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https://www.readbyqxmd.com/read/28922804/hunting-for-agile-prey-trophic-specialisation-in-leptophryid-amoebae-vampyrellida-rhizaria-revealed-by-two-novel-predators-of-planktonic-algae
#1
Sebastian Hess
Vampyrellid amoebae (Vampyrellida, Rhizaria) are widespread in freshwater, marine and terrestrial ecosystems and consume a wide range of eukaryotes, e.g. algae, fungi and micrometazoa. Environmental sequences indicate that only a small fraction of their genetic diversity is phenotypically characterised, emphasising the need to further explore unknown vampyrellids and their interactions with prey organisms. This study tests the prey range specificity of three vampyrellid amoebae with 49 strains of three common groups of freshwater algae (Zygnematophyceae, Euglenophyceae and Volvocales), and documents specific interactions by time-lapse microscopy...
September 1, 2017: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/28922507/randomized-controlled-trial-evaluating-the-temporal-effects-of-high-intensity-exercise-on-learning-short-term-and-long-term-memory-and-prospective-memory
#2
Emily Frith, Eveleen Sng, Paul D Loprinzi
To examine the temporal effects of high-intensity exercise on learning, short-term and long-term retrospective memory and prospective memory. Among a sample of 88 young adult participants, 22 were randomized into one of four different groups: exercise before learning, control group, exercise during learning and exercise after learning. The retrospective assessments (learning, short-term and long-term memory) were assessed using the Rey Auditory Verbal Learning Test. Short-term memory included a 20-min delay assessment, with long-term memory including a 24-hour follow-up assessment...
September 18, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28922213/elastic-resistance-effectiveness-on-increasing-strength-of-shoulders-and-hips
#3
Kelsey J Picha, Muataz R Almaddah, Jordan Barker, Tavis Ciochetty, W Scott Black, Tim L Uhl
Elastic resistance is a common training method used to gain strength. Currently, progression with elastic resistance is based on the perceived exertion of the exercise or completion of targeted repetitions; exact resistance is typically unknown. This study's objective is to determine if knowledge of load during elastic resistance exercise will increase strength gains during exercises. Participants were randomized into two strength training groups, elastic resistance only and elastic resistance using a load cell (LC) that displays force during exercise...
September 12, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28919892/serum-mediated-oxidative-stress-from-systemic-sclerosis-patients-affects-mesenchymal-stem-cell-function
#4
Guillaume Fonteneau, Claire Bony, Radjiv Goulabchand, Alexandre T J Maria, Alain Le Quellec, Sophie Rivière, Christian Jorgensen, Philippe Guilpain, Danièle Noël
OBJECTIVES: Properties of mesenchymal stromal/stem cells (MSCs) from systemic sclerosis (SSc) patients have been reported to be altered. MSC-based therapy may therefore rely on the use of allogeneic MSCs from healthy subjects. Here, we investigated whether heterologous MSCs could exhibit altered properties following exposure to oxidative environment of SSc sera. METHODS: Human bone marrow-derived MSCs were cultured in the presence of various sera: control human serum AB (SAB), SAB with HOCl-induced AOPPs at 400 or 1,000 µmol/L (SAB400 or SAB1000, respectively), or H2O2-induced AOPPs or SSc patient serum (PS)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28919700/construction-and-test-results-of-coil-2-of-a-three-coil-800-mhz-rebco-insert-for-the-1-3-ghz-high-resolution-nmr-magnet
#5
Juan Bascuñán, Philip Michael, Seungyong Hahn, Thibault Lecrevisse, Yukikazu Iwasa
This paper focuses on the construction and test results of Coil 2 that is part of a trio of nested coils composing the REBCO 800 MHz insert. Upon its completion, the REBCO 800 MHz insert will be placed in the bore of a 500 MHz low temperature superconducting (LTS) NMR magnet (L500) to form the MIT 1.3 GHz high-resolution NMR magnet. Coil 2 is a stack of 32 double pancake (DP) coils wound with 6-mm wide REBCO tape using the no-insulation (NI) technique. Each pancake is wound on a stainless steel inner supporting ring to prevent the collapsing of its crossover due to the external pressure exerted by the winding pack...
June 2017: IEEE Transactions on Applied Superconductivity: a Publication of the IEEE Superconductivity Committee
https://www.readbyqxmd.com/read/28919150/in-vitro-anti-tuberculosis-activity-of-azole-drugs-against-mycobacterium-tuberculosis-clinical-isolates
#6
Belén R Imperiale, Ángel A Cataldi, Nora S Morcillo
BACKGROUND: Latent tuberculosis has been associated with the persistence of dormant Mycobacterium tuberculosis in the organism of infected individuals, who are reservoirs of the bacilli and the source for spreading the disease in the community. New active anti-TB drugs exerting their metabolic action at different stages and on latent/dormant bacilli are urgently required to avoid endogenous reactivations and to be part of treatments of multi- and extensively-drug resistant tuberculosis (M/XDR-TB)...
September 14, 2017: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/28917705/long-term-retention-of-ecm-hydrogel-after-implantation-into-a-sub-acute-stroke-cavity-reduces-lesion-volume
#7
Harmanvir Ghuman, Madeline Gerwig, Francesca J Nicholls, Jessie Liu, Julia Donnelly, Stephen F Badylak, Michel Modo
Salvaging or functional replacement of damaged tissue caused by stroke in the brain remains a major therapeutic challenge. In situ gelation and retention of a hydrogel bioscaffold composed of 8 mg/mL extracellular matrix (ECM) can induce a robust invasion of cells within 24 hours and potentially promote a structural remodeling to replace lost tissue. Herein, we demonstrate a long-term retention of ECM hydrogel within the lesion cavity. A decrease of approximately 32% of ECM volume is observed over 12 weeks...
September 13, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28917232/compressed-food-with-added-functional-oligopeptides-improves-performance-during-military-endurance-training
#8
Zhi-Qiang Zheng, Zhan-Hui Geng, Jia-Xi Liu, Shun-Tang Guo
BACKGROUND AND OBJECTIVES: Oligosaccharide or oligopeptide supplementation may have a significant impact on endurance performance. This study evaluated the effects of adding maltooligosaccharides (MO) or soy oligopeptides (SO) to compressed food (CF) on the physical response of soldiers to daily military training. METHODS AND STUDY DESIGN: Twelve soldiers were randomized to four diet groups: regular meals, CF, CFMO, and CFSO (crossover design). They participated in exercise tests including 90 minutes running at 55-65% VO2max and exhaustive running...
2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28917081/evaluation-of-the-ecstasy-influence-on-tramadol-and-its-main-metabolite-plasma-concentration-in-rats
#9
Bardia Jamali, Behjat Sheikholeslami, Yalda Hosseinzadeh Ardakani, Hoda Lavasani, Mohammad-Reza Rouini
BACKGROUND: Tramadol is prone to be abused alone, or in combination with 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy). It was reported that 95% of people with a history of substance abuse in the United States used tramadol in 2004. According to the WHO report in 2016, there was a growing number of tramadol abusers alone or in combination with psychoactive substances such as MDMA in particular in some Middle East countries. Higher concentrations of tramadol in plasma may lead to adverse drug reactions or lethal intoxication...
September 16, 2017: Drug Metabolism and Personalized Therapy
https://www.readbyqxmd.com/read/28915973/compassionomics-hypothesis-and-experimental-approach
#10
Stephen Trzeciak, Brian W Roberts, Anthony J Mazzarelli
Recent reports indicate that healthcare is experiencing a compassion crisis - an absence of (or inconsistency in) compassionate patient care. It is currently unclear if, or to what extent, this exerts significant effects on health and healthcare. Experimental data are few, and this represents a critical knowledge gap for all health sciences. We hypothesize that compassionate care is beneficial for patients (better outcomes), healthcare systems and payers (lower costs), and healthcare providers (lower burnout)...
September 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28915535/isoquercetin-ameliorated-hypoxia-reoxygenation-induced-h9c2-cardiomyocyte-apoptosis-via-a-mitochondrial-dependent-pathway
#11
Heng Cao, Hao Xu, Guoqing Zhu, Shaowen Liu
Isoquercetin exerts multiple pharmacological effects against various diseases. The present research sought to further investigate the role of isoquercetin in hypoxia/reoxygenation (H/R)-treated cardiomyocytes and its potential mechanism involved. The H/R model in H9C2 cells was established to mimic myocardial I/R injury in vitro. Cell proliferation and apoptosis were tested using MTT assay and Annexin V FITC-PI staining assay, respectively. We found that isoquercetin protected H9C2 cells from H/R-induced injury as the evidences that isoquercetin administration attenuated the effects of H/R treatment on H9C2 cell viability, cell apoptosis and ROS generation after H/R treatment...
September 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28914466/supramolecular-hydro-and-ionogels-a-study-of-their-properties-and-antibacterial-activity
#12
Carla Rizzo, Rossella Arrigo, Nadka Tz Dintcheva, Giuseppe Gallo, Francesco Giannici, Renato Noto, Alberto Sutera, Paola Vitale, Francesca D'Anna
Diimidazolium-based organic salts, bearing peptides or aminoacids as anions, have been synthesized and tested for their gelling ability in biocompatible solvents. These low molecular weight salts were successfully used as gelators in phosphate saline buffer and ionic liquids. Then, properties of obtained soft materials were analyzed in terms of melting temperature and gel strength as accounted for by rheological investigation. Gel phase formation was studied using UV-vis and resonance light scattering measurements, whereas morphology of soft materials was analysed using polarized optical microscopy and scanning electron microscopy...
September 15, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28913947/extreme-chromosome-17-copy-number-instability-is-a-prognostic-factor-in-patients-with-gastroesophageal-adenocarcinoma-a-retrospective-cohort-study
#13
Jacqueline E Birkness, Neal G Spada, Caitlyn Miller, James D Luketich, Katie S Nason, Weijing Sun, Jon M Davison
Gastric and esophageal cancers frequently show genomic instability and aneuploidy. Chromosomal copy number instability (CIN) is a form of genomic instability that exerts pleiotropic effects on cellular biology and is a source of genetic heterogeneity in a population of cells. CIN results in cell-to-cell variation in chromosome copy number which can be detected and quantified by fluorescence in situ hybridization (FISH). CIN is a biomarker associated with differential response to a number of chemotherapy compounds...
September 14, 2017: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/28913643/does-oxytocin-lead-to-emotional-interference-during-a-working-memory-paradigm
#14
Marieke S Tollenaar, M Ruissen, B M Elzinga, E R A de Bruijn
BACKGROUND: Oxytocin administration may increase attention to emotional information. We hypothesized that this augmented emotional processing might in turn lead to interference on concurrent cognitive tasks. To test this hypothesis, we examined whether oxytocin administration would lead to heightened emotional interference during a working memory paradigm. Additionally, moderating effects of childhood maltreatment were explored. METHODS: Seventy-eight healthy males received 24 IU of intranasal oxytocin or placebo in a randomized placebo-controlled double-blind between-subjects study...
September 14, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28912778/neuroprotective-effects-of-annexin-a1-tripeptide-after-deep-hypothermic-circulatory-arrest-in-rats
#15
Zhiquan Zhang, Qing Ma, Bijal Shah, G Burkhard Mackensen, Donald C Lo, Joseph P Mathew, Mihai V Podgoreanu, Niccolò Terrando
Resolution agonists, including lipid mediators and peptides such as annexin A1 (ANXA1), are providing novel approaches to treat inflammatory conditions. Surgical trauma exerts a significant burden on the immune system that can affect and impair multiple organs. Perioperative cerebral injury after cardiac surgery is associated with significant adverse neurological outcomes such as delirium and postoperative cognitive dysfunction. Using a clinically relevant rat model of cardiopulmonary bypass (CPB) with deep hypothermic circulatory arrest (DHCA), we tested the pro-resolving effects of a novel bioactive ANXA1 tripeptide (ANXA1sp) on neuroinflammation and cognition...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28911142/deficient-endogenous-glucose-production-during-exercise-after-total-pancreatectomy-islet-autotransplantation
#16
Lindsey D Bogachus, Elizabeth Oseid, Melena Bellin, Adrian Vella, R Paul Robertson
Context: Total pancreatectomy followed by intrahepatic islet autotransplantation (TP/IAT) is performed to alleviate severe, unrelenting abdominal pain caused by chronic pancreatitis, to improve quality of life, and to prevent diabetes. Objective: To determine the cause of exercise-induced hypoglycemia that is a common complaint in TP/IAT recipients. Design: Participants completed 1 hour of steady-state exercise. Setting: Hospital research unit...
September 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28911106/unencumbered-pol-%C3%AE-lyase-activity-in-nucleosome-core-particles
#17
Yesenia Rodriguez, Michael J Howard, Matthew J Cuneo, Rajendra Prasad, Samuel H Wilson
Packaging of DNA into the nucleosome core particle (NCP) is considered to exert constraints to all DNA-templated processes, including base excision repair where Pol β catalyzes two key enzymatic steps: 5'-dRP lyase gap trimming and template-directed DNA synthesis. Despite its biological significance, knowledge of Pol β activities on NCPs is still limited. Here, we show that removal of the 5'-dRP block by Pol β is unaffected by NCP constraints at all sites tested and is even enhanced near the DNA ends. In contrast, strong inhibition of DNA synthesis is observed...
September 6, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28910788/uremia-retention-molecules-and-clinical-outcomes
#18
Fellype Carvalho Barreto, Daniela Veit Barreto, Maria Eugênia Fernandes Canziani
Chronic kidney disease is characterized by the accumulation of organic compounds in the bloodstream that may exert a variety of toxic effects in the body. These compounds, collectively known as uremic toxins, may be classified according to their physicochemical properties as free water-soluble low molecular weight molecules, middle molecules or protein-bound uremic toxins. Most of these retention molecules, due to either their size and/or binding to protein, constitute a complex therapeutic challenge to the nephrologist, particularly in end-stage renal disease, because of their limited removal by conventional dialysis therapies...
2017: Contributions to Nephrology
https://www.readbyqxmd.com/read/28906487/identification-of-11-13-dehydroivaxillin-as-a-potent-therapeutic-agent-against-non-hodgkin-s-lymphoma
#19
Xinhua Xiao, Huiliang Li, Huizi Jin, Jin Jin, Miao Yu, Chunmin Ma, Yin Tong, Li Zhou, Hu Lei, Hanzhang Xu, Weidong Zhang, Wei Liu, Yingli Wu
Despite great advancements in the treatment of non-Hodgkin lymphoma (NHL), sensitivity of different subtypes to therapy varies. Targeting the aberrant activation NF-κB signaling pathways in lymphoid malignancies is a promising strategy. Here, we report that 11(13)-dehydroivaxillin (DHI), a natural compound isolated from the Carpesium genus, induces growth inhibition and apoptosis of NHL cells. Multiple signaling cascades are influenced by DHI in NHL cells. PI3K/AKT and ERK are activated or inhibited in a cell type dependent manner, whereas NF-κB signaling pathway was inhibited in all the NHL cells tested...
September 14, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28906467/underlying-physics-of-conductive-polymer-composites-and-force-sensing-resistors-fsrs-under-static-loading-conditions
#20
Leonel Paredes-Madrid, Carlos A Palacio, Arnaldo Matute, Carlos A Parra Vargas
Conductive polymer composites are manufactured by randomly dispersing conductive particles along an insulating polymer matrix. Several authors have attempted to model the piezoresistive response of conductive polymer composites. However, all the proposed models rely upon experimental measurements of the electrical resistance at rest state. Similarly, the models available in literature assume a voltage-independent resistance and a stress-independent area for tunneling conduction. With the aim of developing and validating a more comprehensive model, a test bench capable of exerting controlled forces has been developed...
September 14, 2017: Sensors
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