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https://www.readbyqxmd.com/read/28212155/molecular-markers-in-lung-cancer-role-of-ebus
#1
Semra Bilaçeroğlu
PURPOSE OF REVIEW: As demonstrated by the recent therapeutic advances in nonsmall cell lung cancer (NSCLC), a personalized approach can considerably reduce its mortality. RECENT FINDINGS: Molecular tests identifying genetic mutations in NSCLC have led to a shift towards more effective and personalized therapies targeted to these alterations. Adequate tissue is required for diagnosing, subcharacterizing, and genotyping NSCLC by morphological, immunohistochemical, and molecular techniques...
February 16, 2017: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/28210939/deep-phenotyping-of-systemic-arterial-hemodynamics-in-hfpef-part-1-physiologic-and-technical-considerations
#2
REVIEW
Julio A Chirinos
A better understanding of the pathophysiology of heart failure with a preserved left ventricular ejection fraction (HFpEF) is important. Detailed phenotyping of pulsatile hemodynamics has provided important insights into the pathophysiology of left ventricular remodeling and fibrosis, diastolic dysfunction, microvascular disease, and impaired oxygen delivery to peripheral skeletal muscle, all of which contribute to exercise intolerance, the cardinal feature of HFpEF. Furthermore, arterial pulsatile hemodynamic mechanisms likely contribute to the frequent presence of comorbidities, such as renal failure and dementia, in this population...
February 16, 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/28210065/the-effects-of-therapeutic-exercise-using-pnf-on-the-size-of-calcium-deposits-pain-self-awareness-and-shoulder-joint-function-in-a-calcific-tendinitis-patient-a-case-study
#3
Dong-Gun Oh, Kyung-Tae Yoo
[Purpose] The purpose of this case study was to identify the effects of independent and intensive therapeutic exercise using Proprioceptive neuromuscular facilitation on the size of calcium deposits, pain self-awareness, and shoulder joint function in a patient with calcific tendonitis. [Subject and Methods] The subject was a 42-year-old female patient with calcific tendonitis and acute pain who had difficulty with active movement and problems with general function. The independent and intensive Proprioceptive neuromuscular facilitation exercise was applied for 40 min twice a day five times a week for two weeks for a total of 20 times...
January 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28205533/a-data-driven-approach-for-evaluating-multi-modal-therapy-in-traumatic-brain-injury
#4
Jenny Haefeli, Adam R Ferguson, Deborah Bingham, Adrienne Orr, Seok Joon Won, Tina I Lam, Jian Shi, Sarah Hawley, Jialing Liu, Raymond A Swanson, Stephen M Massa
Combination therapies targeting multiple recovery mechanisms have the potential for additive or synergistic effects, but experimental design and analyses of multimodal therapeutic trials are challenging. To address this problem, we developed a data-driven approach to integrate and analyze raw source data from separate pre-clinical studies and evaluated interactions between four treatments following traumatic brain injury. Histologic and behavioral outcomes were measured in 202 rats treated with combinations of an anti-inflammatory agent (minocycline), a neurotrophic agent (LM11A-31), and physical therapy consisting of assisted exercise with or without botulinum toxin-induced limb constraint...
February 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28198733/clinical-relevance-of-sarcopenia-in-chronic-kidney-disease
#5
Ranjani N Moorthi, Keith G Avin
PURPOSE OF REVIEW: In this article, we review sarcopenia in chronic kidney disease (CKD). We aim to present how definitions of sarcopenia from the general population may pertain to those with CKD, its assessment by clinicians and emerging therapies for sarcopenia in CKD. For this review, we limit our description and recommendations to patients with CKD who are not on dialysis. RECENT FINDINGS: Poorer parameters of lean mass, strength and physical function are associated with worsening patient-centered outcomes such as limiting mobility, falls and mortality in CKD; however, the magnitude of these associations are different in those with and without CKD...
February 13, 2017: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/28194419/intestinal-barrier-disturbances-in-haemodialysis-patients-mechanisms-consequences-and-therapeutic-options
#6
REVIEW
D S March, M P M Graham-Brown, C M Stover, N C Bishop, J O Burton
There is accumulating evidence that the intestinal barrier and the microbiota may play a role in the systemic inflammation present in HD patients. HD patients are subject to a number of unique factors, some related to the HD process and others simply to the uraemic milieu but with common characteristic that they can both alter the intestinal barrier and the microbiota. This review is intended to provide an overview of the current methods for measuring such changes in HD patients, the mechanisms behind these changes, and potential strategies that may mitigate these modifications...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28194375/rehabilitation-of-hamstring-muscle-injuries-a-literature-review
#7
REVIEW
Gabriel Amorim Ramos, Gustavo Gonçalves Arliani, Diego Costa Astur, Alberto de Castro Pochini, Benno Ejnisman, Moisés Cohen
Hamstring injuries are among the most frequent in sports. The high relapse rate is a challenge for sports medicine and has a great impact on athletes and sport teams. The treatment goal is to provide the athlete the same functional level as before the injury. Thus, functional rehabilitation is very important to the success of the treatment. Currently, several physical therapy modalities are used, according to the stage of the lesion, such as cryotherapy, laser therapy, therapeutic ultrasound, therapeutic exercise, and manual therapy...
January 2017: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/28193888/interleukin-37-reverses-the-metabolic-cost-of-inflammation-increases-oxidative-respiration-and-improves-exercise-tolerance
#8
Giulio Cavalli, Jamie N Justice, Kristen E Boyle, Angelo D'Alessandro, Elan Z Eisenmesser, Jonathan J Herrera, Kirk C Hansen, Travis Nemkov, Rinke Stienstra, Cecilia Garlanda, Alberto Mantovani, Douglas R Seals, Lorenzo Dagna, Leo A B Joosten, Dov B Ballak, Charles A Dinarello
IL-1 family member interleukin 37 (IL-37) has broad antiinflammatory properties and functions as a natural suppressor of innate inflammation. In this study, we demonstrate that treatment with recombinant human IL-37 reverses the decrease in exercise performance observed during systemic inflammation. This effect was associated with a decrease in the levels of plasma and muscle cytokines, comparable in extent to that obtained upon IL-1 receptor blockade. Exogenous administration of IL-37 to healthy mice, not subjected to an inflammatory challenge, also improved exercise performance by 82% compared with vehicle-treated mice (P = 0...
February 13, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28187125/aerobic-exercise-for-alzheimer-s-disease-a-randomized-controlled-pilot-trial
#9
Jill K Morris, Eric D Vidoni, David K Johnson, Angela Van Sciver, Jonathan D Mahnken, Robyn A Honea, Heather M Wilkins, William M Brooks, Sandra A Billinger, Russell H Swerdlow, Jeffrey M Burns
BACKGROUND: There is increasing interest in the role of physical exercise as a therapeutic strategy for individuals with Alzheimer's disease (AD). We assessed the effect of 26 weeks (6 months) of a supervised aerobic exercise program on memory, executive function, functional ability and depression in early AD. METHODS AND FINDINGS: This study was a 26-week randomized controlled trial comparing the effects of 150 minutes per week of aerobic exercise vs. non-aerobic stretching and toning control intervention in individuals with early AD...
2017: PloS One
https://www.readbyqxmd.com/read/28185025/constipation-pathophysiology-and-current-therapeutic-approaches
#10
Amol Sharma, Satish Rao
Chronic constipation is a common, persistent condition affecting many patients worldwide, presenting significant economic burden and resulting in substantial healthcare utilization. In addition to infrequent bowel movements, the definition of constipation includes excessive straining, a sense of incomplete evacuation, failed or lengthy attempts to defecate, use of digital manoeuvres for evacuation of stool, abdominal bloating, and hard consistency of stools. After excluding secondary causes of constipation, chronic idiopathic or primary constipation can be classified as functional defecation disorder, slow-transit constipation (STC), and constipation-predominant irritable bowel syndrome (IBS-C)...
February 10, 2017: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/28183451/the-novel-exercise-induced-hormone-irisin-protects-against-neuronal-injury-via-activation-of-the-akt-and-erk1-2-signaling-pathways-and-contributes-to-the-neuroprotection-of-physical-exercise-in-cerebral-ischemia
#11
Dong-Jie Li, Yong-Hua Li, Hong-Bin Yuan, Le-Feng Qu, Pei Wang
BACKGROUND: Irisin is a novel exercise-induced myokine involved in the regulation of adipose browning and thermogenesis. In this study, we investigated the potential role of irisin in cerebral ischemia and determined whether irisin is involved in the neuroprotective effect of physical exercise in mice. MATERIALS AND METHODS: The middle cerebral artery occlusion (MCAO) model was used to produce cerebral ischemia in mice. First, the plasma irisin levels and changes in expression of the irisin precursor protein FNDC5 in skeletal muscle were determined post ischemic stroke...
March 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28183213/the-ottawa-panel-clinical-practice-guidelines-for-the-management-of-knee-osteoarthritis-part-two-strengthening-exercise-programs
#12
Lucie Brosseau, Jade Taki, Brigit Desjardins, Odette Thevenot, Marlene Fransen, George A Wells, Aline Mizusaki Imoto, Karine Toupin-April, Marie Westby, Inmaculada C Álvarez Gallardo, Wendy Gifford, Lucie Laferrière, Prinon Rahman, Laurianne Loew, Gino De Angelis, Sabrina Cavallo, Shirin Mehdi Shallwani, Ala' Aburub, Kim L Bennell, Martin Van der Esch, Milena Simic, Sara McConnell, Alison Harmer, Glen P Kenny, Gail Paterson, Jean-Philippe Regnaux, Marie-Martine Lefevre-Colau, Linda McLean
OBJECTIVE: To identify effective strengthening exercise programs and provide rehabilitation teams and patients with updated, high-quality recommendations concerning traditional land-based exercises for knee osteoarthritis. METHODS: A systematic search and adapted selection criteria included comparative controlled trials with strengthening exercise programs for patients with knee osteoarthritis. A panel of experts reached consensus on the recommendations using a Delphi survey...
February 1, 2017: Clinical Rehabilitation
https://www.readbyqxmd.com/read/28179228/dietary-nitrate-does-not-reduce-oxygen-cost-of-exercise-or-improve-muscle-mitochondrial-function-in-mitochondrial-myopathy-patients
#13
Miranda Nabben, Joep P J Schmitz, Jolita Ciapaite, Carlijn M P Le Clercq, Natal A van Riel, Harm R Haak, Klaas Nicolay, Irenaeus F de Coo, Hubert J M Smeets, Stephan F Praet, Luc J C van Loon, Jeanine J Prompers
Muscle weakness and exercise intolerance negatively affect the quality of life of mitochondrial myopathy patients. Short-term dietary nitrate supplementation has been shown to improve exercise performance and reduce oxygen cost of exercise in healthy humans and trained athletes. We investigated if 1 week of dietary inorganic nitrate supplementation decreases the oxygen cost of exercise and improves mitochondrial function in mitochondrial myopathy patients. Ten mitochondrial myopathy patients (40 ± 5 years, maximal whole-body oxygen uptake = 21...
February 8, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28177716/a-role-for-maternally-derived-myokines-to-optimize-placental-function-and-fetal-growth-across-gestation
#14
Chantal Dubé, Céline Aguer, Kristi Adamo, Shannon Bainbridge
Exercise during pregnancy is associated with improved health outcomes for both mother and baby, including a reduced risk of future obesity and susceptibility to chronic diseases. Overwhelming evidence demonstrates a protective effect of maternal exercise against fetal birth weight extremes, reducing the rates of both large- and small-for-gestational-age infants. It is speculated that this protective effect is mediated in part through exercise-induced regulation of maternal physiology and placental development/function...
January 17, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28177124/acute-exercise-elicits-differential-expression-of-insulin-resistance-genes-in-the-skeletal-muscle-of-patients-with-polycystic-ovary-syndrome
#15
Wagner Silva Dantas, Igor Hisashi Murai, Luiz Augusto Perandini, Hatylas Azevedo, Carlos Alberto Moreira-Filho, Niels Olsen Saraiva Camara, Hamilton Roschel, Bruno Gualano
OBJECTIVE: This study aimed to explore the role of acute exercise on skeletal muscle gene expression related to insulin resistance in patients with polycystic ovary syndrome (PCOS) and controls. METHODS: Four obese women with PCOS and 4 body controls subjects (CTRL) participated in this study. After an overnight fast, the subjects underwent a single 40-minute bout of aerobic exercise. Muscle samples were obtained from vastus lateralis at baseline and 60 minutes after exercise...
February 8, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28167192/stress-biomarker-responses-to-different-protocols-of-forced-exercise-in-chronically-stressed-rats
#16
Maryam Radahmadi, Hojjatallah Alaei, Mohammad Reza Sharifi, Nasrin Hosseini
Stress is one of the most significant causes of major health problems on a global scale. The beneficial effects of exercise on combating stress, however, are well-established. The present study investigated the stress biomarker responses, such as serum corticosterone, interlukin-1β, and glucose levels, to different (preventive, therapeutic, protective, and continuous) protocols of forced exercise under stress. Male rats were randomly allocated to the following five groups: stressed, preventive, therapeutic, protective, and continuous (and/or pre-stress, post-stress, stress-accompanied, and both pre-stress and stress-accompanied exercise respectively) exercise groups...
January 2017: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/28167176/do-exercises-with-the-foam-roller-have-a-short-term-impact-on-the-thoracolumbar-fascia-a-randomized-controlled-trial
#17
Annika Griefahn, Jan Oehlmann, Christoff Zalpour, Harry von Piekartz
Due to new research results in the past few years, interest in the fascia of the human body has increased. Dysfunctions of the fascia are indicated by various symptoms, amongst others, musculoskeletal pain. As a result stronger focus has been put on researching therapeutic approaches in this area. The main aim of this study was to investigate the effect of Foam Roll exercises on the mobility of the thoracolumbar fascia (TLF). Study has been conducted in a randomized and controlled trial which sampled 38 healthy athletic active men and women...
January 2017: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/28166646/the-meanings-of-physiotherapy-and-exercise-for-people-living-with-progressive-cerebellar-ataxia-an-interpretative-phenomenological-analysis
#18
Elizabeth Cassidy, Sandra Naylor, Frances Reynolds
PURPOSE: To understand the meanings of exercise and physiotherapy for people living with a progressive cerebellar ataxia. METHOD: An interpretative phenomenological analysis was undertaken with 12 participants (4 women, 8 men) recruited via their membership of a national support group. Semistructured interviews were audiorecorded and transcribed. Data were analyzed using interpretivist methods. RESULTS: Two main themes were constructed. Firstly, participants highly valued building collaborative and supportive long-term therapeutic relationships with expert physiotherapists and were not necessarily looking to improve ataxia-related impairments...
February 6, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28163919/therapeutic-effects-of-intensive-inpatient-rehabilitation-in-advanced-parkinson-s-disease
#19
Yumiko Kaseda, Junko Ikeda, Katsunobu Sugihara, Takemori Yamawaki, Tatsuo Kohriyama, Masayasu Matsumoto
BACKGROUND: The importance of rehabilitation therapy in Parkinson's disease is well recognized. However, the effects of an inpatient rehabilitation program for advanced Parkinson's disease have not been fully investigated. AIM: To assess the effects of intensive inpatient rehabilitation. METHODS: We enrolled 31 patients (mean age 69.5 ± 9.4 years; mean disease duration 8.8 ± 6.4 years) with advanced Parkinson's disease, without severe cognitive impairment...
January 2017: Neurology and Clinical Neuroscience
https://www.readbyqxmd.com/read/28163315/effects-of-topical-capsaicin-combined-with-moderate-exercise-on-insulin-resistance-body-weight-and-oxidative-stress-in-hypoestrogenic-obese-rats
#20
J M L Medina-Contreras, J Colado-Velázquez, N L Gómez-Viquez, P Mailloux-Salinas, I Perez-Torres, A Aranda-Fraustro, K Carvajal, G Bravo
BACKGROUND: Hypoestrogenic women are one of the most vulnerable groups for the development of obesity and its complications. Capsaicin and exercise have demonstrated to reduce body weight and to improve insulin sensitivity in different animal models, but it is unknown whether their combination could be useful in hypoestrogenic obese females. METHODS: We investigated whether topical capsaicin, exercise or their combination had better therapeutic effects in an obesity-hypoestrogenism model...
February 6, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
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