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R F van Vollenhoven, I Gunnarsson, E Welin-Henriksson, B Sundelin, A Osterborg, S H Jacobson, L Klareskog
BACKGROUND: The monoclonal anti-B cell antibody rituximab (Rituxin, Mabthera) may be of benefit in antibody-driven diseases, including systemic lupus erythematosus (SLE) nephritis. PATIENTS AND TREATMENT: Two female patients with biopsy-confirmed severe and active SLE nephritis despite treatment with cyclophosphamide (CyX) were given four rituximab infusions plus two additional CyX infusions. RESULTS: Both patients tolerated the treatment well and SLE activity improved...
2004: Scandinavian Journal of Rheumatology
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