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Chronic venous insufficiency

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https://www.readbyqxmd.com/read/28902819/-chronic-venous-diseases-valvular-function-and-leukocyte-endothelial-interaction-possibilities-of-pharmacotherapy
#1
S V Sapelkin, I E Timina, A S Dudareva
This article provides a review of the literature focusing on the data elucidating the pathogenesis of chronic venous diseases from the positions of macrohaemodynamic (venous valvular function) and microcirculatory impairments. Presented herein are confirmations of the interaction between two important mechanisms, as well as the literature data concerning the role of the venous microvalvular structures and possible haemodynamic impairments in functional venous insufficiency. Also presented are substantiations in confirmation of the theory of leukocyte-endothelial interaction, forming the basis for contemporary understanding of the pathogenesis of chronic venous diseases...
2017: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/28902818/-efficacy-of-sulodexide-in-treatment-of-chronic-venous-insufficiency-results-of-the-accord-trial
#2
V Iu Bogachev, O V Golovanova, I N Malysheva
OBJECTIVE: The purpose of our study was to evaluate both clinical and laboratory efficacy of sulodexide given at a daily dose of 500 lipasemic units (LSU) in patients presenting with class C3-C4 chronic venous insufficiency (CVI) according to the CEAP classification. PATIENTS AND METHODS: The study included a total of 25 patients diagnosed with C3-C4 CVI and prescribed to receive sulodexide at a daily dose of 500 LSU for 90 days. Efficacy was comprehensively controlled by the following tools: the disease-specific Chronic Venous Insufficiency Quality of Life Questionnaire (CIVIQ), visual-analogue methods of assessment separate symptoms; the Venous Clinical Severity Score (VCSS), as well as ultrasonographic determination of the thickness of subcutaneous fat and crural fascia...
2017: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/28890859/association-of-aescin-with-%C3%AE-and-%C3%AE-cyclodextrins-studied-by-dft-calculations-and-spectroscopic-methods
#3
Ana I Ramos, Pedro D Vaz, Susana S Braga, Artur M S Silva
Background: Aescin, a natural mixture of saponins occurring in Aesculus hippocastanum, exhibits important flebotonic properties, being used in the treatment of chronic venous insufficiency in legs. The inclusion of aescin into cyclodextrins (CDs) is a technical solution for its incorporation into the textile of stockings, but details of the physicochemistry of these host-guest systems are lacking. This work investigates the inclusion of aescin into the cavities of two native cyclodextrins, β-CD and γ-CD. Results: The continuous variation method applied to aqueous-phase (1)H nuclear magnetic resonance ((1)H NMR) has demonstrated that the preferred CD/aescin inclusion stoichiometries are 2:1 with β-CD and 1:1 with γ-CD...
2017: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/28882115/caught-in-a-no-win-situation-discussions-about-ccsvi-between-persons-with-multiple-sclerosis-and-their-neurologists-a-qualitative-study
#4
S Michelle Driedger, Ryan Maier, Ruth Ann Marrie, Melissa Brouwers
BACKGROUND: In recent years, shared decision making (SDM) has been promoted as a model to guide interactions between persons with MS and their neurologists to reach mutually satisfying decisions about disease management - generally about deciding treatment courses of prevailing disease modifying therapies. In 2009, Dr. Paolo Zamboni introduced the world to his hypothesis of Chronic Cerebrospinal Venous Insufficiency (CCSVI) as a cause of MS and proposed venous angioplasty ('liberation therapy') as a potential therapy...
September 7, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28878840/chronic-venous-insufficiency-a-frequently-underdiagnosed-and-undertreated-pathology
#5
Marilena Spiridon, Dana Corduneanu
The article describes the medical approach of a frequent pathology, chronic venous insufficiency. Chronic venous insufficiency requires early diagnosis as well as an evaluation of the associated risk factors; also, patients need to understand the disease and its treatment, and to become compliant with all their physician's recommendations. Importantly, the physician should correctly evaluate the disease and decide the best option for the patient. These days, it is crucial that the patient benefits from optimal treatment choice in order to prevent complications...
January 2017: Mædica
https://www.readbyqxmd.com/read/28873064/a-systematic-review-and-meta-analysis-of-exercise-intervention-for-the-treatment-of-calf-muscle-pump-impairment-in-individuals-with-chronic-venous-insufficiency
#6
Lyndsay Orr, Kathleen A Klement, Laura McCrossin, Deirdre O'Sullivan Drombolis, Pamela E Houghton, Sandi Spaulding, Shauna Burke
Exercise intervention for individuals with chronic venous insufficiency (CVI) and venous leg ulcers (VLUs) is recommended to improve function of the calf muscle pump (CMP). A systematic review with meta-analysis was conducted to measure the effects of exercise (including function of the CMP, ankle strength, range of motion [ROM], and healing rates) for VLUs. Four (4) databases (Cumulative Index to Nursing and Applied Health Literature, 1981; MEDLINE, 1964; Scopus, 1966; and EMBASE, 1947) were searched for relevant articles from the date of index inception to January 2016...
August 2017: Ostomy/wound Management
https://www.readbyqxmd.com/read/28863078/the-prevalence-of-chronic-deep-venous-thrombosis-in-trauma-implications-for-hospitals-and-patients
#7
Kathleen A Cannon, Jayraan Badiee, James D Wallace, Jason B Brill, Michael J Sise, Vishal Bansal, C Beth Sise, Steven R Shackford
INTRODUCTION: Deep venous thrombosis (DVT) is considered a preventable complication in trauma patients. Hospitals risk financial penalties for DVT rates above accepted benchmarks. These penalties do not apply to chronic DVT which develop prior to admission. Lower-extremity duplex ultrasound (LEDUS) can detect characteristics of thrombus chronicity, allowing differentiation of chronic from acute DVT. The objective of this study was to determine the prevalence of chronic DVT in hospitalized trauma patients...
August 31, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28857522/validation-of-the-croatian-version-of-civiq-quality-of-life-questionnaire-in-patients-with-chronic-venous-disorders
#8
Tamara Sinožić, Ksenija Baždarić, Dina Šverko, Alen Ružić, Milica Katić
AIM: To test the psychometric properties of the Croatian version of the Chronic Venous Insufficiency Quality of Life (CIVIQ) Questionnaire and to assess the quality of life in patients with chronic venous disorders of all stages. METHODS: This cross-sectional study performed between 2014 and 2015 in a private family practice assessed the factorial validity, cross-sectional validity, and reliability of the Croatian CIVIQ 20-item questionnaire completed by 428 adult patients (78% women) with chronic venous disorders classified according to the Clinical-Etiologic-Anatomic-Pathophysiologic (CEAP) C classification as stages C1-C6...
August 31, 2017: Croatian Medical Journal
https://www.readbyqxmd.com/read/28846879/insufficient-sleep-is-associated-with-impaired-nitric-oxide-mediated-endothelium-dependent-vasodilation
#9
Anthony R Bain, Brian R Weil, Kyle J Diehl, Jared J Greiner, Brian L Stauffer, Christopher A DeSouza
BACKGROUND AND AIMS: Habitual short nightly sleep duration is associated with increased atherosclerotic cardiovascular disease risk and morbidity. Vascular endothelial dysfunction represents an important mechanism that may underlie this heightened cardiovascular risk. Impaired endothelium-dependent vasodilation, particularly NO-mediated vasodilation, contributes to the development and progression of atherosclerotic vascular disease and acute vascular events. We tested the hypothesis that chronic insufficient sleep is associated with impaired NO-mediated endothelium-dependent vasodilation in middle-aged adults...
August 18, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28844444/epidemiology-of-the-post-thrombotic-syndrome
#10
Jean-Philippe Galanaud, Manuel Monreal, Susan R Kahn
The post thrombotic syndrome (PTS) refers to clinical manifestations of chronic venous insufficiency (CVI) following a deep-vein thrombosis (DVT). PTS is the most frequent complication of DVT, which develops in 20 to 50% of cases after proximal DVT and is severe in 5-10% of cases. The reported prevalence of PTS differs widely among studies because of differences in study populations, tools used to assess PTS, and time interval between acute DVT and PTS assessment. The two most important predictors of PTS are extensive proximal character of DVT and previous ipsilateral DVT...
July 24, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28818225/patient-centered-outcomes-of-a-dual-action-pneumatic-compression-device-in-comparison-to-compression-stockings-for-patients-with-chronic-venous-disease
#11
Fedor Lurie, Marc Schwartz
OBJECTIVE: The ACTitouch (AT) device (Tactile Medical, Minneapolis, Minn) represents a new generation of pneumatic compression devices by combining sustained compression with intermittent pneumatic compression. The sustained compression mode provides automatic pressure adjustment every 30 minutes, ensuring pressure consistency regardless of leg volume changes and environmental influences. Designed for mobile patients, this device has not been studied in comparison to standard compression stockings (CS)...
September 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/28815700/pseudoangiosarcomatous-squamous-cell-carcinoma-of-the-skin-a-need-for-a-more-rigorous-nomenclature-for-histopathological-variants-of-squamous-cell-carcinoma
#12
Victoria Alegría-Landa, Francisco Jose Navarro-Triviño, Jose Aneiros-Fernandez, Luis Requena
Over the years, squamous cell carcinomas (SCC) that mimicked vascular lesions have been encompassed within different classifications and the underlying etiopathogenic mechanisms have been interpreted in different ways by different authors. Here, we present a case of SCC with pseudovascular areas in the right leg of a 96-year-old woman with chronic venous insufficiency. Histopathological examination closely resembled an angiosarcoma, but the immunohistochemical negativity for endothelial markers and the strong positivity for the pancytokeratin marker AE1/AE3 revealed the epithelial nature of the neoplasm...
August 16, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28808735/-diagnostics-and-endovascular-treatment-of-venous-diseases
#13
L Kamper, A Altenburg, M Das, P Haage
In venous disease, acute thromboses and chronic venous insufficiency have the highest health economics relevance. Duplex sonography is the first line diagnostic assessment tool, while cross-sectional imaging is employed as a supplementary method. Due to the availability and examination times computed tomography is preferred in the emergency setting and is supplemented by magnetic resonance imaging (MRI) for specific questions. Endovascular treatment procedures are increasingly becoming available in addition to classical conservative treatment methods...
August 14, 2017: Der Radiologe
https://www.readbyqxmd.com/read/28804235/management-of-varicose-veins-and-chronic-venous-insufficiency-in-a-comparative-registry-with-nine-venoactive-products-in-comparison-with-stockings
#14
G Belcaro, M Dugall, R Luzzi, M Corsi, A Ledda, A Ricci, L Pellegrini, M R Cesarone, M Hosoi, B M Errichi, U Cornelli, R Cotellese, G Agus, B Feragalli
The aim of this registry study was to compare products used to control symptoms of CVI. Endpoints of the study were microcirculation, effects on volume changes, and symptoms (analogue scale). Pycnogenol, venoruton, troxerutin, the complex diosmin-hesperidin, Antistax, Mirtoselect (bilberry), escin, and the combination Venoruton-Pycnogenol (VE-PY) were compared with compressions. No safety or tolerability problems were observed. At inclusion, measurements in the groups were comparable: 1,051 patients completed the registry...
September 2017: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/28767808/preliminary-results-of-severe-venous-insufficiency-treatment-with-thermal-ablation-of-the-great-saphenous-vein-by-endovascular-technique-with-laser-diode-980nm-developed-in-brazil-associated-with-sclerotherapy-with-polidocanol
#15
Matheus Bertanha, Marcone Lima Sobreira, Paula Angelelli Bueno Camargo, Rafael Elias Farres Pimenta, Jamil Victor Oliveira Mariúba, Regina Moura, Vanderlei Salvador Bagnato, Winston Bonetti Yoshida
The endovenous laser ablation (EVLA) of the insufficient saphenous vein has similar results to open conventional surgery, but less morbidity. The echo-guided polidocanol foam sclerotherapy technique has been used for the same purpose. The combined techniques may play a role for more severe diseases, such as those with varicose ulcers. An EVLA device (called VELAS) has been developed in the Optics and Photonics Research Center of USP-São Carlos in agreement with FMB-UNESP. In this study, we present the preliminary results of the VELAS device (MMO 980nm diode) in patients with chronic venous ulcer, associated with echo-guided polidocanol foam sclerotherapy for the treatment of varicosities...
May 2017: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/28762949/laser-doppler-flowmetry-and-transcutaneous-oximetry-in-chronic-skin-ulcers-a-comparative-evaluation
#16
Edoardo Raposio, Nicolò Bertozzi, Rebecca Moretti, Eugenio Grignaffini, Michele P Grieco
INTRODUCTION/OBJECTIVE: Laser Doppler Flowmetry (LDF) and transcutaneous oximetry (TcpO2) are established methods for investigating cutaneous perfusion. To date, no study previously performed has compared data obtained from these 2 methodologies in cases of chronic cutaneous ulcers. MATERIALS AND METHODS: Laser Doppler Flowmetry and TcpO2 were performed in 25 consecutive outpatients with chronic lower limb ulcers (group A, experimental; 9 women and 16 men; mean age 67 years [range, 52-81 years]) and 25 age- and sex-matched healthy control subjects (group B, control) enrolled for the study...
April 27, 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28745214/nailfold-capillaroscopy-of-fingers-and-toes-variations-of-normal
#17
Sevdalina Lambova, Ulf Müller-Ladner
INTRODUCTION: Nailfold capillaroscopy is the only method for morphological assessment of nutritive capillaries. The literature data about capillaroscopic findings of toes in healthy individuals are scarce. THE AIM OF THE STUDY: To evaluate and compare the capillaroscopic findings of fingers and toes in healthy subjects. MATERIALS AND METHODS: 22 healthy individuals were included in the study. Capillaroscopic examination was performed with videocapillaroscope Videocap 3...
July 26, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/28736157/prevention-and-treatment-of-the-post-thrombotic-syndrome
#18
REVIEW
Oleg Pikovsky, Anat Rabinovich
Post-thrombotic syndrome (PTS) is a complication that develops in up to 50% of patients with deep vein thrombosis (DVT) and manifests as symptoms and signs of chronic venous insufficiency of varying severity. PTS negatively affects patient's quality of life and causes significant burden to the healthcare system. The risk for PTS development can be markedly reduced by preventing DVT and providing appropriate anticoagulation once it develops. Patients with extensive proximal (iliofemoral) DVT may benefit from invasive interventions, such as catheter-directed thrombolysis...
July 15, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28731380/first-experience-of-performing-hybrid-operations-in-chronic-venous-obstructions-of-iliofemoral-segments-in-patients-with-postthrombotic-syndrome
#19
Anatoly Pokrovsky, Igor Ignatyev, Evgeny Gradusov
OBJECTIVE: To assess the first results of hybrid operations in chronic venous obstructions of iliofemoral segments in patients with postthrombotic syndrome (PTS). METHODS: Hybrid operations (open endovenectomy from the common femoral vein with arteriovenous fistula creation and iliac vein stenting) were performed in 12 patients diagnosed with PTS. All of the patients were diagnosed with severe chronic venous insufficiency. The degree of manifestations of PTS was assessed by means of the Villalta score 7 months before and after the surgical intervention...
January 1, 2017: Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28721810/centralized-and-local-color-doppler-ultrasound-reading-agreement-for-diagnosis-of-the-chronic-cerebrospinal-venous-insufficiency-in-patients-with-multiple-sclerosis
#20
Maria Grazia Caprio, Karen Marr, Sirin Gandhi, Dejan Jakimovski, Jesper Hagemeier, Bianca Weinstock-Guttman, Robert Zivadinov, Marcello Mancini
BACKGROUND: An impaired cerebrospinal venous drainage was postulated to be a cofactor in the multifactorial pathogenesis of multiple sclerosis (MS). Chronic cerebrospinal venous insufficiency (CCSVI) is characterized by abnormalities of the main extracranial cerebrospinal venous outflow routes, which can be detected by color Doppler Ultrasound (CDUS) using 5 venous hemodynamic (VH) criteria. Discrepant results between different investigators were reported in the past, therefore the usefulness and applicability of the CCSVI CDUS-based diagnosis in clinical research and practice has been questioned...
2017: Current Neurovascular Research
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