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https://www.readbyqxmd.com/read/28912263/hemodynamic-phenotyping-of-pulmonary-hypertension-in-left-heart-failure
#1
REVIEW
Robert Naeije, Mario Gerges, Jean-Luc Vachiery, Sergio Caravita, Christian Gerges, Irene M Lang
Increased pulmonary venous pressure secondary to left heart disease is the most common cause of pulmonary hypertension (PH). The diagnosis of PH due to left heart disease relies on a clinical probability assessment followed by the invasive measurements of a mean pulmonary artery pressure (PAP) ≥25 mm Hg and mean wedged PAP (PAWP) >15 mm Hg. A combination of mean PAP and mean PAWP defines postcapillary PH. Postcapillary PH is generally associated with a diastolic pulmonary pressure gradient (diastolic PAP minus mean PAWP) <7 mm Hg, a transpulmonary pressure gradient (mean PAP minus mean PAWP) <12 mm Hg, and pulmonary vascular resistance ≤3 Wood units (WU)...
September 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28911059/forcing-the-vicious-circle-sarcopenia-increases-toxicity-decreases-response-to-chemotherapy-and-worsens-with-chemotherapy
#2
F Bozzetti
Sarcopenia has recently emerged as a new condition that, independently from malnutrition, may adversely affect the prognosis of cancer patients. Purpose of this narrative review is to define the prevalence of sarcopenia in different primaries, its role in leading to chemotherapy toxicity and decreased compliance with the oncological therapy and the effect of some drugs on the onset of sarcopenia. Finally, the review aims to describe the current approaches to restore the muscle mass through nutrition, exercise and anti-inflammatory agents or multimodal programmes with a special emphasis on the results of randomized controlled trials...
September 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28902639/the-role-of-specialized-prevention-clinics-for-the-short-term-follow-up-of-acute-coronary-syndromes
#3
Salih Kılıç, Evrim Şimşek, Hatice Soner Kemal, Elif İlkay Yüce, Cüneyt Türkoğlu, Meral Kayıkçıoğlu
OBJECTIVE: This study aimed to investigate the effect of specialized prevention clinics and standard clinics follow-ups on secondary protection after acute coronary syndrome (ACS) on cardiovascular risk factors. METHODS: A total of 118 patients who received thrombolytic therapy after being diagnosed with ST-segment elevation myocardial infarction were followed up for 6 months. After ACS, patients in a specialized prevention clinic (Group 1) (n=67) and those in a standard clinic (Group 2) (n=51) were compared in terms of the change in their lifestyle, management of risk factors, and drug compliance...
September 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28898708/cue-exposure-therapy-reduces-overeating-of-exposed-and-non-exposed-foods-in-obese-adolescents
#4
Ghislaine Schyns, Anne Roefs, Fren T Y Smulders, Anita Jansen
BACKGROUND AND OBJECTIVES: This study tested whether two sessions of food cue exposure therapy reduced eating in the absence of hunger (EAH), specified for exposed and non-exposed food, in overweight and obese adolescents, and whether habituation of food cue reactivity and reduced CS-US expectancies predicted a decrease in EAH. METHODS: 41 overweight adolescents (aged 12-18 years) were randomly assigned to a cue exposure intervention or a lifestyle intervention (control condition)...
September 5, 2017: Journal of Behavior Therapy and Experimental Psychiatry
https://www.readbyqxmd.com/read/28893857/changes-in-dynamic-lung-mechanics-after-lung-volume-reduction-coil-treatment-of-severe-emphysema
#5
Demosthenes Makris, Sylvie Leroy, Johana Pradelli, Jonathan Benzaquen, Hervé Guenard, Jeanne-Marie Perotin, Spyros Zakynthinos, Epaminondas Zakynthinos, Gaëtan Deslee, Charles Hugo Marquette
We assessed the relationships between changes in lung compliance, lung volumes and dynamic hyperinflation in patients with emphysema who underwent bronchoscopic treatment with nitinol coils (coil treatment) (n=11) or received usual care (UC) (n=11). Compared with UC, coil treatment resulted in decreased dynamic lung compliance (CLdyn) (p=0.03) and increased endurance time (p=0.010). The change in CLdyn was associated with significant improvement in FEV1 and FVC, with reduction in residual volume and intrinsic positive end-expiratory pressure, and with increased inspiratory capacity at rest/and at exercise...
September 11, 2017: Thorax
https://www.readbyqxmd.com/read/28891198/targeted-medical-nutrition-for-cachexia-in-chronic-obstructive-pulmonary-disease-a-randomized-controlled-trial
#6
Philip C Calder, Alessandro Laviano, Fredrik Lonnqvist, Maurizio Muscaritoli, Maria Öhlander, Annemie Schols
BACKGROUND: Cachectic patients with chronic obstructive pulmonary disease (COPD) may benefit from nutritional support. This double-blind, randomized, controlled trial evaluated the safety and efficacy of targeted medical nutrition (TMN) vs. an isocaloric comparator in pre-cachectic and cachectic patients with COPD. METHODS: Patients aged ≥50 years with moderate-to-severe COPD and involuntary weight loss or low body mass index (16-18 kg/m(2) ) were randomized 1:1 to receive TMN (~230 kcal; 2 g omega-3 fatty acids; 10 μg 25-hydroxy-vitamin D3) or isocaloric comparator twice daily for 12 weeks (ClinicalTrials...
September 10, 2017: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/28887652/disruption-of-adenylyl-cyclase-type-5-mimics-exercise-training
#7
John J Guers, Jie Zhang, Sara C Campbell, Marko Oydanich, Dorothy E Vatner, Stephen F Vatner
Exercise training is key to healthful longevity. Since exercise training compliance is difficult, it would be useful to have a therapeutic substitute that mimicked exercise training. We compared the effects of exercise training in wild-type (WT) littermates with adenylyl cyclase type 5 knock out (AC5 KO) mice, a model of enhanced exercise performance. Exercise performance, measured by maximal distance and work to exhaustion, was increased in exercise-trained WT to levels already attained in untrained AC5 KO...
September 8, 2017: Basic Research in Cardiology
https://www.readbyqxmd.com/read/28883892/impact-of-post-meal-and-one-time-daily-exercise-in-patient-with-type-2-diabetes-mellitus-a-randomized-crossover-study
#8
Daizy Pahra, Nitasha Sharma, Sandhya Ghai, Abhishek Hajela, Shobhit Bhansali, Anil Bhansali
BACKGROUND: To evaluate the effectiveness of short-timed post-meal and one-time daily exercise on glycemic control in patients with T2DM. METHODS: Sixty-four T2DM patients were randomised into crossover design. Group A (n = 32) underwent post-meal exercise (moderate-intensity brisk walking covering 1500-1600 steps for 15 min, starting 15 min after each meal) from d1 to d60 followed by one-time daily exercise (45 min pre-breakfast brisk walking at stretch covering 4500-4800 steps) from d61 to d120, while it was vice versa for the group B (n = 32)...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28883731/antipsychotic-associated-weight-gain-management-strategies-and-impact-on-treatment-adherence
#9
REVIEW
Madhubhashinee Dayabandara, Raveen Hanwella, Suhashini Ratnatunga, Sudarshi Seneviratne, Chathurie Suraweera, Varuni A de Silva
Antipsychotic-induced weight gain is a major management problem for clinicians. It has been shown that weight gain and obesity lead to increased cardiovascular and cerebrovascular morbidity and mortality, reduced quality of life and poor drug compliance. This narrative review discusses the propensity of various antipsychotics to cause weight gain, the pharmacologic and nonpharmacologic interventions available to counteract this effect and its impact on adherence. Most antipsychotics cause weight gain. The risk appears to be highest with olanzapine and clozapine...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28883720/effect-of-a-rehabilitation-based-chronic-disease-management-program-targeting-severe-copd-exacerbations-on-readmission-patterns
#10
C Lalmolda, R Coll-Fernández, N Martínez, M Baré, M Teixidó Colet, F Epelde, E Monsó
BACKGROUND: Pulmonary rehabilitation (PR) is recommended after a severe COPD exacerbation, but its short- and long-term effects on health care utilization have not been fully established. AIMS: The aims of this study were to evaluate patient compliance with a chronic disease management (CDM) program incorporating home-based exercise training as the main component after a severe COPD exacerbation and to determine its effects on health care utilization in the following year...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28883713/patients-knowledge-of-heart-failure-and-their-perception-of-the-disease
#11
Anna Płotka, Edyta Prokop, Jacek Migaj, Ewa Straburzyńska-Migaj, Stefan Grajek
PURPOSE: The aim of this study was to gain a deeper insight into patients' perception of chronic heart failure (CHF) symptoms by analyzing their compliance with nonpharmacological recommendations. PATIENTS AND METHODS: This was a prospective, single-center survey-based registry. Patients included in this study were hospitalized between December 2014 and January 2016 at the 1(st) Department of Cardiology, University Hospital of Lord's Transfiguration, Poznań University of Medical Sciences, and had been diagnosed with CHF at least 3 months prior to inclusion...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28872765/digital-therapy-in-diabetes
#12
REVIEW
Avivit Cahn, Amit Akirov, Itamar Raz
Diabetes care is largely dependent on patient self-management and empowerment, given that patients with diabetes must make numerous daily decisions of what to eat, when to exercise, and determine their insulin dose and timing if required. Additionally, patients and providers are generating vast amounts of data from many sources including electronic medical records, insulin pumps, sensors, glucometers, other wearables, as well as evolving genomic, proteomic, metabolomic and microbiomic data. Multiple digital tools and apps have been developed to assist patients to choose wisely, as well as enhance their compliance by employing motivational tools and incorporating incentives from social media and gaming techniques...
September 5, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28870836/the-patient-s-experience-with-non-surgical-treatment-for-lumbar-spinal-stenosis-a-qualitative-study
#13
Allyn M Bove, Andrew D Lynch, Carlo Ammendolia, Michael Schneider
BACKGROUND CONTEXT: Lumbar spinal stenosis (LSS) is a highly prevalent disease in older adults that causes significant limitations in walking and other daily activities. There is a lack of research into optimal nonsurgical treatment approaches for LSS. PURPOSE: The purpose of this qualitative study is to assess the opinions of participants in a randomized clinical trial of non-surgical LSS treatments regarding the interventions they received, factors contributing to adherence to the interventions, and methods of outcomes assessment...
September 1, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28866598/a-magnetic-plethysmograph-probe-for-local-pulse-wave-velocity-measurement
#14
Nabeel P M, Jayaraj Joseph, Mohanasankar Sivaprakasam
OBJECTIVE: We present the design and experimental validation of an arterial compliance probe with dual magnetic plethysmograph (MPG) transducers for local pulse wave velocity (PWV) measurement. The MPG transducers (positioned at 23 mm distance apart) utilizes Hall-effect sensors and permanent magnets for arterial blood pulse detection. METHODS: The MPG probe was initially validated on an arterial flow phantom using a reference method. Further, 20 normotensive subjects (14 males, age = 24 ± 3...
August 29, 2017: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28860417/exercise-for-osteoporosis-how-to-navigate-between-overeagerness-and-defeatism
#15
A Ireland, J J Rittweger
Osteoporosis and associated fractures remain a common and costly health problem. Public fears about rare side effects of efficacious drug treatments for osteoporosis have contributed to decreased prescription and compliance. Exercise and physical activity-based interventions have long been proposed as an alternative treatment for osteoporosis. However despite compelling evidence from experimental studies in animals and from observational studies in humans, the use of exercise to improve bone mass in clinical practice does not seem to be justifiable by current human interventional studies...
September 1, 2017: Journal of Musculoskeletal & Neuronal Interactions
https://www.readbyqxmd.com/read/28857336/aerobic-exercise-training-does-not-alter-vascular-structure-and-function-in-chronic-obstructive-pulmonary-disease
#16
Jinelle C Gelinas, Nia C Lewis, Megan I Harper, Bernie Melzer, Gloria Agar, J Douglass Rolf, Neil D Eves
Chronic obstructive pulmonary disease (COPD) has been associated with endothelial dysfunction and arterial stiffening, which are predictive of future cardiovascular events. While aerobic exercise improves vascular function in healthy individuals and those with chronic disease, it is unknown if aerobic exercise can positively modify the vasculature in COPD. We examined the effects of 8-weeks of periodised aerobic training on vascular structure and function and inflammation in 24 patients with COPD (age = 69 ± 7 yrs, FEV1 %pred = 68 ± 19%) and 20 matched controls (age = 64 ± 5 yrs, FEV1 %pred = 113 ± 16%) for comparison...
August 31, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28852492/high-density-lipoprotein-particle-pattern-and-overall-lipid-responses-to-a-short-term-moderate-intensity-aerobic-exercise-training-intervention-in-patients-with-chronic-kidney-disease
#17
Emily M Miele, Samuel A E Headley, Michael Germain, Jyovani Joubert, Sarah Herrick, Charles Milch, Elizabeth Evans, Allen Cornelius, Britton Brewer, Beth Taylor, Richard J Wood
BACKGROUND: Chronic kidney disease (CKD) is associated with abnormal lipid profiles and altered high-density lipoprotein (HDL) particle size patterns. Lower levels of the larger, cardioprotective HDL particles found in CKD may play a role in the increased risk for cardiovascular disease in these patients. The current study was designed to assess the effects of short-term moderate-intensity aerobic exercise training on the HDL particle pattern and overall lipid profiles in stage 3 CKD patients...
August 2017: Clinical Kidney Journal
https://www.readbyqxmd.com/read/28836315/inotropic-myocardial-reserve-deficiency-is-the-predominant-feature-of-exercise-haemodynamics-in-cardiac-amyloidosis
#18
Tor Skibsted Clemmensen, Henning Mølgaard, Jens Sörensen, Hans Eiskjaer, Niels Frost Andersen, Søren Mellemkjaer, Mads Jønsson Andersen, Lars Poulsen Tolbod, Hendrik J Harms, Steen Hvitfeldt Poulsen
AIMS: This study aimed to characterize invasive haemodynamics during exercise in subjects with cardiac amyloidosis (CA). METHODS AND RESULTS: The study population numbered 44 subjects. Group A (CA-positive, n = 24) comprised wild-type transthyretin patients (n = 10), familial transthyretin amyloidosis mutation carriers (ATTRm) with cardiac involvement (n = 5), and light-chain amyloidosis patients with cardiac involvement (n = 9). Group B (CA-negative, n = 20) comprised four healthy ATTRm subjects without cardiac involvement documented by (11) C-PIB positron emission tomography and 16 healthy controls...
August 24, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28833495/decreases-in-left-atrial-compliance-during-early-stage-exercise-are-related-to-exercise-intolerance-in-asymptomatic-significant-mitral-stenosis
#19
Mi-Hyang Jung, Hae Ok Jung, Jung-Won Lee, Ho-Joong Youn
BACKGROUND: Doppler-driven net atrioventricular compliance (Cn ), which represents left atrial (LA) compliance, is an important determinant of pulmonary hypertension in mitral stenosis (MS). HYPOTHESIS: We hypothesized that decreases in Cn during early-stage exercise underlie exercise intolerance in patients with MS. METHODS: Thirty-three asymptomatic patients with significant MS (valve area 1.24 ± 0.16 cm(2) ) underwent resting and bicycle exercise echocardiography...
August 22, 2017: Echocardiography
https://www.readbyqxmd.com/read/28830876/mobile-phone-messaging-delivering-encouragement-reminders-and-education-increases-patient-compliance-with-recommended-exercise-and-results-in-positive-short-term-health-behaviours
#20
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