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Tenascin C

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https://www.readbyqxmd.com/read/28106752/the-promoting-effect-of-the-extracellular-matrix-peptide-tniiia2-derived-from-tenascin-c-in-colon-cancer-cell-infiltration
#1
Hideo Suzuki, Manabu Sasada, Sadahiro Kamiya, Yuka Ito, Hikaru Watanabe, Yuko Okada, Kazuma Ishibashi, Takuya Iyoda, Akinori Yanaka, Fumio Fukai
The extracellular matrix (ECM) molecule tenascin C (TNC) is known to be highly expressed under various pathological conditions such as inflammation and cancer. It has been reported that the expression of TNC is correlated with the malignant potential of cancer. In our laboratory, it was found that the peptide derived from the alternative splicing domain A2 in TNC, termed TNIIIA2, has been shown to influence a variety of cellular processes, such as survival, proliferation, migration, and differentiation. In this study, we investigated the effect of TNC/TNIIIA2 on the invasion and metastasis of colon cancer cells, Colon26-M3...
January 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28095396/tenascin-c-and-fibronectin-expression-divide-early-stage-tongue-cancer-into-low-and-high-risk-groups
#2
Elias Sundquist, Joonas H Kauppila, Johanna Veijola, Rayan Mroueh, Petri Lehenkari, Saara Laitinen, Juha Risteli, Ylermi Soini, Veli-Matti Kosma, Iris Sawazaki-Calone, Carolina Carneiro Soares Macedo, Risto Bloigu, Ricardo D Coletta, Tuula Salo
BACKGROUND: Oral tongue squamous cell carcinoma (OTSCC) metastasises early, especially to regional lymph nodes. There is an ongoing debate on which early stage (T1-T2N0) patients should be treated with elective neck dissection. We need prognosticators for early stage tongue cancer. METHODS: Mice immunisation with human mesenchymal stromal cells resulted in production of antibodies against tenascin-C (TNC) and fibronectin (FN), which were used to stain 178 (98 early stage), oral tongue squamous cell carcinoma samples...
January 17, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28074628/s100a4-metastasin-positive-mesenchymal-canine-mammary-tumour-spheroids-reduce-tenascin-c-synthesis-under-dmso-exposure-in-vitro
#3
S Kau, I Miller, A Tichy, C Gabriel
In breast cancer research S100A4-positive tumour-associated stromal cells are assumed as primary source of Tenascin C (TNC) in the metastatic environment. Aim of the present study was to isolate and characterize S100A4/TNC positive stromal canine mammary tumour (CMT) cells. Cells grown as scaffold-free spheroids were investigated for S100A4, TNC, and proliferative activity under 1.8% DMSO stimulation by means of Western blot and immunohistochemistry. DMSO is a commonly used drug solvent despite well-known side effects on cells including TNC expression...
January 11, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/28071813/sex-differences-in-tendon-structure-and-function
#4
Dylan C Sarver, Yalda Ashraf Kharaz, Kristoffer B Sugg, Jonathan P Gumucio, Eithne Comerford, Christopher L Mendias
Tendons play a critical role in the transmission of forces between muscles and bones, and chronic tendon injuries and diseases are among the leading causes of musculoskeletal disability. Little is known about sex-based differences in tendon structure and function. Our objective was to evaluate the mechanical properties, biochemical composition, transcriptome, and cellular activity of plantarflexor tendons from four month old male and female C57BL/6 mice using in vitro biomechanics, mass spectrometry-based proteomics, genome-wide expression profiling, and cell culture techniques...
January 10, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28054932/hiv-infection-rather-than-concurrent-opportunistic-infections-drives-most-systemic-procoagulant-vascular-and-damage-responses-a-prospective-cohort-study-in-central-africa
#5
Saskia Janssen, Michaela Am Huson, Kara K Osbak, Elie-Gide Rossatanga, Abraham Alabi, René Lutter, Martin P Grobusch, Tom van der Poll
BACKGROUND: HIV infection is accompanied by various systemic host responses, including activation of coagulation and the vascular endothelium. We sought to determine the impact of opportunistic co-infections in a Central-African setting. METHODS: This prospective study included 98 HIV-infected individuals in Gabon initiating combination antiretroviral therapy (cART) and followed them up for 6 months. Patients were stratified according to the presence of active tuberculosis (TB; n=19), mucocutaneous opportunistic infection (n=9), or no opportunistic infection (n=70)...
January 5, 2017: Antiviral Therapy
https://www.readbyqxmd.com/read/28011588/transgenic-overexpression-of-macrophage-matrix-metalloproteinase-9-exacerbates-age-related-cardiac-hypertrophy-vessel-rarefaction-inflammation-and-fibrosis
#6
Hiroe Toba, Presley L Cannon, Andriy Yabluchanskiy, Rugmani Padmanabhan Iyer, Jeanine M D'Armiento, Merry L Lindsey
Advancing age is an independent risk factor for cardiovascular disease. Matrix metalloproteinase-9 (MMP-9) is secreted by macrophages and robustly increases in the left ventricle (LV) with age. The present study investigated the effect of MMP-9 overexpression in macrophages on cardiac aging. We compared 16-21 month old C57/BL6J wild type (WT) and transgenic (TG) male and female mice (n=15-20 /group). MMP-9 overexpression amplified the hypertrophic response to aging, as evidenced by increased LV wall thickness and myocyte cross sectional areas (p<0...
December 23, 2016: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/27991921/rock2-ras-ha-co-operation-induces-malignant-conversion-via-p53-loss-elevated-nf-%C3%AE%C2%BAb-and-tenascin-c-associated-rigidity-but-p21-inhibits-rock2-nf-%C3%AE%C2%BAb-mediated-progression
#7
S F Masre, N Rath, M F Olson, D A Greenhalgh
To study ROCK2 activation in carcinogenesis, mice expressing 4-hydroxytamoxifen (4HT)-activated ROCK2 (K14.ROCK(er)) were crossed with mice expressing epidermal-activated ras(Ha) (HK1.ras(1205)). At 8 weeks, 4HT-treated K14.ROCK(er)/HK1.ras(1205) cohorts exhibited papillomas similar to HK1.ras(1205) controls; however, K14.ROCK(er)/HK1.ras(1205) histotypes comprised a mixed papilloma/well-differentiated squamous cell carcinoma (wdSCC), exhibiting p53 loss, increased proliferation and novel NF-κB expression...
December 19, 2016: Oncogene
https://www.readbyqxmd.com/read/27991696/linking-the-transcriptional-landscape-of-bone-induction-to-biomaterial-design-parameters
#8
Nathalie Groen, Huipin Yuan, Dennie G A J Hebels, Gülistan Koçer, Faustin Mbuyi, Vanessa LaPointe, Roman Truckenmüller, Clemens A van Blitterswijk, Pamela Habibović, Jan de Boer
New engineering possibilities allow biomaterials to serve as active orchestrators of the molecular and cellular events of tissue regeneration. Here, the molecular control of tissue regeneration for calcium phosphate (CaP)-based materials is established by defining the parameters critical for tissue induction and those are linked to the molecular circuitry controlling cell physiology. The material properties (microporosity, ion composition, protein adsorption) of a set of synthesized osteoinductive and noninductive CaP ceramics are parameterized and these properties are correlated to a transcriptomics profile of osteogenic cells grown on the materials in vitro...
December 19, 2016: Advanced Materials
https://www.readbyqxmd.com/read/27974414/the-rodent-liver-undergoes-weaning-induced-involution-and-supports-breast-cancer-metastasis
#9
Erica T Goddard, Ryan C Hill, Travis Nemkov, Angelo D'Alessandro, Kirk C Hansen, Ori Maller, Solange Mongoue-Tchokote, Motomi Mori, Ann H Partridge, Virginia F Borges, Pepper Schedin
Postpartum breast cancer patients are at increased risk for metastasis compared to age-matched nulliparous or pregnant patients. Here, we address whether circulating tumor cells have a metastatic advantage in the postpartum host and find the post-lactation rodent liver preferentially supports metastasis. Upon weaning, we observed liver weight loss, hepatocyte apoptosis, ECM remodeling including deposition of collagen and tenascin-C, and myeloid cell influx, data consistent with weaning-induced liver involution and establishment of a pro-metastatic microenvironment...
December 14, 2016: Cancer Discovery
https://www.readbyqxmd.com/read/27974153/tenascin-c-deficiency-protects-mice-from-experimental-autoimmune-encephalomyelitis
#10
Miljana Momčilović, Vera Stamenković, Miloš Jovanović, Pavle R Andjus, Igor Jakovčevski, Melitta Schachner, Đorđe Miljković
The extracellular matrix glycoprotein tenascin-C (TnC) has been increasingly appreciated as a molecule susceptibly reacting to abnormalities in the mammalian immune system. TnC expression is elevated in inflamed tissues outside the immune system, but also in lymphoid organs. It participates in the promotion of inflammatory responses. Here, the role of TnC in a paradigm of CNS autoimmunity was investigated. Experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis, was induced in mice deficient in TnC (TnC(-/-) mice)...
January 15, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/27943268/non-internalizing-antibody-drug-conjugates-display-potent-anti-cancer-activity-upon-proteolytic-release-of-monomethyl-auristatin-e-in-the-subendothelial-extracellular-matrix
#11
Rémy Gébleux, Marco Stringhini, Ruben Casanova, Alex Soltermann, Dario Neri
Antibody-drug conjugates (ADCs) represent a promising class of biopharmaceuticals with the potential to localize at the tumor site and improve the therapeutic index of cytotoxic drugs. While it is generally believed that ADCs need to be internalized into tumor cells in order to display optimal therapeutic activity, it has recently been shown that non-internalizing antibodies can efficiently liberate disulfide-linked drugs at the extracellular tumor site, leading to potent anti-cancer activity in preclinical animal models...
December 10, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27941141/tenascin-c-is-associated-with-cored-amyloid-%C3%AE-plaques-in-alzheimer-disease-and-pathology-burdened-cognitively-normal-elderly
#12
(no author information available yet)
No abstract text is available yet for this article.
December 2016: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/27933208/detection-of-antibodies-to-citrullinated-tenascin-c-in-patients-with-early-synovitis-is-associated-with-the-development-of-rheumatoid-arthritis
#13
Karim Raza, Anja Schwenzer, Maria Juarez, Patrick Venables, Andrew Filer, Chris D Buckley, Kim S Midwood
No abstract text is available yet for this article.
2016: RMD Open
https://www.readbyqxmd.com/read/27926865/tenascin-c-orchestrates-glioblastoma-angiogenesis-by-modulation-of-pro-and-anti-angiogenic-signaling
#14
Tristan Rupp, Benoit Langlois, Maria M Koczorowska, Agata Radwanska, Zhen Sun, Thomas Hussenet, Olivier Lefebvre, Devadarssen Murdamoothoo, Christiane Arnold, Annick Klein, Martin L Biniossek, Vincent Hyenne, Elise Naudin, Ines Velazquez-Quesada, Oliver Schilling, Ellen Van Obberghen-Schilling, Gertraud Orend
High expression of the extracellular matrix component tenascin-C in the tumor microenvironment correlates with decreased patient survival. Tenascin-C promotes cancer progression and a disrupted tumor vasculature through an unclear mechanism. Here, we examine the angiomodulatory role of tenascin-C. We find that direct contact of endothelial cells with tenascin-C disrupts actin polymerization, resulting in cytoplasmic retention of the transcriptional coactivator YAP. Tenascin-C also downregulates YAP pro-angiogenic target genes, thus reducing endothelial cell survival, proliferation, and tubulogenesis...
December 6, 2016: Cell Reports
https://www.readbyqxmd.com/read/27904024/cartilage-attachment-morphology-of-the-fetal-cruciate-ligaments-of-the-knee-an-immunohistochemical-study-using-human-fetal-specimens
#15
Masahito Yamamoto, Hiromasa Takada, Takeshi Takayama, Sakura Katsumura, Mayumi Sato, Hiroshi Abe, Gen Murakami, Shin-Ichi Abe
Fetal cruciate ligaments of the knee provide two types of cartilage attachments: to a cartilage fovea or a simple continuation to the perichondrium. To examine a difference in matrix substance between a ligament attachment to the fovea and another attachment to the perichondrium. We histologically observed 12 human fetal femurs in which the posterior (or anterior) cruciate ligament provided a fovea-type (or a perichondrium-type) attachment. Immunohistochemistry of matric substances (aggrecan, versican, tenascin-c) was performed...
2016: Okajimas Folia Anatomica Japonica
https://www.readbyqxmd.com/read/27886664/degradation-behaviors-of-geometric-cues-and-mechanical-properties-in-a-3d-scaffold-for-tendon-repair
#16
Yang Wu, Yoke San Wong, Jerry Ying Hsi Fuh
A three-dimensional (3D) scaffold fabricated via electrohydrodynamic jet printing (E-jetting) and thermally uniaxial stretching, has been developed for tendon tissue regeneration in our previous study. In this study, more in-depth biological test showed that the aligned cell morphology guided by the anisotropic geometries of the 3D tendon scaffolds, leading to up-regulated tendious gene expression including collagen type I, decorin, tenascin-C and biglycan, as compared to the electrospun scaffolds. Given the importance of geometric cues to the biological function of the scaffolds, the degradation behaviors of the 3D scaffolds were investigated...
November 25, 2016: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/27878658/role-of-matricellular-proteins-in-disorders-of-the-central-nervous-system
#17
A R Jayakumar, A Apeksha, M D Norenberg
Matricellular proteins (MCPs) are actively expressed non-structural proteins present in the extracellular matrix, which rapidly turnover and possess regulatory roles, as well as mediate cell-cell interactions. MCPs characteristically contain binding sites for other extracellular proteins, cell surface receptors, growth factors, cytokines and proteases, that provide structural support for surrounding cells. MCPs are present in most organs, including brain, and play a major role in cell-cell interactions and tissue repair...
November 23, 2016: Neurochemical Research
https://www.readbyqxmd.com/read/27875272/tenascin-c-at-a-glance
#18
REVIEW
Kim S Midwood, Matthias Chiquet, Richard P Tucker, Gertraud Orend
Tenascin-C (TNC) is a hexameric, multimodular extracellular matrix protein with several molecular forms that are created through alternative splicing and protein modifications. It is highly conserved amongst vertebrates, and molecular phylogeny indicates that it evolved before fibronectin. Tenascin-C has many extracellular binding partners, including matrix components, soluble factors and pathogens; it also influences cell phenotype directly through interactions with cell surface receptors. Tenascin-C protein synthesis is tightly regulated, with widespread protein distribution in embryonic tissues, but restricted distribution of tenascin-C in adult tissues...
December 1, 2016: Journal of Cell Science
https://www.readbyqxmd.com/read/27865025/mr-targeted-imaging-for-the-expression-of-tenascin-c-in-myocardial-infarction-in-vivo
#19
Jiacheng Song, Jing Yu, Yan Li, Shanshan Lu, Zhanlong Ma, Haibin Shi
PURPOSE: To investigate the presence of viable myocardium in mice with acute myocardial infarction (MI) using a molecular targeted probe. MATERIALS AND METHODS: Super paramagnetic iron oxide (SPIO) nanoparticles and tenascin-C antibody were conjugated as an MRI probe. Fifteen mice with infarction were injected with SPIO-anti-tenascin-C (3 days [d], 5d, 7d after infarction; n = 5 for each group). Another five mice with infarction (5d, n = 5) were injected with SPIO for comparison...
November 16, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27853940/novel-role-of-ccn3-that-maintains-the-differentiated-phenotype-of-articular-cartilage
#20
Danilo Janune, Tarek Abd El Kader, Eriko Aoyama, Takashi Nishida, Yasuhiko Tabata, Satoshi Kubota, Masaharu Takigawa
Knowledge of the microenvironment of articular cartilage in health and disease is the key to accomplishing fundamental disease-modifying treatments for osteoarthritis. The proteins comprising the CCN Family are matricellular proteins with a remarkable relevance within the context of cartilage metabolism. CCN2 displays a great capability for regenerating articular cartilage, and CCN3 has been shown to activate the expression of genes related to articular chondrocytes and to repress genes related to endochondral ossification in epiphyseal chondrocytes...
November 16, 2016: Journal of Bone and Mineral Metabolism
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