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https://www.readbyqxmd.com/read/28749494/two-intensified-fluorescence-colors-switching-achieved-by-branched-dye-nanoaggregates
#1
Ge Ding, Yao Lu, Jihong Su, Xiaozhuan Qin, Ziping Luo, Fang Gao, Lingyun Chen, Hongru Li
In this study, a variety of branched target dyes containing double internal proton transfer segments were synthesized. For comparison, some linear analogs including a single internal proton transfer part were synthesized. The corresponding reference molecules lacking proton transfer segments were also prepared. The properties and aggregation modes of these dye aggregates were investigated on the basis of scanning electron microscopy images, transmission electron microscopy images, dynamic light scattering, X-ray diffraction, UV/visible absorption spectra and fluorescence emission spectra...
July 27, 2017: Nanoscale
https://www.readbyqxmd.com/read/28749348/fast-simulation-of-dynamic-ultrasound-images-using-the-gpu
#2
Sigurd Storve, Hans Torp
Simulated ultrasound data is a valuable tool for development and validation of quantitative image analysis methods in echocardiography. Unfortunately, simulation time can become prohibitive for phantoms consisting of a large number of point-scatterers. The COLE algorithm by Gao et al. is a fast convolution-based simulator that trades simulation accuracy for improved speed. We present highly efficient parallelized CPU- and GPU-implementations of the COLE algorithm with an emphasis on dynamic simulations involving moving pointscatterers...
July 25, 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28749338/fast-two-photon-imaging-of-subcellular-voltage-dynamics-in-neuronal-tissue-with-genetically-encoded-indicators
#3
Simon Chamberland, Helen H Yang, Michael M Pan, Stephen W Evans, Sihui Guan, Mariya Chavarha, Ying Yang, Charleen Salesse, Haodi Wu, Joseph C Wu, Thomas R Clandinin, Katalin Toth, Michael Z Lin, François St-Pierre
Monitoring voltage dynamics in defined neurons deep in the brain is critical for unraveling the function of neuronal circuits, but is challenging due to the limited performance of existing tools. In particular, while genetically encoded voltage indicators have shown promise for optical detection of voltage transients, many indicators exhibit low sensitivity when imaged under two-photon illumination. Previous studies thus fell short of visualizing voltage dynamics in individual neurons in single trials. Here, we report ASAP2s, a novel voltage indicator with improved sensitivity...
July 27, 2017: ELife
https://www.readbyqxmd.com/read/28747874/the-functioning-of-a-cortex-without-layers
#4
REVIEW
Julien Guy, Jochen F Staiger
A major hallmark of cortical organization is the existence of a variable number of layers, i.e., sheets of neurons stacked on top of each other, in which neurons have certain commonalities. However, even for the neocortex, variable numbers of layers have been described and it is just a convention to distinguish six layers from each other. Whether cortical layers are a structural epiphenomenon caused by developmental dynamics or represent a functionally important modularization of cortical computation is still unknown...
2017: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/28747782/hybrid-high-order-functional-connectivity-networks-using-resting-state-functional-mri-for-mild-cognitive-impairment-diagnosis
#5
Yu Zhang, Han Zhang, Xiaobo Chen, Seong-Whan Lee, Dinggang Shen
Conventional functional connectivity (FC), referred to as low-order FC, estimates temporal correlation of the resting-state functional magnetic resonance imaging (rs-fMRI) time series between any pair of brain regions, simply ignoring the potentially high-level relationship among these brain regions. A high-order FC based on "correlation's correlation" has emerged as a new approach for abnormality detection of brain disease. However, separate construction of the low- and high-order FC networks overlooks information exchange between the two FC levels...
July 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28747177/acute-coronary-syndrome-and-acute-kidney-injury-role-of-inflammation-in-worsening-renal-function
#6
Jorge Ortega-Hernández, Rashidi Springall, Fausto Sánchez-Muñoz, Julio-C Arana-Martinez, Héctor González-Pacheco, Rafael Bojalil
BACKGROUND: Acute Kidney Injury (AKI), a common complication of acute coronary syndromes (ACS), is associated with higher mortality and longer hospital stays. The role of cytokines and other mediators is unknown in AKI induced by an ACS (ACS-AKI), leading to several unanswered questions. The worsening of renal function is usually seen as a dichotomous phenomenon instead of a dynamic change, so evaluating changes of the renal function in time may provide valuable information in the ACS-AKI setting...
July 26, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28746933/androgen-regulates-dimorphic-f-actin-assemblies-in-the-genital-organogenesis
#7
Liqing Liu, Kentaro Suzuki, Eunice Chun, Aki Murashima, Yuki Sato, Naomi Nakagata, Toshihiko Fujimori, Shigenobu Yonemura, Wanzhong He, Gen Yamada
Impaired androgen activity induces defective sexual differentiation of the male reproductive tract, including hypospadias, an abnormal formation of the penile urethra. Androgen signaling in the urethral mesenchyme cells (UMCs) plays essential roles in driving dimorphic urethral development. However, cellular events for sexual differentiation remain virtually unknown. In this study, histological analyses, fluorescent staining, and transmission electron microscopy (TEM) were performed to reveal the cellular dimorphisms of UMCs...
July 27, 2017: Sexual Development: Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation
https://www.readbyqxmd.com/read/28746807/sharpened-vo2-phase-transition-via-controlled-release-of-epitaxial-strain
#8
Daesu Lee, Jaeseong Lee, Kyung Song, Fei Xue, Si-Young Choi, Yanjun Ma, Jacob Podkaminer, Dong Liu, Shih-Chia Liu, Bongwook Chung, Wenjuan Fan, Weidong Zhou, Jaichan Lee, Longqing Chen, Sang Ho Oh, Zhenqiang Ma, Chang-Beom Eom
Phase transitions in correlated materials can be manipulated at the nanoscale to yield emergent functional properties, promising new paradigms for nanoelectronics and nanophotonics. Vanadium dioxide (VO2), an archetypal correlated material, exhibits a metal‒insulator transition (MIT) above room temperature. At the thicknesses required for heterostructure applications, such as an optical modulator discussed here, the strain state of VO2 largely determines the MIT dynamics critical to the device performance...
July 26, 2017: Nano Letters
https://www.readbyqxmd.com/read/28746386/tracmit-an-effective-pipeline-for-tracking-and-analyzing-cells-on-micropatterns-through-mitosis
#9
Olivier Burri, Benita Wolf, Arne Seitz, Pierre Gönczy
The use of micropatterns has transformed investigations of dynamic biological processes by enabling the reproducible analysis of live cells using time-lapse fluorescence microscopy. With micropatterns, thousands of individual cells can be efficiently imaged in parallel, rendering the approach well suited for screening projects. Despite being powerful, such screens remain challenging in terms of data handling and analysis. Typically, only a fraction of micropatterns is occupied in a manner suitable to monitor a given phenotypic output...
2017: PloS One
https://www.readbyqxmd.com/read/28745804/postprostatectomy-incontinence-is-related-to-pelvic-floor-displacements-observed-with-trans-perineal-ultrasound-imaging
#10
Ryan E Stafford, Wolbert van den Hoorn, Geoff Coughlin, Paul W Hodges
AIMS: To investigate the relationship between post-prostatectomy incontinence and dynamic features of activation of specific pelvic floor muscles in addition to anatomical parameters of the urethra. METHODS: Forty-two men aged 66 (7) years (incontinent [N = 19] and continent [N = 23]) who had undergone prostatectomy participated. Transperineal ultrasound imaging was used to record sagittal images of pelvic structures during involuntary coughing and sustained maximal voluntary contractions...
July 26, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28745766/ac-electric-field-controlled-non-newtonian-filament-thinning-and-droplet-formation-on-the-microscale
#11
Y Huang, Y L Wang, T N Wong
Monodispersity and fast generation are innate advantages of microfluidic droplets. Other than the normally adopted simple Newtonian fluids such as a water/oil emulsion system, fluids with complex rheology, namely, non-Newtonian fluids, which are being widely adopted in industries and bioengineering, have gained increasing research interest on the microscale. However, challenges occur in controlling the dynamic behavior due to their complex properties. In this sense, the AC electric field with merits of fast response and easiness in fulfilling "Lab on a chip" has attracted our attention...
July 26, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28745622/a-graphical-user-interface-for-software-assisted-tracking-of-protein-concentration-in-dynamic-cellular-protrusions
#12
Tanumoy Saha, Isabel Rathmann, Milos Galic
Filopodia are dynamic, finger-like cellular protrusions associated with migration and cell-cell communication. In order to better understand the complex signaling mechanisms underlying filopodial initiation, elongation and subsequent stabilization or retraction, it is crucial to determine the spatio-temporal protein activity in these dynamic structures. To analyze protein function in filopodia, we recently developed a semi-automated tracking algorithm that adapts to filopodial shape-changes, thus allowing parallel analysis of protrusion dynamics and relative protein concentration along the whole filopodial length...
July 11, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28745402/fat-based-registration-of-breast-dynamic-contrast-enhanced-water-images
#13
Subashini Srinivasan, Brian A Hargreaves, Bruce L Daniel
PURPOSE: In this study, a 3D fat-based deformable registration algorithm was developed for registering dynamic contrast-enhanced breast images. METHODS: The mutual information similarity measure with free-form deformation motion correction in rapidly enhancing lesions can introduce motion. However, in Dixon-based fat-water separated acquisitions, the nonenhancing fat signal can directly be used to estimate deformable motion, which can be later used to deform the water images...
July 26, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28744840/organ-dynamics-and-fluid-dynamics-of-the-hh25-chick-embryonic-cardiac-ventricle-as-revealed-by-a-novel-4d-high-frequency-ultrasound-imaging-technique-and-computational-flow-simulations
#14
Sheldon Ho, Germaine Xin Yi Tan, Toon Jin Foo, Nhan Phan-Thien, Choon Hwai Yap
Past literature has provided evidence that a normal mechanical force environment of blood flow may guide normal development while an abnormal environment can lead to congenital malformations, thus warranting further studies on embryonic cardiovascular flow dynamics. In the current study, we developed a non-invasive 4D high-frequency ultrasound technique, and use it to analyze cardiovascular organ dynamics and flow dynamics. Three chick embryos at stage HH25 were scanned with high frequency ultrasound in cine-B-mode at multiple planes spaced at 0...
July 25, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28744784/modeling-left-ventricular-blood-flow-using-smoothed-particle-hydrodynamics
#15
Andrés Caballero, Wenbin Mao, Liang Liang, John Oshinski, Charles Primiano, Raymond McKay, Susheel Kodali, Wei Sun
This study aims to investigate the capability of smoothed particle hydrodynamics (SPH), a fully Lagrangian mesh-free method, to simulate the bulk blood flow dynamics in two realistic left ventricular (LV) models. Three dimensional geometries and motion of the LV, proximal left atrium and aortic root are extracted from cardiac magnetic resonance imaging and multi-slice computed tomography imaging data. SPH simulation results are analyzed and compared with those obtained using a traditional finite volume-based numerical method, and to in vivo phase contrast magnetic resonance imaging and echocardiography data, in terms of the large-scale blood flow phenomena usually clinically measured...
July 25, 2017: Cardiovascular Engineering and Technology
https://www.readbyqxmd.com/read/28742827/the-relationship-between-coronary-artery-distensibility-and-fractional-flow-reserve
#16
Andy S C Yong, Ashkan Javadzadegan, William F Fearon, Abouzar Moshfegh, Jerrett K Lau, Stephen Nicholls, Martin K C Ng, Leonard Kritharides
Discordance between angiography-based anatomical assessment of coronary stenosis severity and fractional flow reserve (FFR) has been attributed to several factors including lesion length and irregularity, and the myocardial territory supplied by the target vessel. We sought to examine if coronary arterial distensibility is an independent contributor to this discordance. There were two parts to this study. The first consisted of "in silico" models of 26 human coronary arteries. Computational fluid dynamics-derived FFR was calculated for fully rigid, partially distensible and fully distensible models of the 26 arteries...
2017: PloS One
https://www.readbyqxmd.com/read/28742153/reconstructing-the-regulatory-circuit-of-cell-fate-determination-in-yeast-mating-response
#17
Bin Shao, Haiyu Yuan, Rongfei Zhang, Xuan Wang, Shuwen Zhang, Qi Ouyang, Nan Hao, Chunxiong Luo
Massive technological advances enabled high-throughput measurements of proteomic changes in biological processes. However, retrieving biological insights from large-scale protein dynamics data remains a challenging task. Here we used the mating differentiation in yeast Saccharomyces cerevisiae as a model and developed integrated experimental and computational approaches to analyze the proteomic dynamics during the process of cell fate determination. When exposed to a high dose of mating pheromone, the yeast cell undergoes growth arrest and forms a shmoo-like morphology; however, at intermediate doses, chemotropic elongated growth is initialized...
July 24, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28742039/reconstructing-interlaced-high-dynamic-range-video-using-joint-learning
#18
Inchang Choi, Seung-Hwan Baek, Min H Kim
For extending the dynamic range of video, it is a common practice to capture multiple frames sequentially with different exposures and combine them to extend the dynamic range of each video frame. However, this approach results in typical ghosting artifacts due to fast and complex motion in nature. As an alternative, video imaging with interlaced exposures has been introduced to extend the dynamic range. However, the interlaced approach has been hindered by jaggy artifacts and sensor noise, leading to concerns over image quality...
July 24, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28742031/patient-specific-left-ventricular-flow-simulations-from-transthoracic-echocardiography-robustness-evaluation-and-validation-against-ultrasound-doppler-and-magnetic-resonance-imaging
#19
David Larsson, Jeannette H Spuhler, Sven Petersson, Tim Nordenfur, Massimiliano Colarieti-Tosti, Johan Hoffman, Reidar Winter, Matilda Larsson
The combination of medical imaging with computational fluid dynamics (CFD) has enabled the study of 3D blood flow on a patient-specific level. However, with models based on gated high-resolution data, the study of transient flows, and any model implementation into routine cardiac care, is challenging. The present paper presents a novel pathway for patient-specific CFD modelling of the left ventricle (LV), using 4D transthoracic echocardiography (TTE) as input modality. To evaluate the clinical usability, two sub-studies were performed...
July 21, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28741941/efficient-delivery-of-quantum-dots-into-the-cytosol-of-cells-using-cell-penetrating-poly-disulfide-s
#20
Emmanuel Derivery, Eline Bartolami, Stefan Matile, Marcos Gonzalez-Gaitan
Quantum dots (QDs) are extremely bright, photostable, nanometer particles broadly used to investigate single molecule dynamics in vitro. However, the use of QDs in vivo to investigate single molecule dynamics is impaired by the absence of an efficient way to chemically deliver them into the cytosol of cells. Indeed, current methods (using cell-penetrating peptides for instance) provide very low yields: QDs stay at the plasma membrane or are trapped in endosomes. Here, we introduce a technology based on cell-penetrating poly(disulfide)s that solves this problem: we deliver about 70 QDs per cell, and 90% appear to freely diffuse in the cytosol...
July 25, 2017: Journal of the American Chemical Society
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