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https://www.readbyqxmd.com/read/28627680/bmp%C3%A2-7-suppresses-excessive-scar-formation-by-activating-the-bmp%C3%A2-7-smad1-5-8-signaling-pathway
#1
Jingdong Guo, Quan Lin, Ying Shao, Li Rong, Duo Zhang
Scarring is the inevitable consequence of wound repair, which may cause significant physical and mental pain to patients when excessive. Bone morphogenetic protein‑7 (BMP‑7) has been proved to inhibit TGF‑β‑induced fibrosis in various tissues including dermal papilla cells. However, the effect of BMP‑7 on hypertrophic scarring, a common proliferative disorder of dermal fibroblasts, has not been determined. To overcome this problem, the present study established a mouse model of thermal injury to investigate the inhibitory effects of BMP‑7 on scar formation...
June 14, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28622875/does-the-severity-of-overactive-bladder-symptoms-correlate-with-risk-for-female-sexual-dysfunction
#2
Cássia Raquel Teatin Juliato, Iane Glauce Ribeiro Melotti, Luiz Carlos Santos Junior, Luiz Gustavo Oliveira Britto, Cássio Luiz Zanettini Riccetto
BACKGROUND: Several studies have associated overactive bladder (OAB) with female sexual dysfunction (FSD); however, there are no reports using a quantitative approach to measure OAB severity and to relate OAB to the risk of FSD. AIM: To evaluate women with OAB and to correlate the severity of their urinary symptoms with their sexual function. METHODS: This cross-sectional study included 267 women older than 18 years with untreated OAB. All subjects completed the International Consultation on Incontinence Questionnaire Overactive Bladder (ICIQ-OAB) and the Female Sexual Function Index (FSFI)...
June 13, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28606406/-quality-of-life-in-patients-with-autosomal-dominant-polycystic-kidney-disease
#3
Laurent Lecardeur, Dominique Joly
Autosomal dominant polycystic kidney disease (ADPKD) is an inherited disease that usually occurs in adulthood. The majority of affected patients will develop renal complications related to cysts during their life, but may sometimes also develop severe extrarenal complications. The aim of this study is to review quantitative and qualitative results of researches that have investigated quality of life of patients suffering ADPKD. The results obtained with health-relative quality of life scales are contradictory and lack of sensibility according to the special features of ADPKD, for psychological impact for instance...
June 9, 2017: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/28600329/effect-of-electroacupuncture-on-thermal-pain-threshold-and-expression-of-calcitonin-gene-related-peptide-substance-p-and-%C3%AE-aminobutyric-acid-in-the-cervical-dorsal-root-ganglion-of-rats-with-incisional-neck-pain
#4
Li-Na Qiao, Jun-Ling Liu, Lian-Hong Tan, Hai-Long Yang, Xu Zhai, Yong-Sheng Yang
OBJECTIVE: Acupuncture therapy effectively reduces post-surgical pain, but its mechanism of action remains unclear. The aim of this study was to investigate whether expression of γ-aminobutyric acid (GABA) and the neuropeptides substance P (SP) and calcitonin gene-related peptide (CGRP) in the primary sensory neurons of cervical dorsal root ganglia (DRG) are involved in electroacupuncture (EA)-induced analgesia in a rat model of incisional neck pain. METHODS: The pain model was established by making a longitudinal midline neck incision in 60 rats...
June 9, 2017: Acupuncture in Medicine: Journal of the British Medical Acupuncture Society
https://www.readbyqxmd.com/read/28598293/stereotactic-body-radiotherapy-for-de-novo-spinal-metastases-systematic-review
#5
Zain A Husain, Arjun Sahgal, Antonio De Salles, Melissa Funaro, Janis Glover, Motohiro Hayashi, Masahiro Hiraoka, Marc Levivier, Lijun Ma, Roberto Martínez-Alvarez, J Ian Paddick, Jean Régis, Ben J Slotman, Samuel Ryu
OBJECTIVE The aim of this systematic review was to provide an objective summary of the published literature pertaining to the use of stereotactic body radiation therapy (SBRT) specific to previously untreated spinal metastases. METHODS The authors performed a systematic review, using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, of the literature found in a search of Medline, PubMed, Embase, and the Cochrane Library up to March 2015. The search strategy was limited to publications in the English language...
June 9, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28593148/endovascular-repair-in-acute-complicated-type-b-aortic-dissection-3-year-results-from-the-valiant-us-investigational-device-exemption-study
#6
REVIEW
Chang Young Lim
Acute complicated type B aortic dissection (TBAD) is a potentially catastrophic, life-threatening condition. If left untreated, there is a high risk of aortic rupture, irreversible organ or limb damage, or death. Several risk factors have been associated with acute complicated TBAD, including age and refractory hypertension. In the acute phase, even uncomplicated patients are more prone to develop complications if hypertension and pain are left medically untreated. Innovations in stent graft technologies have incrementally improved outcomes since their first use for this condition in 1999, though improvement is needed in mitigating periprocedural complications, adverse events, and mortality...
June 2017: Korean Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28573048/brain-oscillations-elicited-by-the-cold-pressor-test-a-putative-index-of-untreated-essential-hypertension
#7
Christos Papageorgiou, Efstathios Manios, Eleftheria Tsaltas, Eleni Koroboki, Maria Alevizaki, Elias Angelopoulos, Meletios-Athanasios Dimopoulos, Charalabos Papageorgiou, Nikolaos Zakopoulos
OBJECTIVE: Essential hypertension is associated with reduced pain sensitivity of unclear aetiology. This study explores this issue using the Cold Pressor Test (CPT), a reliable pain/stress model, comparing CPT-related EEG activity in first episode hypertensives and controls. METHOD: 22 untreated hypertensives and 18 matched normotensives underwent 24-hour ambulatory blood pressure monitoring (ABPM). EEG recordings were taken before, during, and after CPT exposure...
2017: International Journal of Hypertension
https://www.readbyqxmd.com/read/28546767/increase-and-regulation-of-synovial-calcitonin-gene-related-peptide-expression-in-patients-with-painful-knee-osteoarthritis
#8
Shotaro Takano, Kentaro Uchida, Gen Inoue, Atsushi Minatani, Masayuki Miyagi, Jun Aikawa, Dai Iwase, Kenji Onuma, Manabu Mukai, Masashi Takaso
BACKGROUND: Recent studies suggest that the vasodilatory neuropeptide calcitonin gene-related peptide (CGRP) is localized in the synovial tissue and may be involved in the pathology of hip and knee osteoarthritis (OA). However, the regulation and relationship between pain and CGRP expression levels in the synovial tissue of human OA patients are not fully understood. METHODS: Synovial tissues were harvested from 74 participants with radiographic knee OA (unilateral Kellgren/Lawrence grades 3-4) during total knee arthroplasty...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28535821/seven-fractions-to-deliver-partial-breast-irradiation-the-toxicity-is-low
#9
Marco Trovo, Michele Avanzo, Lorenzo Vinante, Carlo Furlan, Francesco Fiorica, Tiziana Perin, Loredana Militello, Simon Spazzapan, Massimiliano Berretta, Rajesh Jena, Joseph Stancanello, Erica Piccoli, Mario Mileto, Elvia Micheli, Mario Roncadin, Samuele Massarut
PURPOSE: To assess toxicity and clinical outcome, in breast cancer patients treated with external beam partial breast irradiation (PBI) consisting of 35 Gy in 7 daily fractions (5 Gy/fraction). MATERIALS AND METHODS: Patients affected by early-stage breast cancer were enrolled in this phase II trial. Patients had to be 60 years old or over and treated with breast conservative surgery for early stage invasive carcinoma. RESULTS: Seventy-three patients were analyzed...
May 23, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28533696/experience-of-dysmenorrhea-among-a-group-of-physical-therapy-students-from-cairo-university-an-exploratory-study
#10
Dalia M Kamel, Sayed A Tantawy, Gehan A Abdelsamea
INTRODUCTION: Dysmenorrhea is a condition describing the painful cramps that women feel before or during the menstrual period. While dysmenorrhea is the most common gynecologic complaint affecting adolescent and young women and there has been significant progress in understanding its pathophysiology and managing the symptoms, many young women do not seek medical consultation and remain untreated. AIM OF THE STUDY: The aim of the study was to explore the prevalence of dysmenorrhea, its physical impact, and associated coping behaviors among university students...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28530768/perioperative-management-of-rheumatoid-medications-in-orthopedic-surgery
#11
Kunal Sindhu, Brian Cohen, Joseph A Gil
Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disorder known to cause progressive joint destruction. Over time, untreated RA can lead to pain and increasing disability, making orthopedic intervention necessary. The treatment of RA revolves around a variety of medications that blunt the overall immune response. However, this may increase the risk of infection and impair wound healing. Given the nature of this disease, orthopedists frequently encounter patients with RA in the operative setting. To optimize surgical outcomes, orthopedists must carefully manage and pay special attention to the adverse side effects of the complicated medication regimens of these patients perioperatively...
May 20, 2017: Orthopedics
https://www.readbyqxmd.com/read/28512432/whole-body-cryotherapy-in-athletes-from-therapy-to-stimulation-an-updated-review-of-the-literature
#12
REVIEW
Giovanni Lombardi, Ewa Ziemann, Giuseppe Banfi
Nowadays, whole-body cryotherapy is a medical physical treatment widely used in sports medicine. Recovery from injuries (e.g., trauma, overuse) and after-season recovery are the main purposes for application. However, the most recent studies confirmed the anti-inflammatory, anti-analgesic, and anti-oxidant effects of this therapy by highlighting the underlying physiological responses. In addition to its therapeutic effects, whole-body cryotherapy has been demonstrated to be a preventive strategy against the deleterious effects of exercise-induced inflammation and soreness...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28510034/improvement-of-fabry-disease-related-gastrointestinal-symptoms-in-a-significant-proportion-of-female-patients-treated-with-agalsidase-beta-data-from-the-fabry-registry
#13
William R Wilcox, Ulla Feldt-Rasmussen, Ana Maria Martins, Alberto Ortiz, Roberta M Lemay, Ana Jovanovic, Dominique P Germain, Carmen Varas, Katherine Nicholls, Frank Weidemann, Robert J Hopkin
Fabry disease, an X-linked inherited lysosomal storage disorder, is caused by mutations in the gene encoding α-galactosidase, GLA. In patients with Fabry disease, glycosphingolipids accumulate in various cell types, triggering a range of cellular and tissue responses that result in a wide spectrum of organ involvement. Although variable, gastrointestinal symptoms are among the most common and significant early clinical manifestations; they tend to persist into adulthood if left untreated. To further understand the effects of sustained enzyme replacement therapy (ERT) with agalsidase beta on gastrointestinal symptoms in heterozygotes, a data analysis of female patients enrolled in the Fabry Registry was conducted...
May 17, 2017: JIMD Reports
https://www.readbyqxmd.com/read/28498142/inflammatory-myopathy-and-axonal-neuropathy-in-a-patient-with-melanoma-following-pembrolizumab-treatment
#14
Panagiotis T Diamantopoulos, Katerina Tsatsou, Olga Benopoulou, Amalia Anastasopoulou, Helen Gogas
Immune-mediated adverse effects of immune checkpoint inhibitors are rather common, but neuromyopathic immune-related adverse events are very rare. In this report, we present a unique case of a patient with a complex neuromyopathic syndrome with axonal neuropathy and inflammatory myopathy after a single dose of pembrolizumab. An 82-year-old patient with a previously untreated stage IIIc melanoma developed ptosis in the left eye, generalized weakness, and neck and shoulder pain 15 days after pembrolizumab administration...
July 2017: Journal of Immunotherapy
https://www.readbyqxmd.com/read/28494833/impact-of-smoking-status-on-lipoprotein-subfractions-data-from-an-untreated-chinese-cohort
#15
Xi Zhao, Hui Wen Zhang, Yan Zhang, Sha Li, Rui Xia Xu, Jing Sun, Cheng Gang Zhu, Na Qiong Wu, Ying Gao, Yuan Lin Guo, Geng Liu, Qian Dong, Jian Jun Li
OBJECTIVE: Cigarette smoking is one of the established risk factors of atherosclerotic cardiovascular disease, however, its impact on lipids is not completely understood, especially in the Chinese population. Therefore, this study evaluated the impact of smoking status (non, former, and current smoking) on the distribution of lipoprotein subfractions in untreated patients with angina-like chest pain. METHODS: A total of 877 patients were consecutively enrolled and divided into nonsmoking (n = 518), former smoking (n = 103), and current smoking (n = 256) groups...
April 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/28493139/-lipedema-up-to-date-of-a%C3%A2-long-forgotten-disease
#16
REVIEW
Uwe Wollina
Lipedema is a chronic disorder of subcutaneous adipose tissue of unknown etiology not uncommon among post-puberty women. The disease has a negative impact on self-esteem, mobility, and quality of life. Lipedema is characterized by symmetrical, disfiguring hyperplastic adipose tissue combined with bruising and pain. Untreated lipedema fosters osteoarthritis, secondary lymphedema, limited mobility, and psychosocial stigmatization. Treatment consists of conservative complex decongestive therapy and surgery by microcannular tumescent liposuction...
May 10, 2017: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28492208/self-reported-dental-pain-and-dental-caries-among-8-12-year-old-school-children-an-exploratory-survey-in-lagos-nigeria
#17
Abiola A Adeniyi, Olumuyiwa O Odusanya
BACKGROUND: Dental pain is considered an important public health problem because it affects the daily life of children. This study was designed to assess the prevalence, associated factors, and impact of dental pain among 8-12-year-old school children in Lagos, Nigeria. SUBJECTS AND METHODS: A cross-sectional survey to determine self-reported dental pain among 8-12-year-old school children using an interviewer-administered questionnaire was conducted. This was followed by a clinical examination to determine the child's oral hygiene status and dental caries status...
January 2017: Nigerian Postgraduate Medical Journal
https://www.readbyqxmd.com/read/28489761/quality-of-life-in-adolescent-patients-with-idiopathic-scoliosis-after-brace-treatment-a-meta-analysis
#18
Zeng-Dong Meng, Tian-Peng Li, Xu-Hua Xie, Chong Luo, Xing-Ye Lian, Ze-Yu Wang
BACKGROUND: Whether brace-treated adolescents with idiopathic scoliosis (AIS) have improved quality of life (QoL) is still unknown. Thus, we conducted a meta-analysis to compare the QoL of brace-treated AIS patients with untreated AIS patients. The pain, self-image/appearance, mental health, function/activity, satisfaction with management, total score without satisfaction, and total score of patients were used to measure the QoL after the intervention. METHODS: Multiple electronic databases including PubMed, Web of Science, and Embase were searched for all years up to June 30, 2016...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28489643/factors-influencing-quality-of-pain-management-in-a-physician-staffed-helicopter-emergency-medical-service
#19
Nicole Oberholzer, Alexander Kaserer, Roland Albrecht, Burkhardt Seifert, Mario Tissi, Donat R Spahn, Konrad Maurer, Philipp Stein
BACKGROUND: Pain is frequently encountered in the prehospital setting and needs to be treated quickly and sufficiently. However, incidences of insufficient analgesia after prehospital treatment by emergency medical services are reported to be as high as 43%. The purpose of this analysis was to identify modifiable factors in a specific emergency patient cohort that influence the pain suffered by patients when admitted to the hospital. METHODS: For that purpose, this retrospective observational study included all patients with significant pain treated by a Swiss physician-staffed helicopter emergency service between April and October 2011 with the following characteristics to limit selection bias: Age > 15 years, numerical rating scale (NRS) for pain documented at the scene and at hospital admission, NRS > 3 at the scene, initial Glasgow coma scale > 12, and National Advisory Committee for Aeronautics score < VI...
July 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28474414/clinical-perineural-invasion-of-the-trigeminal-and-facial-nerves-in-cutaneous-head-and-neck-squamous-cell-carcinoma-outcomes-and-prognostic-implications-of-multimodality-and-salvage-treatment
#20
Serkan Erkan, James M Savundra, Bradley Wood, Aanand N Acharya, Gunesh P Rajan
BACKGROUND: Clinical perineural invasion (PNI) of the trigeminal and facial nerves from cutaneous head and neck squamous cell carcinoma (cutaneous HNSCC) is a rare clinical entity that poses unique therapeutic challenges. METHODS: A retrospective chart review of a skull base oncology database was performed of patients with the diagnosis of clinical PNI from a cutaneous HNSCC. Patients who were previously untreated underwent multimodal treatment entailing surgical resection and postoperative radiotherapy (PORT) and patients who were previously treated with radiotherapy underwent salvage surgical resection between the years 2006 and 2012...
May 5, 2017: Head & Neck
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