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https://www.readbyqxmd.com/read/28431428/computational-and-in-vitro-experimental-investigation-of-intrathecal-drug-distribution-parametric-study-of-the-effect-of-injection-volume-cerebrospinal-fluid-pulsatility-and-drug-uptake
#1
Kevin M Tangen, Roxanne Leval, Ankit I Mehta, Andreas A Linninger
BACKGROUND: Intrathecal drug delivery is an attractive option to circumvent the blood-brain barrier for pain management through its increased efficacy of pain relief, reduction in adverse side effects, and cost-effectiveness. Unfortunately, there are limited guidelines for physicians to choose infusion or drug pump settings to administer therapeutic doses to specific regions of the spine or the brain. Although empiric trialing of intrathecal drugs is critical to determine the sustained side effects, currently there is no inexpensive in vitro method to guide the selection of spinal drug delivery parameters...
May 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28431086/dynamic-ultrasound-imaging-for-quadriceps-tendon-impingement-in-a-patient-with-anterior-knee-pain
#2
Muhammad Dughbaj, Diaa Shehab, Levent Özçakar
No abstract text is available yet for this article.
April 18, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28430860/increased-brainstem-perfusion-but-no-blood-brain-barrier-disruption-during-attacks-of-migraine-with-aura
#3
Anders Hougaard, Faisal M Amin, Casper E Christensen, Samaira Younis, Frauke Wolfram, Stig P Cramer, Henrik B W Larsson, Messoud Ashina
The migraine aura is characterized by transient focal cortical disturbances causing dramatic neurological symptoms that are usually followed by migraine headache. It is currently not understood how the aura symptoms are related to the headache phase of migraine. Animal studies suggest that cortical spreading depression, the likely mechanism of migraine aura, causes disruption of the blood-brain barrier and noxious stimulation of trigeminal afferents leading to activation of brainstem nuclei and triggering of migraine headache...
April 18, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28430477/spatiotemporal-patterns-in-ultraslow-domain-wall-creep-dynamics
#4
Ezequiel E Ferrero, Laura Foini, Thierry Giamarchi, Alejandro B Kolton, Alberto Rosso
In the presence of impurities, ferromagnetic and ferroelectric domain walls slide only above a finite external field. Close to this depinning threshold, they proceed by large and abrupt jumps called avalanches, while, at much smaller fields, these interfaces creep by thermal activation. In this Letter, we develop a novel numerical technique that captures the ultraslow creep regime over huge time scales. We point out the existence of activated events that involve collective reorganizations similar to avalanches, but, at variance with them, display correlated spatiotemporal patterns that resemble the complex sequence of aftershocks observed after a large earthquake...
April 7, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28429391/technical-note-direct-measurement-of-continuous-tmr-data-with-a-1d-tank-and-automated-couch-movements
#5
Nels C Knutson, Matthew C Schmidt, Matthew D Belley, Ngoc Nguyen, H Harold Li, Erno Sajo, Michael Price
PURPOSE: Real-time dynamic control of the linear accelerator, couch, and imaging parameters during radiation delivery was investigated as a novel technique for acquiring tissue maximum ratio (TMR) data. METHODS: TrueBeam Developer Mode (Varian Medical Systems, Palo Alto, CA) was used to control the linear accelerator using the Extensible Markup Language (XML). A single XML file was used to dynamically manipulate the machine, couch, and imaging parameters during radiation delivery...
April 21, 2017: Medical Physics
https://www.readbyqxmd.com/read/28429371/design-of-a-short-non-uniform-acquisition-protocol-for-quantitative-analysis-in-dynamic-cardiac-spect-imaging-a-retrospective-123-i-mibg-animal-study
#6
Yunlong Zan, Yong Long, Kewei Chen, Biao Li, Qiu Huang, Grant T Gullberg
PURPOSE: Our previous works have found that quantitative analysis of (123) I-MIBG kinetics in the heart with dynamic single-photon emission computed tomography (SPECT) offers the potential to quantify the innervation integrity at an early stage of left ventricular hypertrophy. However, conventional protocols involving a long acquisition time for dynamic imaging reduce the animal survival rate and thus make longitudinal analysis difficult. The goal of this work was to develop a procedure to reduce the total acquisition time by selecting non-uniform acquisition times for projection views while maintaining the accuracy and precision of estimated physiologic parameters...
April 21, 2017: Medical Physics
https://www.readbyqxmd.com/read/28429346/dynamic-and-contrast-enhanced-ct-imaging-of-lung-carcinoma-pulmonary-tuberculoma-and-inflammatory-pseudotumor
#7
C-R Li, Y-Z Li, Y-M Li, Y-S Zheng
OBJECTIVE: Our main aim was to investigate the effect of dynamic and contrast enhanced CT imaging on differential diagnosis of lung carcinoma, pulmonary tuberculoma, inflammatory pseudotumor, and coexisting pulmonary tuberculosis and lung cancer. PATIENTS AND METHODS: About, 144 patients with pulmonary sarcoidosis as the study subjects were chosen which included: 36 patients with lung carcinoma, 36 patients with pulmonary tuberculoma, 36 patients with inflammatory pseudotumor, 36 patients with coexisting pulmonary tuberculosis and lung cancer...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28429070/properties-of-synchronous-spontaneous-ca-2-transients-in-the-mural-cells-of-rat-rectal-arterioles
#8
Retsu Mitsui, Hikaru Hashitani
Synchrony of spontaneous Ca(2+) transients among venular mural cells (smooth muscle cells and pericytes) in visceral organs relies on the intercellular spread of L-type voltage-dependent Ca(2+) channel (LVDCC)-dependent depolarisations. However, the mechanisms underlying the synchrony of spontaneous Ca(2+) transients between arteriolar mural cells are less understood. The spontaneous intracellular Ca(2+) dynamics of arteriolar mural cells in the rat rectal submucosa were visualised by Cal-520 Ca(2+) imaging to analyse their synchrony...
April 21, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28428638/dynamic-behaviors-of-condensing-clusters-based-on-rayleigh-scattering-experiment
#9
Zhong Lan, Di Wang, Kejian Cao, Quan Xue, Xuehu Ma
Condensation is a common physical process which widely exists in natural phenomena and thermal energy systems. In a condensation process, cluster is considered as the important bridge between vapor body and condensates. However, limited by the minimum imaging dimension of traditional measurements, early experimental studies about initial stages of condensation process are not sufficient. This paper provides a powerful optical platform for the study of dynamic clusters process. Based on the Rayleigh law, optical experiments were firstly introduced to investigate the clusters spatial distribution close to and far from condensation surface...
April 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28428273/assessing-prostate-cancer-aggressiveness-with-hyperpolarized-dual-agent-3d-dynamic-imaging-of-metabolism-and-perfusion
#10
Hsin-Yu Chen, Peder E Z Larson, Robert A Bok, Cornelius von Morze, Renuka Sriram, Romelyn Delos Santos, Justin Delos Santos, Jeremy W Gordon, Naeim Bahrami, Marcus Ferrone, John Kurhanewicz, Daniel B Vigneron
New magnetic resonance (MR) molecular imaging techniques offer the potential for non-invasive, simultaneous quantification of metabolic and perfusion parameters in tumors. This study applied a 3D dynamic dual-agent hyperpolarized (13)C magnetic resonance spectroscopic imaging (MRSI) approach with (13)C-pyruvate and (13)C-urea to investigate differences in perfusion and metabolism between low and high grade tumors in the TRAMP transgenic mouse model of prostate cancer. Dynamic MR data were corrected for T1 relaxation and RF excitation and modeled to provide quantitative measures of pyruvate to lactate flux (kPL) and urea perfusion (urea AUC) that correlated with TRAMP tumor histologic grade...
April 20, 2017: Cancer Research
https://www.readbyqxmd.com/read/28428254/a-novel-physiological-role-for-arf1-in-the-formation-of-bi-directional-tubules-from-the-golgi
#11
Francesca Bottanelli, Nicole Kilian, Andreas M Ernst, Felix Rivera-Molina, Lena K Schroeder, Emil B Kromann, Mark D Lessard, Roman S Erdmann, Alanna Schepartz, David Baddeley, Joerg Bewersdorf, Derek Toomre, James E Rothman
Capitalizing on CRISPR/Cas9 gene editing techniques and super-resolution nanoscopy, we have explored the role of the small GTPase ARF1 in mediating transport steps at the Golgi. Surprisingly, beside its well-established role in generating COPI vesicles, we find that ARF1 is additionally involved in the formation of long (∼ 3 μm), thin (∼ 110 nm diameter) tubular carriers. The anterograde and retrograde tubular carriers are both largely free of the classical Golgi coat proteins Coatomer (COPI) and Clathrin...
April 20, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28428190/in-vivo-detection-of-egfrviii-in-glioblastoma-via-perfusion-magnetic-resonance-imaging-signature-consistent-with-deep-peritumoral-infiltration-the-%C3%AF-index
#12
Spyridon Bakas, Hamed Akbari, Jared Pisapia, Maria Martinez-Lage, Martin Rozycki, Saima Rathore, Nadia Dahmane, Donald M O'Rourke, Christos Davatzikos
<br />The epidermal growth factor receptor variant III (EGFRvIII) mutation has been considered a driver mutation and therapeutic target in glioblastoma, the most common and aggressive brain cancer. Currently, detecting EGFRvIII requires postoperative tissue analyses, which are ex vivo and unable to capture the tumor's spatial heterogeneity. Considering the increasing evidence of in vivo imaging signatures capturing molecular characteristics of cancer, this study aims to detect EGFRvIII in primary glioblastoma non-invasively, using routine clinically-acquired imaging...
April 20, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28427715/multiplexed-dynamic-imaging-of-genomic-loci-by-combined-crispr-imaging-and-dna-sequential-fish
#13
Yodai Takei, Sheel Shah, Sho Harvey, Lei S Qi, Long Cai
Visualization of chromosome dynamics allows the investigation of spatiotemporal chromatin organization and its role in gene regulation and other cellular processes. However, current approaches to label multiple genomic loci in live cells have a fundamental limitation in the number of loci that can be labeled and uniquely identified. Here we describe an approach we call "track first and identify later" for multiplexed visualization of chromosome dynamics by combining two techniques: CRISPR imaging and DNA sequential fluorescence in situ hybridization...
April 17, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28427629/development-of-a-novel-folate-modified-nanobubbles-with-improved-targeting-ability-to-tumor-cells
#14
Sujuan Duan, Lu Guo, Dandan Shi, Mengmeng Shang, Dong Meng, Jie Li
Conjugation of folate (FOL) to nanobubbles could enhance the selective targeting to tumors expressing high levels of folate receptor (FR). To further improve the selective targeting ability of FOL-modified nanobubbles, a novel FOL-targeted nanobubble ((FOL)2-NB) with increasing FOL content (accomplished by linking two FOL molecules per DSPE-PEG2000 chain) was synthesized, through the methods of mechanical shaking and low-speed centrifugation based on lipid-stabilized perfluoropropane. The bubble size and distribution range were measured by dynamic light scattering (DLS)...
July 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28427220/multiparametric-imaging-using-18f-fdg-pet-ct-heterogeneity-parameters-and-functional-mri-techniques-prognostic-significance-in-patients-with-primary-advanced-oropharyngeal-or-hypopharyngeal-squamous-cell-carcinoma-treated-with-chemoradiotherapy
#15
Sheng-Chieh Chan, Nai-Ming Cheng, Chia-Hsun Hsieh, Shu-Hang Ng, Chien-Yu Lin, Tzu-Chen Yen, Cheng-Lung Hsu, Hung-Ming Wan, Chun-Ta Liao, Kai-Ping Chang, Jiun-Jie Wang
BACKGROUND: In this study, PET heterogeneity was combined with functional MRI techniques to refine the prediction of prognosis in patients with oropharyngeal or hypopharyngeal squamous cell carcinoma (OHSCC). METHODS: A total of 124 patients with primary advanced OHSCC who underwent pretreatment 18F-FDG PET/CT, dynamic contrast-enhanced MR imaging (DCE-MRI), and diffusion-weighted MR imaging (DWI) were enrolled. Conventional and heterogeneity parameters from 18F-FDG PET as well as perfusion parameters from DCE-MRI and diffusion parameter from DWI of primary tumors were analyzed in relation to recurrence-free survival (RFS) and overall survival (OS)...
March 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28426197/photoluminescence-segmentation-within-individual-hexagonal-monolayer-tungsten-disulfide-domains-grown-by-chemical-vapor-deposition
#16
Yuewen Sheng, Xiaochen Wang, Kazunori Fujisawa, Siqi Ying, Ana Laura Elias, Zhong Lin, Wenshuo Xu, Yingqiu Zhou, Alexander M Korsunsky, Harish Bhaskaran, Mauricio Terrones, Jamie H Warner
We show that hexagonal domains of monolayer tungsten disulfide (WS2) grown by chemical vapor deposition (CVD) with powder precursors can have discrete segmentation in their photoluminescence (PL) emission intensity, forming symmetric patterns with alternating bright and dark regions. Two-dimensional maps of the PL reveal significant reduction within the segments associated with the longest sides of the hexagonal domains. Analysis of the PL spectra shows differences in the exciton to trion ratio, indicating variations in the exciton recombination dynamics...
April 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28426133/quantitative-phase-microscopy-spatial-signatures-of-cancer-cells
#17
Darina Roitshtain, Lauren Wolbromsky, Evgeny Bal, Hayit Greenspan, Lisa L Satterwhite, Natan T Shaked
We present cytometric classification of live healthy and cancerous cells by using the spatial morphological and textural information found in the label-free quantitative phase images of the cells. We compare both healthy cells to primary tumor cells and primary tumor cells to metastatic cancer cells, where tumor biopsies and normal tissues were isolated from the same individuals. To mimic analysis of liquid biopsies by flow cytometry, the cells were imaged while unattached to the substrate. We used low-coherence off-axis interferometric phase microscopy setup, which allows a single-exposure acquisition mode, and thus is suitable for quantitative imaging of dynamic cells during flow...
April 20, 2017: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
https://www.readbyqxmd.com/read/28426071/ca-and-sr-tetrafluoroisophthalates-mechanochemical-synthesis-characterization-and-ab-initio-structure-determination
#18
Abdal-Azim Al-Terkawi, Gudrun Scholz, Ana Guilherme Buzanich, Stefan Reinsch, Franziska Emmerling, Erhard Kemnitz
New fluorinated coordination polymers were prepared mechanochemically by milling the alkaline earth metal hydroxides M(II)(OH)2·xH2O (M(II): Ca, Sr) with tetrafluoroisophthalic acid (H2mBDC-F4). The structures of [{Ca(mBDC-F4)(H2O)2}·H2O] (1) and [{Sr(mBDC-F4)(H2O)2}·H2O] (2) were determined based on ab initio calculations and their powder X-ray diffraction (PXRD) data. The compounds are isomorphous and crystallize in the orthorhombic space group P212121. The determined structures were validated by using extended X-ray absorption (EXAFS) data...
April 20, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28425758/agreement-between-mri-and-pathologic-analyses-for-determination-of-tumor-size-and-correlation-with-immunohistochemical-factors-of-invasive-breast-carcinoma
#19
Eun Young Yoo, Sang Yu Nam, Hye-Young Choi, Min Ji Hong
Background There may be discordance between tumor size determined by magnetic resonance imaging (MRI) and that observed during pathologic analyses. Purpose To evaluate MRI-pathology concordance of tumor size in patients with invasive breast carcinoma. Material and Methods Data from 307 invasive breast carcinomas were analyzed retrospectively. Preoperative breast MRI was reviewed for size, lesion type, morphology, and dynamic contrast-enhanced tumor kinetics. MRI tumor size was compared with tumor size measurements from the pathologic analysis...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28425543/in-situ-nuclear-magnetic-resonance-microimaging-of-live-biofilms-in-a-microchannel
#20
R S Renslow, M J Marshall, A E Tucker, W B Chrisler, X-Y Yu
Biofilms are comprised of microbial cells and an extracellular polymeric substance (EPS) matrix that supports interactions between community members and with the local environment. The highly hydrated EPS matrix makes the application of many biofilm visualization techniques difficult. Hence, to better visualize how biofilms interact with their environment, there is a need for imaging techniques to monitor hydrated state biofilm dynamics. We employed an in situ dynamic approach to construct label-free images of biofilms...
April 20, 2017: Analyst
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