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https://www.readbyqxmd.com/read/29035987/low-intensity-pulsed-ultrasound-for-early-stage-lumbar-spondylolysis-in-young-athletes
#1
Masahiro Tsukada, Toshiro Takiuchi, Kota Watanabe
OBJECTIVE: To examine the effect of low-intensity pulsed ultrasound (LIPUS) on early-stage spondylolysis in young athletes. DESIGN: Case-control study. SETTING: A single outpatient orthopedic and sports clinic. PATIENTS: A total of 82 young athletes (80 boys and 2 girls; mean age, 14.8 years; range, 10-18 years) with early-stage lumbar spondylolysis were enrolled in this study. All patients were examined by plain radiography and magnetic resonance imaging...
October 10, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29034529/reliability-of-muscle-blood-flow-and-oxygen-consumption-response-from-exercise-using-near-infrared-spectroscopy
#2
Adam A Lucero, Gifty Addae, Wayne Lawrence, Beemnet Neway, Daniel P Credeur, James Faulkner, David Rowlands, Lee Stoner
Near-infrared spectroscopy (NIRS), coupled with rapid venous (VO) and arterial occlusions (AO) can be used to non-invasively estimate resting local skeletal muscle blood flow (mBF) and oxygen consumption (mV̇O2 ), respectively. However, the day-to-day reliability of mBF and mV̇O2 responses to stressors such as incremental dynamic exercise has not been established. PURPOSE: To determine the reliability of NIRS derived mBF and mV̇O2 response from incremental dynamic exercise. METHODS: Measurements of mBF and mV̇O2 were collected in the vastus lateralis of twelve healthy, physically active adults [7 m and 5 f; 25 y (SD 6)] over 3 non-consecutive visits within 10 days...
October 16, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/29032354/exercise-for-hand-osteoarthritis-a-cochrane-systematic-review
#3
Nina Østerås, Ingvild Kjeken, Geir Smedslund, Rikke H Moe, Barbara Slatkowsky-Christensen, Till Uhlig, Kåre Birger Hagen
OBJECTIVE: To assess the benefits and harms of exercise compared with other interventions, including placebo or no intervention, in people with hand osteoarthritis (OA). METHODS: Systematic review using Cochrane Collaboration methodology. Six electronic databases were searched up until September 2015. INCLUSION CRITERIA: randomized or controlled clinical trials comparing therapeutic exercise versus no exercise, or comparing different exercise programs...
October 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/29028650/fast-digestive-proteins-and-sarcopenia-of-aging
#4
Yves Boirie, Christelle Guillet
PURPOSE OF REVIEW: The speed of dietary protein digestion influences postprandial amino acid availability which is crucial for improving altered anabolic response of skeletal muscle one feature of sarcopenia during aging. RECENT FINDINGS: By analogy with carbohydrate and in reference to their absorption rate, dietary proteins can be classified as 'fast' or 'slow' proteins depending on matrix food structure and technological processes, which can influence amino acids availability and their subsequent metabolic actions...
October 11, 2017: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/29023319/comparison-of-fenofibrate-and-pioglitazone-effects-on-patients-with-nonalcoholic-fatty-liver-disease
#5
Malek Yaghoubi, Sattar Jafari, Behnam Sajedi, Sepehr Gohari, Samira Akbarieh, Amir H Heydari, Maryam Jameshoorani
INTRODUCTION: Nonalcoholic fatty liver disease (NAFLD) is known to be a health-related problem; there is no proven treatment for NAFLD. However, a wide range of possible therapies have been proposed and studied. In the current study, we aimed to compare the therapeutic effects of fenofibrate and pioglitazone on NAFLD. PATIENTS AND METHODS: In this randomized clinical trial study (ethic number: ZUMS.REC.1393.133), patients with NAFLD and alanine aminotransferase in range of 1-1...
October 11, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29022268/physical-exercise-is-a-potential-medicine-for-atherosclerosis
#6
Jian Yang, Richard Y Cao, Rongrong Gao, Qiongyao Mi, Qiying Dai, Fu Zhu
Cardiovascular disease (CVD) has been recognized as the number one killer for decades. The most well-known risk factor is atherosclerosis. Unlike the acuity of CVD, atherosclerosis is a chronic, progressive pathological change. This process involves inflammatory response, oxidative reaction, macrophage activity, and different interaction of inflammatory factors. Physical exercise has long been known as good for health in general. In recent studies, physical exercise has been demonstrated to be a therapeutic tool for atherosclerosis...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29022259/formation-of-new-cardiomyocytes-in-exercise
#7
Liang Shen, Hui Wang, Yihua Bei, Dragos Cretoiu, Sanda Maria Cretoiu, Junjie Xiao
Heart failure is a life-threatening disorder associated with the loss of cardiomyocytes. The heart has some endogenous although limited regenerative capacity, thus enhancing cardiac regeneration or stimulating endogenous repair mechanism after cardiac injury is of great interest. The benefits of exercise in heart diseases have been recognized for centuries. Besides the promotion of a favorable cardiac function, exercise is also associated with new cardiomyocytes formation. Exercise may lead to cardiomyocytes renewal from pre-existing cardiomyocytes proliferation or cardiac stem/progenitor cells differentiation...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29021780/chronic-5-aminoimidazole-4-carboxamide-1-%C3%AE-d-ribofuranoside-treatment-induces-phenotypic-changes-in-skeletal-muscle-but-does-not-improve-disease-outcomes-in-the-r6-2-mouse-model-of-huntington-s-disease
#8
Marie-France Paré, Bernard J Jasmin
Huntington's disease (HD) is an autosomal dominant neurodegenerative genetic disorder characterized by motor, cognitive, and psychiatric symptoms. It is well established that regular physical activity supports brain health, benefiting cognitive function, mental health as well as brain structure and plasticity. Exercise mimetics (EMs) are a group of drugs and small molecules that target signaling pathways in skeletal muscle known to be activated by endurance exercise. The EM 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR) has been shown to induce cognitive benefits in healthy mice...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29020674/obesity-and-type-2-diabetes-two-diseases-with-a-need-for-combined-treatment-strategies-easo-can-lead-the-way
#9
Deborah R Leitner, Gema Frühbeck, Volkan Yumuk, Karin Schindler, Dragan Micic, Euan Woodward, Hermann Toplak
Obesity is a chronic metabolic disease affecting adults and children worldwide. It has become one of the leading causes of death, as obesity is known to be the main risk factor for a number of non-communicable diseases, in particular type 2 diabetes. This close relationship led to the connotation 'diabesity', highlighting the fact that the majority of individuals with diabetes are overweight or obese. Until today the BMI is still used to classify overweight and obesity. Since reduced muscle mass is highly prevalent throughout the BMI range, the measurement of body composition is strongly recommended...
October 12, 2017: Obesity Facts
https://www.readbyqxmd.com/read/29020402/women-with-hypertrophic-cardiomyopathy-have-worse-survival
#10
Jeffrey B Geske, Kevin C Ong, Konstantinos C Siontis, Virginia B Hebl, Michael J Ackerman, David O Hodge, Virginia M Miller, Rick A Nishimura, Jae K Oh, Hartzell V Schaff, Bernard J Gersh, Steve R Ommen
Aims: Sex differences in hypertrophic cardiomyopathy (HCM) remain unclear. We sought to characterize sex differences in a large HCM referral centre population. Methods and results: Three thousand six hundred and seventy-three adult patients with HCM underwent evaluation between January 1975 and September 2012 with 1661 (45.2%) female. Kaplan-Meier survival curves were assessed via log-rank test. Cox proportional hazard regression analyses evaluated the relation of sex with survival...
September 8, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29020182/the-manufacturers-perspective-on-who-prequalification-of-in-vitro-diagnostics
#11
Sébastien Morin, Nelli Bazarova, Philippe Jacon, Stefano Vella
In vitro diagnostic devices (IVDs) help clinicians determine specific conditions, monitor therapeutic efficacy and prevent drug resistance development. While stringent regulatory authorities (SRAs) regulate IVDs in most high-income countries, regulatory authorities in many low- and middle-income countries (LMICs) are non-existent or do not enforce rigorous standards. In 2010, the World Health Organization (WHO) established its Prequalification of In Vitro Diagnostics (PQDx) Programme to ensure "access to safe, appropriate and affordable" IVDs, especially in LMICs with little or no domestic regulatory frameworks, thereby reaching underserved populations...
August 17, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29019274/effects-of-whole-body-vibration-on-balance-and-mobility-in-institutionalized-older-adults-a-randomized-controlled-trial
#12
Freddy Mh Lam, Philip Fl Chan, L R Liao, Jean Woo, Elsie Hui, Charles Wk Lai, Timothy Cy Kwok, Marco Yc Pang
OBJECTIVE: To investigate whether a comprehensive exercise program was effective in improving physical function among institutionalized older adults and whether adding whole-body vibration to the program conferred additional therapeutic benefits. DESIGN: A single-blinded randomized controlled trial was conducted. SETTING: This study was carried out in residential care units. PARTICIPANTS: In total, 73 older adults (40 women, mean age: 82...
October 1, 2017: Clinical Rehabilitation
https://www.readbyqxmd.com/read/29018938/heart-failure-with-preserved-ejection-fraction-current-management-and-future-strategies-expert-opinion-on-the-behalf-of-the-nucleus-of-the-heart-failure-working-group-of-the-german-society-of-cardiology-dkg
#13
REVIEW
Carsten Tschöpe, Christoph Birner, Michael Böhm, Oliver Bruder, Stefan Frantz, Andreas Luchner, Lars Maier, Stefan Störk, Behrouz Kherad, Ulrich Laufs
About 50% of all patients suffering from heart failure (HF) exhibit a reduced ejection fraction (EF ≤ 40%), termed HFrEF. The others may be classified into HF with midrange EF (HFmrEF 40-50%) or preserved ejection fraction (HFpEF, EF ≥ 50%). Presentation and pathophysiology of HFpEF is heterogeneous and its management remains a challenge since evidence of therapeutic benefits on outcome is scarce. Up to now, there are no therapies improving survival in patients with HFpEF. Thus, the treatment targets symptom relief, quality of life and reduction of cardiac decompensations by controlling fluid retention and managing risk factors and comorbidities...
October 10, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28992584/ogt-related-mitochondrial-motility-is-associated-with-sex-differences-and-exercise-effects-in-depression-induced-by-prenatal-exposure-to-glucocorticoids
#14
Weina Liu, Hongmei Wang, Xiangli Xue, Jie Xia, Jiatong Liu, Zhengtang Qi, Liu Ji
BACKGROUND: Prenatal exposure to glucocorticoids (GCs) has been found to trigger abnormal behaviors and deleterious neurological effects on offspring both in animals and in humans. The sex differences in depression have been replicated in numerous studies across cultures, persisting throughout the reproductive years. As an X-linked gene in rodents and in humans, O-GlcNAc transferase (OGT) may provide a novel perspective for the sex differences in depression. METHODS: In the last third of pregnancy (gestational day 14-21), rats were subcutaneously administered either 0...
September 29, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28990434/therapeutic-effect-evaluation-of-neuromuscular-electrical-stimulation-with-or-without-strengthening-exercise-on-spastic-cerebral-palsy
#15
Ya-Chao Qi, Xiao-Li Niu, Ya-Ran Gao, He-Bo Wang, Ming Hu, Li-Peng Dong, Ya-Zhou Li
The aims of this study were to investigate the effect of neuromuscular electrical stimulation (NMES) combined with strengthening exercise on movement in children with spastic cerebral palsy (CP). One hundred children with spastic CP were randomly divided into a treatment group (NMES and strengthening exercise, n = 50) and a control group (only NMES, n = 50). We compared the Comprehensive Spasticity Scale (CSS) score, Gross Motor Function Measure (GMFM) score, and walking speed before treatment and 6 weeks and 3 months after treatment between the 2 groups...
October 1, 2017: Clinical Pediatrics
https://www.readbyqxmd.com/read/28990152/therapeutic-targets-for-the-multi-system-pathophysiology-of-heart-failure-exercise-training
#16
REVIEW
Erik H Van Iterson, Thomas P Olson
Adult chronic heart failure (HF) is a terminal syndrome. While the HF phenotype is inhomogeneous across the ejection fraction spectrum, exercise intolerance remains a cardinal feature of all HF patients. Impairment of a single organ system cannot independently account for exercise intolerance in HF. Thus, the multi-system integrative pathophysiology of HF leads to challenges in identifying an effective medical therapy aimed at targeting a single mechanism to improve exercise tolerance. This unresolved medical care approach raises a number of points for discussion in this field as it is well-recognized that exercise intolerance is accompanied by increased hospitalizations and mortality across the HF spectrum...
October 9, 2017: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28988910/neuroprotection-and-neurorestoration-as-experimental-therapeutics-for-parkinson-s-disease
#17
REVIEW
Veronica Francardo, Yvonne Schmitz, David Sulzer, M Angela Cenci
Disease-modifying treatments remain an unmet medical need in Parkinson's disease (PD). Such treatments can be operationally defined as interventions that slow down the clinical evolution to advanced disease milestones. A treatment may achieve this outcome by either inhibiting primary neurodegenerative events ("neuroprotection") or boosting compensatory and regenerative mechanisms in the brain ("neurorestoration"). Here we review experimental paradigms that are currently used to assess the neuroprotective and neurorestorative potential of candidate treatments in animal models of PD...
October 5, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28987900/cardiorespiratory-responses-to-pool-floor-walking-in-people-post-stroke
#18
Brenda Jeng, Takuto Fujii, Hyosok Lim, Konstantinos Vrongistinos, Taeyou Jung
OBJECTIVE: To compare energy expenditure between pool floor walking (PFW) and overground walking (OW) in people post-stroke. DESIGN: Cross-sectional study. SETTING: University-based therapeutic exercise facility. PARTICIPANTS: 14 community-dwelling individuals post-stroke (5.57±3.57 years post-stroke) and 14 healthy adults, age- and gender-matched (aged 58.00±15.51, men to women ratio of 9:5) participated in the study...
October 5, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28987260/treatment-strategies-for-nonalcoholic-fatty-liver-disease-and-nonalcoholic-steatohepatitis
#19
REVIEW
Pegah Golabi, Haley Bush, Zobair M Younossi
Nonalcoholic fatty liver disease (NAFLD) is recognized as a global health problem and as a common cause of chronic liver disease. Nonalcoholic steatohepatitis (NASH) carries an increased risk for development of advanced liver disease. Lifestyle modifications with diet and exercise have been the initial management recommendation. However, these changes are difficult to achieve and sustain overtime. There are pharmacologic agents being considered for treatment of NASH. Some target insulin resistance and others focus on oxidative stress, inflammation, apoptosis, and fibrosis...
November 2017: Clinics in Liver Disease
https://www.readbyqxmd.com/read/28986358/pulmonary-vasodilation-by-phosphodiesterase-5-inhibition-is-enhanced-and-nitric-oxide-independent-in-early-pulmonary-hypertension-after-myocardial-infarction
#20
Richard W B van Duin, Birgit Houweling, Andre Uitterdijk, Dirk J Duncker, Daphne Merkus
Myocardial infarction (MI) may result in pulmonary hypertension (PH). Inhibition of phosphodiesterase 5 (PDE5), the enzyme responsible for the breakdown of cGMP in vascular smooth muscle, has become part of the contemporary therapeutic armamentarium for pulmonary arterial hypertension and may also be of benefit in PH secondary to MI. Nitric oxide (NO) is an important source of cGMP and can be enhanced in early PH and decreased in severe PH. In the present study we investigated if PDE5-inhibition ameliorates pulmonary hemodynamics in swine with PH secondary to MI and whether NO is essential...
October 6, 2017: American Journal of Physiology. Heart and Circulatory Physiology
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