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https://www.readbyqxmd.com/read/28239934/-reversi-type-virologic-failure-involved-in-the-development-of-ns5a-ravs-in-patients-with-genotype-1b-hcv-carrying-no-signature-ravs-at-baseline
#1
Yoshihito Uchida, Jun-Ichi Kouyama, Kayoko Naiki, Kayoko Sugawara, Mie Inao, Yukinori Imai, Nobuaki Nakayama, Satoshi Mochida
AIMS: The therapeutic efficacy of daclatasvir/asunaprevir was inferior in patients with NS5A-R30Q mutant HCV strains at baseline, compared with those with wild-type strains, even though the EC50 of NS5A inhibitors was lower in mutant strains than in wild-type strains. In these patients, R30Q and Y93H mutant strains, which are highly resistant to NS5A inhibitors, emerged at virologic failure. The mechanisms involved in such virologic failure were examined. METHODS: NS5A-RAVs were evaluated using direct sequencing in 88 patients with virologic failure after daclatasvir/asunaprevir therapy...
February 27, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28239673/effectiveness-of-a-walnut-enriched-diet-on-murine-sperm-involvement-of-reduced-peroxidative-damage
#2
Lauren S Coffua, Patricia A Martin-DeLeon
A walnut supplement for a Western-style diet in men was shown to improve sperm motility, vitality, and morphology. To gain further insights into factors underlying this improvement, we administered a parallel walnut-enriched diet to mice [including those with a defect in sperm motility due to deletion of Plasma Membrane Ca(2+)-ATPase 4 (Pmca4(-/-) )] to determine if there is a similar improvement that is accompanied by reduced sperm membrane peroxidative damage. Although sperm vitality and acrosome reaction rate were unaffected, the diet led to a significant improvement in motility (P < 0...
February 2017: Heliyon
https://www.readbyqxmd.com/read/28239606/influence-of-additive-manufactured-scaffold-architecture-on-the-distribution-of-surface-strains-and-fluid-flow-shear-stresses-and-expected-osteochondral-cell-differentiation
#3
Wim J Hendrikson, Anthony J Deegan, Ying Yang, Clemens A van Blitterswijk, Nico Verdonschot, Lorenzo Moroni, Jeroen Rouwkema
Scaffolds for regenerative medicine applications should instruct cells with the appropriate signals, including biophysical stimuli such as stress and strain, to form the desired tissue. Apart from that, scaffolds, especially for load-bearing applications, should be capable of providing mechanical stability. Since both scaffold strength and stress-strain distributions throughout the scaffold depend on the scaffold's internal architecture, it is important to understand how changes in architecture influence these parameters...
2017: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/28239453/the-sink-as-a-potential-source-of-transmission-of-carbapenemase-producing-enterobacteriaceae-in-the-intensive-care-unit
#4
Deborah De Geyter, Lieve Blommaert, Nicole Verbraeken, Mark Sevenois, Luc Huyghens, Helena Martini, Lieve Covens, Denis Piérard, Ingrid Wybo
BACKGROUND: Carbapenemase-producing Enterobacteriaceae (CPE) are emerging pathogens that represent a major public health threat. In the University Hospital of Brussels, the incidence of new patients with CPE rose from 1 case in 2010 to 35 cases in 2015. Between January and August 2015, five patients became infected/colonized with CPE during their stay in the same room in the intensive care unit (ICU). Since the time period between those patients was relatively short and the strains belonged to different species with different antibiograms and mechanisms of resistance, the hypothesis was that the environment could be a possible source of transmission...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/28239370/capb2-expression-is-associated-with-staphylococcus-aureus-pathogenicity
#5
Dan Li, Yinjuan Guo, Shanshan Wang, Jingnan Lv, Xiuqin Qi, Zengqiang Chen, Lizhong Han, Xueqing Zhang, Liangxing Wang, Fangyou Yu
CapB2 is recognized as a tyrosine kinase and is likely a vital factor in extracellular polysaccharide synthesis in Staphylococcus aureus, but its pathogenicity function and regulatory mechanism remain obscure. Here, we demonstrate that CapB2 enhances bacterial virulence in a murine model. Mice infected with the wild type SA75 strain exhibited significantly larger (P < 0.05) skin lesions from days 4 to 7 of infection than those challenged with the capB2 mutant strain. The effect on virulence was reverted by restoring the capB2 mutation to the wild type...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28239230/experimental-analysis-of-steel-beams-subjected-to-fire-enhanced-by-brillouin-scattering-based-fiber-optic-sensor-data
#6
Yi Bao, Yizheng Chen, Matthew S Hoehler, Christopher M Smith, Matthew Bundy, Genda Chen
This paper presents high temperature measurements using a Brillouin scattering-based fiber optic sensor and the application of the measured temperatures and building code recommended material parameters into enhanced thermomechanical analysis of simply supported steel beams subjected to combined thermal and mechanical loading. The distributed temperature sensor captures detailed, nonuniform temperature distributions that are compared locally with thermocouple measurements with less than 4.7% average difference at 95% confidence level...
January 2017: Journal of Structural Engineering (New York, N.Y.)
https://www.readbyqxmd.com/read/28239200/the-influence-of-pulsed-electroplating-frequency-and-duty-cycle-on-copper-film-microstructure-and-stress-state
#7
James B Marro, Taghi Darroudi, Chukwudi A Okoro, Yaw S Obeng, Kathleen C Richardson
In this work we studied the impact of pulse electroplating parameters on the cross-sectional and surface microstructures of blanket copper films using electron backscattering diffraction and x-ray diffraction. The films evaluated were highly (111) textured in the direction perpendicular to the film surface. The degree of preferential orientation was found to decrease with longer pulse on-times, due to strain energy driven growth of other grain orientations. Residual biaxial stresses were also measured in the films and higher pulse frequencies during deposition led to smaller biaxial stresses in the films...
January 2017: Thin Solid Films
https://www.readbyqxmd.com/read/28238773/inhibition-of-the-tetk-efflux-pump-by-the-essential-oil-of-chenopodium-ambrosioides-l-and-%C3%AE-terpinene-against-staphylococcus-aureus-is-58
#8
Paulo W Limaverde, Fábia F Campina, Francisco A B da Cunha, Francidalva D Crispim, Fernando G Figueredo, Luciene F Lima, Cícera Datiane de M Oliveira-Tintino, Yedda M L S de Matos, Maria Flaviana B Morais-Braga, Irwin R A Menezes, Valdir Q Balbino, Henrique D M Coutinho, José P Siqueira-Júnior, Jackson R G S Almeida, Saulo R Tintino
The use of natural products is crucial to suppress the development of these micro-organisms and to reduce the concentration necessary to inhibit these microrganisms, reducing the toxicity risks also. In this study, the essential oil from Chenopodium ambrosioides Leaves and its main constituent α-Terpinene were used in the antibacterial and potentiating activity of antibiotics and ethidium bromide assays, against the bacterial strains Staphylococcus aureus IS-58, carriers of efflux pumps. The Minimum Inhibitory Concentration (MIC) was determined using a microdilution method...
February 23, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28238564/impact-of-persistent-left-ventricular-regional-wall-motion-abnormalities-in-childhood-cancer-survivors-after-anthracycline-therapy-assessment-of-global-left-ventricular-myocardial-performance-by-3d-speckle-tracking-echocardiography
#9
Hirotsugu Okuma, Nobutaka Noto, Syuntaro Tanikawa, Koji Kanezawa, Maiko Hirai, Katsuyoshi Shimozawa, Hiroshi Yagasaki, Hiroyuki Shichino, Shori Takahashi
AIMS: To identify left ventricular (LV) mechanical impairment by 3D speckle-tracking echocardiography (3DSTE) in long-term childhood cancer survivors after anthracycline therapy with or without persistent LV regional diastolic wall motion abnormalities (WMA) and a preserved LV ejection fraction (EF >53%). METHODS AND RESULTS: Thirty-two patients (median: 14.6 years) and 12 age-matched controls were studied. The patients were divided into two groups according to the existence of WMA: Group 1 (with WMA: n=14), Group 2 (without WMA: n=18)...
February 23, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/28238424/a-transversely-isotropic-coupled-hyperelastic-model-for-the-mechanical-behavior-of-tendons
#10
Thiago André Carniel, Eduardo Alberto Fancello
Several constitutive models for fibrous soft tissues used in literature provide a completely isotropic response when fibers are compressed. However, recent experimental investigations confirm the expectation that tendons behave anisotropically during compression tests. Motivated by these facts, the present manuscript presents an appropriate choice of hyperelastic potentials able to predict the coupled mechanical behaviors of tendons under both tensile and compressive loads with a relatively small number of material parameters...
February 9, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28238067/acquisition-of-tn6018-3-cs-regions-increases-colistin-mics-against-acinetobacter-baumannii-isolates-harboring-new-variants-of-abars
#11
Mohammad Savari, Alireza Ekrami, Saeed Shoja, Abbas Bahador
Colistin is the last hope to treat extensively drug resistance (XDR) Acinetobacter baumannii (A. baumannii) infections, but resistance to colistin is currently reported in clinical centers all over the world. Here, we studied two colistin-resistant A. baumannii isolates with a difference in minimum inhibitory concentrations (MICs) that were isolated from a single burn patient during treatment in the hospitalization period. The international clonal (IC) lineage, multilocus sequence typing (MLST), and multiple loci variable number tandem repeat (VNTR) analysis (MLVA) typing were used to characterize the relatedness of A...
February 25, 2017: Folia Microbiologica
https://www.readbyqxmd.com/read/28237731/rhenium-i-tricarbonyl-compounds-of-bioactive-thiosemicarbazones-synthesis-characterization-and-activity-against-trypanosoma-cruzi
#12
Esteban Rodríguez Arce, Ignacio Machado, Belén Rodríguez, Michel Lapier, María Carolina Zúñiga, Juan Diego Maya, Claudio Olea Azar, Lucía Otero, Dinorah Gambino
American Trypanosomiasis is a chronic infection discovered and described in 1909 by the Brazilian scientist Carlos Chagas. It is caused by the protozoan parasite Trypanosoma cruzi. Although it affects about 10million people in Latin America, the current chemotherapy is still inadequate. The discovery of new drugs is urgently needed. Our group is focused on the development of prospective metal-based drugs mainly based on bioactive ligands and pharmacologically interesting metal ions. In this work three new rhenium(I) tricarbonyl compounds fac-[Re(I)(CO)3Br(HL)] where HL=5-nitrofuryl containing thiosemicarbazones were synthesized and fully characterized in solution and in the solid state...
January 23, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28237724/the-common-autoimmunity-predisposing-620arg%C3%A2-%C3%A2-trp-variant-of-ptpn22-modulates-macrophage-function-and-morphology
#13
Meihang Li, Hugues Beauchemin, Natalija Popovic, Alan Peterson, Eva d'Hennezel, Ciriaco A Piccirillo, Chao Sun, Constantin Polychronakos
The C1858T single nucleotide polymorphism (SNP) in PTPN22 (protein tyrosine phosphatase nonreceptor 22) leads to the 620 Arg to Trp polymorphism in its encoded human protein LYP. This allelic variant is associated with multiple autoimmune diseases, including type 1 diabetes (T1D), Crohn's disease, rheumatoid arthritis and systemic lupus erythematosus. However, the underlying mechanisms are poorly understood. To study how this polymorphism influences the immune system, we generated a mouse strain with a knock-in of the Trp allele, imitating the human disease-associated variant...
February 22, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/28237677/growth-viability-and-architecture-of-biofilms-of-listeria-monocytogenes-formed-on-abiotic-surfaces
#14
Fernanda Barbosa Dos Reis-Teixeira, Virgínia Farias Alves, Elaine Cristina Pereira de Martinis
The pathogenic bacterium Listeria monocytogenes can persist in food processing plants for many years, even when appropriate hygienic measures are in place, with potential for contaminating ready-to-eat products and, its ability to form biofilms on abiotic surfaces certainly contributes for the environmental persistence. In this research, L. monocytogenes was grown in biofilms up 8 days attached to stainless steel and glass surfaces, contributing for advancing the knowledge on architecture of mature biofilms, since many literature studies carried out on this topic considered only early stages of cell adhesion...
February 9, 2017: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/28237622/theiler-s-murine-encephalomyelitis-virus-infection-of-sjl-j-and-c57bl-6j-mice-models-for-multiple-sclerosis-and-epilepsy
#15
REVIEW
Ana Beatriz DePaula-Silva, Tyler J Hanak, Jane E Libbey, Robert S Fujinami
Mouse models are great tools to study the mechanisms of disease development. Theiler's murine encephalomyelitis virus is used in two distinct viral infection mouse models to study the human diseases multiple sclerosis (MS) and epilepsy. Intracerebral (i.c.) infection of the SJL/J mouse strain results in persistent viral infection of the central nervous system and a MS-like disease, while i.c. infection of the C57BL/6J mouse strain results in acute seizures and epilepsy. Our understanding of how the immune system contributes to the development of two disparate diseases caused by the same virus is presented...
February 12, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/28236766/oxidative-stress-metabolomics-profiling-and-mechanism-of-local-anesthetic-induced-cell-death-in-yeast
#16
Cory H T Boone, Ryan A Grove, Dana Adamcova, Javier Seravalli, Jiri Adamec
The World Health Organization designates lidocaine as an essential medicine in healthcare, greatly increasing the probability of human exposure. Its use has been associated with ROS generation and neurotoxicity. Physiological and metabolomic alterations, and genetics leading to the clinically observed adverse effects have not been temporally characterized. To study alterations that may lead to these undesirable effects, Saccharomyces cerevisiae grown on aerobic carbon sources to stationary phase was assessed over 6h...
February 3, 2017: Redox Biology
https://www.readbyqxmd.com/read/28236746/discovery-of-a-novel-antiviral-agent-targeting-the-nonstructural-protein-4-nsp4-of-chikungunya-virus
#17
Yuji Wada, Yasuko Orba, Michihito Sasaki, Shintaro Kobayashi, Michael J Carr, Haruaki Nobori, Akihiko Sato, William W Hall, Hirofumi Sawa
Chikungunya fever (CHIKF) is caused by chikungunya virus (CHIKV) infection which is a re-emerging mosquito-borne zoonosis. At present, there are no approved therapeutics for CHIKF. Herein, we have investigated candidate compounds which can inhibit CHIKV infection. Screening of chemical compound libraries were performed and one candidate, a benzimidazole-related compound designated Compound-A was found to inhibit infection by several CHIKV strains and a Sindbis virus strain at nanomolar concentrations. To investigate the inhibitory mechanism of action, a Compound-A resistant CHIKV (res-CHIKV) was isolated and a key mutation associated with resistance was identified by reverse-genetic recombinant CHIKVs containing amino acid substitutions present in res-CHIKV...
February 22, 2017: Virology
https://www.readbyqxmd.com/read/28236694/on-the-mechanical-characteristics-of-a-self-setting-calcium-phosphate-cement
#18
A Bimis, L P Canal, D Karalekas, J Botsis
OBJECTIVE: To perform a mechanical characterization of a self-setting calcium phosphate cement in function of the immersion time in Ringer solution. MATERIALS AND METHODS: Specimens of self-setting calcium phosphate cement were prepared from pure α-TCP powder. The residual strains developed during hardening stage were monitored using an embedded fiber Bragg grating sensor. Additionally, the evolution of the elastic modulus was obtained for the same time period by conducting low-load indentation tests...
February 14, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28236274/comparative-pan-genome-analysis-of-oral-prevotella-species-implicated-in-periodontitis
#19
Maziya Ibrahim, Ahalyaa Subramanian, Sharmila Anishetty
Prevotella is part of the oral bacterial community implicated in periodontitis. Pan genome analyses of eight oral Prevotella species, P. dentalis, P. enoeca, P. fusca, P. melaninogenica, P. denticola, P. intermedia 17, P. intermedia 17-2 and P. sp. oral taxon 299 are presented in this study. Analysis of the Prevotella pan genome revealed features such as secretion systems, resistance to oxidative stress and clustered regularly interspaced short palindromic repeat (CRISPR)-Cas systems that enable the bacteria to adapt to the oral environment...
February 24, 2017: Functional & Integrative Genomics
https://www.readbyqxmd.com/read/28235872/role-and-characterization-of-a-cyanide-induced-3-cyanoalanine-nitrilase-in-the-cyanide-assimilating-bacterium-pseudomonas-pseudoalcaligenes-cect-5344
#20
Felipe Acera, María Isabel Carmona, Francisco Castillo, Alberto Quesada, Rafael Blasco
Pseudomonas pseudoalcaligenes CECT 5344 is a bacterium able to assimilate cyanide as the sole nitrogen source. Under this growth conditions, a 3-cyanoalanine nitrilase enzymatic activity was induced. This activity was coded by nit4, one of the four nitrilases detected in the genome of this bacterium, and its expression in E. coli enabled the recombinant strain to fully assimilate 3-cyanoalanine. P. pseudoalcaligenes CECT 5344 showed a weak growth level with 3-cyanoalanine as N-source, unless KCN was also added...
February 24, 2017: Applied and Environmental Microbiology
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