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https://www.readbyqxmd.com/read/28820294/k-deficiency-caused-defects-in-renal-tubular-cell-proliferation-oxidative-stress-response-tissue-repair-and-tight-junction-integrity-but-enhanced-energy-production-proteasome-function-and-cellular-k-uptake
#1
Chompunoot Kapincharanon, Visith Thongboonkerd
Hypokalemia is a common electrolyte disorder in hospitalized patients and those with chronic diseases and is associated with renal tubular injury. Our recent expression proteomics study revealed changes in levels of several proteins in renal tubular cells during K(+) deficiency. However, functional significance and mechanisms underlying such changes remained unclear. The present study, thus, aimed to investigate functional changes of renal tubular cells induced by K(+) deficiency. MDCK cells were maintained in normal-K(+) (ANK; [K(+)] = 5...
August 18, 2017: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/28814499/therapeutic-stimulation-for-restoration-of-function-after-spinal-cord-injury
#2
REVIEW
Aiva Ievins, Chet T Moritz
Paralysis due to spinal cord injury can severely limit motor function and independence. This review summarizes different approaches to electrical stimulation of the spinal cord designed to restore motor function, with a brief discussion of their origins and the current understanding of their mechanisms of action. Spinal stimulation leads to impressive improvements in motor function along with some benefits to autonomic functions such as bladder control. Nonetheless, the precise mechanisms underlying these improvements and the optimal spinal stimulation approaches for restoration of motor function are largely unknown...
September 2017: Physiology
https://www.readbyqxmd.com/read/28813918/how-to-prepare-a-person-with-complete-spinal-cord-injury-to-use-surface-electrodes-for-fes-trike-cycling
#3
Raymond K Y Tong, Xiaojun Wang, Kenry W C Leung, Ginny T Y Lee, Cathy C Y Lau, H W Wai, Peter M K Pang, H C Leung
Functional Electrical Stimulation (FES) cycling could benefit people with Spinal Cord Injury (SCI). The FES cycling involves large muscle groups during the training, and thus improves the cardiovascular function, increases the muscle bulk and reduces the secondary complications. This study developed an outdoor FES exercise cycling system for complete SCI persons to exercise their lower limbs without putting extra load on upper extremities. The mechanical structure of the cycling system was specially redesigned to secure the SCI persons in the cycling system...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813859/an-assistive-lower-limb-exoskeleton-for-people-with-neurological-gait-disorders
#4
A Ortlieb, M Bouri, R Baud, H Bleuler
Lower limb exoskeletons have already proven the capability to give back mobility to people suffering from spinal cord injury (SCI). Other important populations such as people with multiple sclerosis or muscular dystrophy, frail elderly and stroke victims, suffer from severe gait impairments and could benefit from similar technology. The work presented in the current paper describes a novel design of a 6-actuated degrees of freedom (DOFs) assistive lower limb exoskeleton for people with moderate mobility impairments...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813833/an-integrated-gait-rehabilitation-training-based-on-functional-electrical-stimulation-cycling-and-overground-robotic-exoskeleton-in-complete-spinal-cord-injury-patients-preliminary-results
#5
S Mazzoleni, E Battini, A Rustici, G Stampacchia
The aim of this study is to investigate the effects of an integrated gait rehabilitation training based on Functional Electrical Stimulation (FES)-cycling and overground robotic exoskeleton in a group of seven complete spinal cord injury patients on spasticity and patient-robot interaction. They underwent a robot-assisted rehabilitation training based on two phases: n=20 sessions of FES-cycling followed by n= 20 sessions of robot-assisted gait training based on an overground robotic exoskeleton. The following clinical outcome measures were used: Modified Ashworth Scale (MAS), Numerical Rating Scale (NRS) on spasticity, Penn Spasm Frequency Scale (PSFS), Spinal Cord Independence Measure Scale (SCIM), NRS on pain and International Spinal Cord Injury Pain Data Set (ISCI)...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28805949/the-reversible-p2y12-antagonist-act-246475-causes-significantly-less-blood-loss-than-ticagrelor-at-equivalent-antithrombotic-efficacy-in-rat
#6
Markus Rey, Markus Kramberg, Patrick Hess, Keith Morrison, Roland Ernst, Franck Haag, Edgar Weber, Martine Clozel, Martine Baumann, Eva Caroff, Francis Hubler, Markus A Riederer, Beat Steiner
The P2Y12 receptor is a validated target for prevention of major adverse cardiovascular events in patients with acute coronary syndrome. The aim of this study was to compare two direct-acting, reversible P2Y12 antagonists, ACT-246475 and ticagrelor, in a rat thrombosis model by simultaneous quantification of their antithrombotic efficacy and surgery-induced blood loss. Blood flow velocity was assessed in the carotid artery after FeCl3 -induced thrombus formation using a Doppler flow probe. At the same time, blood loss after surgical wounding of the spleen was quantified...
October 2017: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/28804223/the-effect-of-transcutaneous-electrical-acupoint-stimulation-on-inflammatory-response-in-patients-undergoing-limb-ischemia-reperfusion
#7
Yunchang Mo, Sijia Chen, Lili Yang, Ledan Huang, Dan Jin, Zhi Yu, Leilei Wang, Liangrong Wang, Shan Luo, Junlu Wang
Reperfusion after tourniquet use can induce inflammation and cause remote organ injury. We evaluated the therapeutic effect of transcutaneous electrical acupoint stimulation (TEAS) on inflammatory mediators and lung function in patients receiving lower limb tourniquets. Forty patients undergoing unilateral lower extremity surgery with tourniquet were randomly assigned to two groups: the TEAS group and ischemia-reperfusion (I/R) group. The C-C motif chemokine ligand 2 (CCL2), C-X-C motif chemokine ligand 8 (CXCL8), interleukin-1 (IL-1), interleukin-6 (IL-6), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α), and arterial blood gas analysis were measured preoperatively and 6 h after tourniquet removal...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28803750/motor-cortex-and-spinal-cord-neuromodulation-promote-corticospinal-tract-axonal-outgrowth-and-motor-recovery-after-cervical-contusion-spinal-cord-injury
#8
N Zareen, M Shinozaki, D Ryan, H Alexander, A Amer, D Truong, N Khadka, A Sarkar, S Naeem, M Bikson, J Martin
Cervical injuries are the most common form of SCI. In this study, we used a neuromodulatory approach to promote skilled movement recovery and repair of the corticospinal tract (CST) after a moderately severe C4 midline contusion in adult rats. We used bilateral epidural intermittent theta burst (iTBS) electrical stimulation of motor cortex to promote CST axonal sprouting and cathodal trans-spinal direct current stimulation (tsDCS) to enhance spinal cord activation to motor cortex stimulation after injury. We used Finite Element Method (FEM) modeling to direct tsDCS to the cervical enlargement...
August 10, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28802391/pathophysiology-of-esophageal-impairment-due-to-button-battery-ingestion
#9
Johannes Völker, Christine Völker, Philipp Schendzielorz, Sebastian P Schraven, Andreas Radeloff, Robert Mlynski, Rudolf Hagen, Kristen Rak
BACKGROUND: The increased use of button batteries with high energy densities in devices of daily life presents a high risk of injury, especially for toddlers and young children. If an accidental ingestion of a button battery occurs, this foreign body can become caught in the constrictions of the esophagus and cause serious damage to the adjacent tissue layers. The consequences can be ulcerations, perforations with fistula formation and damage to the surrounding anatomical structures. In order to gain a better understanding of the pathophysiology after ingestion, we carried out systematic studies on fresh preparations of porcine esophagi...
September 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28801643/the-role-of-pge2-in-alveolar-epithelial-and-lung-microvascular-endothelial-crosstalk
#10
Thomas Bärnthaler, Jovana Maric, Wolfgang Platzer, Viktoria Konya, Anna Theiler, Carina Hasenöhrl, Benjamin Gottschalk, Sandra Trautmann, Yannick Schreiber, Wolfgang F Graier, Rudolf Schicho, Gunther Marsche, Andrea Olschewski, Dominique Thomas, Rufina Schuligoi, Akos Heinemann
Disruption of the blood-air barrier, which is formed by lung microvascular endothelial and alveolar epithelial cells, is a hallmark of acute lung injury. It was shown that alveolar epithelial cells release an unidentified soluble factor that enhances the barrier function of lung microvascular endothelial cells. In this study we reveal that primarily prostaglandin (PG) E2 accounts for this endothelial barrier-promoting activity. Conditioned media from alveolar epithelial cells (primary ATI-like cells) collected from BALB/c mice and A549 cells increased the electrical resistance of pulmonary human microvascular endothelial cells, respectively...
August 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28801484/predicting-outcomes-in-traumatic-out-of-hospital-cardiac-arrest-the-relevance-of-utstein-factors
#11
Ben Beck, Janet E Bray, Peter Cameron, Lahn Straney, Emily Andrew, Stephen Bernard, Karen Smith
BACKGROUND: Given low survival rates in cases of traumatic out-of-hospital cardiac arrest (OHCA), there is a need to identify factors associated with outcomes. We aimed to investigate Utstein factors associated with achieving return of spontaneous circulation (ROSC) and survival to hospital in traumatic OHCA. METHODS: The Victorian Ambulance Cardiac Arrest Registry (VACAR) was used to identify cases of traumatic OHCA that received attempted resuscitation and occurred between July 2008 and June 2014...
August 11, 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/28801220/multiple-reflex-pathways-contribute-to-bladder-activation-by-intraurethral-stimulation-in-persons-with-spinal-cord-injury
#12
Meredith J McGee, Brandon D Swan, Zachary C Danziger, Cindy L Amundsen, Warren M Grill
OBJECTIVES: To measure the urodynamic effects of electrical co-stimulation of two individual sites in the proximal and distal urethra in persons with spinal cord injury (SCI). This work was motivated by preclinical findings that selective co-stimulation of the cranial urethral sensory nerve and the dorsal genital nerve, which innervate the proximal and distal portions of the urethra, respectively, increased reflex bladder activation and voiding efficiency. METHODS: Electrical co-stimulation of urethral afferents was conducted in persons with chronic SCI during urodynamics...
August 8, 2017: Urology
https://www.readbyqxmd.com/read/28800036/improved-outcomes-of-cardiopulmonary-resuscitation-in-rats-treated-with-vagus-nerve-stimulation-and-its-potential-mechanism
#13
Peng Sun, Jiangang Wang, Shen Zhao, Zhengfei Yang, Ziren Tang, Navami Ravindra, Jennifer Bradley, Joseph P Ornato, Mary Ann Peberdy, Wanchun Tang
Studies have demonstrated that vagus nerve stimulation (VNS) reduces ischemia/reperfusion (I/R) injury. In this study, we investigated the protective effects of VNS in a rat model of cardiopulmonary resuscitation (CPR). We further investigated whether the beneficial effects of VNS were dependent on the alpha 7 nicotinic acetylcholine receptor (α7nAChR). Forty animals were randomized into 4 groups and all underwent CPR (n = 10 each): (1) CPR alone (control); (2) VNS during CPR; (3) α7nAChR antagonist methyllycaconitine citrate (MLA) with VNS; (4) α7nAChR agonist 3-(2, 4-dimethoxybenzylidene) anabaseine (GTS-21) without VNS...
August 9, 2017: Shock
https://www.readbyqxmd.com/read/28797571/epidemiology-of-burn-patients-presenting-to-a-tertiary-hospital-emergency-department-in-lebanon
#14
Abou Dagher Gilbert, Eva Rajha, Christopher El Khuri, Ralph Bou Chebl, Aurelie Mailhac, Maha Makki, Mazen El Sayed
BACKGROUND: The epidemiology of burns is well described in the United States, Europe and Asia. However, few studies address this topic in the Levant region. This study aims to describe characteristics of burn victims treated at the emergency department of a tertiary care center in Beirut, Lebanon and to report on factors that affect ED disposition. METHODS: A retrospective cohort study was conducted in the ED of a tertiary care hospital, in Beirut, Lebanon, between 2009 and 2013...
August 7, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28797427/low-level-tragus-stimulation-for-the-treatment-of-ischemia-and-reperfusion-injury-in-patients-with-st-segment-elevation-myocardial-infarction-a-proof-of-concept-study
#15
Lilei Yu, Bing Huang, Sunny S Po, Tuantuan Tan, Menglong Wang, Liping Zhou, Guannan Meng, Shenxu Yuan, Xiaoya Zhou, Xuefei Li, Zhuo Wang, Songyun Wang, Hong Jiang
OBJECTIVES: The aim of this study was to investigate whether low-level tragus stimulation (LL-TS) treatment could reduce myocardial ischemia-reperfusion injury in patients with ST-segment elevation myocardial infarction (STEMI). BACKGROUND: The authors' previous studies suggested that LL-TS could reduce the size of myocardial injury induced by ischemia. METHODS: Patients who presented with STEMI within 12 h of symptom onset, treated with primary percutaneous coronary intervention, were randomized to the LL-TS group (n = 47) or the control group (with sham stimulation [n = 48])...
August 14, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28796107/the-effect-of-functional-mandibular-shift-on-the-muscle-spindle-systems-in-head-neck-muscles-and-the-related-neurotransmitter-histamine
#16
Bing-Li Du, Jiang-Ning Li, Hong-Ming Guo, Song Li, Biao Liu
The aim of this study is to explore the effects of abnormal occlusion and functional recovery caused by functional mandible deviation on the head and neck muscles and muscle spindle sensory-motor system by electrophysiological response and endogenous monoamine neurotransmitters' distribution in the nucleus of the spinal tract. Seven-week-old male Wistar rats were randomly divided into 7 groups: normal control group, 2W experimental control group, 2W functional mandible deviation group, 2W functional mandible deviation recovery group, 4W experimental control group, 4W functional mandible deviation group, 4W functional mandible deviation recovery group...
August 8, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28795657/body-system-effects-of-a-multi-modal-training-program-targeting-chronic-motor-complete-thoracic-spinal-cord-injury
#17
Katie Gant, Kathleen Nagle, Rachel Cowan, Edelle Field-Fote, Mark Nash, Jochen Kressler, Christine K Thomas, Mabelin Castellanos, Eva Widerstrom-Noga, Kimberly D Anderson
The safety and efficacy of pharmacologic and cellular transplantation strategies are currently being evaluated in people with spinal cord injury. In studies of people with chronic spinal cord injuries, it is thought that functional recovery will be best achieved when drug or cell therapies are combined with rehabilitation protocols. However, any functional recovery due to the therapy may be confounded by the conditioned state of the body and by training-induced effects on neuroplasticity. For this reason, we sought to investigate the effects of a multi-modal training program on several body systems...
August 10, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28781176/electrical-neuromodulation-of-the-respiratory-system-after-spinal-cord-injury
#18
REVIEW
Jan T Hachmann, Peter J Grahn, Jonathan S Calvert, Dina I Drubach, Kendall H Lee, Igor A Lavrov
Spinal cord injury (SCI) is a complex and devastating condition characterized by disruption of descending, ascending, and intrinsic spinal circuitry resulting in chronic neurologic deficits. In addition to limb and trunk sensorimotor deficits, SCI can impair autonomic neurocircuitry such as the motor networks that support respiration and cough. High cervical SCI can cause complete respiratory paralysis, and even lower cervical or thoracic lesions commonly result in partial respiratory impairment. Although electrophrenic respiration can restore ventilator-independent breathing in select candidates, only a small subset of affected individuals can benefit from this technology at this moment...
August 3, 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/28775367/abdominal-functional-electrical-stimulation-to-improve-respiratory-function-after-spinal-cord-injury-a-systematic-review-and-meta-analysis
#19
E J McCaughey, R J Borotkanics, H Gollee, R J Folz, A J McLachlan
This corrects the article DOI: 10.1038/sc.2016.31.
August 2017: Spinal Cord
https://www.readbyqxmd.com/read/28774384/overcoming-the-roadblocks-to-cardiac-cell-therapy-using-tissue-engineering
#20
REVIEW
Mounica Yanamandala, Wuqiang Zhu, Daniel J Garry, Timothy J Kamp, Joshua M Hare, Ho-Wook Jun, Young-Sup Yoon, Nenad Bursac, Sumanth D Prabhu, Gerald W Dorn, Roberto Bolli, Richard N Kitsis, Jianyi Zhang
Transplantations of various stem cells or their progeny have repeatedly improved cardiac performance in animal models of myocardial injury; however, the benefits observed in clinical trials have been generally less consistent. Some of the recognized challenges are poor engraftment of implanted cells and, in the case of human cardiomyocytes, functional immaturity and lack of electrical integration, leading to limited contribution to the heart's contractile activity and increased arrhythmogenic risks. Advances in tissue and genetic engineering techniques are expected to improve the survival and integration of transplanted cells, and to support structural, functional, and bioenergetic recovery of the recipient hearts...
August 8, 2017: Journal of the American College of Cardiology
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