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https://www.readbyqxmd.com/read/28889277/neurodegeneration-induced-by-metals-in-caenorhabditis-elegans
#1
Felix Antunes Soares, Daiandra Almeida Fagundez, Daiana Silva Avila
Metals are a component of a variety of ecosystems and organisms. They can generally be divided into essential and nonessential metals. The essential metals are involved in physiological processes once the deficiency of these metals has been associated with diseases. Although iron, manganese, copper, and zinc are important for life, it has been evidenced that they are also involved in neuronal damage in many neurodegenerative disorders. Nonessential metals, which are metals without physiological functions, are present in trace or higher levels in living organisms...
2017: Advances in Neurobiology
https://www.readbyqxmd.com/read/28889273/neurotoxicity-of-vanadium
#2
Hilary Afeseh Ngwa, Muhammet Ay, Huajun Jin, Vellareddy Anantharam, Arthi Kanthasamy, Anumantha G Kanthasamy
Vanadium (V) is a transition metal that presents in multiple oxidation states and numerous inorganic compounds and is also an ultra-trace element considered to be essential for most living organisms. Despite being one of the lightest metals, V offers high structural strength and good corrosion resistance and thus has been widely adopted for high-strength steel manufacturing. High doses of V exposure are toxic, and inhalation exposure to V adversely affects the respiratory system. The neurotoxicological properties of V are just beginning to be identified...
2017: Advances in Neurobiology
https://www.readbyqxmd.com/read/28889272/methylmercury-induced-neurotoxicity-focus-on-pro-oxidative-events-and-related-consequences
#3
Marcelo Farina, Michael Aschner
Methylmercury (MeHg) is a highly neurotoxic environmental pollutant. Even though molecular mechanisms mediating MeHg toxicity are not completely understood, several lines of evidence indicate that the neurotoxic effects resultant from MeHg exposure represent a consequence of its pro-oxidative properties. In this regard, MeHg is a soft electrophile that preferentially interacts with (and oxidize) nucleophilic groups (mainly thiols and selenols) from biomolecules, including proteins and low-molecular-weight molecules...
2017: Advances in Neurobiology
https://www.readbyqxmd.com/read/28846969/effects-of-maternal-exposure-to-bisphenol-af-on-emotional-behaviors-in-adolescent-mice-offspring
#4
Miao Gong, Ziqing Huai, Han Song, Lingyu Cui, Qingjun Guo, Juan Shao, Yuan Gao, Haishui Shi
Exposure to bisphenol A (BPA), one kind of environmental endocrine disruptors (EEDs), exerted significantly detrimental effects on neuro-endocrinological system and related disorders, such as memory dysfunction and depression. Bisphenol AF (BPAF),a newly introduced chemical structurally related to BPA, is used extensively. BPAF has stronger estrogenic activities than BPA. However, the potential neurotoxicological effects of BPAF are still elusive. The present study aimed to investigate the potential effects of maternal BPAF exposure during pregnancy on emotional behaviors of adolescent mice offspring...
August 25, 2017: Chemosphere
https://www.readbyqxmd.com/read/28801915/manganese-and-1-methyl-4-phenylpyridinium-mpp-induced-neurotoxicity-indicate-differences-in-morphological-electrophysiological-and-genome-wide-alterations-implications-for-idiopathic-parkinson-s-disease
#5
Rajeswara Babu Mythri, Narayana Reddy Raghunath, Santosh Chandrakant Narwade, Mirazkar DasharathaRao Pandareesh, Kollarkandi Rajesh Sabitha, Mohamad Aiyaz, Bipin Chand, Manas Sule, Krittika Ghosh, Senthil Kumar, Bhagyalakshmi Shankarappa, Soundarya Soundararajan, Phalguni Anand Alladi, Meera Purushottam, Narayanappa Gayathri, Deepti Dileep Deobagkar, Thenkanidiyoor Rao Laxmi, Srinivas Bharath Muchukunte Mukunda
Idiopathic Parkinson's disease (iPD) and manganese-induced atypical Parkinsonism are characterized by movement disorder and nigrostriatal pathology. Although clinical features, brain region involved and responsiveness to levodopa distinguish both, differences at the neuronal level are largely unknown. We studied the morphological, neurophysiological and molecular differences in dopaminergic neurons exposed to the PD toxin 1-methyl-4-phenylpyridinium ion (MPP(+) ) and manganese (Mn) followed by validation in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and Mn mouse models...
August 12, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28757310/recommendations-for-harmonization-of-data-collection-and-analysis-of-developmental-neurotoxicity-endpoints-in-regulatory-guideline-studies-proceedings-of-workshops-presented-at-society-of-toxicology-and-joint-teratology-society-and-neurobehavioral-teratology
#6
REVIEW
Abby A Li, Larry P Sheets, Kathleen Raffaele, Virginia Moser, Angela Hofstra, Alan Hoberman, Susan L Makris, Robert Garman, Brad Bolon, Wolfgang Kaufmann, Roland Auer, Edmund Lau, Thomas Vidmar, Wayne J Bowers
The potential for developmental neurotoxicity (DNT) of environmental chemicals may be evaluated using specific test guidelines from the US Environmental Protection Agency or the Organisation for Economic Cooperation and Development (OECD). These guidelines generate neurobehavioral, neuropathological, and morphometric data that are evaluated by regulatory agencies globally. Data from these DNT guideline studies, or the more recent OECD extended one-generation reproductive toxicity guideline, play a pivotal role in children's health risk assessment in different world areas...
July 27, 2017: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/28739258/inhibition-by-divalent-metal-ions-of-human-histidine-triad-nucleotide-binding-protein1-hhint1-a-regulator-of-opioid-analgesia-and-neuropathic-pain
#7
Rachit Shah, Tsui-Fen Chou, Kimberly M Maize, Alexander Strom, Barry C Finzel, Carston R Wagner
Human histidine triad nucleotide binding protein 1 (hHint1) is a purine nucleoside phosphoramidase and adenylate hydrolase that has emerged as a potential therapeutic target for the management of pain. However, the molecular mechanism of Hint1 in the signaling pathway has remained less clear. The role of metal ions in regulating postsynaptic transmission is well known, and the active site of hHint1 contains multiple histidines. Here we have investigated the effect of divalent metal ions (Cd(2+), Cu(2+), Mg(2+), Mn(2+), Ni(2+), and Zn(2+)) on the structural integrity and catalytic activity of hHint1...
September 23, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28730575/the-effect-of-chronic-fluorosis-on-calcium-ions-and-camkii%C3%AE-and-c-fos-expression-in-the-rat-hippocampus
#8
Yao Teng, Jing Zhang, Zigui Zhang, Juan Feng
This study investigated neurotoxicity of chronic fluorosis in the rat hippocampus. Newly weaning, male, Sprague-Dawley (SD) rats were administered 15, 30, and 60 mg/L sodium fluoride (NaF) solution (fluorine ion concentration 8.25, 16.50, and 33.00 mg/L, respectively), and tap water, for 18 months. The neurotoxicological mechanism was examined with a focus on intracellular calcium overload. Results showed that as the fluoride concentration increased, calcium ion concentration [Ca(2+)], the expression of calcium/calmodulin-dependent protein kinase II α (CaMKIIα), and the expression of catus proto-oncogene protein c-fos (c-fos) all tend to increase...
July 20, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28626759/sertraline-induces-toxicity-and-behavioral-alterations-in-planarians
#9
Isabela Salvador Thumé, Marcos Emílio Frizzo
Toxicity attributed to sertraline has been demonstrated recently in different cell types and also in some organisms. We investigated the effect of sertraline on planarians, which are considered suitable for investigations in neurotoxicology and currently are widely used as an animal model in neuropharmacological studies. Planarians treated with 10 µM sertraline showed a rapid reduction in their spontaneous movement until they became completely motionless and then showed a series of asynchronous paroxysms (seizures) followed by progressive tissue damage, beginning 48 h after the sertraline treatment, and died approximately 72 h later...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28558143/parsing-disease-relevant-protein-modifications-from-epiphenomena-perspective-on-the-structural-basis-of-sod1-mediated-als
#10
N D Schmitt, J N Agar
Conformational change and modification of proteins are involved in many cellular functions. However, they can also have adverse effects that are implicated in numerous diseases. How structural change promotes disease is generally not well-understood. This perspective illustrates how mass spectrometry (MS), followed by toxicological and epidemiological validation, can discover disease-relevant structural changes and therapeutic strategies. We (with our collaborators) set out to characterize the structural and toxic consequences of disease-associated mutations and post-translational modifications (PTMs) of the cytosolic antioxidant protein Cu/Zn-superoxide dismutase (SOD1)...
July 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28506248/paraquat-and-parkinson-s-disease-a-systematic-review-protocol-according-to-the-ohat-approach-for-hazard-identification
#11
Carolina Vaccari, Regina El Dib, João Lauro V de Camargo
BACKGROUND: Parkinson's disease (PD) is a progressive neurodegenerative condition that has genetic susceptibility, aging, and exposure to certain chemicals as risk factors. In recent decades, epidemiological and experimental studies have investigated the role of pesticides in the development of PD, in particular that of the herbicide paraquat. Here, we, therefore, aim to systematically review the association between paraquat exposure and PD. METHODS: Observational studies (cohort, case-control, and cross-sectional) eligible for this systematic review will enroll any participant who was occupationally and/or environmentally exposed to paraquat...
May 15, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28456551/41st-anniversary-annual-meeting-of-the-developmental-neurotoxicology-society-held-in-conjunction-with-the-57th-annual-meeting-of-the-teratology-society-grand-hyatt-hotel-denver-co-june-24-28-2017
#12
(no author information available yet)
No abstract text is available yet for this article.
April 27, 2017: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/28444486/on-the-necessity-of-translational-cognitive-neurotoxicological-research-in-methamphetamine-abuse-and-addiction
#13
EDITORIAL
Ann-Kathrin Stock, Christian Beste
No abstract text is available yet for this article.
April 25, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28438537/special-issue-of-neurotoxicology-dedicated-to-the-late-toshio-narahashi-a-commentary-from-the-founding-editor-editor-in-chief-of-neurotoxicology
#14
https://www.readbyqxmd.com/read/28347437/neural-mechanisms-of-functional-impairment-across-the-lifespan-the-15th-biennial-meeting-of-the-international-neurotoxicology-association-and-39th-annual-meeting-of-the-neurobehavioral-teratology-society
#15
EDITORIAL
Christoph van Thriel, Ed Levin, Pam Lein, Lucio G Costa, Remco H S Westerink
No abstract text is available yet for this article.
March 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28212724/mechanistic-insight-into-neurotoxicity-induced-by-developmental-insults
#16
REVIEW
Christoffer Tamm, Sandra Ceccatelli
Epidemiological and/or experimental studies have shown that unfavorable prenatal environmental factors, such as stress or exposure to certain neurotoxic environmental contaminants, may have adverse consequences for neurodevelopment. Alterations in neurogenesis can have harmful effects not only for the developing nervous system, but also for the adult brain where neurogenesis is believed to play a role in learning, memory, and even in depression. Many recent advances in the understanding of the complex process of nervous system development can be integrated into the field of neurotoxicology...
January 15, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28190432/acute-neurotoxicology-of-drugs-of-abuse
#17
S J Traub, M D Levine
Many substances can affect the central nervous system, and may cause patients to become critically ill. Acute central neurotoxicologic syndromes associated with drugs of abuse are usually caused by an overdose of sedative-hypnotic agents (including alcohol) or opioids, withdrawal from sedative-hypnotic agents, or an overdose of anticholinergic or sympathomimetic agents. Clinical findings are often syndromic, making physical examination the most important diagnostic tool in the approach to the patient with an unknown ingestion...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/28174116/comparative-study-of-human-neuronal-and-glial-cell-sensitivity-for-in%C3%A2-vitro-neurogenotoxicity-testing
#18
COMPARATIVE STUDY
Blanca Laffon, Natalia Fernández-Bertólez, Carla Costa, Eduardo Pásaro, Vanessa Valdiglesias
Cell cultures from neuronal and glial origin have proven to be powerful tools for elucidating cellular and molecular mechanisms of nervous system development and physiology, and as neurotoxicity models to evaluate in vitro the possible effects of chemicals. But cellular heterogeneity of nervous system is considerable and these cells have been shown to respond diversely to neurotoxic insults, leading to disparate results from different studies. To shed more light on suitability of cellular models of nervous origin for neurotoxicity screening, the objective of this study was to compare the sensitivity to genetic damage induction of two nervous cell lines...
April 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28160021/are-multitasking-abilities-impaired-in-welders-exposed-to-manganese-translating-cognitive-neuroscience-to-neurotoxicology
#19
Christoph van Thriel, Clara Quetscher, Beate Pesch, Anne Lotz, Martin Lehnert, Swaantje Casjens, Tobias Weiss, Rainer Van Gelder, Katrin Plitzke, Thomas Brüning, Christian Beste
Manganese (Mn) is an essential trace element with well characterized neurotoxic effects in high concentrations. Neurochemically, the initial neurotoxic effect of Mn is the perturbation of striatal γ-aminobutyric acid levels. Specific tasks for the assessment of cognitive functions subserved by fronto-striatal loops are available as the stop-change task (SCT) assessing control of multi-component behavior and action cascading. In a cross-sectional study, fifty male welders and 28 age-matched controls completed the SCT during a whole day examination...
February 3, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28109771/assessment-of-learning-memory-and-attention-in-developmental-neurotoxicology-regulatory-testing-commentary-on-essentiality-of-cognitive-assessment-for-protecting-child-health
#20
Charles V Vorhees
This commentary is in response to the remarks of Drs. Christina Sobin, Mari Golub, and David Herr on the Special Issue of this Journal entitled "Assessment of Learning, Memory, and Attention in Developmental Neurotoxicology Regulatory Testing." I endorse the views expressed by Drs. Sobin, Golub, and Herr and add some discussion on a recent Organization for Economic Cooperation and Development (OECD) guideline, the Extended One Generation Reproductive Toxicology Guideline (OECD 446), in which testing for higher cognitive function (learning and memory) has been eliminated...
January 18, 2017: Neurotoxicology and Teratology
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