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https://www.readbyqxmd.com/read/28338115/resveratrol-supplementation-in-patients-with-non-alcoholic-fatty-liver-disease-systematic-review-and-meta-analysis
#1
REVIEW
Ahmed Elgebaly, Ibrahim A I Radwan, Mohamed M AboElnas, Hamza H Ibrahim, Moutaz F M Eltoomy, Ahmed A Atta, Hend A Mesalam, Alaa A Sayed, Amr A Othman
BACKGROUND: Resveratrol is a potential treatment option for management of non-alcoholic fatty liver disease (NAFLD) due to its anti-inflammatory, antioxidant properties, and calorie restriction-like effects. We aimed to synthesise evidence from published randomized clinical trials (RCTs) about the efficacy of resveratrol in the management of NAFLD. METHODS: A computer literature search of PubMed, Scopus, Web of Science, and Cochrane Central was conducted using relevant keywords...
March 2017: Journal of Gastrointestinal and Liver Diseases: JGLD
https://www.readbyqxmd.com/read/28334808/downregulation-of-pathways-implicated-in-liver-inflammation-and-tumorigenesis-of-glycogen-storage-disease-type-ia-mice-receiving-gene-therapy
#2
Goo-Young Kim, Joon Hyun Kwon, Jun-Ho Cho, Lisa Zhang, Brian C Mansfield, Janice Y Chou
Glycogen storage disease type Ia (GSD-Ia) is characterized by impaired glucose homeostasis and long-term risks of hepatocellular adenoma (HCA) and carcinoma (HCC). We have shown that the non-tumor-bearing (NT), recombinant adeno-associated virus (rAAV) vector-treated GSD-Ia mice (AAV-NT mice) expressing a wide range (0.9-63%) of normal hepatic glucose-6-phosphatase-α activity maintain glucose homeostasis and display physiologic features mimicking animals living under calorie restriction (CR). We now show that in AAV-NT mice, the signaling pathways of the CR mediators, AMP-activated protein kinase (AMPK) and sirtuin-1 are activated...
March 13, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28322833/treatment-of-novel-il17a-inhibitor-in-glioblastoma-implementing-3rd-generation-co-culture-cell-line-and-patient-derived-tumor-model
#3
Md Shamsuddin Sultan Khan, Muhammad Asif, Mohammed Khadeer Ahamed Basheer, Cheng Wei Kang, Fouad Saleh Al-Suede, Oon Chern Ein, Jing Tang, Aman Shah Abdul Majid, Amin Malik Shah Abdul Majid
Despite many treatment options, cancer remains a growing problem and has become the second leading cause of death globally. Here, we present fluorescence molecular tomography (FMT) data regarding the reversion of third generation co-cultured U87+DBTRG and patient-derived GBM tumor model after treatment with novel IL17A inhibitor named FLVM and FLVZ (organic derivatives of caffeic acid). FMT was used to determine tumor angiogenesis volume (assessment of number of blood vessel; the expression of angiogenic factors CD34 and other angiogenic cancer bio-markers) in U87+DBTRG and patient-derived gliomas...
March 16, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28321980/relationship-between-food-insecurity-child-weight-status-and-parent-reported-child-eating-and-snacking-behaviors
#4
Tanja V E Kral, Jesse Chittams, Reneé H Moore
PURPOSE: Prior studies showed that food insecurity may increase the odds of obesity in children and adults. We still know very little about the familial aggregation of obesity in food-insecure households or the mechanisms by which food insecurity confers an increased risk of obesity to children. The purpose of this study was to compare children and mothers from food-insecure and food-secure households in their weight status, child eating patterns/behaviors, and maternal feeding practices...
March 21, 2017: Journal for Specialists in Pediatric Nursing: JSPN
https://www.readbyqxmd.com/read/28319441/calorie-restriction-breaks-an-epigenetic-barrier-to-longevity
#5
Diego Molina-Serrano, Antonis Kirmizis
No abstract text is available yet for this article.
March 20, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28314502/nutrient-sensing-and-the-oxidative-stress-response
#6
REVIEW
Hanzhi Luo, Hou-Hsien Chiang, Makensie Louw, Albert Susanto, Danica Chen
The simplicity and effectiveness of calorie restriction (CR) in lifespan and healthspan extension have fascinated generations searching for the Fountain of Youth. CR reduces levels of oxidative stress and damage, which have been postulated in the free radical theory of aging as a major cause of aging and diseases of aging. This reduction has long been viewed as a result of passive slowing of metabolism. Recent advances in nutrient sensing have provided molecular insights into the oxidative stress response and suggest that CR triggers an active defense program involving a cascade of molecular regulators to reduce oxidative stress...
March 14, 2017: Trends in Endocrinology and Metabolism: TEM
https://www.readbyqxmd.com/read/28298393/a-role-for-leukocyte-integrins-and-extracellular-matrix-remodeling-of-adipose-tissue-in-the-risk-of-weight-regain-after-weight-loss
#7
Nadia Jt Roumans, Roel G Vink, Parastoo Fazelzadeh, Marleen A van Baak, Edwin Cm Mariman
Background: Weight loss (WL) is often followed by weight regain after an energy-restricted dietary intervention (DI). When people are following a diet, the volume of an adipocyte decreases by loss of triglycerides, which creates stress between the cell contents and the surrounding extracellular matrix (ECM). Previously, we observed that genetic variations in ECM genes are associated with an increased risk of weight regain.Objective: We investigated the relation between the expression of ECM genes during WL and a period of weight stabilization (WS) and the risk of weight regain...
March 15, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28282965/hyper-and-hypo-nutrition-studies-of-the-hepatic-transcriptome-and-epigenome-suggest-that-ppar%C3%AE-regulates-anaerobic-glycolysis
#8
Anthony R Soltis, Shmulik Motola, Santiago Vernia, Christopher W Ng, Norman J Kennedy, Simona Dalin, Bryan J Matthews, Roger J Davis, Ernest Fraenkel
Diet plays a crucial role in shaping human health and disease. Diets promoting obesity and insulin resistance can lead to severe metabolic diseases, while calorie-restricted (CR) diets can improve health and extend lifespan. In this work, we fed mice either a chow diet (CD), a 16 week high-fat diet (HFD), or a CR diet to compare and contrast the effects of these diets on mouse liver biology. We collected transcriptomic and epigenomic datasets from these mice using RNA-Seq and DNase-Seq. We found that both CR and HFD induce extensive transcriptional changes, in some cases altering the same genes in the same direction...
December 2017: Scientific Reports
https://www.readbyqxmd.com/read/28275127/persistence-of-weight-loss-and-acquired-behaviors-2-y-after-stopping-a-2-y-calorie-restriction-intervention
#9
Kara L Marlatt, Leanne M Redman, Jeff H Burton, Corby K Martin, Eric Ravussin
Background: Calorie restriction (CR) influences aging processes and extends average and maximal life spans. The CALERIE 2 (Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy Phase 2) study was the first randomized clinical trial to examine the metabolic and psychological effects of CR in nonobese humans.Objective: We conducted a 2-y follow-up study of adults who underwent 2 y of CR or ad libitum (control) consumption and determined whether weight loss and acquired behaviors persisted after the study ended when participants determined their own lifestyle behaviors...
March 8, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28274839/dietary-protein-aging-and-nutritional-geometry
#10
REVIEW
Stephen J Simpson, David G Le Couteur, David Raubenheimer, Samantha M Solon-Biet, Gregory J Cooney, Victoria C Cogger, Luigi Fontana
Nearly a century of research has shown that nutritional interventions can delay aging and age- related diseases in many animal models and possibly humans. The most robust and widely studied intervention is caloric restriction, while protein restriction and restriction of various amino acids (methionine, tryptophan) have also been shown to delay aging. However, there is still debate over whether the major impact on aging is secondary to caloric intake, protein intake or specific amino acids. Nutritional geometry provides new perspectives on the relationship between nutrition and aging by focusing on calories, macronutrients and their interactions across a landscape of diets, and taking into account compensatory feeding in ad libitum-fed experiments...
March 6, 2017: Ageing Research Reviews
https://www.readbyqxmd.com/read/28273203/liver-metabolic-changes-induced-by-conjugated-linoleic-acid-in-calorie-restricted-rats
#11
Camila de Moraes, Camila Andrea de Oliveira, Maria Esméria Corezola do Amaral, Gabriela Arcurio Landini, Rosana Catisti
Objective: Complexes like conjugated linoleic acid (CLA) reduce the percentage of body fat by increasing energy expenditure, fat oxidation, or both. The aim of this study was to verify if CLA is able to mimic caloric restriction (CR), and determine the effects of CLA on liver metabolic profile of young adult male Wistar rats. Materials and methods: We divided 36 animals into the following groups: 1) Control; 2) CLA (1% of daily food intake, 21 days, orogastric intubation); 3) Restr (fed 60% of the diet offered to controls); and 4) CLA Restr...
January 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28265411/outcomes-of-an-inpatient-medical-nutritional-rehabilitation-protocol-in-children-and-adolescents-with-eating-disorders
#12
Rebecka Peebles, Andrew Lesser, Courtney Cheek Park, Kerri Heckert, C Alix Timko, Eleni Lantzouni, Ronald Liebman, Laurel Weaver
BACKGROUND: Medical stabilization through inpatient nutritional rehabilitation is often necessary for patients with eating disorders (EDs) but includes the inherent risk of refeeding syndrome. Here we describe our experience of implementing and sustaining an inpatient nutritional rehabilitation protocol designed to strategically prepare patients with EDs and their families for discharge to a home setting in an efficient and effective manner from a general adolescent medicine unit. We report outcomes at admission, discharge, and 4-weeks follow-up...
2017: Journal of Eating Disorders
https://www.readbyqxmd.com/read/28261926/acute-caloric-restriction-counteracts-hepatic-bile-acid-and-cholesterol-deficiency-in-morbid-obesity
#13
S Straniero, F Rosqvist, D Edholm, H Ahlström, J Kullberg, M Sundbom, U Risérus, M Rudling
BACKGROUND: Bile acid (BA) synthesis is regulated by BA signalling in the liver and by fibroblast growth factor 19 (FGF19), synthesized and released from the intestine. In morbid obesity, faecal excretion and hepatic synthesis of BAs and cholesterol are strongly induced and caloric restriction reduces their faecal excretion considerably. We hypothesized that the high intestinal food mass in morbidly obese subjects promotes faecal excretion of BAs and cholesterol, thereby creating a shortage of both BAs and cholesterol in the liver...
March 6, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28259219/non-adherence-in-hypertension-management-deficit-in-information-or-trust
#14
Tamrat M Retta, John Kwagyn, Otelio S Randall
Hypertension, a leading cause of cardiovascular morbidity and mortality worldwide, continues to challenge health professionals. There are too many patients with uncontrolled hypertension who end up with life altering or life ending complications. Over the years so much hypertension research has been conducted; and numerous effective antihypertensive drugs have been discovered and yet the rate of blood pressure control remains unacceptably low. It is high time that we focused our attention on the optimal use of the available knowledge and medications...
April 2017: Journal of the National Medical Association
https://www.readbyqxmd.com/read/28252007/alkylresorcinols-activate-sirt1-and-delay-ageing-in-drosophila-melanogaster
#15
Yasunari Kayashima, Yuki Katayanagi, Keiko Tanaka, Ryuta Fukutomi, Shigeru Hiramoto, Shinjiro Imai
Sirtuins are enzymes that catalyze NAD+ dependent protein deacetylation. The natural polyphenolic compound resveratrol received renewed interest when recent findings implicated resveratrol as a potent SIRT1 activator capable of mimicking the effects of calorie restriction. However, resveratrol directly interacts with fluorophore-containing peptide substrates. It was demonstrated that the SIRT1 activation of resveratrol is affected by the amino acid composition of the substrate. Resveratrol did increase the enzyme activity in cases in which hydrophobic amino acids are at the +1 position to the acetylated lysine in the substrate...
March 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28251799/diet-affects-arctic-ground-squirrel-gut-microbial-metatranscriptome-independent-of-community-structure
#16
Jasmine J Hatton, Timothy J Stevenson, C Loren Buck, Khrystyne N Duddleston
We examined the effect of diet on pre-hibernation fattening and the gut microbiota of captive arctic ground squirrels (Urocitellus parryii). We measured body composition across time and gut microbiota density, diversity, and function prior to and after five-weeks on control, high-fat, low-fat (18%, 40%, and 10% energy from fat, respectively), or restricted calorie (50% of control) diets. Squirrels fattened at the same rate and to the same degree on all diets. Additionally, we found no differences in gut microbiota diversity or short chain fatty acid production across time or with diet...
March 2, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28251782/one-year-calorie-restriction-impacts-gut-microbial-composition-but-not-its-metabolic-performance-in-obese-adolescents
#17
Alicia Ruiz, Tomás Cerdó, Ruy Jáuregui, Dietmar H Pieper, Ascensión Marcos, Alfonso Clemente, Federico García, Abelardo Margolles, Manuel Ferrer, Cristina Campoy, Antonio Suárez
Recent evidence has disclosed a connection between gut microbial glycosidase activity and adiposity in obese. Here, we measured microbial α-glucosidase and β-galactosidase activities and sorted fluorescently labeled β-galactosidase containing (βGAL) microorganisms in faecal samples of eight lean and thirteen obese adolescents that followed a controlled calorie restriction program during one year. β-galactosidase is a highly distributed functional trait, mainly expressed by members of Blautia, Bacteroides, Alcaligenes, Acinetobacter and Propionibacterium...
March 2, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28250801/press-pulse-a-novel-therapeutic-strategy-for-the-metabolic-management-of-cancer
#18
Thomas N Seyfried, George Yu, Joseph C Maroon, Dominic P D'Agostino
BACKGROUND: A shift from respiration to fermentation is a common metabolic hallmark of cancer cells. As a result, glucose and glutamine become the prime fuels for driving the dysregulated growth of tumors. The simultaneous occurrence of "Press-Pulse" disturbances was considered the mechanism responsible for reduction of organic populations during prior evolutionary epochs. Press disturbances produce chronic stress, while pulse disturbances produce acute stress on populations. It was only when both disturbances coincide that population reduction occurred...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/28250449/metabolism-calorie-restriction-for-healthy-ageing
#19
Irene Fernández-Ruiz
No abstract text is available yet for this article.
April 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28244492/impact-of-carbohydrate-restriction-in-the-context-of-obesity-on-prostate-tumor-growth-in-the-hi-myc-transgenic-mouse-model
#20
E H Allott, E Macias, S Sanders, B S Knudsen, G V Thomas, S D Hursting, S J Freedland
BACKGROUND: Previously, we showed that carbohydrate restriction with calorie restriction slowed tumor growth in xenograft mouse prostate cancer models. Herein, we examined the impact of carbohydrate restriction without calorie restriction on tumor development within the context of diet-induced obesity in the Hi-Myc transgenic mouse model of prostate cancer. METHODS: Mice were randomized at 5 weeks of age to ad libitum western diet (WD; 40% fat, 42% carbohydrate; n=39) or ad libitum no carbohydrate ketogenic diet (NCKD; 82% fat, 1% carbohydrate; n=44)...
February 28, 2017: Prostate Cancer and Prostatic Diseases
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