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Aescin

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https://www.readbyqxmd.com/read/29332356/%C3%AE-aescin-shows-potent-antiproliferative-activity-in-osteosarcoma-cells-by-inducing-autophagy-ros-generation-and-mitochondrial-membrane-potential-loss
#1
Zhao-Rui Liu, Li-Zhi Sun, Tang-Hong Jia, Dao-Fu Jia
PURPOSE: Osteosarcoma is one of the frequent bone tumor affecting mainly children and is associated with considerable mortality. The limited availability of anticancer drugs and less efficacious treatment options have led to poor survival rates of patients with osteosarcoma. Therefore, there is need to look for more viable treatment options and against this backdrop, natural products may prove handy. Therefore the aim of the present study was to evaluate the anticancer activity of a natural product of plant origin, β-aescin, against U2OS human osteosarcoma cells...
November 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29211484/correction-to-aescin-incorporation-and-nanodomain-formation-in-dmpc-model-membranes
#2
Ramsia Sreij, Carina Dargel, Lara H Moleiro, Francisco Monroy, Thomas Hellweg
No abstract text is available yet for this article.
December 6, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28985678/aescin-incorporation-and-nanodomain-formation-in-dmpc-model-membranes
#3
Ramsia Sreij, Carina Dargel, Lara H Moleiro, Francisco Monroy, Thomas Hellweg
The saponin aescin from the horse chestnut tree is a natural surfactant well-known to self-assemble as oriented-aggregates at fluid interfaces. Using model membranes in the form of lipid vesicles and Langmuir monolayers, we study the mixing properties of aescin with the phase-segregating phospholipid 1,2-dimyristoyl-sn-glycero-phosphocholine (DMPC). The binary membranes are experimentally studied on different length scales ranging from the lipid headgroup area to the macroscopic scale using small-angle X-ray scattering (SAXS), photon correlation spectroscopy (PCS), and differential scanning calorimetry (DSC) with binary bilayer vesicles and Langmuir tensiometry (LT) with lipid monolayers spread on the surface of aescin solutions...
October 23, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28890859/association-of-aescin-with-%C3%AE-and-%C3%AE-cyclodextrins-studied-by-dft-calculations-and-spectroscopic-methods
#4
Ana I Ramos, Pedro D Vaz, Susana S Braga, Artur M S Silva
Background: Aescin, a natural mixture of saponins occurring in Aesculus hippocastanum, exhibits important flebotonic properties, being used in the treatment of chronic venous insufficiency in legs. The inclusion of aescin into cyclodextrins (CDs) is a technical solution for its incorporation into the textile of stockings, but details of the physicochemistry of these host-guest systems are lacking. This work investigates the inclusion of aescin into the cavities of two native cyclodextrins, β-CD and γ-CD. Results: The continuous variation method applied to aqueous-phase (1)H nuclear magnetic resonance ((1)H NMR) has demonstrated that the preferred CD/aescin inclusion stoichiometries are 2:1 with β-CD and 1:1 with γ-CD...
2017: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/28471233/effect-of-sodium-aescinate-treatment-on-pcos-rat-model-with-insulin-resistance
#5
L Chen, L M Hu, Y F Wang, H Y Yang, X Y Huang, W Zhou, H X Sun
BACKGROUND: Recent studies indicated that insulin resistance may contribute to the pathogenesis of polycystic ovary syndrome (PCOS); however, the specific mechanism is still unclear. OBJECTIVE: To investigate the effect of sodium aescinate (SA) on PCOS-IR rat models. METHODS: Sixty rats were randomly divided into the five groups: un-treated rats (n = 12), PCOS-IR group (n = 12), PCOS-IR group plus 50 mg/kg SA (n = 12), PCOS-IR group plus 10 mg/kg SA (n = 12), PCOS-IR group plus 150 mg/kg metformin (n = 12)...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/28144968/adverse-event-due-to-a-likely-interaction-between-sodium-aescinate-and-ginkgo-biloba-extract-a-case-report
#6
H Ji, G Zhang, F Yue, X Zhou
WHAT IS KNOWN AND OBJECTIVE: Drug-induced nephrotoxicity is potentially lethal. When sodium aescinate is given to surgical inpatients to treat postoperative inflammation and oedema, adverse drug reactions and drug-drug interactions must be closely monitored. CASE DESCRIPTION: We report a case of a 58-year-old man with phalangeal fractures who suffered from acute kidney injury that was most likely induced by the drug interaction between sodium aescinate and ginkgo biloba extract due to the protein-binding and metabolic characteristics of these drugs...
April 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28064552/the-novel-role-of-%C3%AE-aescin-in-attenuating-ccl4-induced-hepatotoxicity-in-rats
#7
Harsimran Singh, Shabir Sidhu, Kanwaljit Chopra, M U Khan
CONTEXT: β-Aescin has anti-inflammatory, anti-oxidant and antiedematous properties. OBJECTIVE: The present study investigated the hepatoprotective effect and underlying mechanisms of β-aescin in CCl4-induced liver damage. MATERIALS AND METHODS: Thirty-five Wistar rats were divided into six groups: normal control, CCl4 control, silymarin (50 mg/kg, p.o) and β-aescin (0.9, 1.8 and 3.6 mg/kg, i.p.) treatment for 14 d. CCl4 (1 mL/kg, i...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27882156/clinical-effects-of-joint-application-of-%C3%AE-sodium-aescinate-and-mannitol-in-treating-early-swelling-after-upper-limb-trauma-surgery
#8
Bin Wang, Ruixiang Yang, Qing Ju, Shaofeng Liu, Yongchun Zhang, Yong Ma
The aim of the present study was to examine the clinical merits of joint application of β-sodium aescinate and mannitol for the treatment of early swelling of upper limb trauma after surgery. We verified whether the expression of serum aquaporin 1 (AQP-1) was involved in swelling mechanism. A total of 102 patients with swelling after upper limb trauma surgery were enrolled into the study and divided randomly into 3 groups (n=34 cases per group). Group A was treated with β-sodium aescinate; group B was treated with with mannitol and group C was treated with both β-sodium aescinate and mannitol...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27831638/aescin-based-topical-formulation-to-prevent-foot-wounds-and-ulcerations-in-diabetic-microangiopathy
#9
S Hu, G Belcaro, M Dugall, M Hosoi, S Togni, G Maramaldi, L Giacomelli
OBJECTIVE: Impairment of the peripheral microcirculation in diabetic patients often leads to severe complications in the lower extremities, such as foot infections and ulcerations. In this study, a novel aescin-based formulation has been evaluated as a potential approach to prevent skin breaks and ulcerations by improving the peripheral microcirculation and skin hydration. PATIENTS AND METHODS: In this registry study, 63 patients with moderate diabetic microangiopathy were recruited...
October 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27596954/aescin-reduces-oxidative-stress-and-provides-neuroprotection-in-experimental-traumatic-spinal-cord-injury
#10
Peng Cheng, Fang Kuang, Gong Ju
Aescin has many physiological functions that are highly relevant to spinal cord injury (SCI), including anti-inflammation, anti-oxidation, anti-oedema, and enhancing vascular tone. The present study investigated the putative therapeutic value of aescin in SCI, with a focus on its neuroprotective, anti-inflammatory, and anti-oxidative properties. Sodium aescinate (1.0mg/kg body weight) or equivalent volume of saline was administered 30min after injury by intravenous injection, with an additional dose daily for seven consecutive days after moderate SCI in rats...
October 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/26952957/male-infertility-lifestyle-factors-and-holistic-complementary-and-alternative-therapies
#11
REVIEW
David F Yao, Jesse N Mills
While we may be comfortable with an allopathic approach to male infertility, we are also responsible for knowledge about lifestyle modifications and holistic, complementary, and alternative therapies that are used by many of our patients. This paper provides an evidence-based review separating fact from fiction for several of these therapies. There is sufficient literature to support weight reduction by diet and exercise, smoking cessation, and alcohol moderation. Supplements that have demonstrated positive effects on male fertility on small randomized controlled trial (RCT) include aescin, coenzyme Q 10 , glutathione, Korean red ginseng, L-carnitine, nigella sativa, omega-3, selenium, a combination of zinc and folate, and the Menevit antioxidant...
May 2016: Asian Journal of Andrology
https://www.readbyqxmd.com/read/26907249/in-vivo-cardiotoxicity-induced-by-sodium-aescinate-in-zebrafish-larvae
#12
Jinfeng Liang, Wangdong Jin, Hongwen Li, Hongcui Liu, Yanfeng Huang, Xiaowen Shan, Chunqi Li, Letian Shan, Thomas Efferth
Sodium aescinate (SA) is a widely-applied triterpene saponin product derived from horse chestnut seeds, possessing vasoactive and organ-protective activities with oral or injection administration in the clinic. To date, no toxicity or adverse events in SA have been reported, by using routine models (in vivo or in vitro), which are insufficient to predict all aspects of its pharmacological and toxicological actions. In this study, taking advantage of transparent zebrafish larvae (Danio rerio), we evaluated cardiovascular toxicity of SA at doses of 1/10 MNLC, 1/3 MNLC, MNLC and LC10 by yolk sac microinjection...
February 23, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/26814064/-efficacy-and-safety-of-microsurgical-varicocelectomy-combined-with-aescine-in-the-treatment-of-varicocele
#13
Ruhui Tian, Peng Li, Junlong Wang, Shijun Zhang, Yan Wang, Fenghua Li, Xiangfeng Chen, Zheng Li
OBJECTIVE: To discuss the efficacy and safety of microsurgical varicocelectomy combined with aescine in the treatment of varicocele. METHODS: A total of 120 patients with varicocele received treatments and follow up in Shanghai Renji Hospital and Shanghai General Hospital between September 2013 and April 2015, 63 patients of which were infertile and 57 patients of which were painful varicocele. A total of 106 patients were unilateral varicocele and 14 patients were bilateral varicocele...
September 22, 2015: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/26790305/-effect-of-sodium-aescinate-in-inducing-human-breast-cancer-mcf-7-cells-apoptosis-by-inhibiting-akt-erk-and-upstream-signal-src-activity
#14
Shi-mei Qi, Jun Lv, Yu Meng, Zhi-lin Qi, Lie-feng Ling
To study the effect of sodium aescinate in inducing human breast cancer MCF-7 cells apoptosis and its possible mechanism. MTT assay was used to detect the inhibitory effect of sodium aescinate on the proliferation of MCF-7 cells. The morphological changes were observed under inverted microscope. DAPI nuclear staining was used to detect the changes in cell nucleus. Annexin V-FITC/PI flow cytometry was adopted to test the apoptosis rate. Changes in apoptosis-related proteins (PARP, cleaved caspase-8 and pro-caspase-3), cell survival-associated signal molecules (AKT and ERK) and their common upstream kinase SRC was detected by Western blotting...
August 2015: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/26296608/otitis-media-induced-by-peptidoglycan-polysaccharide-pgps-in-tlr2-deficient-tlr2-mice-for-developing-drug-therapy
#15
Xiaolin Zhang, Tihua Zheng, Lu Sang, Luke Apisa, Hongchun Zhao, Fenghua Fu, Qingzhu Wang, Yanfei Wang, Qingyin Zheng
BACKGROUND: Toll like receptor 2 (TLR2) signaling can regulate the pathogenesis of otitis media (OM). However, the precise role of TLR2 signaling in OM has not been clarified due to the lack of an optimal animal model. Peptidoglycan-polysaccharide (PGPS) of the bacterial cell wall can induce inflammation by activating the TLR2 signaling. This study aimed at examining the pathogenic characteristics of OM induced by PGPS in Tlr2(-/-) mice, and the potential therapeutic effect of sodium aescinate (SA) in this model...
October 2015: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/26092104/%C3%AE-aescin-at-subinhibitory-concentration-sub-mic-enhances-susceptibility-of-candida-glabrata-clinical-isolates-to-nystatin
#16
Roman Franiczek, Michał Gleńsk, Barbara Krzyżanowska, Maciej Włodarczyk
Aescin (escin) derived from the seeds of horse chestnut (Aesculus hippocastanum L.) is a natural mixture of triterpene saponins exhibiting a wide variety of pharmacological properties, including antiinflammatory, analgesic, and antipyretic activities. However, data concerning antifungal activities of these compounds are limited. This study aims to evaluate the in vitro antifungal susceptibility of Candida glabrata clinical isolates to α-aescin sodium, β-aescin crystalline and β-aescin sodium using the disk diffusion (DD) and broth microdilution (BMD) methods...
November 2015: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/25903967/the-efficacy-of-sodium-aescinate-on-cutaneous-wound-healing-in-diabetic-rats
#17
Zonglin Zhang, Guangchao Cao, Liying Sha, Dazhi Wang, Min Liu
This study is aimed to evaluate the potential effects of sodium aescinate (SA, the sodium salt of aescin) on wound healing in streptozotocin-induced diabetic rats. An excision skin wound was created in diabetic rats, and the wounded rats were divided into three groups: I) control group, II) gel-treated group, and III) SA-treated group. The control group wounds received topically normal saline once daily for 19 days. The gel-treated and SA-treated wounds received topically 400 μl of pluronic F-127 gel (25%) and 400 μl of SA (0...
October 2015: Inflammation
https://www.readbyqxmd.com/read/25787906/the-advantages-of-using-traditional-chinese-medicine-as-an-adjunctive-therapy-in-the-whole-course-of-cancer-treatment-instead-of-only-terminal-stage-of-cancer
#18
REVIEW
Fanghua Qi, Lin Zhao, Aiyan Zhou, Bo Zhang, Anyuan Li, Zhixue Wang, Junqing Han
Recent studies indicate that Traditional Chinese medicine (TCM) can play an important role in the whole course of cancer treatment such as recovery stages of post-operative, radiotherapy or chemotherapy stages instead of only terminal stage of cancer. In this review, we have summarized current evidence for using TCM as adjuvant cancer treatment in different stages of cancer lesions. Some TCMs (e.g., TJ-41, Liu-jun-zi-tang, PHY906, Coumarin, and Aescine) are capable of improving the post-operative symptoms such as fatigue, pain, appetite, diarrhea, nausea, vomiting, and lymphedema...
February 2015: Bioscience Trends
https://www.readbyqxmd.com/read/25632792/-intoxication-by-powdered-seeds-of-horse-chestnut-aesculus-hippocastanum-used-nasally-as-snuff-a-case-report
#19
Maciej Zając, Marek Wiśniewski, Jacek Sein Anand
There are only few reports in the medical literature about side effects and toxicity of horse chestnut (Aesculus hippocastanum). We report a 15-year-old woman who was admitted to the hospital because of symptoms including: vomiting, dyspnea, burning in the nose and throat, and syncope, after intranasal snuff of powdered horse chestnut seeds. Laboratory tests showed no abnormalities. After 2 days of hospitalization the female was discharged home with subjective and objective improvement. Preparation and use of snuff is related to the tradition of the kashubian region...
2014: Przegla̧d Lekarski
https://www.readbyqxmd.com/read/25566665/-optimization-of-process-of-sodium-aescinate-lyophilized-powder
#20
Zhao-Hua Shi, Li-Jun Chen, Wen-Fang Huang, Miao-Miao Liu, Xiang-Ping Liu
OBJECTIVE: To determine the optimal freeze-drying process of Sodium Aescinate lyophilized powder in order to shorten the lyophilization cycle. METHODS: Using the single factor experiment and L9 (3(4)) orthogonal test to optimize parameters of the herbal liquid volume and concentration, pre-freezing time, pressure, drying time and analytical temperature. RESULTS: The best lyophilization process parameters were as follows: 1.0 mL herbal liquid with concentration of 10 mg/mL, phased cooling style, pre-freezing temperature at - 35 degrees C, 6...
July 2014: Zhong Yao Cai, Zhongyaocai, Journal of Chinese Medicinal Materials
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