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https://www.readbyqxmd.com/read/28449156/development-of-multiple-unit-floating-drug-delivery-system-of-clarithromycin-formulation-in-vitro-dissolution-by-modified-dissolution-apparatus-in-vivo-radiographic-studies-in-human-volunteers
#1
Arun B Reddy, Narendar D Reddy
Clarithromycin (CM), a broad spectrum macrolide antibiotic used to eradicate H. pylori in peptic ulcer. Clarithromycin (CM) is well absorbed from the gastrointestinal tract, but has a bioavailability of 50% due to rapid biodegradation. The aim of this investigation was to increase the gastric residence time, and to control the drug release of clarithromycin by formulating into multiple unit floating mini-tablets. Floating tablets were prepared by using direct compression method with HPMC K4M and Polyox WSR 1105 as release retarded polymers and sodium bicarbonate as gas generating agent...
April 27, 2017: Drug Research
https://www.readbyqxmd.com/read/28447959/using-measurable-dosimetric-quantities-to-characterize-the-inter-structural-tradeoff-in-inverse-planning
#2
Hongcheng Liu, Peng Dong, Lei Xing
Traditional inverse planning relies on the use of weighting factors to balance the conflicting requirements of different structures. The manual trial-and-error determination of the weighting factors has long been recognized as a time-consuming part of treatment planning. The purpose of this work is to develop an inverse planning framework that parameterizes the dosimetric tradeoff among the structures with physically meaningful quantities to simplify the search for clinically sensible plans. In this formalism, instead of using the weighting factors, permissible variation range of the prescription dose or dose volume histogram (DVH) of the involved structures are used to characterize the "importance" of the structures...
April 27, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28447456/numerical-modeling-of-electroosmotic-push-pull-perfusion-and-assessment-of-its-application-to-quantitative-determination-of-enzymatic-activity-in-the-extracellular-space-of-mammalian-tissue
#3
Yangguang Ou, Stephen G Weber
Many sampling methods have been developed to measure the extracellular concentrations of solutes in the extracellular space of mammalian tissue. However, few have been used to quantitatively study the various processes, such as enzymatic degradation, that determines the fate of these solutes. For a method to be useful in this pursuit, it must be able to 1) perfuse tissue and collect the perfusate for quantitative analysis of the solutes introduced and reaction products produced, 2) control the average residence time of the active solutes, and 3) have the appropriate spatial resolution for the process of interest...
April 27, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28445631/treating-prolonged-grief-disorder-a-2-year-follow-up-of-a-randomized-controlled-trial
#4
Richard A Bryant, Lucy Kenny, Amy Joscelyne, Natasha Rawson, Fiona Maccallum, Catherine Cahill, Sally Hopwood, Angela Nickerson
BACKGROUND: Prolonged grief disorder (PGD) causes significant impairment in approximately 7% of bereaved people. Although cognitive-behavioral therapy (CBT) has been shown to effectively treat PGD, there is no evidence of long-term effects of CBT. OBJECTIVE: To determine the long-term efficacies of CBT with exposure or CBT without exposure in treating PGD by assessing outcome at 2 years. METHODS: A randomized controlled trial of PGD patients (N = 80) attending an outpatient clinic took place between September 2007 and June 2010, and a 2-year follow-up occurred between December 2009 and October 2012...
April 25, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28445595/ventricular-fibrillation-cardiac-arrest-produces-a-chronic-striatal-hyperdopaminergic-state-that-is-worsened-by-methylphenidate-treatment
#5
Gerald J Nora, Rashed Harun, David F Fine, Daniel Hutchison, Adam C Grobart, Jason P Stezoski, Miranda Munoz, Patrick M Kochanek, Rehana K Leak, Tomas Drabek, Amy K Wagner
Cardiac arrest survival rates have improved with modern resuscitation techniques, but many survivors experience impairments associated with hypoxic-ischemic brain injury. Currently, little is understood about chronic changes in striatal dopamine (DA) systems after hypoxic-ischemic brain injury. Given the common empiric clinical use of DA enhancing agents in neurorehabilitation, investigation evaluating dopaminergic alterations after cardiac arrest (CA) is necessary to optimize rehabilitation approaches. We hypothesized that striatal DA neurotransmission would be altered chronically after ventricular fibrillation cardiac arrest (VF-CA)...
April 26, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28445508/error-model-of-geomagnetic-field-measurement-and-extended-kalman-filter-based-compensation-method
#6
Zhilei Ge, Suyun Liu, Guopeng Li, Yan Huang, Yanni Wang
The real-time accurate measurement of the geomagnetic-field is the foundation to achieving high-precision geomagnetic navigation. The existing geomagnetic-field measurement models are essentially simplified models that cannot accurately describe the sources of measurement error. This paper, on the basis of systematically analyzing the source of geomagnetic-field measurement error, built a complete measurement model, into which the previously unconsidered geomagnetic daily variation field was introduced. This paper proposed an extended Kalman-filter based compensation method, which allows a large amount of measurement data to be used in estimating parameters to obtain the optimal solution in the sense of statistics...
2017: PloS One
https://www.readbyqxmd.com/read/28445298/barcelona-clinic-liver-cancer-stage-c-hepatocellular-carcinoma-a-novel-approach-to-subclassification-and-treatment
#7
Chung Hwan Jun, Jae Hyun Yoon, Eunae Cho, Sang Soo Shin, Sung Bum Cho, Hee Joon Kim, Chang Hwan Park, Hyun Soon Kim, Sung Kyu Choi, Jong Sun Rew
Barcelona clinic liver cancer-stage C (BCLC-C) encompasses a broad spectrum of tumor burdens, liver function statuses, patient prognoses, and treatment strategies. Currently, sorafenib is the only recommended treatment for patients with BCLC-C and outcomes remain suboptimal. The aims of this study were to assess the heterogeneity of BCLC-C hepatocellular carcinoma (HCC) cases, propose a novel subclassification for these cases, and suggest optimal treatment strategies other than sorafenib.We retrospectively analyzed 196 consecutive BCLC-C HCC patients who were diagnosed and treated between January 2008 and December 2015...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28445186/the-hip-fracture-patient-on-warfarin-evaluating-blood-loss-and-time-to-surgery
#8
Matthew R Cohn, Ashley E Levack, Nikunj N Trivedi, Jordan C Villa, David S Wellman, John P Lyden, Dean G Lorich, Joseph M Lane
OBJECTIVES: To compare blood loss, delay of surgery, and short term adverse events in (1) patients admitted on warfarin versus non-anticoagulated controls and (2) warfarin patients with day of surgery (DOS) INR of 1.5 or greater versus below 1.5. DESIGN: Retrospective cohort. SETTING: Academic level I trauma center. PATIENTS/PARTICIPANTS: One hundred twenty four patients treated surgically for hip fractures including patients presenting on warfarin (n=62) and matched controls (n=62)...
April 24, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28445169/continuous-size-and-shape-control-synthesis-of-hollow-silica-nanoparticles-enabled-by-a-microreactor-assisted-rapid-mixing-process
#9
Yujuan He, Ki-Joong Kim, Chih-Hung Alex Chang
Hollow silica nanoparticles (HSNPs) were synthesized using a microreactor-assisted system with a hydrodynamic focusing micromixer (HFM). Due to the fast mixing of each precursor in the system, the PAA thermodynamic-locked (TML) conformations were protected from their random aggregations by the immediately initiated growth of silica shells. When altering the mixing time through varying flow rates and flow rate ratios, the different degrees of the aggregation of PAA TML conformations were observed. The globular and necklace-like TML conformations were successfully captured by modifying the PAA concentration at the optimized mixing condition...
April 26, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28444800/endoscopic-meatus-scoring-scale-versus-sniff-test-to-predict-insertability-before-transnasal-endoscopy-a-prospective-randomized-study
#10
Chi-Tan Hu, Wei-Yi Lei, Jen-Shung Lin, Jui-Sheng Hung
BACKGROUND AND AIM: Sniff test is a common method before unsedated transnasal EGD (UT-EGD) to select a nostril insertion site. Yet, there is no objective method to select a more specific meatus insertion tract for anesthesia and insertion. We devised a endoscopic meatus scoring scale by anterior meatuscopy to select the most optimal meatus insertion tract. We hypothesized that meatuscopy instead of sniff test might improve tolerance and reduce adverse events during nasal anesthesia and UT-EGD...
April 26, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28444640/diagnostic-value-of-the-dual-luciferase-report-assay-for-predicting-response-to-glucocorticoid-in-children-with-acute-lymphoblastic-leukemia
#11
X Wang, P Chen, Y Sun, Y Chen, M Mao, T Jiang, J Ouyang
OBJECTIVE: Resistance to glucocorticoid (GC) is a significant clinical problem in some cases of acute lymphoblastic leukemia (ALL). Current methods of assessing GC resistance are time consuming and have limited reproducibility; in this study, we sought to define a new method of evaluating GC sensitivity and resistance in vitro. METHODS: Based on the mechanisms of GC resistance, we hypothesized that the dual-luciferase report (DLR) assay could reflect the transcription effects of GC downstream of the GC-glucocorticoid receptor signaling pathway, thereby allowing the evaluation of reactions to GC...
April 25, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28444320/complex-skill-training-transfers-to-improved-performance-and-control-of-simpler-tasks-after-stroke
#12
Shailesh S Kantak, Nazaneen Zahedi, Robert McGrath
Background: Given limited therapy time, it is important to practice tasks that optimize transfer to other tasks that cannot be practiced during therapy. However, little is known about how tasks can be selected for practice to optimize generalization. Objective: One dimension of task selection is the complexity of the task. The purpose of the current study was to test if learning of a complex motor skill with the paretic arm would transfer to simpler unpracticed goal-directed reaching task...
April 21, 2017: Physical Therapy
https://www.readbyqxmd.com/read/28443828/controlled-synthesis-of-mno2-nanosheets-vertically-covered-feco2o4-nanoflakes-as-binder-free-electrode-for-high-power-and-durable-asymmetric-supercapacitor
#13
Hongyan Gao, Junjie Xiang, Yan Cao
We developed a simple and controlled method to synthesize FeCo2O4@MnO2 core-sheath nanoarchitecture (CSN) grown on the Ni foam. Ultrathin FeCo2O4 nanoflakes with an average thickness of 10 nm served as the scaffold to deposit MnO2 nanosheets. The MnO2 nanosheets were able to vertically grow on FeCo2O4 nanoflakes to form a sheath via a hydrothermal reaction. The nanocomposites' thickness can be tailored from 80 nm to 550 nm by changing the reaction times. Electrochemical measurements demonstrated that FeCo2O4@MnO2 CSN with an optimal thickness about 400 nm achieved an areal capacitance of 3...
April 26, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28443510/a-combination-of-egg-yolk-igy-and-phosvitin-inhibits-the-growth-of-enterotoxigenic-escherichia-coli-k88-and-k99
#14
Naiyana Gujral, Heejoo Yoo, Fatemeh Bamdad, Kwang Yong Lee, Joo-Won Suh, Hoon Sunwoo
BACKGROUND: Enterotoxigenic Escherichia coli (ETEC) is the main cause of fatal diarrhea in piglets during the first week of life and over the time of weaning. Pathogenesis of ETEC-causing diarrhea involves intestinal colonization mediated by fimbriae. Although, both IgY and egg yolk phosvitin (PV) possess antimicrobial activity, their combined activity has not been explored. A combination of IgY specific for ETEC and metal-chelating PV may show synergistic effect in reducing the growth of ETEC by inhibiting bacterial proliferation and stipulating protection against ETEC infection...
April 25, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28443356/sham-or-no-sham-control-that-is-the-question-in-trials-of-renal-denervation-for-resistant-hypertension-a-systematic-meta-analysis
#15
Fadl Elmula M Fadl Elmula, Ying-Mei Feng, Lotte Jacobs, Anne C Larstorp, Sverre E Kjeldsen, Alexandre Persu, Jan A Staessen
BACKGROUND: Studies of renal denervation (RDN) in patients with apparent treatment resistant hypertension have been hampered by a number of patient and physician related confounders on blood pressure (BP) including poor drug adherence. It remains uncertain whether RDN lowers BP. We aimed to investigate whether the use of sham control is essential in RDN studies or whether systematic use of 24-hour ambulatory BP provides enough information thereby making an invasive sham control redundant...
April 26, 2017: Blood Pressure
https://www.readbyqxmd.com/read/28443015/cross-subject-eeg-feature-selection-for-emotion-recognition-using-transfer-recursive-feature-elimination
#16
Zhong Yin, Yongxiong Wang, Li Liu, Wei Zhang, Jianhua Zhang
Using machine-learning methodologies to analyze EEG signals becomes increasingly attractive for recognizing human emotions because of the objectivity of physiological data and the capability of the learning principles on modeling emotion classifiers from heterogeneous features. However, the conventional subject-specific classifiers may induce additional burdens to each subject for preparing multiple-session EEG data as training sets. To this end, we developed a new EEG feature selection approach, transfer recursive feature elimination (T-RFE), to determine a set of the most robust EEG indicators with stable geometrical distribution across a group of training subjects and a specific testing subject...
2017: Frontiers in Neurorobotics
https://www.readbyqxmd.com/read/28442997/high-spatiotemporal-resolution-ecog-recording-of-somatosensory-evoked-potentials-with-flexible-micro-electrode-arrays
#17
Taro Kaiju, Keiichi Doi, Masashi Yokota, Kei Watanabe, Masato Inoue, Hiroshi Ando, Kazutaka Takahashi, Fumiaki Yoshida, Masayuki Hirata, Takafumi Suzuki
Electrocorticogram (ECoG) has great potential as a source signal, especially for clinical BMI. Until recently, ECoG electrodes were commonly used for identifying epileptogenic foci in clinical situations, and such electrodes were low-density and large. Increasing the number and density of recording channels could enable the collection of richer motor/sensory information, and may enhance the precision of decoding and increase opportunities for controlling external devices. Several reports have aimed to increase the number and density of channels...
2017: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/28442934/effect-of-glomerular-filtration-rate-at-dialysis-initiation-on-survival-in-patients-with-advanced-chronic-kidney-disease-what-is-the-effect-of-lead-time-bias
#18
Cynthia J Janmaat, Merel van Diepen, Raymond T Krediet, Marc H Hemmelder, Friedo W Dekker
PURPOSE: Current clinical guidelines recommend to initiate dialysis in the presence of symptoms or signs attributable to kidney failure, often with a glomerular filtration rate (GFR) of 5-10 mL/min/1.73 m(2). Little evidence exists about the optimal kidney function to start dialysis. Thus far, most observational studies have been limited by lead-time bias. Only a few studies have accounted for lead-time bias, and showed contradictory results. We examined the effect of GFR at dialysis initiation on survival in chronic kidney disease patients, and the role of lead-time bias therein...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/28442714/mitigating-herding-in-hierarchical-crowdsourcing-networks
#19
Han Yu, Chunyan Miao, Cyril Leung, Yiqiang Chen, Simon Fauvel, Victor R Lesser, Qiang Yang
Hierarchical crowdsourcing networks (HCNs) provide a useful mechanism for social mobilization. However, spontaneous evolution of the complex resource allocation dynamics can lead to undesirable herding behaviours in which a small group of reputable workers are overloaded while leaving other workers idle. Existing herding control mechanisms designed for typical crowdsourcing systems are not effective in HCNs. In order to bridge this gap, we investigate the herding dynamics in HCNs and propose a Lyapunov optimization based decision support approach - the Reputation-aware Task Sub-delegation approach with dynamic worker effort Pricing (RTS-P) - with objective functions aiming to achieve superlinear time-averaged collective productivity in an HCN...
December 5, 2016: Scientific Reports
https://www.readbyqxmd.com/read/28442687/postoperative-management-of-penetrating-and-nonpenetrating-external-filtering-procedures
#20
Paolo Bettin, Federico Di Matteo
Correct postoperative management is fundamental to prevent and treat complications and to optimize the success of filtering surgery. Timely control visits and appropriate actions and prescriptions ensure the best outcomes, allow recovery from a number of untoward events, and can reestablish filtration when failure seems imminent. In contrast, a slack follow-up and wrong interventions or prescriptions can lead to the failure of any surgery, no matter how accurately it was carried out, sometimes jeopardizing vision and even the anatomy of the globe...
2017: Developments in Ophthalmology
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