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ADT and cognition deficit

J Yang, F Zhong, J Qiu, H Cheng, K Wang
The primary purpose of this study was to evaluate the event-based prospective memory (EBPM) and time-based prospective memory (TBPM) in androgen-deprivation therapy (ADT)-induced cognitive impairment in patients with prostate cancer (PC). Participants included PC patients who had undergone ADT (ADT group, n = 43) or patients who did not undergo ADT (non-ADT group, n = 35), as well as age and education-matched healthy controls (HC group, n = 40). All participants were administered with a battery of neuropsychological tests including EBPM and TBPM tasks...
March 2015: European Journal of Cancer Care
Heather L McGinty, Kristin M Phillips, Heather S L Jim, Julie M Cessna, Yasmin Asvat, Mallory G Cases, Brent J Small, Paul B Jacobsen
PURPOSE: Prior research examining the impact of androgen deprivation therapy (ADT) for prostate cancer on cognitive performance has found inconsistent relationships. The purpose of this study was to systematically review the existing literature and determine the effect of ADT on performance across seven cognitive domains using meta-analysis. METHODS: A search of PubMed Medline, PsycINFO, Cochrane Library, and Web of Knowledge/Science databases yielded 157 unique abstracts reviewed by independent pairs of raters...
August 2014: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Kathryn Bylow, William Dale, Karen Mustian, Walter M Stadler, Miriam Rodin, William Hall, Mark Lachs, Supriya G Mohile
OBJECTIVES: Men experience a decrease in lean muscle mass and strength during the first year of androgen deprivation therapy (ADT). The prevalence of falls and physical and functional impairment in this population have not been well described. METHODS: A total of 50 men aged 70 years and older (median 78) receiving ADT for systemic prostate cancer (80% biochemical recurrence) underwent functional and physical assessments. The functional assessments included Katz's Activities of Daily Living (ADLs) and Lawton's Instrumental Activities of Daily Living (IADLs)...
August 2008: Urology
Roberto Gallassi, Rita Di Sarro, Angela Morreale, Mario Amore
BACKGROUND: Cognitive deficits have been described in patients with major depression (MD), although many aspects remain unsettled. METHOD: During an episode of MD and after remission we used tasks exploring attention, implicit, anterograde and retrograde memory to investigate 48 drug-free patients aged over 50 years without dementia, comparing them with 15 normal volunteer controls (NC). We also evaluated the effect of antidepressant therapy (ADT) with fluoxetine (F) or reboxetine (R) at baseline (T0) and six months later (T6)...
April 2006: Journal of Affective Disorders
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