Adeola Oluwatosin Adedara, Getúlio Nicola Bressan, Matheus Mulling Dos Santos, Roselei Fachinetto, Amos Olalekan Abolaji, Nilda Vargas Barbosa
The study investigated the protective effects of Hesperetin (HSP) and Hesperidin (HSD) on 1 methyl, 4 phenyl, 1,2,3,6 tetrahydropyridine hydrochloride (MPTP)-induced Parkinsonism in Drosophila melanogaster (D. melanogaster). After a lifespan curve to choose exposure time and concentrations, flies were co-exposed to MPTP (0.4mg/g diet), Hesperetin (0.2 and 0.4mg/g diet), and Hesperidin (0.1 and 0.4mg/g) for 7 days. In addition to in vivo parameters, we assayed some markers of oxidative stress (lipid peroxidation, protein carbonylation, thiol content, hydrogen peroxide, and nitrate/nitrite levels, mRNA expression of Keap-1 (Kelch-like ECH associated protein 1)/Nrf2 (Nuclear factor erythroid 2 related factor 2), catalase (CAT), glutathione-S-transferase (GST) activities), and cholinergic (acetyl cholinesterase activity (AchE) and dopaminergic signaling (content and the mRNA expression of tyrosine hydroxylase (TH), monoamine oxidase (MAO) activity)...
February 27, 2024: Neurotoxicology