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journal of applied physiology

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https://www.readbyqxmd.com/read/27904147/penile-constitutive-nitric-oxide-synthase-expression-in-rats-exposed-to-unpredictable-chronic-mild-stress-role-of-inflammation
#1
T D Şahin, Y Yazır, T Utkan, S S Göçmez, D Bayramgürler
Chronic psychological stress cause erectile dysfunction (ED). Considering recent evidence that tumor necrosis factor-α (TNF-α) levels are increased in serum of patients with ED, the present study investigated the effects of infliximab (a TNF-α blocker) on endothelial nitric oxide synthase (eNOS) and neuronal NOS (nNOS) immunoreactivity of rat penile corpus cavernosum in unpredictable chronic mild stress (UCMS). Male adult rats were randomly divided into three groups (n=8 per group): Control, UCMS and UCMS+infliximab...
December 1, 2016: International Journal of Impotence Research
https://www.readbyqxmd.com/read/27885692/physiologically-based-pharmacokinetic-model-for-ethyl-tertiary-butyl-ether-and-tertiary-butyl-alcohol-in-rats-contribution-of-binding-to-%C3%AE-2u-globulin-in-male-rats-and-high-exposure-nonlinear-kinetics-to-toxicity-and-cancer-outcomes
#2
Susan J Borghoff, Caroline Ring, Marcy I Banton, Teresa L Leavens
In cancer bioassays, inhalation, but not drinking water exposure to ethyl tertiary-butyl ether (ETBE), caused liver tumors in male rats, while tertiary-butyl alcohol (TBA), an ETBE metabolite, caused kidney tumors in male rats following exposure via drinking water. To understand the contribution of ETBE and TBA kinetics under varying exposure scenarios to these tumor responses, a physiologically based pharmacokinetic model was developed based on a previously published model for methyl tertiary-butyl ether, a structurally similar chemical, and verified against the literature and study report data...
November 24, 2016: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/27885153/karl-otto-landsteiner-1868-1943-physician-biochemist-immunologist
#3
Armond S Goldman, Frank C Schmalsteig
Karl Landsteiner applied the sciences of biochemistry, pathology, microbiology, and immunology in medical research to great success during the first half of the 20th century. Although he is principally known for elucidating the major blood group antigens A and B and their isoantibodies for which he was awarded the Nobel Prize in Physiology or Medicine, Landsteiner made many other important medical discoveries. In that respect, he ascertained that paralytic poliomyelitis was due to a virus, the pancreas was damaged in cystic fibrosis, simple chemicals called haptens were able to combine with antibodies, and the Rh antigen that was later found to be the principal cause of hemolytic anemia of the newborn was found in most humans...
November 24, 2016: Journal of Medical Biography
https://www.readbyqxmd.com/read/27860520/social-life-in-arid-environments-the-case-study-of-cataglyphis-ants
#4
Raphaël Boulay, Serge Aron, Xim Cerdá, Claudie Doums, Paul Graham, Abraham Hefetz, Thibaud Monnin
Unlike most desert-dwelling animals, Cataglyphis ants do not attempt to escape the heat; rather, they apply their impressive heat tolerance to avoid competitors and predators. This thermally defined niche has promoted a range of adaptations both at the individual and colony levels. We have also recently discovered that within the genus Cataglyphis there are incredibly diverse social systems, modes of reproduction, and dispersal, prompting the tantalizing question of whether social diversity may also be a consequence of the harsh environment within which we find these charismatic ants...
November 17, 2016: Annual Review of Entomology
https://www.readbyqxmd.com/read/27832032/accuracy-and-efficiency-of-recording-pediatric-early-warning-scores-using-an-electronic-physiological-surveillance-system-compared-with-traditional-paper-based-documentation
#5
Gerri Sefton, Steven Lane, Roger Killen, Stuart Black, Max Lyon, Pearl Ampah, Cathryn Sproule, Dominic Loren-Gosling, Caitlin Richards, Jean Spinty, Colette Holloway, Coral Davies, April Wilson, Chung Shen Chean, Bernie Carter, E D Carrol
Pediatric Early Warning Scores are advocated to assist health professionals to identify early signs of serious illness or deterioration in hospitalized children. Scores are derived from the weighting applied to recorded vital signs and clinical observations reflecting deviation from a predetermined "norm." Higher aggregate scores trigger an escalation in care aimed at preventing critical deterioration. Process errors made while recording these data, including plotting or calculation errors, have the potential to impede the reliability of the score...
November 9, 2016: Computers, Informatics, Nursing: CIN
https://www.readbyqxmd.com/read/27588539/sources-of-misspecification-bias-in-assessments-of-risks-related-to-alcohol-use
#6
Paul J Gruenewald, Meme Wang-Schweig, Christina Mair
OBJECTIVE: Many different measures of alcohol use are applied in survey-based epidemiological studies of alcohol-related risks. Differences in the selection of drinking measures and alternative specifications of quantitative relationships of these measures to problem outcomes limit researchers' abilities to compare and assess alcohol effects across studies. We used a quantitative definition of drinking patterns to identify relationships among drinking measures and uncover sources of bias in assessments of drinking risks...
September 2016: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/27334280/factors-that-influence-the-performance-of-elite-sprint-cross-country-skiers
#7
Kim Hébert-Losier, Christoph Zinner, Simon Platt, Thomas Stöggl, Hans-Christer Holmberg
BACKGROUND: Sprint events in cross-country skiing are unique not only with respect to their length (0.8-1.8 km), but also in involving four high-intensity heats of ~3 min in duration, separated by a relatively short recovery period (15-60 min). OBJECTIVE: Our aim was to systematically review the scientific literature to identify factors related to the performance of elite sprint cross-country skiers. METHODS: Four electronic databases were searched using relevant medical subject headings and keywords, as were reference lists, relevant journals, and key authors in the field...
June 22, 2016: Sports Medicine
https://www.readbyqxmd.com/read/27125848/the-emergence-of-applied-physiology-within-the-discipline-of-physiology
#8
Charles M Tipton
Despite the availability and utilization of the physiology textbooks authored by Albrecht von Haller during the 18th century that heralded the modern age of physiology, not all physicians or physiologists were satisfied with its presentation, contents, or application to medicine. Initial reasons were fundamental disagreements between the "mechanists," represented by Boerhaave, Robinson, and von Haller, and the "vitalists," represented by the faculty and graduates of the Montpellier School of Medicine in France, notably, Bordeu and Barthez...
August 1, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/26783263/noteworthy-articles-in-2015-for-the-cardiothoracic-anesthesiologist
#9
Dirk J Varelmann, J Daniel Muehlschlegel
Large multicenter, randomized controlled trials published in reputable journals had a large impact on the world of cardiothoracic anesthesia in 2015. We as cardiac anesthesiologists pride ourselves as being experts in applied physiology, physics, ultrasonography, and pharmacology/pharmacotherapy. The selected studies added to our knowledge in the fields of echocardiography, pharmacology, molecular biology, and genetics. Outcome studies shine a light on important topics that are relevant to all cardiac anesthesiologists: does surgical atrial fibrillation ablation during mitral valve surgery reduce the recurrence of atrial fibrillation at 1 year after surgery? Does remote ischemic preconditioning live up to its promise to reduce postoperative major cardiac and cerebral events? Although we still do not have the answer to all the questions, the year 2015 has been a great step toward the goal of understanding molecular mechanisms of ischemic myocardial injury and toward providing evidence-based medicine for improving patient outcome...
March 2016: Seminars in Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/26732374/dermal-bioaccessibility-of-flame-retardants-from-indoor-dust-and-the-influence-of-topically-applied-cosmetics
#10
Gopal Pawar, Mohamed Abou-Elwafa Abdallah, Eugenia Villaverde de Sáa, Stuart Harrad
Despite extensive literature on their potential adverse health effects, there is a lack of information on human dermal exposure to organic flame retardant chemicals (FRs). This study applies an in vitro physiologically based extraction test to provide new insights into the dermal bioaccessibility of various FRs from indoor dust to synthetic sweat/sebum mixture (SSSM). The bioaccessible fractions of α-, β- and γ-hexabromocyclododecane (HBCD) and tetrabromobisphenol A (TBBPA) to 1:1 (sweat/sebum) mixture were 41%, 47%, 50% and 40%, respectively...
January 6, 2016: Journal of Exposure Science & Environmental Epidemiology
https://www.readbyqxmd.com/read/26708189/histochemistry-in-biology-and-medicine-a-message-from-the-citing-journals
#11
REVIEW
Carlo Pellicciari
Especially in recent years, biomedical research has taken advantage of the progress in several disciplines, among which microscopy and histochemistry. To assess the influence of histochemistry in the biomedical field, the articles published during the period 2011-2015 have been selected from different databases and grouped by subject categories: as expected, biological and biomedical studies where histochemistry has been used as a major experimental approach include a wide of basic and applied researches on both humans and other animal or plant organisms...
2015: European Journal of Histochemistry: EJH
https://www.readbyqxmd.com/read/26591003/airway-clearance-techniques-for-bronchiectasis
#12
REVIEW
Annemarie L Lee, Angela T Burge, Anne E Holland
BACKGROUND: People with non-cystic fibrosis bronchiectasis commonly experience chronic cough and sputum production, features that may be associated with progressive decline in clinical and functional status. Airway clearance techniques (ACTs) are often prescribed to facilitate expectoration of sputum from the lungs, but the efficacy of these techniques in a stable clinical state or during an acute exacerbation of bronchiectasis is unclear. OBJECTIVES: Primary: to determine effects of ACTs on rates of acute exacerbation, incidence of hospitalisation and health-related quality of life (HRQoL) in individuals with acute and stable bronchiectasis...
2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26543889/combining-two-dimensional-gel-electrophoresis-and-metabolomic-data-in-support-of-dry-season-survival-in-the-two-main-species-of-the-malarial-mosquito-anopheles-gambiae
#13
K Hidalgo, K Mouline, W Mamai, N Foucreau, K R Dabiré, A Bouchereau, F Simard, D Renault
In dry savannahs of West-Africa, the malarial mosquitoes of the Anopheles gambiae sensu stricto complex annually survive the harsh desiccating conditions of the dry season. However, the physiological and biochemical mechanisms underlying how these mosquitoes survive such desiccating conditions are still undefined, and controversial. In this context, we provide the first work examining both proteomic and metabolomic changes in the two molecular forms of A. gambiae s.s (M and S forms) experimentally exposed to the rainy and dry season conditions as they experience in the field...
December 2015: Data in Brief
https://www.readbyqxmd.com/read/26525577/assessing-the-performance-of-maternity-care-in-europe-a-critical-exploration-of-tools-and-indicators
#14
REVIEW
Ramón Escuriet, Joanna White, Katrien Beeckman, Lucy Frith, Fatima Leon-Larios, Christine Loytved, Ans Luyben, Marlene Sinclair, Edwin van Teijlingen
BACKGROUND: This paper critically reviews published tools and indicators currently used to measure maternity care performance within Europe, focusing particularly on whether and how current approaches enable systematic appraisal of processes of minimal (or non-) intervention in support of physiological or "normal birth". The work formed part of COST Actions IS0907: "Childbirth Cultures, Concerns, and Consequences: Creating a dynamic EU framework for optimal maternity care" (2011-2014) and IS1405: Building Intrapartum Research Through Health - an interdisciplinary whole system approach to understanding and contextualising physiological labour and birth (BIRTH) (2014-)...
2015: BMC Health Services Research
https://www.readbyqxmd.com/read/25942496/sweet-tasting-solutions-for-reduction-of-needle-related-procedural-pain-in-children-aged-one-to-16-years
#15
REVIEW
Denise Harrison, Janet Yamada, Thomasin Adams-Webber, Arne Ohlsson, Joseph Beyene, Bonnie Stevens
BACKGROUND: Extensive evidence exists showing analgesic effects of sweet solutions for newborns and infants. It is less certain if the same analgesic effects exist for children one year to 16 years of age. This is an updated version of the original Cochrane review published in Issue 10, 2011 (Harrison 2011) titled Sweet tasting solutions for reduction of needle-related procedural pain in children aged one to 16 years. OBJECTIVES: To determine the efficacy of sweet tasting solutions or substances for reducing needle-related procedural pain in children beyond one year of age...
2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/25870835/a-bibliometric-analysis-of-publications-on-pluripotent-stem-cell-research
#16
Changshuan L Lin, Yuh-Shan Ho
OBJECTIVE: Human pluripotent stem cells are self-renewing cells with the ability to differentiate into a variety of cells and are viewed to have great potential in the field of regenerative medicine. Research in pluripotent stem cells holds great promise for patient specific therapy in various diseases. In this study, pluripotent stem cell articles published from 1991 to 2012 were screened and retrieved from Science Citation Index Expanded (SCI-EXPANDED). MATERIALS AND METHODS: In this retrospective study, the publication trend, citation trends for top articles, distributions of journals and Web of Science categories were analyzed...
2015: Cell Journal
https://www.readbyqxmd.com/read/25590812/blue-journal-conference-aging-and-susceptibility-to-lung-disease
#17
REVIEW
Victor J Thannickal, Mahadev Murthy, William E Balch, Navdeep S Chandel, Silke Meiners, Oliver Eickelberg, Moisés Selman, Annie Pardo, Eric S White, Bruce D Levy, Paula J Busse, Rubin M Tuder, Veena B Antony, Jacob I Sznajder, G R Scott Budinger
The aging of the population in the United States and throughout the developed world has increased morbidity and mortality attributable to lung disease, while the morbidity and mortality from other prevalent diseases has declined or remained stable. Recognizing the importance of aging in the development of lung disease, the American Thoracic Society (ATS) highlighted this topic as a core theme for the 2014 annual meeting. The relationship between aging and lung disease was discussed in several oral symposiums and poster sessions at the annual ATS meeting...
February 1, 2015: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/25571648/-statistical-analysis-of-papers-in-chinese-journal-of-applied-physiology-from-2009-to-2013
#18
Jing-Ran Sun, Yun-Mei Tian
OBJECTIVE: To analyze the status and papers information of Chinese Journal of Applied Physiology, and provide a guide for authors, readers and editing staffs. METHODS: We retrieved papers of Chinese Journal of Applied Physiology from 2009 to 2013 from CNKI, and performed a statistical analysis of papers information contained in the text using bibliometrics method. Papers information such as document type, found support, author affiliation type, and discipline classification, etc...
September 2014: Chinese Journal of Applied Physiology
https://www.readbyqxmd.com/read/25485723/implementing-a-mobile-stroke-unit-program-in-the-united-states-why-how-and-how-much
#19
Suja S Rajan, Suja Rajan, Sarah Baraniuk, Stephanie Parker, Tzu-Ching Wu, Ritvij Bowry, James C Grotta
IMPORTANCE: There are many ways a mobile stroke unit (MSU) might prove valuable for patients with ischemic and hemorrhagic stroke, such as earlier recognition, more accurate triage, improved management of blood pressure and other critical physiological variables, and eventually earlier implementation of effective therapies. The MSU may be particularly valuable for treatment of patients with acute ischemic stroke with tissue plasminogen activator (tPA) within 4.5 hours of symptom onset, the most evidence-based effective emergency treatment for the most prevalent stroke diagnosis...
February 2015: JAMA Neurology
https://www.readbyqxmd.com/read/25327152/-uterine-torsion-in-cattle-therapy-and-consequences-for-calf-and-cow
#20
REVIEW
E Erteld, J Krohn, I T Dzhakupov, A Wehrend
AIM: To summarize the available literature on the therapy of uterine torsion in cattle and the consequences for cow and calf. MATERIAL AND METHODS: Analysis of the literature using electronic libraries (PubMed, Medline), German veterinary medical journals and obstetrical textbooks. RESULTS: The therapy includes the attempt to rotate the uterus back into its physiological position. Direct and indirect methods of retorsion are available and applied according to the case conditions...
2014: Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere
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