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Radiation dose measurements

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https://www.readbyqxmd.com/read/29149496/predictive-factors-for-osteoradionecrosis-of-the-jaws-a-retrospective-study
#1
Hans P Sathasivam, Gareth R Davies, Nicholas M Boyd
BACKGROUND: Osteoradionecrosis of the jaw (ORNJ) is a well-recognized complication of radiotherapy. The purpose of this study was to assess predictive factors for the development of ORNJ. METHODS: A retrospective study of 325 patients with head and neck squamous cell carcinoma (HNSCC) treated at one institution between January 1, 1999, and December 31, 2008, was conducted. Outcome measure was the presence/absence of ORNJ. Time to event was recorded and Cox proportional hazard regression analysis was used to determine statistically significant predictive factors...
November 17, 2017: Head & Neck
https://www.readbyqxmd.com/read/29149420/blood-clearance-and-occupational-exposure-for-177-lu-dotatate-compared-to-177-lu-psma-radionuclide-therapy
#2
Mohammad Abuqbeitah, Mustafa Demir, Lebriz Uslu-Beşli, Nami Yeyin, Kerim Sönmezoğlu
The main target of this work is to examine blood clearance and external exposure for (177)Lu-DOTATATE compared with new emerging (177)Lu-PSMA therapy. Blood clearance and radiation exposure of 31 patients treated with 5.5 ± 1.1 GBq (177)Lu-DOTATATE were compared to those of 23 patients treated with 7.4 GBq (177)Lu-PSMA. Dose rates were measured at several distances and time points up to 120 h after treatment. Blood samples were collected conjunctively after infusion. Caregiver's cumulative dose was measured by means of an OSL (optically stimulated luminescence) dosimeter for 4-5 days and medical staff's dose was also estimated using electronic personal dosimeters...
November 17, 2017: Radiation and Environmental Biophysics
https://www.readbyqxmd.com/read/29149320/organic-scintillator-for-real-time-neutron-dosimetry
#3
Kyle A Beyer, Angela Di Fulvio, Liliana Stolarczyk, Wiktor Parol, Natalia Mojzeszek, Renata Kopéc, Shaun D Clarke, Sara A Pozzi
We developed a radiation detector based on an organic scintillator for spectrometry and dosimetry of out-of-field secondary neutrons from clinical proton beams. The detector consists of an EJ-299-34 crystalline organic scintillator, coupled by fiber optic cable to a silicon photomultiplier (SiPM). Proof of concept measurements were taken with 137Cs and 252Cf, and corresponding simulations were performed in MCNPX-PoliMi. Despite its small size, the detector is able to discriminate between neutron and gamma-rays via pulse shape discrimination...
November 15, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29145639/assessment-of-intake-according-to-ideas-guidance-case-study
#4
A Bitar, M Maghrabi
Estimation of radiation intake and internal dose can be carried out through direct or indirect measurements during routine or special monitoring program. In case of Iodine-131 contamination, direct measurements, such as thyroid counting, are fast and efficient to give quick results. Generally, the calculation method implements suitable values for known parameters whereas default values are used if no information is available. However, in view to avoid significant discrepancies, IDEAS guidelines put in route a comprehensive method to evaluate the monitoring data for one and different types of monitoring...
November 14, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29141779/five-field-imrt-class-solutions-and-dosimetric-planning-guidelines-for-implementing-accelerated-partial-breast-irradiation
#5
Sarah Quirk, Petra Grendarova, Michael Roumeliotis
PURPOSE: A comprehensive set of planning guidelines was developed to aid in achieving reproducible dosimetric results for external beam accelerated partial breast irradiation (APBI). The methodology for the development of class solutions for dosimetric planning of the APBI technique, including dose constraint recommendations, is presented for target coverage and conformity as well as normal tissues. METHODS AND MATERIALS: A conservative patient setup was simulated on a linear accelerator, and a comprehensive arrangement of gantry and couch angles was measured for clearance...
September 28, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29141658/thioredoxin-mitigates-radiation-induced-hematopoietic-stem-cell-injury-in-mice
#6
Pasupathi Sundaramoorthy, Qinhong Wang, Zhihong Zheng, Yiqun Jiao, Benny J Chen, Phuong L Doan, Nelson J Chao, Yubin Kang
BACKGROUND: Radiation exposure poses a significant threat to public health. Hematopoietic injury is one of the major manifestations of acute radiation sickness. Protection and/or mitigation of hematopoietic stem cells (HSCs) from radiation injury is an important goal in the development of medical countermeasure agents (MCM). We recently identified thioredoxin (TXN) as a novel molecule that has marked protective and proliferative effects on HSCs. In the current study, we investigated the effectiveness of TXN in rescuing mice from a lethal dose of total body radiation (TBI) and in enhancing hematopoietic reconstitution following a lethal dose of irradiation...
November 15, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29140505/the-nrpi-multi-purpose-on-line-monitoring-station-for-measurement-of-natural-radioactivity-in-the-ambient-atmosphere-and-in-the-soil
#7
K Jílek, M Slezáková, A Fronka, T Prokop, L Neubauer
During years 2010-12 an automated, on-line and wireless outdoor measurement station of atmospheric radon, gamma dose rate and meteorological parameters was realised at the National Radiation Protection Institute (NRPI) in Prague. At the turn of the year 2013 an expansion of the existing station was completed. Under the project funded by the Czech Technological Agency a new updated station was established, additionally equipped with modules for measurement of atmospheric radon/thoron short-lived decay products, radon in water and soil and radon exhalation rate from soil...
November 13, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29140117/comparison-of-radiation-dose-and-image-quality-of-abdominopelvic-ct-using-iterative-aidr-3d-and-conventional-reconstructions
#8
Caroline Duarte de Mello-Amoedo, Aparecido Nakano Martins, Adriano Tachibana, Daniella Ferraro Pinho, Ronaldo Hueb Baroni
OBJECTIVE: The purpose of this study is to compare radiation dose and image quality of abdominopelvic CT studies reconstructed with iterative and conventional techniques. MATERIALS AND METHODS: This retrospective study enrolled 99 patients who underwent abdominopelvic CT examinations with the portal venous phase images reconstructed with both filtered back projection and Adaptive Iterative Dose Reduction 3D (AIDR 3D) at different time points. Subjective assessment of image quality was performed by two radiologists who scored axial images for overall quality, sharpness, noise, and acceptability in a blinded fashion...
November 15, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29139310/pudendal-nerve-injury-impairs-anorectal-function-and-health-related-quality-of-life-measures-%C3%A2-2-years-after-3d-conformal-radiotherapy-for-prostate-cancer
#9
Eng Eric Yeoh, Rochelle Botten, Addolorata Di Matteo, Marcus Tippett, Jonathon Hutton, Robert Fraser, Phillip G Dinning, David Wattchow
PURPOSE: To compare GI symptoms, measures of generic and disease specific health related quality of life (HRQoL), anorectal and pudendal nerve function and anal sphincter morphology between (i) patients ≥2 years after 3D conformal radiotherapy (3D-CRT)±high dose rate (HDR) brachytherapy for carcinoma of the prostate and aged matched patients before radiotherapy and (ii) symptomatic and asymptomatic patients ≥2 years after 3D-CRT ± HDR brachytherapy. MATERIAL AND METHODS: Methodology included: (i) modified LENT-SOMA scales for GI symptoms, (ii) EORTC QLQ-C30 and EORTC QLQ-PR25 questionnaires for generic and disease specific HRQoL, (iii) anorectal manometry and terminal motor latency for anorectal and pudendal nerve function and (iv) endorectal ultrasound for anal sphincter morphology...
November 15, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29137011/a-prospective-observational-study-evaluating-the-efficacy-of-prophylactic-internal-iliac-artery-balloon-catheterization-in-the-management-of-placenta-previa-accreta-a-strobe-compliant-article
#10
Yao Fan, Xun Gong, Nan Wang, Ketao Mu, Ling Feng, Fuyuan Qiao, Suhua Chen, Wanjiang Zeng, Haiyi Liu, Yuanyuan Wu, Qiong Zhou, Yuan Tian, Qiang Li, Meitao Yang, Fanfan Li, Mengzhou He, Rajluxmee Beejadhursing, Dongrui Deng
We studied the efficacy of prophylactic internal iliac artery balloon catheterization for managing severe hemorrhage caused by pernicious placenta previa.This prospective observational study was conducted in Tongji Hospital, Wuhan, China. One hundred sixty-three women past 32-week's gestation with placenta previa-accreta were recruited and managed. Women in the balloon group accepted prophylactic internal iliac artery balloon catheterization before scheduled caesarean delivery and controls had a conventional caesarean delivery...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29136230/high-dose-tl-dosimetry-of-reactor-neutrons
#11
Barbara Obryk, Klaudia Malik, Pawel Bilski, Andrzej Igielski, Jan Dankowski, Arkadiusz Kurowski, Rafal Prokopowicz, Krzysztof Pytel
Radiation dose was measured with set of TL dosimeters during checkout of neutron radiation hardness of the ORTEC preamplifier type 142A in the experiment at the MARIA nuclear reactor at the National Centre for Nuclear Research (NCBJ), Otwock-Świerk, Poland. Different types of LiF-based TL detectors have been used for measurements in order to evaluate neutron and non-neutron components of the radiation field in the reactor channel during exposure and to check their relevancy for dose measurements in the reactor environment...
November 10, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29136218/measurement-of-radiation-doses-to-the-eye-lens-during-orthopedic-surgery-using-an-c-arm-x-ray-system
#12
Akira Suzuki, Kosuke Matsubara, Yuko Sasa
The present study aimed to determine doses delivered to the eye lenses of surgeons while using the inverted-C-arm technique and the protective effect of leaded spectacles during orthopedic surgery. The kerma in air was measured at five positions on leaded glasses positioned near the eye lens and on the neck using small optically stimulated luminescence (OSL) dosemeters. The lens equivalent dose was also measured at the neck using an OSL dosemeter. The maximum equivalent dose to the eye lens and the maximum kerma were 0...
November 10, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29136194/fast-skin-dose-estimation-system-for-interventional-radiology
#13
Takeshi Takata, Jun'ichi Kotoku, Hideyuki Maejima, Shinobu Kumagai, Norikazu Arai, Takenori Kobayashi, Kenshiro Shiraishi, Masayoshi Yamamoto, Hiroshi Kondo, Shigeru Furui
To minimise the radiation dermatitis related to interventional radiology (IR), rapid and accurate dose estimation has been sought for all procedures. We propose a technique for estimating the patient skin dose rapidly and accurately using Monte Carlo (MC) simulation with a graphical processing unit (GPU, GTX 1080; Nvidia Corp.). The skin dose distribution is simulated based on an individual patient's computed tomography (CT) dataset for fluoroscopic conditions after the CT dataset has been segmented into air, water and bone based on pixel values...
November 10, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/29135471/first-patients-treated-with-a-1-5-t-mri-linac-clinical-proof-of-concept-of-a-high-precision-high-field-mri-guided-radiotherapy-treatment
#14
B W Raaymakers, I M Jürgenliemk-Schulz, G H Bol, M Glitzner, A N T J Kotte, B van Asselen, J C J de Boer, J J Bluemink, S L Hackett, M A Moerland, S J Woodings, J W H Wolthaus, H M van Zijp, M E P Philippens, R Tijssen, J G M Kok, E N de Groot-van Breugel, I Kiekebosch, L T C Meijers, C N Nomden, G G Sikkes, P A H Doornaert, W S C Eppinga, N Kasperts, L G W Kerkmeijer, J H A Tersteeg, K J Brown, B Pais, P Woodhead, J J W Lagendijk
The integration of 1.5 T MRI functionality with a radiotherapy linear accelerator (linac) has been pursued since 1999 by the UMC Utrecht in close collaboration with Elekta and Philips. The idea behind this integrated device is to offer unrivalled, online and real-time, soft-tissue visualization of the tumour and the surroundings for more precise radiation delivery. The proof of concept of this device was given in 2009 by demonstrating simultaneous irradiation and MR imaging on phantoms, since then the device has been further developed and commercialized by Elekta...
November 14, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29132682/-biomarkers-of-radiation-induced-dna-repair-processes
#15
REVIEW
Alexis Vallard, Chloé Rancoule, Jean-Baptiste Guy, Sophie Espenel, Sylvie Sauvaigo, Claire Rodriguez-Lafrasse, Nicolas Magné
The identification of DNA repair biomarkers is of paramount importance. Indeed, it is the first step in the process of modulating radiosensitivity and radioresistance. Unlike tools of detection and measurement of DNA damage, DNA repair biomarkers highlight the variations of DNA damage responses, depending on the dose and the dose rate. The aim of the present review is to describe the main biomarkers of radiation-induced DNA repair. We will focus on double strand breaks (DSB), because of their major role in radiation-induced cell death...
November 10, 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/29131773/update-on-cardiovascular-applications-of-multienergy-ct
#16
Kevin Kalisz, Sandra Halliburton, Suhny Abbara, Jonathon A Leipsic, Moritz H Albrecht, U Joseph Schoepf, Prabhakar Rajiah
Advances in scanner technology enabling shorter scan times, improvements in spatial and temporal resolution, and more dose-efficient data reconstruction coupled with rapidly growing evidence from clinical trials have established computed tomography (CT) as an important imaging modality in the evaluation of cardiovascular disorders. Multienergy (or spectral or dual-energy) CT is a relatively recent advance in which attenuation data from different energies are used to characterize materials beyond what is possible at conventional CT...
November 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29131409/field-size-correction-factors-of-a-radiophotoluminescent-glass-dosimeter-for-small-field-and-intensity-modulated-radiation-therapy-beams
#17
Shimpei Hashimoto, Yukio Fujita, Tetsurou Katayose, Hideyuki Mizuno, Hidetoshi Saitoh, Katsuyuki Karasawa
PURPOSE: We evaluated the energy responses of a radiophotoluminescent glass dosimeter (RPLD) to variations in small-field and intensity-modulated radiation therapy (IMRT) conditions using experimental measurements and Monte Carlo simulation. METHODS: Several sizes of the jaw and multileaf collimator fields and various plan-class IMRT-beam measurements were performed using the RPLD and an ionization chamber. The field-size correction factor for the RPLD was determined for 6- and 10-MV X-rays...
November 13, 2017: Medical Physics
https://www.readbyqxmd.com/read/29131343/extracting-wair-from-the-electron-beam-measurements-of-domen-and-lamperti
#18
Frédéric Tessier, Claudiu Dorin Cojocaru, Carl Kenneth Ross
PURPOSE: The average energy expended by an energetic electron to create an ion pair in dry air, Wair, is a key quantity in radiation dosimetry. Although Wair is well established for electron energies up to about 3 MeV there is limited data for higher energies. The measurements by Domen and Lamperti [Med. Phys. 3, 294{301 (1976)] using electron beams in the energy range from 15 to 50 MeV can, in principle, be used to deduce values for Wair, if the electron stopping power of graphite and air are known...
November 13, 2017: Medical Physics
https://www.readbyqxmd.com/read/29128167/a-prospective-evaluation-of-hippocampal-radiation-dose-volume-effects-and-memory-deficits-following-cranial-irradiation
#19
Ting Martin Ma, Jimm Grimm, Riley McIntyre, Heather Anderson-Keightly, Lawrence R Kleinberg, Russell K Hales, Joseph Moore, Tracy Vannorsdall, Kristin J Redmond
BACKGROUND AND PURPOSE: To prospectively evaluate hippocampal radiation dose volume effects and memory decline following cranial irradiation. MATERIAL AND METHODS: Effects of hippocampal radiation over a wide range of doses were investigated by combining data from three prospective studies. In one, adults with small cell lung cancer received hippocampal-avoidance prophylactic cranial irradiation. In the other two, adults with glioblastoma multiforme received neural progenitor cell sparing radiation or no sparing with extra dose delivered to subventricular zone...
November 8, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29128147/using-indocyanine-green-extraction-to-predict-liver-function-after-stereotactic-body-radiation-therapy-for-hepatocellular-carcinoma
#20
Krithika Suresh, Dawn Owen, Latifa Bazzi, William Jackson, Randall K Ten Haken, Kyle Cuneo, Mary Feng, Theodore S Lawrence, Matthew J Schipper
PURPOSE: To test the hypothesis that mid-treatment measures of the retention of indocyanine green after 15 minutes (ICGR15) would improve the prediction of posttreatment liver function in the setting of hepatocellular carcinoma. METHODS AND MATERIALS: Between 2006 and 2015, 144 patients with hepatocellular carcinoma received 175 courses of stereotactic body radiation therapy (SBRT). Patient data, such as age, sex, portal vein thrombosis, cirrhosis, Child-Pugh (CP) score, prior liver-directed therapies, and liver function tests, including albumin-bilirubin (ALBI) and ICG clearance, and dosimetric data, such as tumor volume and radiation dose, were collected...
September 22, 2017: International Journal of Radiation Oncology, Biology, Physics
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