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https://www.readbyqxmd.com/read/27847208/synthesis-and-characterization-of-chrysin-loaded-pcl-peg-pcl-nanoparticle-and-its-effect-on-breast-cancer-cell-line
#1
Ali Eatemadi, Hadis Daraee, Hammed T Aiyelabegan, Babak Negahdari, Bahram Rajeian, Nosratollah Zarghami
BACKGROUND: Nano-therapy exhibit the potential of revolutionizing cancer therapy. This field introduces nanovectors/nanocarriers for anticancer drugs targeted delivery, and also finds application in imaging. Chrysin, a natural flavonoid, was recently studied as having important biological roles in chemical defenses, nitrogen fixation, anti-inflammatory, and anti-oxidant properties. We aim at studying the effect of nano-chrysin on breast cancer cell line. METHODS: The effect of chrysin loaded PCL-PEG-PCL was studied on T47D breast cancer cell line...
November 12, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27829468/fat-mass-obesity-associated-fto-rs9939609-and-melanocortin-4-receptor-mc4r-rs17782313-snp-are-positively-associated-with-obesity-and-blood-pressure-in-mexican-school-aged-children
#2
Pablo García-Solís, Marissa Reyes-Bastidas, Karla Flores, Olga P García, Jorge L Rosado, Lorena Méndez-Villa, Carlota Garcia-G, David García-Gutiérrez, Aarón Kuri-García, Hebert L Hernández-Montiel, Ofelia Soriano-Leon, Maria Elena Villagrán-Herrera, Juan C Solis-Sainz
Childhood overweight and obesity are worldwide public health problems and risk factors for chronic diseases. The presence of SNP in several genes has been associated with the presence of obesity. A total of 580 children (8-13 years old) from Queretaro, Mexico, participated in this cross-sectional study, which evaluated the associations of rs9939609 (fat mass obesity-associated (FTO)), rs17782313 (melanocortin 4 receptor (MC4R)) and rs6548238 (transmembrane protein 18 (TMEM18)) SNP with obesity and metabolic risk factors...
November 10, 2016: British Journal of Nutrition
https://www.readbyqxmd.com/read/27827997/fto-deficiency-affects-the-gene-and-microrna-expression-involved-in-brown-adipogenesis-and-browning-of-white-adipose-tissue-in-mice
#3
Justiina Ronkainen, Eleonora Mondini, Francesca Cinti, Saverio Cinti, Sylvain Sebért, Markku J Savolainen, Tuire Salonurmi
Genetic variants in the fat mass- and obesity-associated gene Fto are linked to the onset of obesity in humans. The causal role of the FTO protein in obesity is supported by evidence obtained from transgenic mice; however, the underlying molecular pathways pertaining to the role of FTO in obesity have yet to be established. In this study, we investigate the Fto gene in mouse brown adipose tissue and in the browning process of white adipose tissue. We analyze distinct structural and molecular factors in brown and white fat depots of Fto-deficient mice under normal and obesogenic conditions...
November 7, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27820839/fto-gene-polymorphism-is-associated-with-type-2-diabetes-through-its-effect-on-increasing-the-maximum-bmi-in-japanese-men
#4
Yutaka Kamura, Minoru Iwata, Shiro Maeda, Satomi Shinmura, Yukiko Koshimizu, Hisae Honoki, Kazuhito Fukuda, Manabu Ishiki, Isao Usui, Yasuo Fukushima, Atsuko Takano, Hiromi Kato, Shihou Murakami, Kiyohiro Higuchi, Chikaaki Kobashi, Kazuyuki Tobe
AIM: Several studies have demonstrated that polymorphisms within the fat-mass and obesity-associated gene (FTO) are associated with type 2 diabetes (T2D). However, whether the effects of the FTO locus on T2D susceptibility are independent of fat-mass increases remains controversial. To investigate this issue, we examined the association of FTO variants with T2D and various aspects of BMI history during adult life in a Japanese population. METHODS: We genotyped SNPs within FTO (rs1121980 and rs1558902) in 760 Japanese patients with T2D who had reached a lifetime maximum BMI (BMImax) before or at the time of diagnosis and 693 control individuals with information regarding their BMImax...
2016: PloS One
https://www.readbyqxmd.com/read/27773536/dynamics-of-human-and-viral-rna-methylation-during-zika-virus-infection
#5
Gianluigi Lichinchi, Boxuan Simen Zhao, Yinga Wu, Zhike Lu, Yue Qin, Chuan He, Tariq M Rana
Infection with the flavivirus Zika (ZIKV) causes neurological, immunological, and developmental defects through incompletely understood mechanisms. We report that ZIKV infection affects viral and human RNAs by altering the topology and function of N(6)-adenosine methylation (m(6)A), a modification affecting RNA structure and function. m(6)A nucleosides are abundant in ZIKV RNA, with twelve m(6)A peaks identified across full-length ZIKV RNA. m(6)A in ZIKV RNA is controlled by host methyltransferases METTL3 and METTL14 and demethylases ALKBH5 and FTO, and knockdown of methyltransferases increases, while silencing demethylases decreases, ZIKV production...
November 9, 2016: Cell Host & Microbe
https://www.readbyqxmd.com/read/27768255/the-obesity-associated-fto-gene-variant-and-the-risk-of-adverse-pregnancy-outcomes-evidence-from-the-scope-study
#6
Prabha H Andraweera, Gustaaf A Dekker, Shalem Leemaqz, Lesley McCowan, Claire T Roberts
OBJECTIVE: To investigate whether the FTO rs9939609 single nucleotide polymorphism (SNP), which is a risk factor for obesity and vascular diseases, is also associated with pregnancy complications including pre-eclampsia, gestational hypertension, small for gestational age pregnancy (SGA), and spontaneous preterm birth (sPTB). METHODS: A case-control study of 1,741 nulliparous Caucasian women, their partners, and infants was conducted. DNA was extracted from peripheral blood or saliva from parents and cord blood from infants and genotyped using the Sequenom MassARRAY system...
October 21, 2016: Obesity
https://www.readbyqxmd.com/read/27759977/association-of-the-rs9939609-gene-variant-in-fto-with-insulin-resistance-cardiovascular-risk-factor-and-serum-adipokine-levels-in-obese-patients
#7
Daniel A De Luis, Rocío Aller, Olatz Izaola, David Primo, E Romero
INTRODUCTION: The aim of our study was to analyze the relationship of the rs9939609 FTO gene polymorphism with insulin resistance and serum adipokine levels. MATERIAL AND METHODS: A population of 610 patients with obesity was analyzed in a cross sectional design. Weight, blood pressure, basal glucose, c-reactive protein (CRP), insulin, insulin resistance (HOMA), lipid profile and adipocytokines (leptin, adiponectin, resistin, TNF alpha, and interleukin 6) levels were measured...
September 20, 2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/27753951/os-08-01-association-of-ace-fabp2-pparg2-gst-fto-and-cyp46a1-genes-polymorphism-with-essential-hypertension-among-north-indian-population
#8
Syed Tasleem Raza, Shania Abbas, Farzana Mahdi
OBJECTIVE: Hypertension (HTN) is the most common cardiovascular disease and is assuming epidemic proportions in developing countries. Genetic and environmental factors play important role in the development of hypertension.The objective of this study was to investigate the possible association of ACE, FABP2, PPARG2, GST, FTO and CYP46A1 genes polymorphism and susceptibility of individuals to HTN. DESIGN AND METHOD: This case control study includes 123 essential HTN cases and 102 controls...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27701175/evaluation-of-the-obesity-genes-fto-and-mc4r-for-contribution-to-the-risk-of-large-artery-atherosclerotic-stroke-in-a-chinese-population
#9
Zhi Song, Lingling Qiu, Zhongyang Hu, Jia Liu, Ding Liu, Deren Hou
BACKGROUND: Obesity is a well-established risk factor for large artery atherosclerotic (LAA) stroke. The aim of the study was to explore whether obesity genes, such as MC4R and FTO, contribute to LAA stroke risk in the Chinese Han population. METHODS: 322 LAA stroke patients and 473 controls were recruited. Gene polymorphism of MC4R (rs17782313) and FTO (rs8050136 and rs9939609) were genotyped. RESULTS: No differences were observed in genotype frequencies of variants of FTO (rs8050136 and rs9939609) or MC4R (rs17782313) between LAA stroke patients and control subjects...
October 5, 2016: Obesity Facts
https://www.readbyqxmd.com/read/27695486/expression-of-candidate-genes-associated-with-obesity-in-peripheral-white-blood-cells-of-mexican-children
#10
Marcela Ulloa-Martínez, Ana I Burguete-García, Selvasankar Murugesan, Carlos Hoyo-Vadillo, Miguel Cruz-Lopez, Jaime García-Mena
INTRODUCTION: Obesity is a chronic, complex, and multifactorial disease, characterized by excess body fat. Diverse studies of the human genome have led to the identification of susceptibility genes that contribute to obesity. However, relatively few studies have addressed specifically the association between the level of expression of these genes and obesity. MATERIAL AND METHODS: We studied 160 healthy and obese unrelated Mexican children aged 6 to 14 years. We measured the transcriptional expression of 20 genes associated with obesity, in addition to the biochemical parameters, in peripheral white blood cells...
October 1, 2016: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/27659330/association-of-a-common-rs9939609-variant-in-the-fat-mass-and-obesity-associated-fto-gene-with-obesity-and-metabolic-phenotypes-in-a-taiwanese-population-a-replication-study
#11
Tun-Jen Hsiao, Eugene Lin
It is a key challenge to conduct reproducibility in genetic research, especially association studies in obesity. While susceptibility of a single-nucleotide polymorphism (SNP), rs9939609, in the fat mass and obesity-associated (FTO) gene to obesity has been reported in various populations, data from Asians is less conclusive. This replication study was carried out to test whether the FTO rs9939609 SNP is a predictive factor for obesity and obesity-related metabolic traits in a Taiwanese population. A total of 1188 Taiwanese subjects were recruited for this study...
September 2016: Journal of Genetics
https://www.readbyqxmd.com/read/27651333/hepatic-fto-expression-is-increased-in-nash-and-its-silencing-attenuates-palmitic-acid-induced-lipotoxicity
#12
Andrea Lim, Jin Zhou, Rohit A Sinha, Brijesh K Singh, Sujoy Ghosh, Kiat-Hon Lim, Pierce Kah-Hoe Chow, Esther C Y Woon, Paul M Yen
Non-alcoholic steatohepatitis (NASH) is one of the most common causes of liver failure worldwide. It is characterized by excess fat accumulation, inflammation, and increased lipotoxicity in hepatocytes. Currently, there are limited treatment options for NASH due to lack of understanding of its molecular etiology. In the present study, we demonstrate that the expression of fat mass and obesity associated gene (FTO) is significantly increased in the livers of NASH patients and in a rodent model of NASH. Furthermore, using human hepatic cells, we show that genetic silencing of FTO protects against palmitate-induced oxidative stress, mitochondrial dysfunction, ER stress, and apoptosis in vitro...
October 21, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27650503/fto-genotype-and-weight-loss-systematic-review-and-meta-analysis-of-9563-individual-participant-data-from-eight-randomised-controlled-trials
#13
Katherine M Livingstone, Carlos Celis-Morales, George D Papandonatos, Bahar Erar, Jose C Florez, Kathleen A Jablonski, Cristina Razquin, Amelia Marti, Yoriko Heianza, Tao Huang, Frank M Sacks, Mathilde Svendstrup, Xuemei Sui, Timothy S Church, Tiina Jääskeläinen, Jaana Lindström, Jaakko Tuomilehto, Matti Uusitupa, Tuomo Rankinen, Wim H M Saris, Torben Hansen, Oluf Pedersen, Arne Astrup, Thorkild I A Sørensen, Lu Qi, George A Bray, Miguel A Martinez-Gonzalez, J Alfredo Martinez, Paul W Franks, Jeanne M McCaffery, Jose Lara, John C Mathers
OBJECTIVE:  To assess the effect of the FTO genotype on weight loss after dietary, physical activity, or drug based interventions in randomised controlled trials. DESIGN:  Systematic review and random effects meta-analysis of individual participant data from randomised controlled trials. DATA SOURCES:  Ovid Medline, Scopus, Embase, and Cochrane from inception to November 2015. ELIGIBILITY CRITERIA FOR STUDY SELECTION:  Randomised controlled trials in overweight or obese adults reporting reduction in body mass index, body weight, or waist circumference by FTO genotype (rs9939609 or a proxy) after dietary, physical activity, or drug based interventions...
2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27650258/a-multianalytical-approach-to-evaluate-the-association-of-55-snps-in-28-genes-with-obesity-risk-in-north-indian-adults
#14
Apurva Srivastava, Balraj Mittal, Jai Prakash, Pranjal Srivastava, Nimisha Srivastava, Neena Srivastava
OBJECTIVES: The aim of the study was to investigate the association of 55 SNPs in 28 genes with obesity risk in a North Indian population using a multianalytical approach. METHODS: Overall, 480 subjects from the North Indian population were studied using strict inclusion/exclusion criteria. SNP Genotyping was carried out by Sequenom Mass ARRAY platform (Sequenom, San Diego, CA) and validated Taqman(®) allelic discrimination (Applied Biosystems(®) ). Statistical analyses were performed using SPSS software version 19...
September 21, 2016: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/27643346/os-08-01-association-of-ace-fabp2-pparg2-gst-fto-and-cyp46a1-genes-polymorphism-with-essential-hypertension-among-north-indian-population
#15
Syed Tasleem Raza, Shania Abbas, Farzana Mahdi
OBJECTIVE: Hypertension (HTN) is the most common cardiovascular disease and is assuming epidemic proportions in developing countries. Genetic and environmental factors play important role in the development of hypertension.The objective of this study was to investigate the possible association of ACE, FABP2, PPARG2, GST, FTO and CYP46A1 genes polymorphism and susceptibility of individuals to HTN. DESIGN AND METHOD: This case control study includes 123 essential HTN cases and 102 controls...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27634552/effects-of-mc4r-fto-and-nmb-gene-variants-to-obesity-physical-activity-and-eating-behavior-phenotypes
#16
Deniz Kirac, Ozgur Kasimay Cakir, Tuba Avcilar, Oguzhan Deyneli, Hizir Kurtel, Dilek Yazici, Elif Cigdem Kaspar, Nurgul Celik, Ahmet Ilter Guney
Obesity is a major contributory factor of morbidity and mortality. It has been suggested that biological systems may be involved in the tendency to be and to remain physically inactive also behaviors such as food and beverage preferences and nutrient intake may at least partially genetically determined. Consequently, besides environment, genetic factors may also contribute to the level of physical activity and eating behaviors thus effect obesity. Therefore the aim of this study is to investigate the effect of various gene mutations on obesity, physical activity levels and eating behavior phenotypes...
October 2016: IUBMB Life
https://www.readbyqxmd.com/read/27601774/genetic-variants-influencing-effectiveness-of-exercise-training-programmes-in-obesity-an-overview-of-human-studies
#17
REVIEW
A Leońska-Duniec, I I Ahmetov, P Zmijewski
Frequent and regular physical activity has significant benefits for health, including improvement of body composition and help in weight control. Consequently, promoting training programmes, particularly in those who are genetically predisposed, is a significant step towards controlling the presently increasing epidemic of obesity. Although the physiological responses of the human body to exercise are quite well described, the genetic background of these reactions still remains mostly unknown. This review not only summarizes the current evidence, through a literature review and the results of our studies on the influence of gene variants on the characteristics and range of the body's adaptive response to training, but also explores research organization problems, future trends, and possibilities...
September 2016: Biology of Sport
https://www.readbyqxmd.com/read/27600277/interaction-between-the-obesity-risk-gene-fto-and-the-dopamine-d2-receptor-gene-ankk1-taqia-on-insulin-sensitivity
#18
Martin Heni, Stephanie Kullmann, Emma Ahlqvist, Robert Wagner, Fausto Machicao, Harald Staiger, Hans-Ulrich Häring, Peter Almgren, Leif C Groop, Dana M Small, Andreas Fritsche, Hubert Preissl
AIMS/HYPOTHESIS: Variations in FTO are the strongest common genetic determinants of adiposity, and may partly act by influencing dopaminergic signalling in the brain leading to altered reward processing that promotes increased food intake. Therefore, we investigated the impact of such an interaction on body composition, and peripheral and brain insulin sensitivity. METHODS: Participants from the Tübingen Family study (n = 2245) and the Malmö Diet and Cancer study (n = 2921) were genotyped for FTO SNP rs8050136 and ANKK1 SNP rs1800497...
September 6, 2016: Diabetologia
https://www.readbyqxmd.com/read/27596730/multiple-novel-gene-by-environment-interactions-modify-the-effect-of-fto-variants-on-body-mass-index
#19
Alexander I Young, Fabian Wauthier, Peter Donnelly
Genetic studies have shown that obesity risk is heritable and that, of the many common variants now associated with body mass index, those in an intron of the fat mass and obesity-associated (FTO) gene have the largest effect. The size of the UK Biobank, and its joint measurement of genetic, anthropometric and lifestyle variables, offers an unprecedented opportunity to assess gene-by-environment interactions in a way that accounts for the dependence between different factors. We jointly examine the evidence for interactions between FTO (rs1421085) and various lifestyle and environmental factors...
2016: Nature Communications
https://www.readbyqxmd.com/read/27560134/fto-obesity-risk-variants-are-linked-to-adipocyte-irx3-expression-and-bmi-of-children-relevance-of-fto-variants-to-defend-body-weight-in-lean-children
#20
Kathrin Landgraf, Markus Scholz, Peter Kovacs, Wieland Kiess, Antje Körner
BACKGROUND: Genome-wide association studies have identified variants within the FTO (fat mass and obesity associated) locus as the strongest predictors of obesity amongst all obesity-associated gene loci. Recent evidence suggests that variants in FTO directly affect human adipocyte function through targeting IRX3 and IRX5 and thermogenesis regulation. AIM: We addressed the relevance of this proposed FTO-IRX pathway in adipose tissue (AT) of children. RESULTS: Expression of IRX3 was higher in adipocytes compared to SVF...
2016: PloS One
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