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https://www.readbyqxmd.com/read/29756708/hypercalcemia-and-hypophosphatemia-among-preterm-infants-receiving-aggressive-parenteral-nutrition
#1
Pablo H Brener Dik, María F Galletti, Leticia T Bacigalupo, Silvia Fernández Jonusas, Gonzalo L Mariani
INTRODUCTION: Aggressive parenteral nutrition is the standard of care among very-low-birth weight preterm infants. However, in recent studies, its impact on short-term outcomes, has been evaluated. The objective was to compare the prevalence of hypercalcemia and hypophosphatemia among preterm infants receiving aggressive or standard parenteral nutrition. METHODS: Observational, retrospective study comparing a group of preterm infants weighing less than 1250 grams who received aggressive parenteral nutrition with a historical control group...
June 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29753994/effect-of-intermittent-vs-daily-calorie-restriction-on-changes-in-weight-and-patient-reported-outcomes-in-people-with-multiple-sclerosis
#2
Kathryn C Fitzgerald, Diane Vizthum, Bobbie Henry-Barron, Amy Schweitzer, Sandra D Cassard, Eric Kossoff, Adam L Hartman, Dimitrios Kapogiannis, Patrick Sullivan, David J Baer, Mark P Mattson, Lawrence J Appel, Ellen M Mowry
An intermittent fasting or calorie restriction diet has favorable effects in the mouse forms of multiple sclerosis (MS) and may provide additional anti-inflammatory and neuroprotective advantages beyond benefits obtained from weight loss alone. We conducted a pilot randomized controlled feeding study in 36 people with MS to assess safety and feasibility of different types of calorie restriction (CR) diets and assess their effects on weight and patient reported outcomes in people with MS. Patients were randomized to receive 1 of 3 diets for 8 weeks: daily CR diet (22% daily reduction in energy needs), intermittent CR diet (75% reduction in energy needs, 2 days/week; 0% reduction, 5 days/week), or a weight-stable diet (0% reduction in energy needs, 7 days/week)...
May 5, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29745797/reversing-age-associated-arterial-dysfunction-insight-from-preclinical-models
#3
Venkateswara Reddy Gogulamudi, Jinjin Cai, Lisa A Lesniewski
Cardiovascular diseases (CVDs) remain the leading causes of death in the US, and advancing age is a primary risk factor. Impaired endothelium dependent dilation and increased stiffening of the arteries with aging are independent predictors of CVD. Increased tissue and systemic oxidative stress and inflammation underlie this age-associated arterial dysfunction. Calorie restriction (CR) is the most powerful intervention known to increase lifespan and improve age-related phenotypes, including arterial dysfunction...
May 10, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29724529/the-effect-of-daily-fortified-yogurt-consumption-on-weight-loss-in-adults-with-metabolic-syndrome-a-10-week-randomized-controlled-trial
#4
M Mohammadi-Sartang, N Bellissimo, J O Totosy de Zepetnek, N R Brett, S M Mazloomi, M Fararouie, A Bedeltavana, M Famouri, Z Mazloom
BACKGROUND AND AIMS: Obesity is a complex and multifaceted condition. Thus, functional foods need investigation as novel adjunct treatments for obesity. The objective was to determine the effects of daily consumption of a fortified yogurt (FY) on weight loss in overweight and obese patients with metabolic syndrome on a caloric-restricted diet. METHODS AND RESULTS: This was a randomized, double-blind, 10-week study. Participants were randomly allocated to two groups receiving either two servings (2 × 250 g)/day of FY with whey protein, calcium, vitamin D, prebiotic fibre and probiotic cultures (n = 44) or a low-fat plain yogurt (PY) (n = 43)...
March 10, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29720572/endospanin-2-enhances-skeletal-muscle-energy-metabolism-and-running-endurance-capacity
#5
Steve Lancel, Matthijs Kc Hesselink, Estelle Woldt, Yves Rouillé, Emilie Dorchies, Stephane Delhaye, Christian Duhem, Quentin Thorel, Alicia Mayeuf-Louchart, Benoit Pourcet, Valérie Montel, Gert Schaart, Nicolas Beton, Florence Picquet, Olivier Briand, Jean Pierre Salles, Hélène Duez, Patrick Schrauwen, Bruno Bastide, Bernard Bailleul, Bart Staels, Yasmine Sebti
Metabolic stresses such as dietary energy restriction or physical activity exert beneficial metabolic effects. In the liver, endospanin-1 and endospanin-2 cooperatively modulate calorie restriction-mediated (CR-mediated) liver adaptations by controlling growth hormone sensitivity. Since we found CR to induce endospanin protein expression in skeletal muscle, we investigated their role in this tissue. In vivo and in vitro endospanin-2 triggers ERK phosphorylation in skeletal muscle through an autophagy-dependent pathway...
May 3, 2018: JCI Insight
https://www.readbyqxmd.com/read/29720342/-the-refeeding-syndrome-in-anorexia-nervosa
#6
Iman Badr Ibrahim, Alia Arif Hussain, Jan Magnus Sjögren
The refeeding syndrome (RFS) is a potentially fatal condition involving fluid and electrolyte imbalances after refeeding in patients with anorexia nervosa. Low-calorie diet added thiamine and minerals is the standard approach to prevent RFS. In a recent systematic review starting with a higher calorie amount than earlier has been recommended, and in another review, it is proposed that a restriction in the amount of carbohydrates may allow for a higher calorie intake early on to enable a safe and faster weight gain...
April 30, 2018: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29718123/the-effects-of-graded-levels-of-calorie-restriction-xiii-global-metabolomics-screen-reveals-graded-changes-in-circulating-amino-acids-vitamins-and-bile-acids-in-the-plasma-of-c57bl-6-mice
#7
Cara L Green, Quinlyn A Soltow, Sharon E Mitchell, Davina Derous, Yingchun Wang, Luonan Chen, Jing-Dong J Han, Daniel E L Promislow, David Lusseau, Alex Douglas, Dean P Jones, John R Speakman
Calorie restriction (CR) remains the most robust intervention to extend life span and improve health span. Using a global mass spectrometry-based metabolomics approach, we identified metabolites that were significantly differentially expressed in the plasma of C57BL/6 mice, fed graded levels of calorie restriction (10% CR, 20% CR, 30% CR, and 40% CR) compared with mice fed ad libitum for 12 hours a day. The differential expression of metabolites increased with the severity of CR. Pathway analysis revealed that graded CR had an impact on vitamin E and vitamin B levels, branched chain amino acids, aromatic amino acids, and fatty acid pathways...
April 30, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29715067/the-variable-role-of-sirt1-in-the-maintenance-and-differentiation-of-mesenchymal-stem-cells
#8
Kayvan Zainabadi
SIRT1 is an NAD+ -dependent deacetylase that acts as a nutrient sensitive regulator of longevity. SIRT1 also acts as a key regulator of mesenchymal stem cells (MSCs), adult stem cells that give rise to tissues such as bone, fat, muscle and cartilage. This review focuses on how SIRT1 regulates the self-renewal, multipotency and differentiation of MSCs. The variable role of SIRT1 in promoting the differentiation of MSCs towards certain lineages, while repressing others, will be examined within the broader context of aging, calorie restriction, and regenerative medicine...
April 2018: Regenerative Medicine
https://www.readbyqxmd.com/read/29708496/reduced-expression-of-c-ebp%C3%AE-lip-extends-health-and-lifespan-in-mice
#9
Christine Müller, Laura M Zidek, Tobias Ackermann, Tristan de Jong, Peng Liu, Verena Kliche, Mohamad Amr Zaini, Gertrud Kortman, Liesbeth Harkema, Dineke S Verbeek, Jan P Tuckermann, Julia von Maltzahn, Alain de Bruin, Victor Guryev, Zhao-Qi Wang, Cornelis F Calkhoven
Ageing is associated with physical decline and the development of age-related diseases such as metabolic disorders and cancer. Few conditions are known that attenuate the adverse effects of ageing, including calorie restriction (CR) and reduced signalling through the mechanistic target of rapamycin complex 1 (mTORC1) pathway. Synthesis of the metabolic transcription factor C/EBPβ-LIP is stimulated by mTORC1, which critically depends on a short upstream open reading frame (uORF) in the Cebpb -mRNA. Here we describe that reduced C/EBPβ-LIP expression due to genetic ablation of the uORF delays the development of age-associated phenotypes in mice...
April 30, 2018: ELife
https://www.readbyqxmd.com/read/29706024/overexpression-of-cyb5r3-and-nqo1-two-nad-producing-enzymes-mimics-aspects-of-caloric-restriction
#10
Alberto Diaz-Ruiz, Michael Lanasa, Joseph Garcia, Hector Mora, Frances Fan, Alejandro Martin-Montalvo, Andrea Di Francesco, Miguel Calvo-Rubio, Andrea Salvador-Pascual, Miguel A Aon, Kenneth W Fishbein, Kevin J Pearson, Jose Manuel Villalba, Placido Navas, Michel Bernier, Rafael de Cabo
Calorie restriction (CR) is one of the most robust means to improve health and survival in model organisms. CR imposes a metabolic program that leads to increased stress resistance and delayed onset of chronic diseases, including cancer. In rodents, CR induces the upregulation of two NADH-dehydrogenases, namely NAD(P)H:quinone oxidoreductase 1 (Nqo1) and cytochrome b5 reductase 3 (Cyb5r3), which provide electrons for energy metabolism. It has been proposed that this upregulation may be responsible for some of the beneficial effects of CR, and defects in their activity are linked to aging and several age-associated diseases...
April 28, 2018: Aging Cell
https://www.readbyqxmd.com/read/29704862/a-nonrestrictive-weight-loss-diet-focused-on-fiber-and-lean-protein-increase
#11
Lijuan Zhang, Sherry Pagoto, Barbara Olendzki, Gioia Persuitte, Linda Churchill, Jessica Oleski, Yunsheng Ma
OBJECTIVE: We examined the feasibility and acceptability of a non-restrictive diet that was focused on increasing dietary fiber and lean protein intake for weight loss. METHODS: Dietary intake was assessed using three randomly selected 24-h dietary recalls. Fifteen obese adults enrolled in a 12-wk study that included six biweekly individual dietary counseling sessions to attain a daily goal of higher fiber (35 g/d) and lean protein (0.8 g/kg/d of individual's ideal body weight) intake...
March 22, 2018: Nutrition
https://www.readbyqxmd.com/read/29696418/causes-of-emotional-eating-and-matched-treatment-of-obesity
#12
REVIEW
Tatjana van Strien
PURPOSE OF THE REVIEW: Eating in response to negative emotions (EE) may be an explanatory factor of the weight regain of many dieters. This narrative review presents evidence on possible causes of EE and the association of EE with depression and obesity and discusses implications of these findings for the treatment of obesity. RECENT FINDINGS: Possible causes of EE are high dietary restraint, poor interoceptive awareness, alexithymia, emotion dysregulation and a reversed hypothalamic pituitary adrenal (HPA) stress axis...
April 25, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/29696385/effects-of-different-weight-loss-approaches-on-cvd-risk
#13
REVIEW
Peter M Clifton, Jennifer B Keogh
PURPOSE OF REVIEW: In this review, we aimed to answer the question as to whether deliberate weight loss can reduce cardiovascular events or improve cardiovascular risk factors and whether different methods of weight loss can have a differential effect on risk factor improvement. RECENT FINDINGS: It would appear that deliberate weight loss reduces total mortality by 16% in obese people with risk factors including type 2 diabetes. People with type 2 diabetes who lose at least 10% of their initial body weight reduce CVD end points by 21% with dietary weight loss while the effect is greater with the greater weight loss induced by bariatric surgery with a 32% reduction in events...
April 25, 2018: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/29696035/comparison-of-two-calorie-reduced-diets-of-different-carbohydrate-and-fiber-contents-and-a-simple-dietary-advice-aimed-to-modify-carbohydrate-intake-on-glycemic-control-and-inflammatory-markers-in-type-2-diabetes-a-randomized-trial
#14
Hamid Ghalandari, Mahdieh Kamalpour, Ashraf Alimadadi, Javad Nasrollahzadeh
Objectives: The aim of this study was to compare the effect of a simple dietary advice with two energy-restricted diets with different carbohydrate and fiber contents on anthropometric, biochemical, and inflammatory markers over an 8-wk intervention period in individuals with diabetes. Methods: Forty-seven patients with type 2 diabetes (31 women and 16 men; age: 52.9 ± 8.0 years, body mass index: 29.5 ± 4.9 kg.m-2 ) completed an 8-wk randomized intervention trial that compared a simple dietary advice aimed to modulate carbohydrate intake (n = 13) with the two calorie-restricted (CR) diets (25% caloric restriction from total energy requirements) differing with regard to carbohydrate and fiber content, one with higher fiber (CRHF) containing 55% energy from carbohydrate plus a tablespoon of psyllium powder (n = 18) and the other with lower carbohydrate (CRLC) containing 40% energy from carbohydrate plus placebo powder (n = 16)...
January 2018: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29695055/efficacy-of-a-moderately-low-carbohydrate-diet-in-a-36-month-observational-study-of-japanese-patients-with-type-2-diabetes
#15
Mariko Sanada, Chinatsu Kabe, Hisa Hata, Junichi Uchida, Gaku Inoue, Yoko Tsukamoto, Yoshifumi Yamada, Junichiro Irie, Shogo Tabata, Mitsuhisa Tabata, Satoru Yamada
We previously showed that a non-calorie-restricted, moderately low-carbohydrate diet (mLCD) is more effective than caloric restriction for glycemic and lipid profile control in patients with type 2 diabetes. To determine whether mLCD intervention is sustainable, effective, and safe over a long period, we performed a 36-month observational study. We sequentially enrolled 200 patients with type 2 diabetes and taught them how to follow the mLCD. We compared the following parameters pre- and post-dietary intervention in an outpatient setting: glycated hemoglobin (HbA1c), body weight, lipid profile (total cholesterol, low and high-density lipoprotein cholesterol, triglycerides), systolic and diastolic blood pressure, liver enzymes (aspartate aminotransferase, alanine aminotransferase), and renal function (urea nitrogen, creatinine, estimated glomerular filtration rate)...
April 24, 2018: Nutrients
https://www.readbyqxmd.com/read/29693729/inflammatory-bowel-disease-and-immunonutrition-novel-therapeutic-approaches-through-modulation-of-diet-and-the-gut-microbiome
#16
REVIEW
Larissa S Celiberto, Franziska A Graef, Genelle R Healey, Else S Bosman, Kevan Jacobson, Laura M Sly, Bruce A Vallance
Inflammatory Bowel Disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract, thought to at least in part reflect an aberrant immune response to gut bacteria. IBD is increasing in incidence, particularly in populations that have recently immigrated to Western countries. This suggests that environmental factors are involved in its pathogenesis. We hypothesize that the increase in IBD rates might reflect the consumption of an unhealthy Western diet, containing excess calories and lacking in key nutritional factors, such as fiber and vitamin D...
April 25, 2018: Immunology
https://www.readbyqxmd.com/read/29684966/-nutritional-assessment-and-management-for-patients-with-chronic-liver-disease
#17
REVIEW
Tae Hee Lee
When liver disease is severe, the prognosis can be worse if the patient is malnourished. Adequate nutritional support for patients with liver diseases can improve the patient's condition and prognosis. In the case of liver cirrhosis, malnutrition can occur due to a variety of causes, including poor oral intake, maldigestion, malabsorption, associated renal disease, and metabolic abnormalities. For a nutritional assessment, it is important to check the dietary intake, change in body composition, including anthropometry, and a functional assessment of muscle...
April 25, 2018: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/29680359/effects-of-6-vs-3-eucaloric-meal-patterns-on-glycaemic-control-and-satiety-in-people-with-impaired-glucose-tolerance-or-overt-type-2-diabetes-a-randomized-trial
#18
E Papakonstantinou, M D Kontogianni, P Mitrou, E Magriplis, D Vassiliadi, T Nomikos, V Lambadiari, E Georgousopoulou, G Dimitriadis
BACKGROUND/OBJECTIVES: The study aimed to compare the effects of two eucaloric meal patterns (3 vs 6 meals/day) on glycaemic control and satiety in subjects with impaired glucose tolerance and plasma glucose (PG) levels 140-199mg/dL at 120min (IGT-A) or PG levels 140-199mg/dL at 120min and >200mg/dL at 30/60/90min post-oral glucose load on 75-g OGTT (IGT-B), or overt treatment-naïve type 2 diabetes (T2D). SUBJECTS/METHODS: In this randomized crossover study, subjects with IGT-A (n=15, BMI: 32...
April 6, 2018: Diabetes & Metabolism
https://www.readbyqxmd.com/read/29678606/ketogenic-diet-high-intensity-interval-training-hiit-and-memory-training-in-the-treatment-of-mild-cognitive-impairment-a-case-study
#19
Kaitlyn Dahlgren, Kelly J Gibas
Alzheimer's disease (AD) deaths have increased by 89% since 2000. This alarming trajectory of neurological disease highlights the failure of current best practice. Deteriorating brain fuel supply is the nemesis of intact neurological health. Cerebral hypo-metabolism associated with AD occurs years before onset. Both the ketogenic diet and calorie restriction (fasting) lead to a compensatory rise in ketones to improve energy deficits in the brain derived from cerebral insulin resistance. Two forms of ketone bodies, β-hydroxybutyrate and acetoacetate, fuel the brain during starvation, fasting and strenuous exercise...
April 11, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29670847/changes-of-insulin-resistance-and-adipokines-following-supplementation-with-glycyrrhiza-glabra-l-extract-in-combination-with-a-low-calorie-diet-in-overweight-and-obese-subjects-a-randomized-double-blind-clinical-trial
#20
Mohammad Alizadeh, Nazli Namazi, Elham Mirtaheri, Nafiseh Sargheini, Sorayya Kheirouri
Purpose: Adipose tissue is a highly active endocrine organ which plays a key role in energy homeostasis. The aim of this study was to determine the effects of dried licorice extract along with a calorie restricted diet on body composition, insulin resistance and adipokines in overweight and obese subjects. Methods: Sixty-four overweight and obese volunteers (27 men, 37 women) were recruited into this double-blind, placebo-controlled, randomized, clinical trial. Participants were randomly allocated to the Licorice (n=32) or the placebo group (n=32), and each group received a low-calorie diet with either 1...
March 2018: Advanced Pharmaceutical Bulletin
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