidermal growth factor insulin-like growth factor I and angiopoetins is proposed to monitor in given patients the reparative bone formation.
April 2013: Klinicheskaia Laboratornaia Diagnostika
https://www.readbyqxmd.com/read/23742074/transplantation-of-modified-human-adipose-derived-stromal-cells-expressing-vegf165-results-in-more-efficient-angiogenic-response-in-ischemic-skeletal-muscle
#18
Evgeny K Shevchenko, Pavel I Makarevich, Zoya I Tsokolaeva, Maria A Boldyreva, Veronika Yu Sysoeva, Vsevolod A Tkachuk, Yelena V Parfyonova
BACKGROUND: Modified cell-based angiogenic therapy has become a promising novel strategy for ischemic heart and limb diseases. Most studies focused on myoblast, endothelial cell progenitors or bone marrow mesenchymal stromal cells transplantation. Yet adipose-derived stromal cells (in contrast to bone marrow) are abundantly available and can be easily harvested during surgery or liposuction. Due to high paracrine activity and availability ADSCs appear to be a preferable cell type for cardiovascular therapy...
2013: Journal of Translational Medicine
https://www.readbyqxmd.com/read/23660186/platelet-rich-plasma-extract-promotes-angiogenesis-through-the-angiopoietin1-tie2-pathway
#19
Tadanori Mammoto, Amanda Jiang, Elisabeth Jiang, Akiko Mammoto
Development and regeneration of tissues and organs require precise coordination among endothelial, epithelial and mesenchymal morphogenesis. Angiogenesis plays key roles in normal development, wound healing, recovery from ischemic disease, and organ regeneration. It has been recognized that the combination of various angiogenic factors in an appropriate physiological ratio is critical for long-term functional blood vessel formation. Here we show that mouse soluble platelet-rich-plasma (PRP) extract, which includes abundant angiopoetin-1 (Ang1) and other angiogenic factors, stimulates endothelial cell growth, migration and differentiation in cultured human dermal microvascular endothelial cells in vitro and neonatal mouse retinal angiogenesis in vivo...
September 2013: Microvascular Research
https://www.readbyqxmd.com/read/23371031/suppression-of-the-proliferation-of-human-u-87-mg-glioblastoma-cells-by-new-antagonists-of-growth-hormone-releasing-hormone-in-vivo-and-in-vitro
#20
Miklos Jaszberenyi, Andrew V Schally, Norman L Block, Marta Zarandi, Ren-Zhi Cai, Irving Vidaurre, Luca Szalontay, Arumugam R Jayakumar, Ferenc G Rick
Five-year survival of patients afflicted with glioblastoma multiforme (GBM) is rare, making this cancer one of the most feared malignancies. Previously, we reported that growth hormone-releasing hormone (GHRH) is a potent growth factor in cancers. The present work evaluated the effects of two antagonistic analogs of GHRH (MIA-604 and MIA-690) on the proliferation of U-87 MG GBM tumors, in vivo as well as in vitro. Both analogs were administered subcutaneously and dose-dependently inhibited the growth of tumors transplanted into nude mice (127 animals in seven groups)...
December 2013: Targeted Oncology
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