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https://www.readbyqxmd.com/read/28534951/contribution-of-methylglyoxal-to-delayed-healing-of-bone-injury-in-diabetes
#1
Takao Aikawa, Hidenori Matsubara, Shuhei Ugaji, Junichi Shirakawa, Ryoji Nagai, Seiichi Munesue, Ai Harashima, Yasuhiko Yamamoto, Hiroyuki Tsuchiya
Patients with diabetes are vulnerable to delayed bone fracture healing or pseudoarthrosis. Chronic sustained hyperglycemia, reactive intermediate derivatives of glucose metabolism, such as methylglyoxal (MGO), and advanced glycation end‑products (AGEs) are implicated in diabetic complications. In the present study, it was examined whether MGO is able to cause disturbed bone healing in diabetes. Diabetes was induced in male mice by injection of streptozotocin (50 mg/kg) for 5 days. A bone defect (1.0‑mm diameter) was created in the left distal femur, and bone repair was assessed from an examination of computed tomography scans...
May 16, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28534298/formulation-and-in-vitro-characterization-of-bioactive-mesoporous-silica-with-doxorubicin-and-metronidazole-intended-for-bone-treatment-and-regeneration
#2
Katarzyna Czarnobaj, Magdalena Prokopowicz, Wiesław Sawicki
The purpose of this study was to evaluate the surface mineralization activity and in vitro drug behavior potential of two forms of mesoporous silica: powder and granulate. Ordered mesoporous SiO2 powder was synthesized by surfactant-assisted sol-gel process using tetraethoxysilane as a silica precursor and hexadecyltrimethylammonium bromide as the structure-directing agent. The granulate was prepared using silica powder and ethyl cellulose as a binding agent. Metronidazole (MT)-an anti-inflammatory substance and doxorubicin hydrochloride (ChD)-an anti-cancer drug were chosen as drug models for delivery studies...
May 22, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28534146/detection-of-glass-particles-on-bone-lesions-using-sem-eds
#3
Romain Montoriol, Céline Guilbeau-Frugier, Elodie Chantalat, Mathieu Roumiguié, Marie-Bernadette Delisle, Bruno Payré, Norbert Telmon, Frédéric Savall
The problem of identifying the wounding agent in forensic cases is recurrent. Moreover, when several tools are involved, distinguishing the origin of lesions can be difficult. Scanning electron microscopy (SEM)/energy dispersive X-ray analysis (EDS) equipment is increasingly available to the scientific and medical community, and some studies have reported its use in forensic anthropology. However, at our knowledge, no study has reported the use of SEM-EDS in forensic cases involving glass tools, whether in case reports or experiments...
May 23, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28533938/radionuclide-bone-scan-spect-ct-lowering-the-dose-of-ct-significantly-reduces-radiation-dose-without-impacting-ct-image-quality
#4
Sandeep Kumar Gupta, Scott Trethewey, Bree Brooker, Natalie Rutherford, Jenny Diffey, Suresh Viswanathan, John Attia
The CT component of SPECT-CT is required for attenuation correction and anatomical localization of the uptake on SPECT but there is no guideline about the optimal CT acquisition parameters. In our department, a standard CT acquisition protocol was changed in 2013 to give lower radiation dose to the patient. In this study, we retrospectively compared the effects on patient dose as well as the CT image quality with current versus older CT protocols. Ninety nine consecutive patients [n=51 Standard dose 'old' protocol (SDP); n=48 lower dose 'new' protocol (LDP)] with lumbar spine SPECT-CT for bone scan were examined...
2017: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28533650/extensive-visceral-calcification-demonstrated-on-99m-tc-mdp-bone-scan-in-patient-with-carcinoma-penis-and-hypercalcemia-of-malignancy
#5
Sunny J Gandhi, Bhavdeep Rabadiya
Hypercalcemia is a common life-threatening complication associated with several malignancies. Parathyroid-related peptide has been shown to cause hypercalcemia in several solid tumors but rarely in penile cancer. We report a case of penile cancer with hypercalcemia causing metastatic visceral calcification in lungs, liver, and stomach detected on bone scan without significant abnormalities on CT scan.
April 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/28532096/preparation-of-nanocrystalline-forsterite-by-combustion-of-different-fuels-and-their-comparative-in-vitro-bioactivity-dissolution-behaviour-and-antibacterial-studies
#6
Rajan Choudhary, Prasanth Manohar, Jana Vecstaudza, Maria Josefa Yáñez-Gascón, Horacio Pérez Sánchez, Ramesh Nachimuthu, Janis Locs, Sasikumar Swamiappan
This study presents different fuels (Glycine and Urea) that can be used to synthesize nanocrystalline forsterite by the sol-gel combustion method. The weight change of precursor during thermal treatment was studied by thermo-gravimetric analysis (TGA). Pure forsterite was characterized by heating microscopy, Fourier transform infrared spectroscopy, X-ray Diffraction, Brunauer-Emmett-Teller, Scanning Electron Microscopy, and Energy dispersive X-ray spectroscopy. The HAP (hydroxyapatite) deposition ability, degradation and dissolution behaviour of forsterite was examined in simulated body fluid (SBF)...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532092/cytocompatibility-studies-of-titania-doped-calcium-borosilicate-bioactive-glasses-in-vitro
#7
Rajkumar Samudrala, Abdul Azeem P, Vasudevarao Penugurti, Bramanandam Manavathi
The present study aims to elucidate the applications of Titania (TiO2) doped calcium borosilicate glass as a biocompatible material in regenerative orthopedic applications. In this context, we have examined the bioactivity of various concentrations of TiO2 doped glasses with the help of simulated body fluid (SBF). Cytocompatibility, cell proliferation, and protein expression studies revealed the potential candidature of TiO2 doped glasses on osteoblast cell lines (MG-63). We hypothesized that TiO2 doped calcium borosilicate glasses are most cytocompatible material for bone implants...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532085/mesoporous-nano-bioglass-designed-for-the-release-of-imatinib-and-in-vitro-inhibitory-effects-on-cancer-cells
#8
Muhammad Shoaib, Aamer Saeed, Muhammad Saif Ur Rahman, Muhammad Moazzam Naseer
For treating bone cancer, controlled drug delivery is an important strategy. Bioactive scaffolds are widely used biomaterials due to their usefulness in localized drug delivery. The aim of this study was to develop mesoporous bioglass (MBG) with improved bioactivity and controllable drug delivery rate. By using pluronic 123 (P123) as a template, a facile sol-gel route was employed for the synthesis of MBG nanoparticles (NPs). The composition of the prepared sample was estimated by using energy dispersive X-ray spectroscopy (EDX)...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532060/design-and-characterization-of-biodegradable-macroporous-hybrid-inorganic-organic-polymer-for-orthopedic-applications
#9
Sunita PremVictor, Jibin Kunnumpurathu, M G Gayathri Devi, K Remya, Vineeth M Vijayan, Jayabalan Muthu
We have engineered hybrid polymer products based on a hybrid inorganic-organic comacromer consisting of hydroxyapatite (HA), carboxyl terminated polypropylene fumarate (CTPPF), PEG300 and ascorbic acid (AA) as a bone graft material. The integration and the spatial distribution of HA in the polymer backbone were facilitated by silanisation and 1-ethyl-3-(-3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) coupling technique. These comacromers and crosslinked polymer products were characterized by Fourier transform infrared spectroscopy (FTIR), Nuclear magnetic resonance (NMR), Scanning electron microscopy (SEM) and Raman mapping techniques...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532015/effect-of-sintering-temperature-rise-from-870-to-920%C3%A2-c-on-physicomechanical-and-biological-quality-of-nano-hydroxyapatite-an-explorative-multi-phase-experimental-in-vitro-vivo-study
#10
Ahad Khoshzaban, Vahid Rakhshan, Farhood Najafi, Leila Aghajanpour, Seyed Jafar Hashemian, Saeed Heidari Keshel, Ikuya Watanabe, Alireza Valanezhad, Tahereh Sadat Jafarzadeh Kashi
Hydroxyapatite (HA) is a proper scaffold for bone repair, however, it is not of excellent mechanical properties. Most previous studies on the effect of temperature increases were in vitro and had assessed merely improvements of HA's physicomechanical quality. This in vitro/vivo study investigated the effect of temperature increases from 870 to 920°C on physicomechanical and biological quality of Nano-HA. Forty experimentally produced HA disks sintered at 870 to 920°C were prepared (n=20×2). Disks were subjected to Vickers microindentation test (1 disk from each group divided into 4 quarters), Fourier transform infrared spectroscopy (1 disk), X-ray diffraction (XRD) [1 disk together with non-sintered HA], field emission scanning electron microscopy (FSEM, 1 disk from each group together with non-sintered HA), cell seeding and SEM assessment (2 disks), MTT assay over 4 different time periods (16 quadrants of 4 disks from each group), 6 one-thirds of 2 disks from each group for immunocytochemical (ICC) assay, and 8 disks from each group [as well as non-sintered HA] for the animal study (implantation in 4 sockets in 8 rabbits [32 specimens], histomorphometry, and computerized tomography) over two time periods...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28531974/biomimetic-collagen-phospholipid-coatings-improve-formation-of-hydroxyapatite-nanoparticles-on-titanium
#11
Gilia C M Ruiz, Marcos A E Cruz, Amanda N Faria, Daniela C Zancanela, Pietro Ciancaglini, Ana P Ramos
Osseointegration between the surface of a certain material and the host tissue helps to evaluate the potential use of biomaterials in bone replacement. The physicochemical properties and biochemical composition of the material's surface regulates osseointegration. This study investigates how collagen into biomimetic matrixes affects hydroxyapatite (HAp) growth. Collagen was inserted into insoluble Langmuir monolayers containing either 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC) or octadecylphosphonic acid (OPA) and transferred to titanium (Ti) supports by means of the Langmuir-Blodgett (LB) technique...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28531940/contusional-cerebellar-hemorrhage-related-to-placement-in-the-protrusion-position-after-atlantoaxial-fusion
#12
Yoshinari Miyaoka, Mikinobu Takeuchi, Norimitsu Wakao, Masahiro Aoyama, Kazuhiro Hongo, Masakazu Takayasu
BACKGROUND: Various complications after C1 lateral mass and C2 pedicle screw fusion surgery (C1LM-C2PSFS) have been reported. However, to our knowledge, this is the first report of contusional cerebellar hemorrhage caused by placement in the protrusion (chin-out) position after C1LM-2PSFS. CASE DESCRIPTION: An 81-year-old woman complaining of gait disturbance and clumsiness of both hands was diagnosed with cervical myelopathy with atlantoaxial subluxation. After we performed C1LM-C2PSFS, her neurologic deficits gradually improved, and there was no radiologic evidence of construct failure...
May 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28529633/noninvasive-assessment-of-elimination-and-retention-using-ct-fmt-and-kinetic-whole-body-modeling
#13
Wa'el Al Rawashdeh, Simin Zuo, Andrea Melle, Lia Appold, Susanne Koletnik, Yoanna Tsvetkova, Nataliia Beztsinna, Andrij Pich, Twan Lammers, Fabian Kiessling, Felix Gremse
Fluorescence-mediated tomography (FMT) is a quantitative three-dimensional imaging technique for preclinical research applications. The combination with micro-computed tomography (µCT) enables improved reconstruction and analysis. The aim of this study is to assess the potential of µCT-FMT and kinetic modeling to determine elimination and retention of typical model drugs and drug delivery systems. We selected four fluorescent probes with different but well-known biodistribution and elimination routes: Indocyanine green (ICG), hydroxyapatite-binding OsteoSense (OS), biodegradable nanogels (NG) and microbubbles (MB)...
2017: Theranostics
https://www.readbyqxmd.com/read/28528791/microct-based-finite-element-models-as-a-tool-for-virtual-testing-of-cortical-bone
#14
Masoud Ramezanzadehkoldeh, Bjørn H Skallerud
The aim of this study was to assess a virtual biomechanics testing approach purely based on microcomputed tomography (microCT or µCT) data, providing non-invasive methods for determining the stiffness and strength of cortical bone. Mouse femurs were µCT scanned prior to three-point-bend tests. Then microCT-based finite element models were generated with spatial variation in bone elastoplastic properties and subject-specific femur geometries. Empirical relationships of density versus Young's moduli and yield stress were used in assigning elastoplastic properties to each voxel...
May 18, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28528264/baseline-and-longitudinal-variability-of-normal-tissue-uptake-values-of-18-f-fluorothymidine-pet-images
#15
Matthijs C F Cysouw, Gerbrand M Kramer, Virginie Frings, Adrianus J De Langen, Mariëlle J Wondergem, Laura M Kenny, Eric O Aboagye, Carsten Kobe, Jürgen Wolf, Otto S Hoekstra, Ronald Boellaard
PURPOSE: [(18)F]-fluorothymidine ([(18)F]-FLT) is a PET-tracer enabling in-vivo visualization and quantification of tumor cell proliferation. For qualitative and quantitative analysis, adequate knowledge of normal tissue uptake is indispensable. This study aimed to quantitatively investigate baseline tracer uptake of blood pool, lung, liver and bone marrow and their precision, and to assess the longitudinal effect of systemic treatment on biodistribution. METHODS: (18)F-FLT-PET(/CT) scans (dynamic or static) of 90 treatment-naïve oncological patients were retrospectively evaluated...
May 10, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28527187/quantitative-stereological-analysis-of-the-highly-porous-hydroxyapatite-scaffolds-using-x-ray-cm-and-sem
#16
Justyna Zygmuntowicz, Aneta Zima, Joanna Czechowska, Karol Szlazak, Anna Ślosarczyk, Katarzyna Konopka
BACKGROUND: Material properties of the scaffolds as well as their microstructure are vital in determining in vivo cellular response. Three-dimensional (3D), highly porous scaffolds are used in tissue engineering to provide a suitable microenvironment and to support regeneration of bone. Both pore sizes and their architecture, in particular interconnection density, impact functionality of scaffold during its biomedical applications. OBJECTIVE: In this paper a comparative study of the microstructure of highly porous hydroxyapatite scaffolds produced via gelcasting of foamed slurries and replication of polyurethane sponge were carried out...
2017: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/28526418/prevalence-of-measurable-disease-in-metastatic-castration-resistant-prostate-cancer
#17
Guru Sonpavde, Ankit Madan, Mary K Baker, Jori E May, Gurudatta Naik, Sejong Bae
BACKGROUND: Because of the low historical prevalence of measurable disease in metastatic castration-resistant prostate cancer (mCRPC), phase II trials have used prostate-specific antigen (PSA) and bone scan changes as primary end points. Frequent whole-body imaging and improved computed tomography technology currently identify measurable disease more frequently, warranting consideration of objective response as a major end point. PATIENTS AND METHODS: Data from reported phase III trials of mCRPC were analyzed...
April 26, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28526235/zero-echo-time-mri-only-treatment-planning-for-radiation-therapy-of-brain-tumors-after-resection
#18
C Boydev, B Demol, D Pasquier, H Saint-Jalmes, G Delpon, N Reynaert
Using magnetic resonance imaging (MRI) as the sole imaging modality for patient modeling in radiation therapy (RT) is a challenging task due to the need to derive electron density information from MRI and construct a so-called pseudo-computed tomography (pCT) image. We have previously published a new method to derive pCT images from head T1-weighted (T1-w) MR images using a single-atlas propagation scheme followed by a post hoc correction of the mapped CT numbers using local intensity information. The purpose of this study was to investigate the performance of our method with head zero echo time (ZTE) MR images...
May 16, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28525774/development-and-validation-of-a-physical-model-to-investigate-the-biomechanics-of-infant-head-impact
#19
M Jones, D Darwall, G Khalid, R Prabhu, A Kemp, O Arthurs, P Theobald
Head injury in childhood is the single most common cause of death or permanent disability from injury. However, despite its frequency and significance, there is little understanding of the response of a child's head to injurious loading. This is a significant limitation when making early diagnoses, informing clinical and/or forensic management or injury prevention strategies. With respect to impact vulnerability, current understanding is predominantly based on a few post-mortem-human-surrogate (PMHS) experiments...
April 13, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28525684/223ra-dichloride-response-in-a-patient-with-paget-disease-and-bone-metastases-secondary-to-castration-resistant-prostate-cancer
#20
Lina García Cañamaque, Cristina Rioja Parada, Paloma García De la Peña
PURPOSE: Paget disease is commonly asymptomatic and discovered when an imaging test is performed for another clinical indication or when elevated serum alkaline phosphatase is found. Bone pain usually appears late in the disease process and is only present in a minority of patients. For diagnosis, X-ray and bone scan are the most recommended imaging methods; radionuclide imaging of the skeleton has become the standard, since it is the most sensitive test for detecting increased bone activity...
May 18, 2017: Tumori
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