keyword
MENU ▼
Read by QxMD icon Read
search

fto gene

keyword
https://www.readbyqxmd.com/read/28636007/analysis-of-association-of-gene-variants-with-obesity-traits-in-new-zealand-european-children-at-6-years-of-age
#1
Mohanraj Krishnan, John M D Thompson, Edwin A Mitchell, Rinki Murphy, Lesley M E McCowan, Andrew N Shelling, G On Behalf Of The Children Of Scope Study Group
Childhood obesity is a public health problem, which is associated with a long-term increased risk of cardiovascular disease and premature mortality. Several gene variants have previously been identified that have provided novel insights into biological factors that contribute to the development of obesity. As obesity tracks through childhood into adulthood, identification of the genetic factors for obesity in early life is important. The objective of this study was to identify putative associations between genetic variants and obesity traits in children at 6 years of age...
June 21, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28626215/genetic-variation-in-the-obesity-gene-fto-is-not-associated-with-decreased-fat-oxidation-the-neo-study
#2
L L Blauw, R Noordam, S Trompet, J F P Berbée, F R Rosendaal, D van Heemst, K W van Dijk, D O Mook-Kanamori, R de Mutsert, P C N Rensen
BACKGROUND: The FTO gene harbours the strongest common genetic variant associated with obesity. Recently, rs1421085-T to -C substitution mapped in FTO was shown to induce a developmental shift of human adipocytes from an energy-combusting beige to an energy-storing white phenotype in vitro. As browning of adipocytes selectively enhances fat oxidation (FatOx), we hypothesized that rs1421085-C in FTO is associated with deceased FatOx compared with carbohydrate oxidation (CarbOx) and an increased respiratory quotient (RQ)...
June 19, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28626026/protein-kinase-c%C3%AE-activates-fat-mass-and-obesity-associated-protein-by-influencing-its-ubiquitin-proteasome-degradation
#3
Haoran Tai, Xiaobo Wang, Jiao Zhou, Xiaojuan Han, Tingting Fang, Hui Gong, Ning Huang, Honghan Chen, Jianqiong Qin, Ming Yang, Xiawei Wei, Li Yang, Hengyi Xiao
PKCβ is a serine-threonine kinase associated with obesity and diabetic complications; its activation contributes to weight gain, and deletion of its gene results in resistance to genetic- and diet-induced obesity. Fat mass and obesity-associated (FTO) protein is a recently identified RNA demethylase, and its overexpression in mice leads to increased body weight as well as fat mass. Although sharing some features in anabolism regulation, PKCβ and FTO have not been investigated together; therefore, their relationship has not been established...
June 16, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28615046/the-association-of-insertions-deletions-indels-and-variable-number-tandem-repeats-vntrs-with-obesity-and-its-related-traits-and-complications
#4
REVIEW
Yee-How Say
BACKGROUND: Despite the fact that insertions/deletions (INDELs) are the second most common type of genetic variations and variable number tandem repeats (VNTRs) represent a large portion of the human genome, they have received far less attention than single nucleotide polymorphisms (SNPs) and larger forms of structural variation like copy number variations (CNVs), especially in genome-wide association studies (GWAS) of complex diseases like polygenic obesity. This is exemplified by the vast amount of review papers on the role of SNPs and CNVs in obesity, its related traits (like anthropometric measurements, biochemical variables, and eating behavior), and its related complications (like hypertension, hypertriglyceridemia, hypercholesterolemia, and insulin resistance-collectively known as metabolic syndrome)...
June 14, 2017: Journal of Physiological Anthropology
https://www.readbyqxmd.com/read/28607931/genetic-epidemiology-of-type-2-diabetes-in-mexican-mestizos
#5
REVIEW
Eiralí Guadalupe García-Chapa, Evelia Leal-Ugarte, Valeria Peralta-Leal, Jorge Durán-González, Juan Pablo Meza-Espinoza
There are currently about 415 million people with diabetes worldwide, a figure likely to increase to 642 million by 2040. In 2015, Mexico was the second Latin American country and sixth in the world in prevalence of this disorder with nearly 11.5 million of patients. Type 2 diabetes (T2D) is the main kind of diabetes and its etiology is complex with environmental and genetic factors involved. Indeed, polymorphisms in several genes have been associated with this disease worldwide. To estimate the genetic epidemiology of T2D in Mexican mestizos a systematic bibliographic search of published articles through PubMed, Scopus, Google Scholar, and Web of Science was conducted...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28607773/fto-gene-associates-and-interacts-with-obesity-risk-physical-activity-energy-intake-and-time-spent-sitting-pilot-study-in-a-nigerian-population
#6
Bolaji Fatai Oyeyemi, Charles Ayorinde Ologunde, Ayonposi Bukola Olaoye, Nanfizat Abiket Alamukii
Fat mass and obesity-associated (FTO) gene influences obesity but studies have shown that environmental/lifestyle variables like physical activity (PA), time spent sitting (TSS), and energy intake might mediate the effect. However, this is poorly understood in Nigeria due to scarce studies. We demystified association and interaction between FTO rs9939609, obesity, PA, TSS, and energy intake in Nigeria. FTO gene variant was genotyped by restriction fragment length polymorphism and gene sequencing analysis in 103 people with obesity and 98 controls...
2017: Journal of Obesity
https://www.readbyqxmd.com/read/28607568/review-of-studies-on-the-fat-mass-and-obesity-associated-fto-gene-interactions-with-environmental-factors-affecting-on-obesity-and-its-impact-on-lifestyle-interventions
#7
REVIEW
Naser Kalantari, Saeid Doaei, Nastaran Keshavarz-Mohammadi, Maryam Gholamalizadeh, Naeimeh Pazan
BACKGROUND: The prevalence of obesity is influenced by environmental and genetic factors. Recently, it has been reported that an interaction between genotype and environmental factors can affect each other's effects on the phenotype. The purpose of this study is to evaluate the recent studies on the fat mass and obesity-associated (FTO) gene interactions with environmental factors affecting on obesity and the impact of these interactions on the success level of the lifestyle intervention...
November 2016: ARYA Atherosclerosis
https://www.readbyqxmd.com/read/28603074/fto-gene-polymorphisms-rs9939609-and-rs17817449-as-predictors-of-type-2-diabetes-mellitus-in-obese-iraqi-population
#8
Laith A Younus, Abdul Hussein A Algenabi, Mohammed S Abdul-Zhara, Majid K Hussein
BACKGROUND: The variation of the SNPs in FTO (fat mass and obesity associated) gene are improved to be associated with obesity and type 2 diabetes (T2DM) in some ethnic groups for example in European while, this consistency is controversial in Asians and there were few studies in Iraqi population about the effect of this gene on the development of T2DM in obese patients. Therefore, the objective of this study is to investigate the impact of the two common FTO gene variants in the development of T2DM in obese Iraqi patients...
June 8, 2017: Gene
https://www.readbyqxmd.com/read/28599470/the-lipid-metabolism-gene-fto-influences-breast-cancer-cell-energy-metabolism-via-the-pi3k-akt-signaling-pathway
#9
Yazhuo Liu, Ruoyu Wang, Lichuan Zhang, Jianhua Li, Keli Lou, Bingyin Shi
The present study assessed the effect of the lipid metabolism, fat mass and the obesity-associated gene (FTO), on energy metabolism of breast cancer cells. The human breast cancer cell lines, MCF-7 and MDA-MB-231, and HCC1937 human breast cells were studied. Real-time PCR was used to measure the levels of FTO mRNA from breast cancer cells and normal breast cells. MDA-MB-231 cells were transfected with miFTO inhibitor or inhibitor control, and cells were assessed for levels of lactic acid, ATP, pyruvate kinase activity, and hexokinase activity assay using specific kits...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28591216/modification-effects-of-genetic-polymorphisms-in-fto-il-6-and-hspd1-on-the-associations-of-diabetes-with-breast-cancer-risk-and-survival
#10
Rui-Mei Zhu, Wei Lin, Wei Zhang, Jun-Ting Ren, Yi Su, Jian-Rong He, Ying Lin, Feng-Xi Su, Xiao-Ming Xie, Lu-Ying Tang, Ze-Fang Ren
The contribution of diabetes to breast cancer remains uncertain among Chinese females, which may result from different genetic factors. We evaluated the associations of diabetes, combined with the polymorphisms in the genes of fat mass and obesity-associated gene (FTO), interleukin 6 (IL-6), and heat shock protein 60 (HSPD1), with breast cancer risk and survival in a Chinese Han population. The information on the history of diabetes was collected from 1551 incident breast cancer cases and 1605 age-frequency matched controls in Guangzhou, China...
2017: PloS One
https://www.readbyqxmd.com/read/28585683/the-age-of-developing-diabetes-and-fto-polymorphisms-rs9939609-rs1421085-and-rs9930506
#11
Władysław Grzeszczak, Maciej Molsa, Marek Tłuczykont, Anna Markowicz, Ryszard Swoboda, Marta Biedak, Anna Kałuża, Sebastian Sirek, Krzysztof Strojek
INTRODUCTION: Type 2 diabetes (T2DM) is a common complex metabolic disorder that has a strong genetic predisposition. Fat mass and obesity-associated protein (FTO) is one of the genes of interest to us. Hypomethylation of a CpG site in the FTO gene was significantly associated with the risk of T2DM. The aim of the study was to find the answer to the question of whether the polymorphism changes of the FTO gene in the pathogenesis of type 2 diabetes are comparable in young, middle aged, and elderly people...
June 6, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28566238/correlation-of-resistin-serum-level-with-fat-mass-and-obesity-associated-gene-fto-rs9939609-polymorphism-in-obese-women-with-type-2-diabetes
#12
Maryam Abbasi Majdi, Naser Aga Mohammadzadeh, Hajie Lotfi, Rasoul Mahmoudi, Farzaneh Ghafarian Alipour, Fatemeh Shool, Mehdi Niknam Moghanloo, Sadeg Porfaraj, Nosratollah Zarghami
AIMS: The aim of this study was to detect any association of fat mass and obesity-associated (FTO) rs9939609 variant to metabolic and anthropometric parameters and resistin level as adipokines in Iranian obese women with type 2 diabetes mellitus. MATERIAL AND METHODS: Totally, 42 diabetic and 36 non-diabetic women were selected. The PCR amplicons of FTO gene were sequenced and metabolic, anthropometric parameters and resistin level were measured. RESULTS: Serum resistin concentrations were not different between diabetic and non-diabetic subjects (p>0...
May 13, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28559540/rs9939609-fto-genotype-associations-with-fto-methylation-level-influences-body-mass-and-telomere-length-in-an-australian-rural-population
#13
Y Zhou, D Simmons, D Lai, B D Hambly, C S McLachlan
BACKGROUND: the fat mass- and obesity-associated (FTO) gene influences energy homeostasis in humans. While the obesity-related variant, rs9939609 has been replicated across a number of cohort studies, there remain significant variance and a low modest association. Telomere length is another commonly reported obesity risk factor. We hypothesize understanding the associations between FTO rs9939609 with FTO methylation and telomere length will provide a more accurate assessment of obesity risk...
May 31, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28547937/lack-of-association-of-the-fat-mass-and-obesity-associated-fto-gene-rs9939609-polymorphism-with-breast-cancer-risk-a-systematic-review-and-meta-analysis-based-on-case-control-studies
#14
Jamal Jafari Nedooshan, Saeed Kargar, Hossein Neamatzadeh, Fatemeh Haghighi, Reihaneh Dehghani Mohammad Abadi, Niloofar Seddighi
Background: Previously published data on any association of the fat mass and obesity-associated (FTO) gene with breast cancer risk remain inconclusive. Therefore, we conducted the present meta-analysis of links between breast cancer and the FTO rs9939609 polymorphism. Methods: We have conducted a systematic review of the English literature by searching PubMed, Google Scholar and ISI Web of Knowledge databases for studies on associations between the FTO rs9939609 polymorphism and breast cancer risk. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to estimate the strength of the association using fixed- or random-effects model...
April 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28539834/complex-relationship-between-obesity-and-the-fat-mass-and-obesity-locus
#15
REVIEW
Qingyun Yang, Tiancun Xiao, Jiao Guo, Zhengquan Su
In the 21st century, obesity has become a serious problem because of increasing obese patients and numerous metabolic complications. The primary reasons for this situation are environmental and genetic factors. In 2007, FTO (fat mass and obesity associated) was the first gene identified through a genome-wide association study (GWAS) associated with obesity in humans. Subsequently, a cluster of single nucleotide polymorphisms (SNPs) in the first intron of the FTO gene was discovered to be associated with BMI and body composition...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28507607/gene-variants-in-the-fto-gene-are-associated-with-adiponectin-and-tnf-alpha-levels-in-gestational-diabetes-mellitus
#16
Renata Saucedo, Jorge Valencia, Claudia Gutierrez, Lourdes Basurto, Marcelino Hernandez, Edgardo Puello, Guadalupe Rico, Gloria Vega, Arturo Zarate
BACKGROUND: Obesity may have a role in the development of gestational diabetes mellitus (GDM). Single-nucleotide-polymorphisms (SNPs) of the FTO (fat mass and obesity associated) gene have been associated with obesity. The aim of this study was to investigate SNPs rs8050136, rs9939609, and rs1421085 of the FTO gene in women with GDM and their associations with maternal pre-pregnancy weight and body mass index, gestational weight gain and mediators of insulin resistance in GDM like leptin, adiponectin, ghrelin and tumor necrosis factor-alpha (TNF-alpha), compared with healthy pregnant controls...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28464932/interaction-between-fto-rs9939609-and-the-native-american-origin-abca1-rs9282541-affects-bmi-in-the-admixed-mexican-population
#17
Marisela Villalobos-Comparán, Bárbara Antuna-Puente, María Teresa Villarreal-Molina, Samuel Canizales-Quinteros, Rafael Velázquez-Cruz, Paola León-Mimila, Hugo Villamil-Ramírez, Juan Antonio González-Barrios, José Luis Merino-García, María Rocío Thompson-Bonilla, Diego Jarquin, Osvaldo Erik Sánchez-Hernández, Martha Eunice Rodríguez-Arellano, Carlos Posadas-Romero, Gilberto Vargas-Alarcón, Francisco Campos-Pérez, Manuel Quiterio, Jorge Salmerón-Castro, Alessandra Carnevale, Sandra Romero-Hidalgo
BACKGROUND: The aim of this study was to explore whether interactions between FTO rs9939609 and ABCA1 rs9282541 affect BMI and waist circumference (WC), and could explain previously reported population differences in FTO-obesity and FTO-BMI associations in the Mexican and European populations. METHODS: A total of 3938 adults and 636 school-aged children from Central Mexico were genotyped for both polymorphisms. Subcutaneous and visceral adipose tissue biopsies from 22 class III obesity patients were analyzed for FTO and ABCA1 mRNA expression...
May 2, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/28460778/macronutrients-and-the-fto-gene-expression-in-hypothalamus-a-systematic-review-of-experimental-studies
#18
REVIEW
Saeid Doaei, Naser Kalantari, Nastaran Keshavarz Mohammadi, Ghasem Azizi Tabesh, Maryam Gholamalizadeh
The various studies have examined the relationship between FTO gene expression and macronutrients levels. In order to obtain better viewpoint from this interactions, all of existing studies were reviewed systematically. All published papers have been obtained and reviewed using standard and sensitive keywords from databases such as CINAHL, Embase, PubMed, PsycInfo, and the Cochrane, from 1990 to 2016. The results indicated that all of 6 studies that met the inclusion criteria (from a total of 428 published article) found FTO gene expression changes at short-term follow-ups...
March 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/28459029/association-of-fat-mass-and-obesity-associated-gene-variant-with-lifestyle-factors-and-body-fat-in-indian-children
#19
Lavanya S Parthasarthy, Nikhil Phadke, Shashi Chiplonkar, Anuradha Khadilkar, Kavita Khatod, Veena Ekbote, Surabhi Shah, Vaman Khadilkar
CONTEXT: Common intronic variants of the fat mass and obesity-associated (FTO) gene have been associated with obesity-related traits in humans. AIMS: (1) The aim of this study is to study the distribution of FTO gene variants across different body mass index (BMI) categories and (2) to explore the association between FTO gene variants and lifestyle factors in obese and normal weight Indian children. SUBJECTS AND METHODS: Fifty-six children (26 boys, mean age 10...
March 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28451524/fat-mass-and-obesity-associated-gene-polymorphism-and-the-risk-of-polycystic-ovary-syndrome-a-meta-analysis
#20
REVIEW
Ying Liu, Yongxia Chen
BACKGROUND: We aimed to elucidate the association between fat mass and obesity associated gene (FTO) polymorphism and the risk of polycystic ovary syndrome (PCOS) by meta-analysis. METHODS: We searched PubMed and Embase databases to find the relevant studies. Odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were used for pooled analysis. Statistical analyses were carried out by using R 3.12 software. Heterogeneity was assessed using I (2) and Q statistics...
January 2017: Iranian Journal of Public Health
keyword
keyword
64399
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"