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Untreated pain

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https://www.readbyqxmd.com/read/28930940/the-relationship-between-women-s-intention-to-request-a-labor-epidural-analgesia-actually-delivering-with-labor-epidural-analgesia-and-postpartum-depression-at-6-weeks-a-prospective-observational-study
#1
Sharon Orbach-Zinger, Ruth Landau, Avi Ben Harousch, Oren Ovad, Liron Caspi, Evgeniya Kornilov, Alexander Ioscovich, Danielle Bracco, Atara Davis, Shlomo Fireman, Moshe Hoshen, Leonid A Eidelman
BACKGROUND: Postpartum depression (PPD) is associated with pain during and after delivery, with studies showing reduced rates among women delivering with labor epidural analgesia (LEA). We hypothesized that women who intend to deliver with LEA but do not receive it are at higher risk for PPD at 6 weeks due to the combined experience of untreated labor pain and unmatched expectations during labor, and evaluated the interaction between labor plans related to LEA, satisfaction with pain control when actually delivering with LEA, and PPD at 6 weeks after delivery...
September 19, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28919835/high-resolution-infrared-thermography-a-new-tool-to-assess-tungiasis-associated-inflammation-of-the-skin
#2
Angela Schuster, Marlene Thielecke, Vaomalala Raharimanga, Charles Emile Ramarokoto, Christophe Rogier, Ingela Krantz, Hermann Feldmeier
BACKGROUND: Tungiasis is highly prevalent in low- and middle-income countries but remains often under diagnosed and untreated eventually leading to chronic sequels. The objective of the study was to assess whether tungiasis-associated inflammation can be detected and quantified by high-resolution infrared thermography (HRIT) and whether after removal of the parasite inflammation resolves rapidly. METHODS: Patients with tungiasis were identified through active case finding...
2017: Tropical Medicine and Health
https://www.readbyqxmd.com/read/28910997/paediatric-nuclear-medicine-imaging
#3
Lorenzo Biassoni, Marina Easty
Background: Nuclear medicine imaging explores tissue viability and function by using radiotracers that are taken up at cellular level with different mechanism. This imaging technique can also be used to assess blood flow and transit through tubular organs. Nuclear medicine imaging has been used in paediatrics for decades and this field is continuously evolving. Sources of data: The data presented comes from clinical experience and some milestone papers on the subject...
September 1, 2017: British Medical Bulletin
https://www.readbyqxmd.com/read/28904545/the-effects-of-massage-and-breastfeeding-on-response-to-venipuncture-pain-among-hospitalized-neonates
#4
Ali Zargham-Boroujeni, Azamolmolouk Elsagh, Majid Mohammadizadeh
BACKGROUND: Untreated procedural pain leads to long-term and short-term complications in neonates. Preventing pain in sick infants and neonates, whose conditions are getting worse, not only is a professional and legal duty but also a prevention measure to decrease future psychological and even neurological complications. Therefore, nurses should prevent newborns' pain. The aim of this study was to compare the effects of massage and breastfeeding on the pain of the neonates. MATERIALS AND METHODS: This was a clinical trial conducted among 75 full-term and near-term infants who underwent venipuncture...
July 2017: Iranian Journal of Nursing and Midwifery Research
https://www.readbyqxmd.com/read/28900573/the-effects-of-a-multimodal-rehabilitation-program-on-pain-kinesiophobia-and-function-in-a-runner-with-patellofemoral-pain
#5
Samuele Passigli, Pietro Capacci, Emanuele Volpi
BACKGROUND AND PURPOSE: Multimodal interventions possess the strongest evidence in the long-term management of patellofemoral pain, but despite receiving evidence-based treatments that are initially effective many patients report recurrent or persistent symptoms for years after the initial diagnosis. Untreated psychological factors could be a possible explanation for persistent symptoms and poor treatment outcome. The purpose of this case report was to describe and evaluate the effects of a multimodal rehabilitation program that included pain education, a graded program of lower limb strengthening, and running retraining on pain, kinesiophobia, and function in a runner with patellofemoral pain...
August 2017: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/28893570/phytoestrogenic-effect-of-inula-racemosa-hook-f-a-cardioprotective-root-drug-in-traditional-medicine
#6
Mangathayaru Kalachaveedu, Divya Raghavan, Srivani Telapolu, Sarah Kuruvilla, Balakrishna Kedike
ETHNOPHARMACOLOGICAL RELEVANCE: Roots of Inula racemosa are used as a cardio protective in Ayurveda in India, being prescribed as a medicine for precordial chest pain, cough and dyspnoea, both singly and as a poly herbal. AIM: Evaluation of Phytoestrogenic activity of the root extracts of Inula racemosa and compounds isolated therefrom in vivo, in silico and in vitro. MATERIALS AND METHODS: Alcohol (IrA) and hexane (IrH) extracts characterized by HPTLC/GC-MS analysis respectively and processed for compound isolation were evaluated for estrogenic activity (100 & 250mg/kg bw) by the Immature rat uterotrophic assay using ethinylestradiol (EE -30µg/kg bw) as standard drug...
September 8, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28891448/a-special-focus-on-selexipag-treatment-of-pulmonary-arterial-hypertension
#7
Louise Marqvard Sørensen, Markus Wehland, Marcus Krüger, Ulf Simonsen, Mohamed Zakaria Nassef, Manfred Infanger, Daniela Grimm
BACKGROUND: This review focuses on the treatment of pulmonary arterial hypertension (PAH) with selexipag and compares its drug-related therapeutic effects with those of prostacyclin analogues. METHODS: We searched the relevant literature and summarized the current clinical trials concerning selexipag and PAH. RESULTS: With only few cases per million, PAH is a rare disease, but when untreated it can be life threatening. PAH is linked to elevated levels of endothelin (ET-1) and decreased levels of nitric oxide (NO) and prostacyclin (PGI2)...
September 7, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28889146/celiac-disease-in-saudi-children-evaluation-of-clinical-features-and-diagnosis
#8
Anjum Saeed, Asaad Assiri, Hebah Assiri, Anhar Ullah, Mohsin Rashid
 Objectives: To characterize the clinical presentations and diagnosis including serological tests and histopathological findings in children with celiac disease. Methods: All children (less than 18 years) with confirmed celiac disease diagnosed over a 6 year period at a private tertiary care health care center in Riyadh,  Saudi Arabia were studied retrospectively. Information collected included demographics, clinical presentation and diagnostic modalities with serology and small intestinal histology reported by Marsh grading...
September 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28887247/rare-presentation-of-a-syphilitic-aneurysm-of-the-infra-renal-aorta-with-contained-rupture
#9
Gautham Chitragari, Anne T Laux, Taylor D Hicks, Mark G Davies, Georges M Haidar
We report, to our knowledge, the first case of a rare syphilitic infra-renal aorto-uni-iliac aneurysm with contained rupture that presented with mid-epigastric abdominal pain. Review of the patient's medical history revealed untreated syphilis and poorly treated congestive heart failure. Given his comorbidities, the patient was treated with an emergent endovascular aneurysm repair (EVAR). His 30-day post-operative recovery period was uneventful and follow up imaging revealed complete resolution of the aneurysms...
September 5, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28885122/clinicopathological-variables-of-sporadic-schwannomas-of-peripheral-nerve-in-291-patients-and-expression-of-biologically-relevant-markers
#10
Eric D Young, Davis Ingram, William Metcalf-Doetsch, Dilshad Khan, Ghadah Al Sannaa, Francois Le Loarer, Alexander J F Lazar, John Slopis, Keila E Torres, Dina Lev, Raphael E Pollock, Ian E McCutcheon
OBJECTIVE While sporadic peripheral schwannomas (SPSs) are generally well treated with surgery, their biology is not well understood. Consequently, treatment options are limited. The aim of this study was to provide a comprehensive description of SPS. The authors describe clinicopathological features and treatment outcomes of patients harboring these tumors, and they assess expression of biomarkers using a clinically annotated tissue microarray. Together, these data give new insight into the biology and management of SPS...
September 8, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28882536/gemcitabine-and-docetaxel-versus-doxorubicin-as-first-line-treatment-in-previously-untreated-advanced-unresectable-or-metastatic-soft-tissue-sarcomas-geddis-a-randomised-controlled-phase-3-trial
#11
Beatrice Seddon, Sandra J Strauss, Jeremy Whelan, Michael Leahy, Penella J Woll, Fiona Cowie, Christian Rothermundt, Zoe Wood, Charlotte Benson, Nasim Ali, Maria Marples, Gareth J Veal, David Jamieson, Katja Küver, Roberto Tirabosco, Sharon Forsyth, Stephen Nash, Hakim-Moulay Dehbi, Sandy Beare
BACKGROUND: For many years, first-line treatment for locally advanced or metastatic soft-tissue sarcoma has been doxorubicin. This study compared gemcitabine and docetaxel versus doxorubicin as first-line treatment for advanced or metastatic soft-tissue sarcoma. METHODS: The GeDDiS trial was a randomised controlled phase 3 trial done in 24 UK hospitals and one Swiss Group for Clinical Cancer Research (SAKK) hospital. Eligible patients had histologically confirmed locally advanced or metastatic soft-tissue sarcoma of Trojani grade 2 or 3, disease progression before enrolment, and no previous chemotherapy for sarcoma or previous doxorubicin for any cancer...
September 4, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28881348/accelerating-topical-anaesthesia-using-microneedles
#12
Lleucu B Davies, Christopher Gateley, Phillip Holland, Siôn A Coulman, James C Birchall
BACKGROUND/AIMS: Topical anaesthetics reduce pain during venous access procedures in children. However, clinical use is hindered by a significant anaesthetic onset time. Restricted diffusion of the topical anaesthetic through the stratum corneum barrier is the principal reason for the delayed onset. Microneedles can painlessly pierce the skin. This study evaluated microneedle pre-treatment of ex vivo human skin as a means to increase the rate of tetracaine permeation, in order to accelerate the onset of anaesthesia...
September 8, 2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/28877850/gabapentin-regulates-expression-of-fgf2-and-fgfr1-in-dorsal-root-ganglia-via-microrna-15a-in-the-arthritis-rat-model
#13
Dexu Sun, Junxia Yang, Deguang Wang, Xiangyang Li, Lin Wang, Qian Yu, Suping Qin, Renxian Tang
BACKGROUND: Arthritis is an inflammatory disease with a prevalence rate of approximately 10% in China, which commonly manifests as pain. The aim of the current study was to investigate the function of gabapentin in the dorsal root ganglion in an arthritis rat model, and assess the effect of gabapentin on the expression of fibroblast growth factor 2 (FGF2) and FGF receptor 1 (FGFR1). METHODS: A total of 30 healthy male Sprague-Dawley rats were randomly divided into the following three groups: Untreated group, control group and gabapentin group...
September 3, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28877139/randomized-controlled-trial-of-telephone-delivered-cognitive-behavioral-therapy-versus-supportive-care-for-chronic-back-pain
#14
Thomas Rutledge, J Hampton Atkinson, Tatiana Chircop-Rollick, John D'Andrea, Steven Garfin, Shetal Patel, Donald B Penzien, Mark Wallace, Anne L Weickgenant, Mark Slater
OBJECTIVE: To evaluate the efficacy of a telephone-delivered, home-based cognitive behavioral intervention for chronic low back pain in comparison to a matched supportive care treatment. METHODS: Participants (N=66) were patients with chronic back pain that were randomized to either an 8-week Cognitive-Behavioral Therapy (CBT) or a Supportive Care condition (SC) matched for contact frequency, format, and time. Participants completed validated measures of improvement in back pain disability, pain severity, and overall improvement...
September 1, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28874080/low-molecular-weight-gel-fraction-of-aloe-vera-exhibits-gastroprotection-by-inducing-matrix-metalloproteinase-9-inhibitory-activity-in-alcohol-induced-acute-gastric-lesion-tissues
#15
Chul-Hong Park, Hyeong-U Son, Chi-Yeol Yoo, Sang-Han Lee
CONTEXT: Aloe has been used for the prevention and cure of various diseases and symptoms including burns, injuries, oedema and pain. OBJECTIVE: This study determines the specific inhibitory activity of matrix metalloproteinase (MMP)-9 induced by the low molecular-weight gel fraction of Aloe vera (L.) Burm.f. (lgfAv) on alcohol-induced acute gastric lesions. MATERIALS AND METHODS: We examined the protective effects of oral (p.o.) administration of lgfAv (molecular weight cutoff <50...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28871571/acute-aortic-dissection-pathogenesis-risk-factors-and-diagnosis
#16
Joanna Gawinecka, Felix Schönrath, Arnold von Eckardstein
Acute aortic dissection is a rare but life-threatening condition with a lethality rate of 1 to 2% per hour after onset of symptoms in untreated patients. Therefore, its prompt and proper diagnosis is vital to increase a patient's chance of survival and to prevent grievous complications. Typical symptoms of acute aortic dissection include severe chest pain, hypotension or syncope and, hence, mimic acute myocardial infarction or pulmonary embolism. Advanced age, male gender, long-term history of arterial hypertension and the presence of aortic aneurysm confer the greatest population attributable risk...
September 5, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28859173/vitamin-d-supplementation-to-palliative-cancer-patients-shows-positive-effects-on-pain-and-infections-results-from-a-matched-case-control-study
#17
Maria Helde-Frankling, Jonas Höijer, Jenny Bergqvist, Linda Björkhem-Bergman
BACKGROUND: We previously showed an association between low vitamin D levels and high opioid doses to alleviate pain in palliative cancer patients. The aim of this case-controlled study was to investigate if vitamin D supplementation could improve pain management, quality of life (QoL) and decrease infections in palliative cancer patients. METHODS: Thirty-nine palliative cancer patients with levels of 25-hydroxyvitamin D < 75 nmol/L were supplemented with vitamin D 4000 IE/day, and were compared to 39 untreated, matched "control"-patients from a previous study at the same ward...
2017: PloS One
https://www.readbyqxmd.com/read/28851682/on-a-mission-to-relieve-the-global-epidemic-of-untreated-pain
#18
Richard Hurley
No abstract text is available yet for this article.
August 29, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28847020/effect-of-encapsulated-artemisia-aucheri-l-magnetic-nanogel-extract-on-shoulder-block-in-rat
#19
Siavash Beiranvand, Arash Karimi
Introduction Due to the severe pain generated after shoulder surgery, we aim to formulate and intravenously (IV) inject magnetic nanogel encapsulated Artemisia aucheri. L extract for inducing shoulder block in the rat. Methods Artemisia aucheri. L extract encapsulated magnetic nanoparticles (MNPs) was fabricated and tested in rat using paw withdrawal latencies (PWL) from thermal stimuli on the forepaw. The animals were divided into two groups; the untreated left forepaw (control group), and the test group with treated right forepaw...
August 28, 2017: Drug Research
https://www.readbyqxmd.com/read/28842139/daunorubicin-90-mg-m-2-in-acute-myeloid-leukemia-induction-increased-toxicity-in-young%C3%A2-patients
#20
Rodrigo Portugal, Renata Lyrio, Monique Loureiro, Kátia Urago, Johny Bard, Aline Borchardt, Márcia Garnica, Márcio Nucci
BACKGROUND: The combination of an anthracycline and cytosine arabinoside has been the standard induction therapy for acute myeloid leukemia for more than 3 decades. The clinical benefit of intensification of the daunorubicin dose to 90 mg/m(2) has been supported by randomized trials. Based on these promising results, in 2010 we changed our induction protocol of acute myeloid leukemia, increasing the dose of daunorubicin. PATIENTS AND METHODS: We retrospectively analyzed the treatment outcome of patients treated with high-dose daunorubicin (90 mg/m(2) on days 1-3) and cytosine arabinoside (200 mg/m(2)/day continuous infusion on days 1-7) compared with patients receiving 45 to 60 mg/m(2) of daunorubicin...
August 2017: Clinical Lymphoma, Myeloma & Leukemia
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