Peng Liu, Lichun Ye, Yongshen Ren, Guodun Zhao, Yun Zhang, Shaojuan Lu, Qiang Li, Chen Wu, Lijie Bai, Zhongyun Zhang, Zhongqiu Zhao, Zhaohua Shi, Shijin Yin, Maochuan Liao, Zhou Lan, Jing Feng, Lvyi Chen
BACKGROUND AND PURPOSE: Intravenous infusion of chemotherapy drugs can cause severe chemotherapy-induced phlebitis (CIP) in patients. However, the underlying mechanism of CIP remains unclear. EXPERIMENTAL APPROACH: RNA-seq analysis to identify potential disease target in CIP. GBP5 genetic deletion approaches were used to investigate the role of GBP5 in NLRP3 inflammasome activation in lipopolysaccharides (LPS)-primed bone-marrow-derived macrophages (BMDMs) induced by vinorelbine (VIN) in vitro and in mouse models of VIN-induced CIP in vivo...
December 7, 2022: British Journal of Pharmacology