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Post chemotherapy cognitive deficit

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https://www.readbyqxmd.com/read/27907849/association-between-dehydroepiandrosterone-sulfate-and-attention-in-long-term-survivors-of-childhood-acute-lymphoblastic-leukemia-treated-with-only-chemotherapy
#1
Yin Ting Cheung, Wassim Chemaitilly, Daniel A Mulrooney, Tara M Brinkman, Wei Liu, Pia Banerjee, Deokumar Srivastava, Ching-Hon Pui, Leslie L Robison, Melissa M Hudson, Kevin R Krull
Long-term survivors of childhood acute lymphoblastic leukemia (ALL) are at risk for neurocognitive impairment, as well as compromised hypothalamic-pituitary-adrenal (HPA) function. Dehydroepiandrosterone-sulfate (DHEAS) is an adrenal androgen commonly used as a marker of HPA function. In the general population, a low level of DHEAS has been associated with poorer cognition. At ≥2years post-treatment, we examined the association of DHEAS with attention outcomes in 35 male and 34 female long-term survivors of childhood ALL (mean[standard deviation] age at evaluation 14...
November 16, 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27478140/long-lasting-impairments-in-adult-neurogenesis-spatial-learning-and-memory-from-a-standard-chemotherapy-regimen-used-to-treat-breast-cancer
#2
Catarina Rendeiro, Andrew Sheriff, Tushar K Bhattacharya, Joseph V Gogola, Jeffrey H Baxter, Hong Chen, William G Helferich, Edward J Roy, Justin S Rhodes
The negative impact of chemotherapy on cognitive function in cancer patients has gained increasing attention in the last decade. Whilst the short-term acute effects on cognition are expected following chemotherapy, the persistence of such impairments in the long-term is still in question. This is despite clinical evidence indicating cognitive difficulties may persist well beyond treatment and affect quality of life. In the present study, we assessed the long-term (3 months) cognitive impact of chemotherapy in a mouse model intended to mimic the human female post-menopausal population receiving chemotherapy for breast cancer...
December 15, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27463220/a-meta-analysis-of-the-neuropsychological-effects-of-chemotherapy-in-the-treatment-of-childhood-cancer
#3
Cory Pierson, Erin Waite, Ben Pyykkonen
BACKGROUND: Long-term neuropsychological deficits associated with pediatric cancers and the related treatments have been consistently reported. Whole brain cranial radiation therapy (CRT) is associated with neurocognitive impairment. As a result, physicians are reticent to use CRT in favor of systemic or intrathecal chemotherapy, which have a less clear impact on cognition. PROCEDURE: The current meta-analysis examined post-treatment neuropsychological performance of children diagnosed with cancer and treated with chemotherapy to better understand the impact of chemotherapy upon cognition...
November 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27264632/late-effects-after-umbilical-cord-blood-transplantation-in-very-young-children-after-busulfan-based-myeloablative-conditioning
#4
Heather Allewelt, Jill El-Khorazaty, Adam Mendizabal, Mahsa Taskindoust, Paul L Martin, Vinod Prasad, Kristin Page, Jean Sanders, Joanne Kurtzberg
Infants and young children who undergo allogeneic cord blood transplantation (CBT) are at increased risk for late effects because of exposure of developing organs to chemotherapy and radiation therapy typically used in transplant conditioning regimens. Busulfan (Bu)-based myeloablative regimens were developed to eliminate radiation exposure in these young children with the hope that late effects would be minimized. We now describe the late effects in 102 consecutive patients surviving a minimum of 5 years (median follow-up, 12...
September 2016: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/27054041/feasibility-and-acceptability-of-a-remotely-administered-computerized-intervention-to-address-cognitive-late-effects-among-childhood-cancer-survivors
#5
Lauren E Cox, Jason M Ashford, Kellie N Clark, Karen Martin-Elbahesh, Kristina K Hardy, Thomas E Merchant, Robert J Ogg, Sima Jeha, Victoria W Willard, Lu Huang, Hui Zhang, Heather M Conklin
BACKGROUND: Childhood cancer survivors frequently develop working memory (WM) deficits as a result of disease and treatment. Medication-based and therapist-delivered interventions are promising but have limitations. Computerized interventions completed at home may be more appealing for survivors. We evaluated the feasibility and acceptability of a remotely administered, computerized WM intervention (Cogmed) for pediatric cancer survivors using a single-blind, randomized, wait-list control design...
June 2015: Neuro-oncology Practice
https://www.readbyqxmd.com/read/27044316/neurocognitive-deficits-and-neurocognitive-rehabilitation-in-adult-brain-tumors
#6
REVIEW
Julia Day, David C Gillespie, Alasdair G Rooney, Helen J Bulbeck, Karolis Zienius, Florien Boele, Robin Grant
Neurocognitive deficits are common with brain tumors. If assessed at presentation using detailed neurocognitive tests, problems are detected in 80 % of cases. Neurocognition may be affected by the tumor, its treatment, associated medication, mood, fatigue, and insomnia. Interpretation of neurocognitive problems should be considered in the context of these factors. Early post-operative neurocognitive rehabilitation for brain tumor patients will produce rehabilitation outcomes (e.g., quality of life, improved physical function, subjective neurocognition) equivalent to stroke, multiple sclerosis, and head injury, but the effect size and duration of benefit needs further research...
May 2016: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/26853338/dose-dependent-cortical-thinning-after-partial-brain-irradiation-in-high-grade-glioma
#7
Roshan Karunamuni, Hauke Bartsch, Nathan S White, Vitali Moiseenko, Ruben Carmona, Deborah C Marshall, Tyler M Seibert, Carrie R McDonald, Nikdokht Farid, Anithapriya Krishnan, Joshua Kuperman, Loren Mell, James B Brewer, Anders M Dale, Jona A Hattangadi-Gluth
PURPOSE: Radiation-induced cognitive deficits may be mediated by tissue damage to cortical regions. Volumetric changes in cortex can be reliably measured using high-resolution magnetic resonance imaging (MRI). We used these methods to study the association between radiation therapy (RT) dose and change in cortical thickness in high-grade glioma (HGG) patients. METHODS AND MATERIALS: We performed a voxel-wise analysis of MRI from 15 HGG patients who underwent fractionated partial brain RT...
February 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/26809289/cognitive-dysfunction-and-symptom-burden-in-women-treated-for-breast-cancer-a-prospective-behavioral-and-fmri-analysis
#8
Mi Sook Jung, Min Zhang, Mary K Askren, Marc G Berman, Scott Peltier, Daniel F Hayes, Barbara Therrien, Patricia A Reuter-Lorenz, Bernadine Cimprich
Neural dysfunction and cognitive complaints are associated with chemotherapy for breast cancer although trajectory and contributory factors remain unclear. We prospectively examined neurocognition using fMRI and self-reported cognitive, physical and psychological symptoms in women treated with adjuvant chemotherapy over one year. Patients treated with (n = 28) or without (n = 34) chemotherapy for localized breast cancer and healthy controls (n = 30) performed a Verbal Working Memory Task (VWMT) during fMRI and provided self-reports at baseline (pre-adjuvant treatment), five- (M5) and 12-months (M12)...
January 25, 2016: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/26612628/examining-the-effects-of-adjuvant-chemotherapy-on-cognition-and-the-impact-of-any-cognitive-impairment-on-quality-of-life-in-colorectal-cancer-patients-study-protocol
#9
Marie-Rose Dwek, Lorna Rixon, Alice Simon, Catherine Hurt, Stanton Newman
BACKGROUND: Research suggests that chemotherapy can cause deficits in both patients' objectively measured and self-reported cognitive abilities which can in turn affect their quality of life (QoL). The majority of research studies have used post-treatment retrospective designs or have not included a control group in prospective cohorts. This has limited the conclusions that can be drawn from the results. There have also been a disproportionate number of studies focussed on women with breast cancer, which has limited the generalisability of the results to other cancer populations...
2015: BMC Psychology
https://www.readbyqxmd.com/read/25868929/sustained-attention-abnormalities-in-breast-cancer-survivors-with-cognitive-deficits-post-chemotherapy-an-electrophysiological-study
#10
J W Y Kam, C A Brenner, T C Handy, L A Boyd, T Liu-Ambrose, H J Lim, S Hayden, K L Campbell
OBJECTIVE: Many breast cancer survivors (BCS) report cognitive problems following chemotherapy, yet controversy remains concerning which cognitive domains are affected. This study investigated a domain crucial to daily function: the ability to maintain attention over time. METHODS: We examined whether BCS who self-reported cognitive problems up to 3 years following cancer treatment (n=19) performed differently from healthy controls (HC, n=12) in a task that required sustained attention...
January 2016: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/24789331/longitudinal-assessment-of-cognitive-changes-associated-with-adjuvant-treatment-for-breast-cancer-the-impact-of-apoe-and-smoking
#11
Tim A Ahles, Yuelin Li, Brenna C McDonald, Gary N Schwartz, Peter A Kaufman, Gregory J Tsongalis, Jason H Moore, Andrew J Saykin
PURPOSE: This study examined the association of post-treatment changes in cognitive performance, apolipoprotein E (APOE), and smoking in breast cancer patients treated with adjuvant therapy. PARTICIPANTS AND METHODS: Breast cancer patients treated with chemotherapy (N = 55, age = 51.9 ± 7.1, education = 15.7 ± 2.6) were evaluated with a battery of neuropsychological tests prior to chemotherapy and at 1, 6, and 18 months post-chemotherapy. Matched groups of breast cancer patients not exposed to chemotherapy (N = 68, age = 56...
December 2014: Psycho-oncology
https://www.readbyqxmd.com/read/24727743/cognitive-control-in-opioid-dependence-and-methadone-maintenance-treatment
#12
Ding-Lieh Liao, Cheng-Yi Huang, Sien Hu, Su-Chen Fang, Chi-Shin Wu, Wei-Ti Chen, Tony Szu-Hsien Lee, Pau-Chung Chen, Chiang-Shan R Li
BACKGROUND: Substance misuse is associated with cognitive dysfunction. We used a stop signal task to examine deficits in cognitive control in individuals with opioid dependence (OD). We examined how response inhibition and post-error slowing are compromised and whether methadone maintenance treatment (MMT), abstinence duration, and psychiatric comorbidity are related to these measures in individuals with OD. METHODS: Two-hundred-and-sixty-four men with OD who were incarcerated at a detention center and abstinent for up to 2 months (n = 108) or at a correctional facility and abstinent for approximately 6 months (n = 156), 65 OD men under MMT at a psychiatric clinic, and 64 age and education matched healthy control (HC) participants were assessed...
2014: PloS One
https://www.readbyqxmd.com/read/24173681/long-term-evaluation-of-cognition-after-glioma-surgery-in-eloquent-areas
#13
Djaina Satoer, Evy Visch-Brink, Marion Smits, Alfred Kloet, Caspar Looman, Clemens Dirven, Arnaud Vincent
Preservation of cognition is an important outcome measure in eloquent area glioma surgery. Glioma patients may have pre-operative deficits in one or more cognitive domains which could deteriorate post-operatively. It is assumed that these impairments recover within 3 months; some studies however, still detected cognitive decline. Longer follow-up is necessary to elucidate the conclusive effects of surgery. 45 patients with gliomas (low- and high-grade, but without contrast enhancement at diagnosis) in eloquent areas were assessed pre-operatively, 3 months and 1 year post-operatively with a neuropsychological test-protocol...
January 2014: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/24105672/acute-cognitive-impairment-in-patients-with-multiple-myeloma-undergoing-autologous-hematopoietic-stem-cell-transplant
#14
Desiree Jones, Elisabeth G Vichaya, Xin Shelley Wang, Mary H Sailors, Charles S Cleeland, Jeffrey S Wefel
BACKGROUND: Few studies have examined the acute effects of autologous hematopoietic stem cell transplantation (Au-HSCT) on the neuropsychological functioning of patients with multiple myeloma (MM). The prevalence of cognitive deficits after induction chemotherapy (pre-AuHSCT) was examined in patients with MM, clinically significant changes in cognitive function 1 and 3 months post-AuHSCT were determined, and patients who may be vulnerable to cognitive decline during this period were identified...
December 1, 2013: Cancer
https://www.readbyqxmd.com/read/24039108/cognitive-function-in-children-with-brain-tumors-in-the-first-year-after-diagnosis-compared-to-healthy-matched-controls
#15
COMPARATIVE STUDY
Robert I Shortman, Stephen P Lowis, Anthony Penn, Renee J McCarter, Linda P Hunt, Caroline C Brown, Michael C G Stevens, Andrew L Curran, Peta M Sharples
BACKGROUND: Improved survival of children with brain tumors (BTs) has increased focus on ameliorating morbidity. To reduce the risk of progressive cognitive decline, remedial strategies need to be instituted early, based upon accurate appraisal of need, yet few studies have investigated cognition in BT children early post-diagnosis. The study aims were to investigate cognition in children with primary BTs 1, 6, and 12 months post-diagnosis compared with healthy children, exploring the impact of disease and treatment variables...
March 2014: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/23852814/chemotherapy-altered-brain-functional-connectivity-in-women-with-breast-cancer-a-pilot-study
#16
Julie A Dumas, Jenna Makarewicz, Geoffrey J Schaubhut, Robert Devins, Kimberly Albert, Kim Dittus, Paul A Newhouse
Adjuvant chemotherapy is associated with improvements in long-term cancer survival. However, reports of cognitive impairment following treatment emphasize the importance of understanding the long-term effects of chemotherapy on brain functioning. Cognitive deficits found in chemotherapy patients suggest a change in brain functioning that affects specific cognitive domains such as attentional processing and executive functioning. This study examined the processes potentially underlying these changes in cognition by examining brain functional connectivity pre- and post-chemotherapy in women with breast cancer...
December 2013: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/23768778/late-effects-of-adjuvant-chemotherapy-for-adult-onset-non-cns-cancer-cognitive-impairment-brain-structure-and-risk-of-dementia
#17
REVIEW
Vincent Koppelmans, Monique M B Breteler, Willem Boogerd, Caroline Seynaeve, Sanne B Schagen
Few studies have investigated the late (i.e. ≥ 5 years post-treatment) effects of chemotherapy for non-central nervous system (non-CNS) cancer on the brain. Here we discuss the studies that have investigated the late effects of adjuvant chemotherapy for non-CNS cancer on cognitive function (n=6); brain structure and function (n=5); and incidence of dementia (n=4). The neuropsychological studies showed long-term adverse cognitive problems in chemotherapy-exposed breast cancer survivors. This is in line with results from neuroimaging studies that report long-term brain structural alterations after chemotherapy...
October 2013: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/23657969/tibetan-sound-meditation-for-cognitive-dysfunction-results-of-a-randomized-controlled-pilot-trial
#18
RANDOMIZED CONTROLLED TRIAL
K Milbury, A Chaoul, K Biegler, T Wangyal, A Spelman, C A Meyers, B Arun, J L Palmer, J Taylor, L Cohen
OBJECTIVE: Although chemotherapy-induced cognitive impairment is common among breast cancer patients, evidence for effective interventions addressing cognitive deficits is limited. This randomized controlled trial examined the feasibility and preliminary efficacy of a Tibetan Sound Meditation (TSM) program to improve cognitive function and quality of life in breast cancer patients. METHODS: Forty-seven breast cancer patients (mean age 56.3 years), who were staged I-III at diagnosis, 6-60 months post-chemotherapy, and reported cognitive impairment at study entry were recruited...
October 2013: Psycho-oncology
https://www.readbyqxmd.com/read/23549020/leptomeningeal-metastasis-from-prostate-cancer
#19
Domenico Cante, Pierfrancesco Franco, Piera Sciacero, Giuseppe Girelli, Valeria Casanova Borca, Massimo Pasquino, Fernanda Migliaccio, Santi Tofani, Lucia Grassi, Annamaria Marra, Franca Ozzello, Maria Rosa La Porta, Umberto Ricardi
AIMS AND BACKGROUND: Metastatic prostate carcinoma commonly involves bones and extrapelvic lymph nodes, with occasional visceral deposits. Central nervous system involvement is unusual and particularly the occurrence of leptomeningeal metastasis (LM) is extremely rare, with few cases described in the medical literature. The clinical presentation is characterized by multifocal neurological deficit and the prognosis is generally dismal, with survival ranging between 3 and 6 months. We report on a patient affected by LM due to prostate cancer who was treated with a combined-modality approach consisting of sequential chemotherapy and radiotherapy...
January 2013: Tumori
https://www.readbyqxmd.com/read/23536015/elevated-prefrontal-myo-inositol-and-choline-following-breast-cancer-chemotherapy
#20
Shelli R Kesler, Christa Watson, Della Koovakkattu, Clement Lee, Ruth O'Hara, Misty L Mahaffey, Jeffrey S Wefel
Breast cancer survivors are at increased risk for cognitive dysfunction, which reduces quality of life. Neuroimaging studies provide critical insights regarding the mechanisms underlying these cognitive deficits as well as potential biologic targets for interventions. We measured several metabolite concentrations using (1)H magnetic resonance spectroscopy as well as cognitive performance in 19 female breast cancer survivors and 17 age-matched female controls. Women with breast cancer were all treated with chemotherapy...
December 2013: Brain Imaging and Behavior
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