keyword
https://read.qxmd.com/read/38508915/mavacamten-a-novel-agent-for-hypertrophic-cardiomyopathy
#21
REVIEW
J Chase Cole, Samantha F Benvie, Marci DeLosSantos
PURPOSE: Hypertrophic cardiomyopathy (HCM) is an under-recognized genetic cardiac disorder affecting the muscles and contractility of the heart, which in turn can result in heart failure symptoms, arrhythmia, and sudden cardiac death. Previously, pharmacotherapy options for HCM were not disease-specific, often poorly tolerated, and overall inadequate for optimal management. This narrative review discusses the pharmacology of the novel drug mavacamten, the clinical trials supporting its use, and considerations for its use in clinical practice...
March 19, 2024: Clinical Therapeutics
https://read.qxmd.com/read/38508342/musculoskeletal-crosstalk-in-chronic-obstructive-pulmonary-disease-and-comorbidities-emerging-roles-and-therapeutic-potentials
#22
REVIEW
Kevin Mou, Stanley M H Chan, Ross Vlahos
Chronic Obstructive Pulmonary Disease (COPD) is a multifaceted respiratory disorder characterized by progressive airflow limitation and systemic implications. It has become increasingly apparent that COPD exerts its influence far beyond the respiratory system, extending its impact to various organ systems. Among these, the musculoskeletal system emerges as a central player in both the pathogenesis and management of COPD and its associated comorbidities. Muscle dysfunction and osteoporosis are prevalent musculoskeletal disorders in COPD patients, leading to a substantial decline in exercise capacity and overall health...
March 18, 2024: Pharmacology & Therapeutics
https://read.qxmd.com/read/38507704/implementation-of-an-enhanced-recovery-protocol-for-lung-volume-reduction-surgery-an-observational-cohort-study
#23
JOURNAL ARTICLE
Christelle M Vandervelde, Stephanie Everaerts, Walter Weder, Siebe Orolé, Pieter-Jan Hermans, Paul De Leyn, Philippe Nafteux, Herbert Decaluwé, Hans Van Veer, Lieven Depypere, Steve Coppens, Arne P Neyrinck, Sofian Bouneb, Johan De Coster, Johan Coolen, Christophe Dooms, Dirk E Van Raemdonck, Wim Janssens, Laurens J Ceulemans
OBJECTIVES: Lung volume reduction surgery (LVRS) is an established therapeutic option for advanced emphysema. To improve patients' safety and reduce complications, an enhanced recovery protocol (ERP) was implemented. This study aims to describe and evaluate the short-term outcome of this ERP. METHODS: This retrospective single-center study included all consecutive LVRS patients (January 1st, 2017 until September 15th, 2020). An ERP for LVRS was implemented and stepwise optimized from August 1st, 2019, it consisted of changes in pre-, peri- and postoperative care pathways...
March 20, 2024: European Journal of Cardio-thoracic Surgery
https://read.qxmd.com/read/38507469/the-clc-1-chloride-channel-inhibitor-nmd670-improves-skeletal-muscle-function-in-rat-models-and-patients-with-myasthenia-gravis
#24
RANDOMIZED CONTROLLED TRIAL
Martin Skov, Titia Q Ruijs, Thomas S Grønnebæk, Marianne Skals, Anders Riisager, Jeppe Blichfeldt Winther, Kamilla Løhde Tordrup Dybdahl, Anders Findsen, Jeanette J Morgen, Nete Huus, Martin Broch-Lips, Ole B Nielsen, Catherine M K E de Cuba, Jules A A C Heuberger, Marieke L de Kam, Martijn Tannemaat, Jan J G M Verschuuren, Lars J S Knutsen, Nicholas M Kelly, Klaus G Jensen, William D Arnold, Arthur H Burghes, Claus Olesen, Jane Bold, Thomas K Petersen, Jorge A Quiroz, John Hutchison, Eva R Chin, Geert J Groeneveld, Thomas H Pedersen
Myasthenia gravis (MG) is a neuromuscular disease that results in compromised transmission of electrical signals at the neuromuscular junction (NMJ) from motor neurons to skeletal muscle fibers. As a result, patients with MG have reduced skeletal muscle function and present with symptoms of severe muscle weakness and fatigue. ClC-1 is a skeletal muscle specific chloride (Cl- ) ion channel that plays important roles in regulating neuromuscular transmission and muscle fiber excitability during intense exercise...
March 20, 2024: Science Translational Medicine
https://read.qxmd.com/read/38504162/photobiomodulation-combination-therapy-as-a-new-insight-in-neurological-disorders-a-comprehensive-systematic-review
#25
JOURNAL ARTICLE
Narmin Farazi, Hanieh Salehi-Pourmehr, Fereshteh Farajdokht, Javad Mahmoudi, Saeed Sadigh-Eteghad
Preclinical and clinical studies have indicated that combining photobiomodulation (PBM) therapy with other therapeutic approaches may influence the treatment process in a variety of disorders. The purpose of this systematic review was to determine whether PBM-combined therapy provides additional benefits over monotherapies in neurologic and neuropsychiatric disorders. In addition, the review describes the most commonly used methods and PBM parameters in these conjunctional approaches.To accomplish this, a systematic search was conducted in Google Scholar, PubMed, and Scopus databases through January 2024...
March 19, 2024: BMC Neurology
https://read.qxmd.com/read/38503423/evaluating-the-impact-of-movement-tracking-feedback-on-engagement-with-home-exercise-programmes-of-children-with-cerebral-palsy-using-a-new-therapy-app-a-protocol-for-a-mixed-methods-single-case-experimental-design-with-alternating-treatments
#26
JOURNAL ARTICLE
Marina Petrevska, F Virginia Wright, Ajmal Khan, Sarah Munce, Darcy Fehlings, Elaine Biddiss
INTRODUCTION: Children with cerebral palsy (CP) are prescribed home exercise programmes (HEPs) to increase the frequency of movement practice, yet adherence to HEPs can be low. This paper outlines the protocol for a single-case experimental design (SCED) with alternating treatments, using a new home therapy exercise application, Bootle Boot Camp (BBCamp), offered with and without movement tracking feedback. This study will explore the impact of feedback on engagement, movement quality, lower limb function and family experiences to help understand how technology-supported HEPs should be translated and the added value, if any, of movement tracking technology...
March 18, 2024: BMJ Open
https://read.qxmd.com/read/38502558/therapeutic-approach-to-dysphagia-in-post-covid-patients-in-a-rehabilitation-unit-a-descriptive-longitudinal-study
#27
JOURNAL ARTICLE
Anna Guillen-Sola, Cindry Ramírez, Sonia Nieto, Esther Duarte, Marta Tejero, Christian Grillo, Helena Bel, Roser Boza
BACKGROUND: A high rate of hospitalized patients for COVID-19 had dysphagia, frequently underdiagnosed, and not treated, inducing a prolonged dysphagia with protracted recovery. Specific treatments and protocols have not been well described yet. AIM: Given the potential benefits of respiratory muscle training (IEMT) and neuromuscular stimulation (NMES) in dysphagia treatment, this study aimed to assess the feasibility of the protocol used for treating dysphagia in patients who experienced prolonged hospitalization for COVID-19...
March 19, 2024: European Journal of Physical and Rehabilitation Medicine
https://read.qxmd.com/read/38502164/association-of-digital-engagement-with-relaxation-tools-and-stress-level-reduction-retrospective-cohort-study
#28
JOURNAL ARTICLE
Inbar Breuer-Asher, Marilyn D Ritholz, David L Horwitz, Omar Manejwala, Ephraim Behar, Yifat Fundoiano-Hershcovitz
BACKGROUND: Stress is an emotional response caused by external triggers and is a high-prevalence global problem affecting mental and physical health. Several different digital therapeutic solutions are effective for stress management. However, there is limited understanding of the association between relaxation components and stress levels when using a digital app. OBJECTIVE: This study investigated the contribution of relaxation tools to stress levels over time...
March 19, 2024: JMIR Formative Research
https://read.qxmd.com/read/38500549/causal-effects-of-various-types-of-physical-activities-on-psychiatric-disorders-a-mendelian-randomization-study
#29
JOURNAL ARTICLE
Lan Yu, Xu Zhang, Wangshu Li
BACKGROUND: Psychiatric disorders (PD) pose a significant burden, with vast prevalence and mortality, inflicting substantial costs on individuals and society. Despite its widespread prevalence, the complex pathogenesis of PD remains elusive, leading to limited and challenging therapeutic development. An emerging risk factor for chronic diseases, prolonged sedentary behavior, contrasts with the therapeutic potential of exercise, regardless of its intensity, for various ailments, including PD...
2024: Frontiers in sports and active living
https://read.qxmd.com/read/38500351/new-insights-into-nanomedicines-for-oral-delivery-of-glucagon-like-peptide-1-analogs
#30
REVIEW
Soraia Filipa Tavares Pinto, Hélder Almeida Santos, Bruno Filipe Carmelino Cardoso Sarmento
Type 2 diabetes mellitus (T2DM) is a metabolic disorder that arises when the body cannot respond fully to insulin, leading to impaired glucose tolerance. Currently, the treatment embraces non-pharmacological actions (e.g., diet and exercise) co-associated with the administration of antidiabetic drugs. Metformin is the first-line treatment for T2DM; nevertheless, alternative therapeutic strategies involving glucagon-like peptide-1 (GLP-1) analogs have been explored for managing the disease. GLP-1 analogs trigger insulin secretion and suppress glucagon release in a glucose-dependent manner thereby, reducing the risk of hyperglycemia...
2024: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://read.qxmd.com/read/38500326/effects-of-the-elongated-needling-combined-with-routine-acupuncture-therapy-in-the-patients-with-post-stroke-hemiplegia-and-central-pain%C3%AF-a-randomized-controlled-trial
#31
RANDOMIZED CONTROLLED TRIAL
Yi-Lei Liu, Ying Wang, Zong-Liang Xie, Yan-Yan DU, Yun Tang
OBJECTIVES: To investigate the effects of the elongated needling at the points of hand and foot yang meridians and the Governor Vessel combined with the routine acupuncture therapy on pain, balance function and muscle strength of the patients with post-stroke hemiplegia and central post-stroke pain (CPSP), and to investigate whether its therapeutic mechanism is related to antioxidant damage. METHODS: Ninety-four patients with post-stroke hemiplegia and CPSP admitted from March 2020 to September 2021 were divided into a trial group (47 cases, 1 cases dropped out) and a control group (47 cases 3 cases dropped out)...
March 25, 2024: Zhen Ci Yan Jiu, Acupuncture Research
https://read.qxmd.com/read/38495575/osteoporosis-management-current-and-future-perspectives-a-systemic-review
#32
REVIEW
Rajamohanan Jalaja Anish, Aswathy Nair
INTRODUCTION: Osteoporosis is a geriatric metabolic ailment distinguished by low bone mineral density (BMD) and strength with enhanced micro-architectural retrogression of the extracellular matrix, further increasing bone fragility risk. Osteoporotic fractures and associated complications become common in women and men after 55 and 65 years, respectively. The loss in BMD markedly enhances the risk of fracture, non-skeletal injury, and subsequent pain, adversely affecting the quality of life...
July 2024: Journal of Orthopaedics
https://read.qxmd.com/read/38495287/metabolic-associated-fatty-liver-disease-and-sarcopenia-a-double-whammy
#33
REVIEW
Aditya Viswanath, Sherouk Fouda, Cornelius James Fernandez, Joseph M Pappachan
The prevalence of metabolic-associated fatty liver disease (MAFLD) has increased substantially in recent years because of the global obesity pandemic. MAFLD, now recognized as the number one cause of chronic liver disease in the world, not only increases liver-related morbidity and mortality among sufferers but also worsens the complications associated with other comorbid conditions such as cardiovascular disease, type 2 diabetes mellitus, obstructive sleep apnoea, lipid disorders and sarcopenia. Understanding the interplay between MAFLD and these comorbidities is important to design optimal therapeutic strategies...
February 27, 2024: World Journal of Hepatology
https://read.qxmd.com/read/38493812/irisin-delays-the-onset-of-type-1-diabetes-in-nod-mice-by-enhancing-intestinal-barrier
#34
JOURNAL ARTICLE
Yujing Sun, Yilin Wang, Ziang Lin, Fuhua Zhang, Yan Zhang, Tongxin Ren, LiNa Wang, Qincheng Qiao, Mengyang Shen, Juncheng Wang, Youchen Song, Yu Sun, Peng Lin
Type 1 diabetes (T1D), a complex autoimmune disease, is intricately linked to the gut's epithelial barrier function. Emerging evidence emphasizes the role of irisin, an exercise-related hormone, in preserving intestinal integrity. This study investigates whether irisin could delay T1D onset by enhancing the colon intestinal barrier. Impaired colon intestinal barriers were observed in newly diagnosed T1D patients and non-obese diabetic (NOD) mice, worsening with age and accompanied by islet inflammation. Using an LPS-induced colonic inflammation model, a dose-dependent impact of LPS on colon cells irisin expression, secretion, and barrier function was revealed...
March 15, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38491439/daoyin-therapy-in-chronic-neck-pain-study-protocol-for-a-randomized-controlled-trial
#35
JOURNAL ARTICLE
Xiangxu Chen, Mingze Zhu, Wei Li, Daan Wang, Jing Liu
BACKGROUND: Daoyin therapy (DT), an ancient therapeutic approach with a history spanning thousands of years, has traditionally been employed to address musculoskeletal pain and psychosomatic disorders. However, the application of DT for chronic neck pain (CNP) has received limited attention in the existing literature, and systematic randomized clinical trials (RCTs) in this context remain scarce. This manuscript outlines an RCT protocol designed to investigate whether DT is more effective at alleviating CNP in adult individuals compared to other interventions...
March 15, 2024: BMC complementary medicine and therapies
https://read.qxmd.com/read/38490497/unveiling-the-interplay-of-ampk-sirt1-pgc-1%C3%AE-axis-in-brain-health-promising-targets-against-aging-and-ndds
#36
REVIEW
Pratik Shankar Rakshe, Bhaskar Jyoti Dutta, Shivani Chib, Niyogita Maurya, Sanjiv Singh
The escalating prevalence of neurodegenerative diseases (NDDs) within an aging global population presents a pressing challenge. The multifaceted pathophysiological mechanisms underlying these disorders, including oxidative stress, mitochondrial dysfunction, and neuroinflammation, remain complex and elusive. Among these, the AMPK/SIRT1/PGC-1α pathway emerges as a pivotal network implicated in neuroprotection against these destructive processes. This review sheds light on the potential therapeutic implications of targeting this axis, specifically emphasizing the promising role of flavonoids in mitigating NDD-related complications...
March 13, 2024: Ageing Research Reviews
https://read.qxmd.com/read/38489710/a-randomized-controlled-study-investigating-the-efficacy-of-electro-acupuncture-and-exercise-based-swallowing-rehabilitation-for-post-stroke-dysphagia-impacts-on-brainstem-auditory-evoked-potentials-and-cerebral-blood-flow
#37
RANDOMIZED CONTROLLED TRIAL
Wen Zhang, Hai-Tao Jin, Fei Wang, Jing-Lan Zhang, Yuan Bao, Song Wang
BACKGROUND: Swallowing rehabilitation behavioral therapy and traditional Chinese acupuncture therapy are widely used in the treatment of post-stroke dysphagia (PSD). This study investigated the therapeutic effect of electro-acupuncture combined with exercise-based swallowing rehabilitation on PSD and its effect on brainstem auditory evoked potential (BAEP) and cerebral blood flow. METHODS: The 120 PSD patients were divided into 2 groups (n = 60 each) by simple random grouping method, that is, an experimental and control group, receiving routine swallowing training, or additional intervention with electro-acupuncture at a frequency of 5 times/week...
March 15, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38488566/relative-energy-deficiency-in-sport-reds-endocrine-manifestations-pathophysiology-and-treatments
#38
JOURNAL ARTICLE
Angeliki M Angelidi, Konstantinos Stefanakis, Sharon H Chou, Laura Valenzuela-Vallejo, Konstantina Dipla, Chrysoula Boutari, Konstantinos Ntoskas, Panagiotis Tokmakidis, Alexander Kokkinos, Dimitrios G Goulis, Helen A Papadaki, Christos S Mantzoros
Research on lean, energy-deficient athletic and military cohorts has broadened the concept of the Female Athlete Triad into the Relative Energy Deficiency in Sport (REDs) syndrome. REDs represents a spectrum of abnormalities induced by low energy availability (LEA), which serves as the underlying cause of all symptoms described within the REDs concept, affecting exercising populations of either biological sex. Both short- and long-term LEA, in conjunction with other moderating factors, may produce a multitude of maladaptive changes that impair various physiological systems and adversely affect health, well-being, and sport performance...
March 15, 2024: Endocrine Reviews
https://read.qxmd.com/read/38486359/the-effects-of-exergame-telerehabilitation-in-persons-with-subjective-cognitive-decline
#39
JOURNAL ARTICLE
Dereck L Salisbury, Keenan A Pituch, Fang Yu
BACKGROUND AND OBJECTIVES: The primary aim of this Stage IB randomized controlled trial (RCT) was to test the preliminary effects of a dual-task exergaming telerehabilitation intervention on cognition and aerobic fitness, compared to aerobic exercise (AEx) only and attention control (stretching) in older adults with SCD. RESEARCH DESIGN AND METHODS: This RCT randomized 39 participants on a 2:1:1 allocation ratio to supervised exergame (n=20), AEx (n=11), and stretching (n=8) for 12 weeks...
March 15, 2024: Gerontologist
https://read.qxmd.com/read/38483350/mixed-potential-type-isoprene-sensor-for-the-application-in-real-time-monitoring-of-biomarker-gases
#40
JOURNAL ARTICLE
Li Jiang, Qiule Li, Siyuan Lv, Bin Wang, Si Pan, Peng Sun, Jie Zheng, Fangmeng Liu, Geyu Lu
Monitoring of isoprene in exhaled breath is expected to provide a noninvasive and painless method for dynamic monitoring of physiological and metabolic states during exercise. However, for real-time and portable detection of isoprene, gas sensors have become the best choice for gas detection technology, which are crucial to achieving the goal of anytime, anywhere, human-centered healthcare in the future. Here, we first report a mixed potential type isoprene sensor based on a Gd2Zr2O7 solid electrolyte and a CdSb2O6 sensing electrode, which enables sensitive detection for isoprene with sensitivities of -21...
March 14, 2024: ACS Sensors
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