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https://www.readbyqxmd.com/read/28227639/investigation-of-a-passive-capstan-based-grasp-enhancement-feature-in-a-voluntary-closing-prosthetic-terminal-device
#1
Kevin D Gemmell, Michael T Leddy, Joseph T Belter, Aaron M Dollar, Kevin D Gemmell, Michael T Leddy, Joseph T Belter, Aaron M Dollar, Joseph T Belter, Kevin D Gemmell, Michael T Leddy, Aaron M Dollar
Body-powered prosthetic terminal devices fall into two main categories: voluntary-closing devices, which require the user to exert a force to maintain a grasp, and voluntary opening devices, which generally utilize springs to close and maintain a force. As a result, voluntary-closing devices often have a locking feature that allows the user to relax and transport objects while maintaining a firm grip. In this paper, we examine a new type of capstan-based passive brake mechanism in a voluntary-closing prosthetic terminal device...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28224106/impact-of-high-dose-vitamin-c-on-platelet-function
#2
Bassem M Mohammed, Kimberly W Sanford, Bernard J Fisher, Erika J Martin, Daniel Contaifer, Urszula Osinska Warncke, Dayanjan S Wijesinghe, Charles E Chalfant, Donald F Brophy, Alpha A Fowler Iii, Ramesh Natarajan
AIM: To examine the effect of high doses of vitamin C (VitC) on ex vivo human platelets (PLTs). METHODS: Platelet concentrates collected for therapeutic or prophylactic transfusions were exposed to: (1) normal saline (control); (2) 0.3 mmol/L VitC (Lo VitC); or (3) 3 mmol/L VitC (Hi VitC, final concentrations) and stored appropriately. The VitC additive was preservative-free buffered ascorbic acid in water, pH 5.5 to 7.0, adjusted with sodium bicarbonate and sodium hydroxide...
February 4, 2017: World Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28223824/mir182-activates-the-ras-mek-erk-pathway-in-human-oral-cavity-squamous-cell-carcinoma-by-suppressing-rasa1-and-spred1
#3
Jinhui Wang, Wei Wang, Jichen Li, Liji Wu, Mei Song, Qinggang Meng
PURPOSE: The constitutive activation of the Ras-MEK-ERK signaling pathway in oral cavity squamous cell carcinoma (OSCC) has been found to be tightly controlled at multiple levels under physiological conditions. RASA1 and SPRED1 are two important negative regulators of this pathway, but the exact regulating mechanism remains unclear. In this study, we aimed to explore the potential regulating mechanisms involved in the Ras-MEK-ERK signaling pathway in OSCC. MATERIALS AND METHODS: MicroRNA (miRNA) expression was detected by quantitative reverse-transcription polymerase chain reaction...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28218473/epigenetic-silencing-of-diacylglycerol-kinase-gamma-in-colorectal-cancer
#4
Masahiro Kai, Eiichiro Yamamoto, Akiko Sato, Hiro-O Yamano, Takeshi Niinuma, Hiroshi Kitajima, Taku Harada, Hironori Aoki, Reo Maruyama, Mutsumi Toyota, Tomo Hatahira, Hiroshi Nakase, Tamotsu Sugai, Toshiharu Yamashita, Minoru Toyota, Hiromu Suzuki
Diacylglycerol kinases (DGKs) are important regulators of cell signaling and have been implicated in human malignancies. Whether epigenetic alterations are involved in the dysregulation of DGKs in cancer is unknown, however. We therefore analyzed methylation of the promoter CpG islands of DGK genes in colorectal cancer (CRC) cell lines. We found that DGKG, which encodes DGKγ, was hypermethylated in all CRC cell lines tested (n = 9), but was not methylated in normal colonic tissue. Correspondingly, DGKG expression was suppressed in CRC cell lines but not in normal colonic tissue, and was restored in CRC cells by treatment with the DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine (5-aza-dC)...
February 20, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28216900/trichosanthes-kirilowii-exerts-androgenic-activity-via-regulation-of-psa-and-klk2-in-22rv1-prostate-cancer-cells
#5
Soo-Jin Jeong, Ji-Yoon Choi, Mi-Sook Dong, Chang-Seob Seo, Hyeun-Kyoo Shin
BACKGROUND: The androgen comprises a group of hormones that play roles in male reproductive activity as well as personal characteristics. OBJECTIVE: We investigated the androgenic activity of various herbal medicines in human prostate cancer 22Rv1 cells. MATERIALS AND METHODS: Herbal extracts of Trichosanthes kirilowii (TK), Asarum sieboldii (AS), Sanguisorba officinalis (SO), and Xanthium strumarium (XS) were selected to have androgenic effects based on a preliminary in vitro screening system...
January 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28212537/itraconazole-exerts-its-anti-melanoma-effect-by-suppressing-hedgehog-wnt-and-pi3k-mtor-signaling-pathways
#6
Guanzhao Liang, Musang Liu, Qiong Wang, Yongnian Shen, Huan Mei, Dongmei Li, Weida Liu
Malignant melanoma is the deadliest form of all skin cancers. Itraconazole, a commonly used systemic antifungal drug, has been tested for its anti-tumor effects on basal cell carcinoma, prostate cancer, and non-small cell lung cancer. Whether itraconazole has any specific anti-tumor effect on melanoma remains unknown. However, the goal of this study is to investigate the effect of itraconazole on melanoma and to reveal some details of its underlying mechanism. In the in vivo xenograft mouse model, we find that itraconazole can inhibit melanoma growth and extend the survival of melanoma xenograft mice, compared to non-itraconazole-treated mice...
February 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/28211068/dentine-matrix-proteins-isolation-and-effects-on-human-pulp-cells
#7
M Widbiller, A Eidt, S R Lindner, K-A Hiller, H Schweikl, W Buchalla, K M Galler
AIM: To establish a simplified and efficient protocol for the isolation and concentration of matrix proteins from human dentine, and to assess the effects of extracted dentine matrix proteins (eDMP) on the behavior of human pulp cells. METHODOLOGY: Matrix proteins were isolated from human dentine, purified, concentrated and characterized with protein and enzyme-linked immunosorbent assays. Culture media were supplemented with eDMP in different concentrations, referred to as eDMP 1 to 10,000, to assess viability and proliferation of human pulp cells by DNA and MTT assays; apoptotic events were quantified by flow cytometry...
February 17, 2017: International Endodontic Journal
https://www.readbyqxmd.com/read/28204978/characterization-and-cytotoxic-effect-of-aqua-2-2-2-nitrilotriacetato-oxo-vanadium-salts-on-human-osteosarcoma-cells
#8
Aleksandra Tesmar, Dariusz Wyrzykowski, Rafał Kruszyński, Karolina Niska, Iwona Inkielewicz-Stępniak, Joanna Drzeżdżon, Dagmara Jacewicz, Lech Chmurzyński
The use of protonated N-heterocyclic compound, i.e. 2,2'-bipyridinium cation, [bpyH(+)], enabled to obtain the new nitrilotriacetate oxidovanadium(IV) salt of the stoichiometry [bpyH][VO(nta)(H2O)]H2O. The X-ray measurements have revealed that the compound comprises the discrete mononuclear [VO(nta)(H2O)](-) coordination ion that can be rarely found among other known compounds containing nitrilotriacetate oxidovanadium(IV) moieties. The antitumor activity of [bpyH][VO(nta)(H2O)]H2O and its phenanthroline analogue, [phenH][VO(nta)(H2O)](H2O)0...
February 15, 2017: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/28202007/diffusible-substances-from-lactic-acid-bacterial-cultures-exert-strong-inhibitory-effects-on-listeria-monocytogenes-and-salmonella-enterica-serovar-enteritidis-in-a-co-culture-model
#9
Solomon H Mariam, Nigus Zegeye, Abraham Aseffa, Rawleigh Howe
BACKGROUND: Food-borne infections cause huge economic and human life losses. Listeria monocytogenes and Salmonella enterica serovar Enteritidis are among the top ranking pathogens causing such losses. Control of such infections is hampered by persistent contamination of foods and food-processing environments, resistance of pathogens to sanitizing agents, existence of heterogeneous populations of pathogens (including culturable and viable but non-culturable cells) within the same food items, and inability to detect all such pathogens by culture-based methods...
February 15, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28194830/parasternal-intercostal-muscle-activity-during-methacholine-induced-bronchoconstriction
#10
Victoria MacBean, Claire L Pringle, Alan C Lunt, Keith D Sharp, Ashraf Ali, Anne Greenough, John Moxham, Gerrard F Rafferty
Neural respiratory drive, measured via the parasternal intercostal electromyogram (EMGpara), provides a non-invasive index of the load-capacity balance of the respiratory muscle pump. Previous studies in patients with obstructive lung disease have shown strong relationships between EMGpara and the extent of both airflow obstruction and hyperinflation. The relative influence of the two factors has not, however, been described. Airflow obstruction was induced via methacholine challenge testing in twenty-five adult humans...
February 14, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28188858/analysis-of-the-in-vitro-and-in-vivo-effects-of-photodynamic-therapy-on-prostate-cancer-by-using-new-photosensitizers-protoporphyrin-ix-polyamine-derivatives
#11
Chloë Fidanzi-Dugas, Bertrand Liagre, Guillaume Chemin, Aurélie Perraud, Claire Carrion, Claude-Yves Couquet, Robert Granet, Vincent Sol, David Yannick Léger
BACKGROUND: Photodynamic therapy, using porphyrins as photosensitizers (PS), has been approved in treatment of several solid tumors. However, commonly used PS induce death but also resistance pathways in cancer cells and an alteration of surrounding normal tissues. Because polyamines (PA) are actively accumulated in cancer cells by the Polyamine Transport System (PTS), they may enable PS to specifically target cancer cells. Here, we investigated whether new protoporphyrin IX-polyamine derivatives were effective PS against prostate cancer and whether PA increased PDT specificity after red light irradiation...
February 7, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28186709/in-vitro-evaluation-of-the-biological-compatibility-and-antibacterial-activity-of-a-bone-substitute-material-consisting-of-silver-doped-hydroxyapatite-and-bio-oss-%C3%A2
#12
Jingjue Gong, Lei Yang, Qi He, Ting Jiao
This study evaluated biological compatibility and antibacterial activity of a bone substitute material consisting of silver-doped hydroxyapatite (AgHA) and Bio-Oss(®) with different mixture ratios in vitro and investigated its antibacterial mechanism. AgHA was synthesized by a chemical precipitation method. After characterization, AgHA was mixed with Bio-Oss(®) at three ratios: 1:1, 1:2, and 1:4 by weight. Then, Porphyromonas gingivalis (Pg) and Fusobacterium nucleatum (Fn) were used to test the antibacterial activity of the mixture...
February 10, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28167931/the-active-component-of-aspirin-salicylic-acid-promotes-staphylococcus-aureus-biofilm-formation-in-a-pia-dependent-manner
#13
Cristian Dotto, Andrea Lombarte Serrat, Natalia Cattelan, María S Barbagelata, Osvaldo M Yantorno, Daniel O Sordelli, Monika Ehling-Schulz, Tom Grunert, Fernanda R Buzzola
Aspirin has provided clear benefits to human health. But salicylic acid (SAL) -the main aspirin biometabolite- exerts several effects on eukaryote and prokaryote cells. SAL can affect, for instance, the expression of Staphylococcus aureus virulence factors. SAL can also form complexes with iron cations and it has been shown that different iron chelating molecules diminished the formation of S. aureus biofilm. The aim of this study was to elucidate whether the iron content limitation caused by SAL can modify the S...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28167456/antidepressant-and-anxiolytic-like-activity-of-sodium-selenite-after-acute-treatment-in-mice
#14
Ewa Kędzierska, Jarosław Dudka, Ewa Poleszak, Jolanta H Kotlińska
BACKGROUND: Selenium (Se) is an essential trace element for humans and animals, that is needed for a broad variety of physiological functions including thyroid hormone metabolism, protection against oxidative stress, and immunity associated functions. Human nutritional Se deficiencies are associated with neuropsychiatric diseases, like Alzheimer's disease, Parkinson's disease, obsessive - compulsive disorder, stroke, epilepsy as well as depressive behaviours. In this study we examined antidepressant- and anxiolytic-like activity of Se in the inorganic form of sodium selenite and investigated whether Se influence on the locomotor activity in mice...
November 11, 2016: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28167444/lipophilic-antioxidants-and-lipid-peroxidation-in-yellow-perch-subjected-to-various-anthropogenic-influences-along-the-st-lawrence-river-qc-canada
#15
Catherine Landry, Magali Houde, Philippe Brodeur, Philip Spear, Monique Boily
In Lake Saint-Pierre (LSP), the last great widening of the St. Lawrence River (province of Québec, Canada), the yellow perch has been experiencing a significant decline since the mid-1990s. The combined effect of several stressors (deterioration of habitats appropriate for reproduction and growth, invasive species and poor water quality) seems to exert considerable influence on the yellow perch population in LSP, characterized by low recruitment. To better understand possible stressor effects at the biochemical level, LSP yellow perch were compared with other sites along a gradient of increasing human influences from upstream to downstream along the St...
February 7, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28165063/heavy-chain-hyaluronan-pentraxin-3-from-amniotic-membrane-suppresses-inflammation-and-scarring-in-murine-lacrimal-gland-and-conjunctiva-of-chronic-graft-versus-host-disease
#16
Yoko Ogawa, Hua He, Shin Mukai, Toshihiro Imada, Shigeru Nakamura, Chen-Wei Su, Megha Mahabole, Scheffer C G Tseng, Kazuo Tsubota
Chronic graft-versus-host disease (cGVHD) is a major complication of hematopoietic stem cell transplantation. Dry eye disease is the prominent ocular sequel of cGVHD and is caused by excessive inflammation and fibrosis in the lacrimal glands. Heavy chain-Hyaluronan/Pentraxin 3 (HC-HA/PTX3) is a complex purified from human amniotic membrane (AM) and known to exert anti-inflammatory and anti-scarring actions. In this study, we utilized a mouse model of cGVHD to examine whether HC-HA/PTX3 could attenuate dry eye disease elicited by cGVHD...
February 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28164790/phytochemicals-for-human-disease-an-update-on-plant-derived-compounds-antibacterial-activity
#17
REVIEW
Ramona Barbieri, Erika Coppo, Anna Marchese, Maria Daglia, Eduardo Sobarzo-Sánchez, Seyed Fazel Nabavi, Seyed Mohammad Nabavi
In recent years, many studies have shown that phytochemicals exert their antibacterial activity through different mechanisms of action, such as damage to the bacterial membrane and suppression of virulence factors, including inhibition of the activity of enzymes and toxins, and bacterial biofilm formation. In this review, we summarise data from the available literature regarding the antibacterial effects of the main phytochemicals belonging to different chemical classes, alkaloids, sulfur-containing phytochemicals, terpenoids, and polyphenols...
March 2017: Microbiological Research
https://www.readbyqxmd.com/read/28159472/metformin-activation-of-ampk-suppresses-age-induced-inflammatory-response-in-hnscs
#18
Ming-Min Chung, Christopher J Nicol, Yi-Chuan Cheng, Kuan-Hung Lin, Yen-Lin Chen, Dee Pei, Chien-Hung Lin, Yi-Nuo Shih, Chia-Hui Yen, Shiang-Jiuun Chen, Rong-Nan Huang, Ming-Chang Chiang
A growing body of evidence suggests type 2 diabetes mellitus (T2DM) is linked to neurodegenerative diseases such as Alzheimer's disease (AD). Although the precise mechanisms remain unclear, T2DM may exacerbate neurodegenerative processes. AMP-activated protein kinase (AMPK) signaling is an evolutionary preserved pathway that is important during homeostatic energy biogenesis responses at both the cellular and whole-body levels. Metformin, a ubiquitously prescribed anti-diabetic drug, exerts its effects by AMPK activation...
January 31, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28153636/quercetin-derivatives-as-potent-inducers-of-selective-cytotoxicity-in-glioma-cells
#19
Paola Dell'Albani, Barbara Di Marco, Sonia Grasso, Concetta Rocco, Mario C Foti
Quercetin (Q) is a flavonoid widely distributed in the plant kingdom and well-known for its ability to exert antioxidant, prooxidant and anticarcinogenic activities in several tumor cells. Furthermore, quercetin plays an important role both in the regulation of key elements in cellular signal transduction pathways related to apoptotic cell death, and in cell cycle progression. Several studies have reported of toxic effects of Q against glioma cell lines. In this study, the effects of Q and of some Q-derivatives (acyl esters and bromo-derivatives) on U373-MG and 9L glioma cell lines survival are analyzed...
January 30, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28148724/neural-predictors-of-decisions-to-cognitively-control-emotion
#20
Bruce Pierre Doré, Jochen Weber, Kevin Nicholas Ochsner
: Deciding to control emotional responses is a fundamental means of responding to environmental challenges, but little is known about the neural mechanisms that predict the outcome of such decisions. We used fMRI to test whether human brain responses during initial viewing of negative images could be used to predict decisions to regulate affective responses to those images. We found that 1) decisions to regulate were more frequent in individuals exhibiting higher average levels of activity within the amygdala and regions of prefrontal cortex known a priori to be involved in the cognitive control of emotion and 2) within-person expression of a distributed brain pattern associated with regulating emotion predicted choosing to regulate responses to particular stimuli, beyond the predictive value of stimulus intensity or self-reports of emotion...
February 1, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
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