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https://www.readbyqxmd.com/read/29236035/short-communication-a-comparison-of-the-in-vitro-angiotensin-1-converting-enzyme-inhibitory-capacity-of-dairy-and-plant-protein-supplements
#1
Carlotta Giromini, Ágnes A Fekete, D Ian Givens, Antonella Baldi, Julie A Lovegrove
The consumption of supplements based on dairy or plant proteins may be associated with bioactive potential, including angiotensin-1-converting enzyme inhibitory (ACE-1i) activity, which is linked with blood pressure reduction in vivo. To gain insight into this proposed mechanism, the ACE-1i potential of protein-based supplements, including a selection of dairy (n = 10) and plant (n = 5) proteins were in vitro digested. The total digest was filtered and permeate and retentate were obtained. ACE-1i activity was measured as the ability of proteins (pre-digestion, 'gastric', permeate, and retentate) to decrease the hydrolysis of furanacroloyl-Phe-Glu-Glu (FAPGG) substrate for the ACE-1 enzyme...
December 13, 2017: Nutrients
https://www.readbyqxmd.com/read/29233689/in-vitro-toxicity-evaluation-of-estragole-containing-preparations-derived-from-foeniculum-vulgare-mill-fennel-on-hepg2-cells
#2
Sara Levorato, Luca Dominici, Cristina Fatigoni, Claudia Zadra, Rita Pagiotti, Massimo Moretti, Milena Villarini
Estragole, a common component of herbs and spices, is a wellknown genotoxic hepatocarcinogen in rodents, whereas its potential toxic effect in humans is still debated. In the European contest, one of the major sources of human exposure to this phytochemical is Foeniculum vulgare Mill. (fennel). Therefore, the aim of this study was to evaluate the in vitro toxicity of estragole in the context of two complex phytochemical mixtures derived from fennel: fennel seed powder (FSPw) and fennel seed essential oil (FSEO)...
December 9, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29229353/novel-1-4-benzothazines-obliterate-cox-2-mediated-jak-2-stat-3-signals-with-potential-regulation-of-oxidative-and-metabolic-stress-during-colorectal-cancer
#3
Amit Rai, Umesh Kumar, Vinit Raj, Ashok K Singh, Pranesh Kumar, Amit K Keshari, Dinesh Kumar, Biswanath Maity, Arnab De, Amalesh Samanta, Sneha Nath, Anand Prakash, Sunil Babu Gosipatala, Gyan Chand, Sudipta Saha
1,4-benzothiazines have ameliorative effects through inhibition of COX-2 mediated STAT-3 pathways at G-protein couple receptor site. As per this scenario, we recently prepared and tested novel 1,4-benzothiazine derivatives against HT-29 human colon cancer cell line. Two compounds namely AR13 and AR15 showed higher inhibitions among all the synthesized compounds. In the present context, we conducted the in vivo antiproliferative action and identified the molecular mechanism associated to cytotoxic action of AR13 and AR15 in dimethylhydrazine (DMH) induced colorectal carcinoma (CRC) model...
December 8, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29221702/screening-plant-derived-dietary-phenolic-compounds-for-bioactivity-related-to-cardiovascular-disease
#4
Kevin D Croft, Yoko Yamashita, Helen O'Donoghue, Daishi Shirasaya, Natalie Ward, Hitoshi Ashida
The potential health benefits of phenolic acids found in food and beverages has been suggested from a number of large population studies. However, the mechanism of how these compounds may exert biological effects is less well established. It is also now recognised that many complex polyphenols in the diet are metabolised to simple phenolic acids which can be taken up in the circulation. In this paper a number of selected phenolic compounds have been tested for their bioactivity in two cell culture models. The expression and activity of endothelial nitric oxide synthase (eNOS) in human aortic endothelial cells and the uptake of glucose in muscle cells...
December 5, 2017: Fitoterapia
https://www.readbyqxmd.com/read/29218021/the-effects-of-different-isocaloric-oral-nutrient-solutions-on-psychophysical-metabolic-cognitive-and-olfactory-function-in-young-male-subjects
#5
Stephan Bachlechner, Melanie Y Denzer-Lippmann, Jan Wielopolski, Marie Fischer, Andrea Buettner, Arndt Doerfler, Christof Schöfl, Gerald Münch, Johannes Kornhuber, Norbert Thürauf
Food intake influences human cognition, olfaction, hunger, and food craving. However, little research has been done in this field to elucidate the effects of different nutrients. Thus, the goal of our study was to investigate the effects of oral ingestion of different nutrient solutions on olfactory, cognitive, metabolic and psychophysical function. Twenty healthy men participated in our study employing a double-blind, cross-over, repeated measurement design. Participants were tested on four different study days...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29213495/impact-of-sociodemographic-variables-on-executive-functions
#6
Kenia Repiso Campanholo, Izadora Nogueira Fonte Boa, Flávia Cristina da Silva Araujo Hodroj, Glaucia Rosana Benute Guerra, Eliane Correa Miotto, Mara Cristina Souza de Lucia
Executive functions (EFs) regulate human behavior and allow individuals to interact and act in the world. EFs are sensitive to sociodemographic variables such as age, which promotes their decline, and to others that can exert a neuroprotective effect. Objective: To assess the predictive role of education, occupation and family income on decline in executive functions among a sample with a wide age range. Methods: A total of 925 participants aged 18-89 years with 1-28 years' education were submitted to assessment of executive functions using the Card Sorting Test (CST), Phonemic Verbal Fluency (FAS) Task and Semantic Verbal Fluency (SVF) Task...
January 2017: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29210076/in-vitro-effect-of-antiretroviral-drugs-on-cultured-primary-astrocytes-analysis-of-neurotoxicity-and-matrix-metalloproteinase-inhibition
#7
Tiziana Latronico, Ilaria Pati, Rossana Ciavarella, Anna Fasano, Fabio Mengoni, Miriam Lichtner, Vincenzo Vullo, Claudio Maria Mastroianni, Grazia Maria Liuzzi
There is little information available on the possible toxic effects that antiretroviral (ARV) drugs used for the treatment of human immunodeficiency virus (HIV)-infected subjects, may have on the central nervous system (CNS) resident cells. Moreover, it is unclear whether the efficacy of the ARV drugs may also be due to their ability to exert extravirological effects on factors responsible for the development of HIV brain injury, e.g. matrix metalloproteinases (MMPs). This study investigates the toxicity of three different ARV drugs and on their ability to modulate levels and expression of gelatinases A (MMP-2) and B (MMP-9) in astrocytes...
December 6, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29203273/the-traditional-use-of-vachellia-nilotica-for-sexually-transmitted-diseases-is-substantiated-by-the-antiviral-activity-of-its-bark-extract-against-sexually-transmitted-viruses
#8
Manuela Donalisio, Valeria Cagno, Andrea Civra, Davide Gibellini, Giuseppina Musumeci, Massimo Rittà, Manik Ghosh, David Lembo
ETHNOPHARMACOLOGICAL RELEVANCE: Vachellia (Acacia) nilotica and other plants of this genus have been used in traditional medicine of Asian and African countries to treat many disorders, including sexually transmitted diseases, but few studies were performed to validate their anti-microbial and anti-viral activity against sexually transmitted infections. AIM OF THE STUDY: The present study was undertaken to explore whether the ethnomedical use of V.nilotica to treat genital lesions is substantiated by its antiviral activity against the human immunodeficiency virus (HIV), the herpes simplex virus (HSV) and the human papillomavirus (HPV)...
December 1, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29202825/antibacterial-activity-and-effects-of-colla-corii-asini-on-salmonella-typhimurium-invasion-in-vitro-and-in-vivo
#9
Kwang-Il Park, Mi-Ra Lee, Tae-Woo Oh, Kwang-Youn Kim, Jin-Yeul Ma
BACKGROUND: Salmonella enterica serovar Typhimurium is a foodborne pathogen that triggers inflammatory responses in the intestines of humans and livestock. Colla corii asini is a traditional medicine used to treat gynecologic and chronic diseases in Korea and China. However, the antibacterial activity of Colla corii asini has been unknown. In this study, we investigated the antibacterial activity and effects of Colla corii asini extract on Salmonella typhimurium invasion. METHODS: To tested for antibacterial effects of Colla corii asini extracts, we confirmed the agar diffusion using Luria solid broth medium...
December 4, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29201086/esters-of-quinoxaline-1-4-di-n-oxide-with-cytotoxic-activity-on-tumor-cell-lines-based-on-nci-60-panel
#10
Gildardo Rivera, Syed Shoaib Ahmad Shah, Daniel Arrieta-Baez, Isidro Palos, Antonio Mongue, Luvia Enid Sánchez-Torres
Quinoxalines display diverse and interesting pharmacological activities as antibacterial, antiviral, antiparasitic and anticancer agents. Particularly, their 1`4-di-N-oxide derivatives have proved to be cytotoxic agents that are active under hypoxic conditions as that of solid tumours. A new series of quinoxaline 1`4-di-N-oxide substitutes at 7-position with esters group were synthetized and characterized by infrared (IR), proton nuclear magnetic resonance (1H-NMR), spectroscopy, and elemental analysis. Seventeen derivatives (M1-M3, E1-E8, P1-P3 and DR1-DR3) were selected and evaluated for antitumor activities using the NCI-60 human tumor cell lines screen...
2017: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/29199565/cytotoxic-activities-of-fractions-of-the-willow-bracket-medicinal-mushroom-phellinus-igniarius-agaricomycetes-and-the-induction-of-cell-cycle-arrest-and-apoptosis-in-mgc-803-cells
#11
Fei-Fei Wang, Feng Liu, Chao Shi, Wei Ma, Kai-Jin Wang, Ning Li
Phellinus igniarius, a perennial medicinal mushroom, has been used in China and other countries of East Asia for the treatment of various diseases, including cancer. The purpose of this study is to evaluate the cytotoxic activities of different fractions of an ethanol extract from Ph. igniarius and to elucidate a possible antitumor mechanism. An ethanol extract of Ph. igniarius was partitioned into a petroleum ether fraction, an ethyl acetate fraction (EAF), an n-butanol fraction, and a water-soluble fraction...
2017: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/29198811/preparation-of-pegylated-liposomes-incorporating-lipophilic-lomeguatrib-derivatives-for-the-sensitization-of-chemo-resistant-gliomas
#12
Rea D Signorell, Alexandros Papachristodoulou, Jiawen Xiao, Bianca Arpagaus, Tommaso Casalini, Joanes Grandjean, Jana Thamm, Frank Steiniger, Paola Luciani, Davide Brambilla, Beat Werner, Ernst Martin, Michael Weller, Patrick Roth, Jean-Christophe Leroux
Liposomal delivery is a well-established approach to increase the therapeutic index of drugs, mainly in the field of cancer chemotherapy. Here, we report the preparation and characterization of a new liposomal formulation of a derivative of lomeguatrib, a potent O6-methylguanine-DNA methyltransferase (MGMT) inactivator. The drug had been tested in clinical trials to revert chemoresistance, but was associated with a low therapeutic index. A series of lomeguatrib conjugates with distinct alkyl chain lengths - i...
November 30, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29191793/combined-therapies-to-treat-complex-diseases-the-role-of-the-gut-microbiota-in-multiple-sclerosis
#13
REVIEW
Laura Calvo-Barreiro, Herena Eixarch, Xavier Montalban, Carmen Espejo
The commensal microbiota has emerged as an environmental risk factor for multiple sclerosis (MS). Studies in experimental autoimmune encephalomyelitis (EAE) models have shown that the commensal microbiota is an essential player in triggering autoimmune demyelination. Likewise, the commensal microbiota modulates the host immune system, alters the integrity and function of biological barriers and has a direct effect on several types of central nervous system (CNS)-resident cells. Moreover, a characteristic gut dysbiosis has been recognized as a consistent feature during the clinical course of MS, and the MS-related microbiota is gradually being elucidated...
November 27, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29191791/electrophysiological-investigation-of-the-effect-of-structurally-different-bispyridinium-non-oxime-compounds-on-human-%C3%AE-7-nicotinic-acetylcholine-receptor-activity-an-in-vitro-structure-activity-analysis
#14
Corinna Scheffel, Karin V Niessen, Sebastian Rappenglück, Klaus T Wanner, Horst Thiermann, Franz Worek, Thomas Seeger
Organophosphorus compounds, including nerve agents and pesticides, exert their toxicity through irreversible inhibition of acetylcholinesterase (AChE) resulting in an accumulation of acetylcholine and functional impairment of muscarinic and nicotinic acetylcholine receptors. Current therapy comprises oximes to reactivate AChE and atropine to antagonize effects induced by muscarinic acetylcholine receptors. Nicotinic malfunction leading to depression of the central and peripheral respiratory system is not directly treated calling for alternative therapeutic interventions...
November 27, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/29189140/polyphenols-effect-on-circulating-lipids-and-lipoproteins-from-biochemistry-to-clinical-evidence
#15
Arrigo Fg Cicero, Alessandro Colletti
BACKGROUND: Polyphenols are a family of natural antioxidants that in recent years have been studied and tested for their potential benefits towards cardiovascular diseases. OBJECTIVE: The aim of this review is to focus the attention on the presumed lipid-lowering and atheroprotective effects of polyphenols, administered either as individual molecules (nutritional supplements) and as functional foods, on the basis of the evidence coming from randomized controlled trials (RCTs) and their meta-analyses...
November 27, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29180970/cebranopadol-a-mixed-opioid-agonist-reduces-cocaine-self-administration-through-nociceptin-opioid-and-mu-opioid-receptors
#16
Qianwei Shen, Yulin Deng, Roberto Ciccocioppo, Nazzareno Cannella
Cocaine addiction is a widespread psychiatric condition still waiting for approved efficacious medications. Previous studies suggested that simultaneous activation of nociceptin opioid (NOP) and mu opioid (MOP) receptors could be a successful strategy to treat cocaine addiction, but the paucity of molecules co-activating both receptors with comparable potency has hampered this line of research. Cebranopadol is a non-selective opioid agonist that at nanomolar concentration activates both NOP and MOP receptors and that recently reached phase-III clinical trials for cancer pain treatment...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29180113/two-common-mild-analgesics-have-no-effect-on-general-endocrine-mediated-endpoints-in-zebrafish-danio-rerio
#17
Jane E Morthorst, Birgit F Lund, Henrik Holbech, Poul Bjerregaard
Mild analgesics such as acetylsalicylic acid (ASA) and acetaminophen (APAP) exert their pain-relieving effect in humans by inhibition of prostaglandin synthesis. Prostaglandins play key roles in developmental and reproductive processes in vertebrates, and in recent years, it has been suggested that weak analgesics might also act as endocrine disrupters. In a set of experiments we investigated if ASA and APAP affect well-established endocrine endpoints in zebrafish (Danio rerio), which is a commonly used model organism in the investigation of endocrine disrupting chemicals...
November 24, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29179876/syndemic-synergy-of-hpv-and-other-sexually-transmitted-pathogens-in-the-development-of-high-grade-anal-squamous-intraepithelial-lesions
#18
Jenny C McCloskey, W Martin Kast, James P Flexman, Dugald McCallum, Martyn A French, Michael Phillips
BACKGROUND: Anal intraepithelial neoplasia is associated with high-risk human papillomavirus (hrHPV) as a precursor to anal cancer. However, factors other than hrHPV are likely to be involved and further study of cofactors is required because of the possibility of syndemic interactions. METHODS: Three hundred and fourteen patients underwent 457 operations. Histopathology and hrHPV testing using the Digene Hybrid Capture 2 (HC 2) method were performed. Demographic factors and sexually transmissible infections (STIs) were recorded...
December 2017: Papillomavirus Research
https://www.readbyqxmd.com/read/29178328/mineralocorticoid-receptor-blockade-improves-glucocorticoid-induced-skin-atrophy-but-partially-ameliorates-anti-inflammatory-actions-in-an-irritative-model-in-human-skin-explants
#19
Julia Boix, Van Tuan Nguyen, Nicolette Farman, Sélim Aractingi, Paloma Pérez
We recently demonstrated that blockade of the mineralocorticoid receptor (MR) effectively ameliorated GC-induced skin atrophy in healthy human skin explants and epidermal MR knock-out mice. However, whether MR blockade improves the therapeutic index of GCs in skin pathology was not investigated. We assessed the effects of GCs, MR antagonists (MRA), or both, in SDS-treated human skin explants. All treatments restored SDS-augmented epidermal thickness but only GC plus MRA restored the expression of COL1A1. However, MRA alone or in combination with GCs may exert a dual role in regulating inflammatory cytokines...
November 27, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/29176935/restoration-of-mir-29b-exerts-anti-cancer-effects-on-glioblastoma
#20
Jaekyung Shin, Hyun Geun Shim, Taeyoung Hwang, Hyungsin Kim, Shin-Hyuk Kang, Yun-Sik Dho, Sung-Hye Park, Sang Jeong Kim, Chul-Kee Park
Background: Glioblastoma multiforme (GBM) is known as one of the most fatal forms of cancer. MicroRNAs have been widely implicated in the regulation of mammalian development and pathogenesis. The brain-enriched miR-29 subfamilies are known to be exclusively expressed in the developing brain, and they are aberrantly down-regulated in GBM. This study aims to elucidate the role of miR-29b in GBM development and the feasibility of therapeutic targeting using conjugated nanoparticles. Methods: After confirmation of miR-29b expression levels in GBM tissues by analysis of open source data, the anticancer effect of miR-29b was tested by the introduction of syn-hsa-miR-29b-3p in the A172 GBM cell line...
2017: Cancer Cell International
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