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uterine neoplasm

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https://www.readbyqxmd.com/read/29035655/focal-uterine-t-cell-lymphoma-in-an-ovariectomized-cat
#1
Bérénice Conversy, Anne-Laure Freulon, Mélanie Graille
CASE DESCRIPTION A 14-year-old ovariectomized domestic shorthair cat was evaluated because of periuria and perineal licking of 3 days' duration. CLINICAL FINDINGS On initial examination, an abdominal mass was palpable cranial to the urinary bladder. The perineal area was soiled with a blood-tinged mucous fluid. Abdominal ultrasonography revealed a vascularized, focal, and circumferential thickening of the right uterine horn, involving particularly the muscular layer. No evidence of dissemination was noted. TREATMENT AND OUTCOME Hysterectomy was performed, revealing a localized, 2...
November 1, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29033610/a-pilot-randomized-controlled-clinical-trial-of-second-uterine-curettage-versus-usual-care-to-determine-the-effect-of-re-curettage-on-patients-need-for-chemotherapy-among-women-with-low-risk-nonmetastatic-gestational-trophoblastic-neoplasm-in-urmia-iran
#2
Haleh Ayatollahi, Zahra Yekta, Elnaz Afsari
OBJECTIVE: The objective of this study was to determine if second curettage was associated with a decreased need for the number of chemotherapy treatments compared to usual care. METHODS: A pilot randomized controlled clinical trial was designed at Motahhari Referral Hospital in 2014. Fifty-two patients with low risk, nonmetastatic gestational trophoblastic neoplasm were assigned randomly to two arms. The interventional arm included a repeat uterine curettage, and the control group received standard care (chemotherapy)...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/28984674/targeted-genomic-profiling-reveals-recurrent-kras-mutations-in-mesonephric-like-adenocarcinomas-of-the-female-genital-tract
#3
Jelena Mirkovic, Marie McFarland, Elizabeth Garcia, Lynette M Sholl, Neal Lindeman, Laura MacConaill, Fei Dong, Michelle Hirsch, Marisa R Nucci, Charles M Quick, Christopher P Crum, W Glenn McCluggage, Brooke E Howitt
Mesonephric adenocarcinoma most commonly arises in the cervix and is presumed to be derived from normal or hyperplastic mesonephric remnants. It is characterized by recurrent KRAS mutations and lack of PIK3CA/PTEN alterations. Adenocarcinomas of the uterine corpus and ovary characterized by morphologic and immunophenotypic similarities to mesonephric adenocarcinoma have been reported. The pathogenesis of these tumors, which have been designated "mesonephric-like adenocarcinomas" is unknown, and it has been debated whether these represent mesonephric adenocarcinomas that arise in the endometrium/ovary or endometrioid adenocarcinomas that closely mimic mesonephric adenocarcinoma...
October 3, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28982650/incidental-detection-of-maternal-neoplasia-in-noninvasive-prenatal-testing
#4
Nilesh G Dharajiya, Daniel S Grosu, Daniel H Farkas, Ron M McCullough, Eyad Almasri, Youting Sun, Sung K Kim, Taylor J Jensen, Juan-Sebastian Saldivar, Eric J Topol, Dirk van den Boom, Mathias Ehrich
BACKGROUND: Noninvasive prenatal testing (NIPT) uses cell-free DNA (cfDNA)(5) as an analyte to detect copy-number alterations in the fetal genome. Because maternal and fetal cfDNA contributions are comingled, changes in the maternal genome can manifest as abnormal NIPT results. Circulating tumor DNA (ctDNA) present in cases of maternal neoplasia has the potential to distort the NIPT readout to a degree that prevents interpretation, resulting in a nonreportable test result for fetal aneuploidy...
October 5, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28982163/oncogenic-hrasg12v-expression-plus-knockdown-of-cdkn2a-using-ecotropic-lentiviral-vectors-induces-high-grade-endometrial-stromal-sarcoma
#5
Laura P Brandt, Joachim Albers, Tomas Hejhal, Antonella Catalano, Peter J Wild, Ian J Frew
The uterine corpus represents the most common site for tumour development in the female genital system. Uterine neoplasms are categorised as epithelial, mesenchymal, mixed epithelial-mesenchymal or trophoblastic tumours. In this study we employed a mouse genetic approach using the MuLE lentiviral gene regulatory system to functionally test the ability of ecotropic lentiviruses to model epithelial and mesenchymal uterine malignancies ex vivo and in vivo. We discovered that MuLE lentiviruses efficiently infect uterine stromal cells but not endometrial epithelial cells when injected into the uterus of cycling, pseudopregnant or ovarectomized mice...
2017: PloS One
https://www.readbyqxmd.com/read/28930821/sonographic-image-of-cervix-epithelioid-trophoblastic-tumor-coexisting-with-mucinous-adenocarcinoma-in-a-postmenopausal-woman-a-case-report
#6
Yi Zhu, Guo-Nan Zhang, Rui-Bo Zhang, Yu Shi, Deng-Feng Wang, Rong He
RATIONALE: Epithelioid trophoblastic tumor (ETT) is a distinctive but rare gestational trophoblastic neoplasia (GTN) composed of chorionic-type intermediate trophoblast cells. Approximately 50% ETT arose from the uterine cervix or lower uterine segment following a previous pregnancy with vaginal bleeding. With its unusual ability to simulate an invasive epithelioid neoplasm, ETT frequently poses a diagnostic challenge, especially involving the uterine cervix. PATIENT CONCERNS: We herein report the case of a 60-year-old female with persistent vaginal bleeding and middle-level elevation of serum human chorionic gonadotropin (hCG)...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28922305/mayer-rokitansky-k%C3%A3-ster-hauser-syndrome-with-bilateral-ovarian-sertoli-cell-tumors-review-of-the-literature-and-report-of-a-rare-case
#7
Alexander L Juusela, Ilana Naghi, Suresh Thani
BACKGROUND: Patients with Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome are infertile secondary to hypoplasia or complete agenesis of the uterus, yet they remain at risk of primary neoplasms of the ovaries because embryologically the uterus and ovaries develop via separate mechanisms. CASE: A 72-year-old nulliparous woman with a history of primary amenorrhea underwent an exploratory laparotomy for a suspected uterine fibroid. In addition to the pelvic mass, the patient was found to have findings consistent with MRKH syndrome...
September 15, 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/28914670/endometrial-stromal-neoplasm-in-the-placenta-report-of-a-case-and-review-of-the-literature
#8
Debra S Heller, Fadi Hatem
Placental neoplasms involving the fetal membranes are exceptionally rare. In leiomyomas and endometrial stromal neoplasms, a uterine origin for nodules in the membranes is also a possibility. We present a case of an incidental endometrial stromal nodule found in the decidua of the free membranes and review the literature.
September 13, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28905674/angioleiomyoma-of-uterus-a-clinicopathologic-study-of-6-cases
#9
Mayank Gupta, Mayur Suryawanshi, Ramani Kumar, Abraham Peedicayil
BACKGROUND AND OBJECTIVES: Angioleiomyoma is a benign perivascular neoplasm commonly involving subcutaneous tissue of extremities, head, and trunk region. They rarely involve the female genital tract. This study analyses clinicopathological features of 6 cases of uterine angioleiomyoma. METHODS: Routine sections of 6 cases were reviewed and immunohistochemical markers namely muscle-specific actin, h-caldesmon, desmin, CD10, WT-1, HMB-45, and melan-A were done. RESULTS: Of the 6 cases, 4 cases had tumor involving the corpus and 2 cases had tumor in the cervix...
September 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28904795/cervical-superficial-myofibroblastoma-case-report-and-review-of-the-literature
#10
Mohamed Abdelaziz, Noura Eziba, Suash Sharma, Daniel Kleven, Ayman Al-Hendy
Superficial myofibroblastoma of the lower female genital tract is a rare benign, recently recognized neoplasm that mostly affects the vulvovaginal area. Our report discusses a case of cervical superficial myofibroblastoma of the lower female genital tract in a 45-year-old patient who is presented with menometrorrhagia. On examination, she had multiple uterine fibroids and a circumscribed submucosal mass lesion involving the anterior lip of cervix. At hysterectomy, histopathological examination of the cervical mass revealed a relatively hypocellular tumor consisted of bland spindled and stellate cells...
2017: SAGE open medical case reports
https://www.readbyqxmd.com/read/28878659/a-case-of-cervical-carcinoid-and-review-of-the-literature
#11
Georgios Papatsimpas, Ioannis Samaras, Paraskevi Theodosiou, Konstantina Papacharalampous, Eleni Maragkouli, N Vasileios Papadopoulos, Konstantinos Tsapakidis, Ioannis Litos, Eleni Sogka, Evanthia Kostopoulou, Georgios K Koukoulis
Uterine cervix carcinoids are distinct neuroendocrine cervical tumors, representing a comparatively small percentage of them. These well-differentiated neoplasms are far less prevalent than small- and large-cell carcinomas, characterized by a more favorable biological course. We report a case of a 43-year-old woman with a nonmetastatic cervical carcinoid, managed with radical hysterectomy. She still remains free of disease. Scant reports in the literature prohibit any reliable prediction of cervical carcinoid prognosis...
May 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28878648/acquired-pulmonary-arteriovenous-fistula-within-metastasis-from-choriocarcinoma-a-case-report
#12
Tassia Yamanari, Marcio Sawamura, Hye Ju Lee, Chang Kai Chi, Artur Katz
Choriocarcinoma is a highly malignant neoplasm arising from the trophoblast of a human pregnancy, which may have distant spread to multiple organs, particularly to the lung. We report a case of a pulmonary arteriovenous fistula that developed after chemotherapy within a choriocarcinoma metastasis. A 24-year-old female with a history of uterine choriocarcinoma presented with multiple hypervascular pulmonary nodules on the initial chest computed tomography (CT) scan, consistent with lung metastases. Four months after chemotherapy, follow-up chest CT revealed a decrease in the size and vascularity of the lung metastases, except for 1 nodule that persisted with marked contrast enhancement and developed a communication with a pulmonary artery and vein...
May 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28877059/choriocarcinoma-in-women-analysis-of-a-case-series-with-genotyping
#13
Johanna Savage, Emily Adams, Emanuela Veras, Kathleen M Murphy, Brigitte M Ronnett
Choriocarcinoma is an uncommon malignant neoplasm, which can be either gestational or nongestational in origin. Distinction of these subtypes has prognostic and therapeutic implications. Twenty-two tumors were genotyped using polymerase chain reaction amplification of 15 short tandem repeat loci and the amelogenin locus (XY determination). DNA patterns from tumor and maternal tissue, as well as villous tissue from any available prior or concurrent gestation, were compared, to determine gestational versus nongestational nature (containing vs...
September 4, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28869333/lung-metastases-of-a-uterine-tumor-resembling-ovarian-sex-cord-tumor-report-of-a-rare-case
#14
Yasuto Kondo, Shinobu Sakaguchi, Masashi Mikubo, Masahito Naito, Kazu Shiomi, Makoto Ohbu, Yukitoshi Satoh
Uterine tumor resembling an ovarian sex-cord tumor (UTROSCT) is a rare type of uterine neoplasm. We present an extremely rare case of lung metastases from a UTROSCT focusing on the cytologic features. A 69-year-old Japanese woman was admitted to our hospital for further examination and treatment for abnormal shadows in the right lung field. She had a history of total hysterectomy for UTROSCT. Moreover, she underwent wedge resection of the right middle lobe for lung metastasis of UTROSCT in 2011. Enhanced chest computed tomography scan revealed a solid nodule 8 mm in diameter in the right upper lobe and a well-demarcated 33-mm mass or nodule in the lower lobe...
September 4, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28844824/all-cause-mortality-in-young-women-with-endometrial-cancer-receiving-progesterone-therapy
#15
Maria P Ruiz, Yongmei Huang, June Y Hou, Ana I Tergas, William M Burke, Cande V Ananth, Alfred I Neugut, Dawn L Hershman, Jason D Wright
BACKGROUND: Uterine-preserving therapy with progesterone may be used in young women with endometrial cancer who desire fertility preservation. Such therapy delays definitive treatment with hysterectomy. OBJECTIVE: We examined the use and safety of progestational therapy in young women with endometrial cancer. The primary outcome of the analysis was overall survival. STUDY DESIGN: We identified women ≤49 years of age with stage I endometrial cancer in the National Cancer Database from 2004 through 2014...
August 24, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28829815/effect-of-vitamin-e-supplementation-on-uterine-cervical-neoplasm-a-meta-analysis-of-case-control-studies
#16
Xiaoli Hu, Saisai Li, Lulu Zhou, Menghuang Zhao, Xueqiong Zhu
Several epidemiological studies have suggested that vitamin E could reduce the risk of uterine cervical neoplasm. However, controversial data were presented by different reports. Hence, we conducted a meta-analysis to assess the relationship between vitamin E and the risk of cervical neoplasia. We performed a comprehensive search of the PubMed, Embase and Cochrane databases through December 31, 2016. Based on a fixed-effects or random-effects model, the odds ratio (OR) and 95% confidence intervals (CIs) were calculated to assess the combined risk...
2017: PloS One
https://www.readbyqxmd.com/read/28819773/tlr9-gene-polymorphism-1486t-c-rs187084-is-associated-with-uterine-cervical-neoplasm-in-mexican-female-population
#17
Cecilia Martínez-Campos, Margarita Bahena-Román, Kirvis Torres-Poveda, Ana I Burguete-García, Vicente Madrid-Marina
PURPOSE: The aim of this work was to evaluate the association of single nucleotide polymorphisms in TLR9 (-1486 T/C [rs187084], -1237T/C [rs5743836] and G2848A [rs352140]) with HPV infection, squamous intraepithelial lesions, and uterine cervical neoplasm in a Mexican population. Additionally, the peripheral expression of TLR9 was evaluated to evaluate the differences in the TLR9 expression associated with every genotype in the locus -1486 of the TLR9 gene. The serum concentration of TLR9 was evaluated in a randomly selected subsample...
August 17, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28815060/defective-expression-of-atg4d-abrogates-autophagy-and-promotes-growth-in-human-uterine-fibroids
#18
Abdeljabar El Andaloussi, Samar Habib, Gizem Soylemes, Archana Laknaur, Heba Elhusseini, Ayman Al-Hendy, Nahed Ismail
Uterine fibroids (UF) are the most common pelvic tumors in women of reproductive-age and they usually cause heavy menstrual bleeding, pain and infertility. Autophagy is a collection of processes that enables the cells to digest and recycle their cytoplasmic contents, such as toxic protein aggregates, defunct or disused organelles and invading microorganisms. Dysregulation in autophagy process were described in neoplasms; however, the contribution of autophagy to the pathogenesis of UF remains unknown. In this study, we demonstrate that autophagy is deregulated in human UF as evidenced by significant accumulation of autophagosome in human UF cells compared to normal myometrium cells...
2017: Cell Death Discovery
https://www.readbyqxmd.com/read/28801511/paraneoplastic-mucous-membrane-pemphigoid-with-ocular-and-laryngeal-involvement
#19
Silvia Lambiel, Pavel Dulguerov, Emmanuel Laffitte, Igor Leuchter
A 73-year-old woman was treated 8 years previously for synchronous breast and uterine neoplasms. She presented with a severe sore throat, odynophagia, dysphonia, dyspnoea, ocular irritation and weight loss over the last 3 months. Physical examination revealed ulcerations in the oral cavity, posterior pharyngeal wall and supraglottic larynx, nasal crusting, bilateral conjunctivitis and three cutaneous blisters. A diagnosis of anti-laminin 5 mucous membrane pemphigoid was retained, based on skin biopsy, direct immunofluorescence and immunoprecipitation...
August 11, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28795131/primary-pouch-of-douglas-malignancies-a-case-series-and-review-of-the-literature
#20
Ker Yi Wong, Ada Xinhui Ng, Timothy Yong Kuei Lim
•POD lesions are often diagnosed as ovarian or uterine in origin on imaging.•POD malignancies with concomitant endometriosis, appear to be of lower grade.•There is no consensus on the optimal treatment for rare primary POD neoplasms.
August 2017: Gynecologic Oncology Reports
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