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https://www.readbyqxmd.com/read/29674668/author-correction-exercise-induced-changes-in-cerebrospinal-fluid-mirnas-in-gulf-war-illness-chronic-fatigue-syndrome-and-sedentary-control-subjects
#1
James N Baraniuk, Narayan Shivapurkar
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
April 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29660926/abnormal-rheological-properties-of-red-blood-cells-as-a-potential-marker-of-gulf-war-illness-a-preliminary-study
#2
Michael J Falvo, Yang Chen, Jacquelyn C Klein, Duncan Ndirangu, Michael R Condon
BACKGROUND: Veterans with Gulf War Illness (GWI) experience chronic symptoms that include fatigue, pain, and cognitive impairment. This symptom cluster may be the consequence of impaired tissue oxygen delivery due to red blood cell (RBC) dysfunction. OBJECTIVE: The purpose of this preliminary study was to determine whether the microrheological behavior of RBCs is altered in GWI. METHODS: We recruited 17 cases of GWI (GWI+) and 10 age matched controls (GWI-), and examined RBC deformability and aggregation via ektacytometry along with measurement of complete blood counts...
2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29649711/the-interaction-of-bdnf-val66met-ptsd-and-child-abuse-on-psychophysiological-reactivity-and-hpa-axis-function-in-a-sample-of-gulf-war-veterans
#3
Dmitri A Young, Thomas C Neylan, Aoife O'Donovan, Thomas Metzler, Anne Richards, Jessica A Ross, Sabra S Inslicht
INTRODUCTION: While the BDNF Val66Met polymorphism has been linked to various psychological disorders, limited focus has been on its relationship to posttraumatic stress disorder (PTSD) and early traumas such as child abuse. Therefore, we assessed whether Val66Met was associated with fear potentiated psychophysiological response and HPA axis dysfunction and whether PTSD status or child abuse history moderated these outcomes in a sample of Veterans. METHODS: 226 and 173 participants engaged in a fear potentiated acoustic startle paradigm and a dexamethasone suppression test (DST) respectively...
April 3, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29619588/autoimmune-inflammatory-syndrome-induced-by-mineral-oil-a-health-problem
#4
Olga Vera-Lastra, Gabriela Medina, María Pilar Cruz-Domínguez, Gabriel Medrano Ramírez, Raymundo Benjamin Priego Blancas, Ana Lilia Peralta Amaro, Anabel Villanueva Martínez, Jesús Sepúlveda Delgado, Luis J Jara
Autoimmune/inflammatory syndrome induced by adjuvant (ASIA) includes the following conditions: siliconosis, Gulf War syndrome, macrophagic myofasciitis syndrome, and post-vaccination phenomena. Afterward, other syndromes have been recognized, such as in ASIA by mineral oil (ASIA-MO). These conditions are triggered by adjuvants and they are the result of the interplay of genetic and environmental factors. ASIA-MO is defined as the infiltration of oily type modeling substances for cosmetic purposes. It has been reported in many countries and used surreptitiously...
April 4, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29606907/detecting-chromosome-condensation-defects-in-gulf-war-illness-patients
#5
Guo Liu, Christine J Ye, Saroj K Chowdhury, Batoul Y Abdallah, Steven D Horne, Denise Nichols, Henry H Heng
Background: Gulf War Illness (GWI) impacts 25-30% of gulf war veterans. Due to its heterogeneity in both etiology and symptoms, it has been challenging to establish the commonly accepted case definition for GWI. Equally challenging are the understanding of the general mechanism of GWI and the development of biomarkers useful for its clinical diagnosis and treatment. Objective: We have observed that chromosome condensation defects can be detected in GWI patients...
April 2018: Current Genomics
https://www.readbyqxmd.com/read/29600591/veteran-centred-content-in-medical-education
#6
Paula T Ross, Monica L Lypson
BACKGROUND: Veterans have unique experiences that warrant special consideration in health care. Unfortunately, training in veteran-centred care has not been a clear focus of medical education, and only a very small proportion of medical schools include military cultural competency in their curricula. METHODS: We conducted an 80-minute focus group with six US veterans. Open-ended questions were used to elicit their perceptions of the health care that they receive, and how it can be improved...
March 30, 2018: Clinical Teacher
https://www.readbyqxmd.com/read/29590473/disability-rating-age-at-death-and-cause-of-death-in-u-s-veterans-with-service-connected-conditions
#7
Charles Maynard, Ranak Trivedi, Karin Nelson, Stephan D Fihn
Introduction: The association between disability and cause of death in Veterans with service-connected disabilities has not been studied. The objective of this study was to compare age at death, military service and disability characteristics, including disability rating, and cause of death by year of birth. We also examined cause of death for specific service-connected conditions. Materials and methods: This study used information from the VETSNET file, which is a snapshot of selected items from the Veterans Benefits Administration corporate database...
March 26, 2018: Military Medicine
https://www.readbyqxmd.com/read/29590409/motor-unit-number-estimate-and-isometric-hand-grip-strength-in-military-veterans-with-or-without-muscular-complaints-reference-values-for-longitudinal-follow-up
#8
Mian Li, Wenguo Yao, Cynthia Sundahl
Introduction: It remains unclear if Gulf War (GW) veterans have a higher risk of developing motor neuron disorder. We intended to establish baseline neurophysiological values, including thenar motor unit number estimate (MUNE) and isometric hand grip (IHG) strength, to compare future follow-ups of deployed GW veterans with or without muscular complaints. Materials and Methods: We evaluated 19 GW veterans with self-reported weakness, cramps, or excessive muscle fatigue (Ill-19) and compared them with 18 controls without such muscular complaints (C-18)...
March 26, 2018: Military Medicine
https://www.readbyqxmd.com/read/29576410/the-effects-of-early-trauma-and-the-fkbp5-gene-on-ptsd-and-the-hpa-axis-in-a-clinical-sample-of-gulf-war-veterans
#9
Dmitri A Young, Sabra S Inslicht, Thomas J Metzler, Thomas C Neylan, Jessica A Ross
Previous research indicates that interactions between FKBP5 single nucleotide polymorphisms (SNPs) and child abuse are associated with posttraumatic stress disorder (PTSD) in adulthood. We examined the relationship between the T-allele of the rs1360780 FKBP5 SNP and child abuse on PTSD and the HPA axis in a clinical sample of Gulf War veterans. Genotyping was completed on 266 veterans and 174 veterans additionally participated in a low dose dexamethasone suppression test (DST). The CAPS was used to determine PTSD status and the THQ was used to determine child abuse operationalized as either childhood physical or sexual abuse...
March 16, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29570102/evidence-for-somatic-hypersensitivity-in-veterans-with-gulf-war-illness-and-gastrointestinal-symptoms
#10
QiQi Zhou, Meghan L Verne, Buyi Zhang, G Nicholas Verne
INTRODUCTION: Over 25% of Persian Gulf War (PGW) veterans with Gulf War Illness (GWI) (chronic health complaints of undetermined etiology) developed GI symptoms (diarrhea and abdominal pain) and somatic complaints. OBJECTIVES: Our study objective was to determine if veterans with GWI and GI symptoms exhibit heightened patterns of somatic pain perception (hypersensitivity) across nociceptive stimuli modalities. METHODS: Subjects were previously deployed GW Veterans with GWI and GI symptoms (n=53); veterans with GWI without GI symptom (n=47); and veteran controls (n=38)...
March 21, 2018: Clinical Journal of Pain
https://www.readbyqxmd.com/read/29549885/epigenetic-impacts-of-stress-priming-of-the-neuroinflammatory-response-to-sarin-surrogate-in-mice-a-model-of-gulf-war-illness
#11
David G Ashbrook, Benjamin Hing, Lindsay T Michalovicz, Kimberly A Kelly, Julie V Miller, Wilfred C de Vega, Diane B Miller, Gordon Broderick, James P O'Callaghan, Patrick O McGowan
BACKGROUND: Gulf War illness (GWI) is an archetypal, medically unexplained, chronic condition characterised by persistent sickness behaviour and neuroimmune and neuroinflammatory components. An estimated 25-32% of the over 900,000 veterans of the 1991 Gulf War fulfil the requirements of a GWI diagnosis. It has been hypothesised that the high physical and psychological stress of combat may have increased vulnerability to irreversible acetylcholinesterase (AChE) inhibitors leading to a priming of the neuroimmune system...
March 17, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29548999/the-potential-of-treating-gulf-war-illness-with-curcumin
#12
Jeffrey A Leibowitz, Brandi K Ormerod
A large proportion of Gulf War Veterans suffer from Gulf War Illness (GWI) - a devastating chronic disorder characterized by heterogeneous fatigue, pain and neuropsychological symptoms. In their recent Brain, Behavior and Immunity publication entitled "Curcumin Treatment Leads to Better Cognitive and Mood Function in a Model of Gulf War Illness with Enhanced Neurogenesis, and Alleviation of Inflammation and Mitochondrial Dysfunction in the Hippocampus", Kodali and colleagues (2018) report that the polyphenol curcumin improves cognition and mood in a rat model of GWI, potentially by increasing the expression of antioxidant genes and by reversing the effects of chronic combined acetylcholinesterase inhibitor exposure on neuroinflammation, mitochondrial respiration and hippocampal neurogenesis...
March 13, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29526635/perspective-scientific-and-ethical-concerns-pertaining-to-animal-models-of-autoimmune-autoinflammatory-syndrome-induced-by-adjuvants-asia
#13
REVIEW
Rohan Ameratunga, Daman Langguth, David Hawkes
The autoimmune/autoinflammatory syndrome induced by adjuvants (ASIA) was first described in 2011. The aluminium containing adjuvants of vaccines were stated to be one of the main causes of the condition. Other disorders associated with ASIA include siliconosis, Gulf war syndrome, sick building syndrome and the macrophagic myositis syndrome. We have recently reviewed ASIA as defined by its authors. We have shown that the definition of ASIA is imprecise and includes all patients with an autoimmune disorder as well as potentially the entire population...
March 8, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29526630/the-value-of-autoimmune-syndrome-induced-by-adjuvant-asia-shedding-light-on-orphan-diseases-in-autoimmunity
#14
REVIEW
Yahel Segal, Shani Dahan, Kassem Sharif, Nicola Luigi Bragazzi, Abdulla Watad, Howard Amital
Autoimmune Syndrome Induced by Adjuvant (ASIA) is a definition aimed to describe the common etiological process at the root of five clinical entities sharing similar symptomatology: macrophagic myofasciitis syndrome (MMF), Gulf War Syndrome (GWS), sick building syndrome (SBS), siliconosis, and post vaccination autoimmune phenomena. ASIA illustrates the role of environmental immune stimulating agents, or adjuvants, in the instigation of complex autoimmune reactions among individuals bearing a genetic preponderance for autoimmunity...
March 8, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29526415/corrigendum-to-anxiety-neuroinflammation-cholinergic-and-gabaergic-abnormalities-are-early-markers-of-gulf-war-illness-in-a-mouse-model-of-the-disease-brain-res-1681-2018-34-43
#15
Isabel Carreras, Nurgul Aytan, Tiffany Mellott, Ji-Kyung Choi, Margaret Lehar, Leah Crabtree, Kimberly Leite-Morris, Bruce G Jenkins, Jan Krzysztof Blusztajn, Alpaslan Dedeoglu
No abstract text is available yet for this article.
March 8, 2018: Brain Research
https://www.readbyqxmd.com/read/29514346/report-of-autonomic-symptoms-in-a-clinical-sample-of-veterans-with-gulf-war-illness
#16
Apollonia Fox, Drew Helmer, Chin-Lin Tseng, Lydia Patrick-DeLuca, Omowunmi Osinubi
Introduction: Previous studies suggest that autonomic dysfunction may be an underlying factor in Gulf War Illness. This study examined self-reported symptoms of autonomic dysfunction and their relationship with physical functioning among veterans with Gulf War Illness. Materials and Methods: We abstracted medical records of Gulf War Veterans clinically evaluated at the New Jersey War Related Illness and Injury Study Center between 2010 and 2016. The outcome measure was the Veteran version of the Short Form Health Survey (VR-36) physical functioning scale...
March 1, 2018: Military Medicine
https://www.readbyqxmd.com/read/29475630/access-to-care-and-health-outcomes-among-women-veterans-using-veteran-s-administration-health-care-association-with-food-insufficiency
#17
Kimberly Narain, Bevanne Bean-Mayberry, Donna L Washington, Ismelda A Canelo, Jill E Darling, Elizabeth M Yano
BACKGROUND: Food insecurity has been associated with worse health outcomes in the civilian population. Male veterans of the Gulf Wars have been shown to have a higher prevalence of food insecurity than similarly situated civilians. Women veterans have more risk factors for food insecurity, relative to male veterans, yet little is known about the prevalence of food insecurity in this cohort. METHODS: We used the Women Veterans' Health Utilization and Experience Survey for this analysis...
February 20, 2018: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/29454881/curcumin-treatment-leads-to-better-cognitive-and-mood-function-in-a-model-of-gulf-war-illness-with-enhanced-neurogenesis-and-alleviation-of-inflammation-and-mitochondrial-dysfunction-in-the-hippocampus
#18
M Kodali, B Hattiangady, G A Shetty, A Bates, B Shuai, A K Shetty
Diminished cognitive and mood function are among the most conspicuous symptoms of Gulf War Illness (GWI). Our previous studies in a rat model of GWI have demonstrated that persistent cognitive and mood impairments are associated with substantially declined neurogenesis, chronic low-grade inflammation, increased oxidative stress and mitochondrial dysfunction in the hippocampus. We tested the efficacy of curcumin (CUR) to maintain better cognitive and mood function in a rat model of GWI because of its neurogenic, antiinflammatory, antioxidant, and memory and mood enhancing properties...
March 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29452862/protective-effect-of-human-leukocyte-antigen-hla-allele-drb1-13-02-on-age-related-brain-gray-matter-volume-reduction-in-healthy-women
#19
Lisa M James, Peka Christova, Scott M Lewis, Brian E Engdahl, Angeliki Georgopoulos, Apostolos P Georgopoulos
BACKGROUND: Reduction of brain volume (brain atrophy) during healthy brain aging is well documented and dependent on genetic, lifestyle and environmental factors. Here we investigated the possible dependence of brain gray matter volume reduction in the absence of the Human Leukocyte Antigen (HLA) allele DRB1*13:02 which prevents brain atrophy in Gulf War Illness (James et al., 2017). METHODS: Seventy-one cognitively healthy women (32-69years old) underwent a structural Magnetic Resonance Imaging (sMRI) scan to measure the volumes of total gray matter, cerebrocortical gray matter, and subcortical gray matter...
February 8, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29440208/meta-analysis-of-self-reported-health-symptoms-in-1990-1991-gulf-war-and-gulf-war-era-veterans
#20
Alexis L Maule, Patricia A Janulewicz, Kimberly A Sullivan, Maxine H Krengel, Megan K Yee, Michael McClean, Roberta F White
OBJECTIVES: Across diverse groups of Gulf War (GW) veterans, reports of musculoskeletal pain, cognitive dysfunction, unexplained fatigue, chronic diarrhoea, rashes and respiratory problems are common. GW illness is a condition resulting from GW service in veterans who report a combination of these symptoms. This study integrated the GW literature using meta-analytical methods to characterise the most frequently reported symptoms occurring among veterans who deployed to the 1990-1991 GW and to better understand the magnitude of ill health among GW-deployed veterans compared with non-deployed GW-era veterans...
February 13, 2018: BMJ Open
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