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https://www.readbyqxmd.com/read/29454881/curcumin-treatment-leads-to-better-cognitive-and-mood-function-in-a-model-of-gulf-war-illness-with-enhanced-neurogenesis-and-alleviation-of-inflammation-and-mitochondrial-dysfunction-in-the-hippocampus
#1
M Kodali, B Hattiangady, G A Shetty, A Bates, B Shuai, A K Shetty
Diminished cognitive and mood function are among the most conspicuous symptoms of Gulf WarIllness(GWI). Our previous studies in a rat model of GWI have demonstrated that persistent cognitive and mood impairments are associated with substantially declined neurogenesis, chronic low-grade inflammation, increased oxidative stress and mitochondrial dysfunction in the hippocampus. We tested the efficacy of curcumin (CUR) to maintain better cognitive and mood function in a rat model of GWI because of its neurogenic, antiinflammatory, antioxidant, and memory and mood enhancing properties...
February 15, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29452862/protective-effect-of-human-leukocyte-antigen-hla-allele-drb1-13-02-on-age-related-brain-gray-matter-volume-reduction-in-healthy-women
#2
Lisa M James, Peka Christova, Scott M Lewis, Brian E Engdahl, Angeliki Georgopoulos, Apostolos P Georgopoulos
BACKGROUND: Reduction of brain volume (brain atrophy) during healthy brain aging is well documented and dependent on genetic, lifestyle and environmental factors. Here we investigated the possible dependence of brain gray matter volume reduction in the absence of the Human Leukocyte Antigen (HLA) allele DRB1*13:02 which prevents brain atrophy in Gulf War Illness (James et al., 2017). METHODS: Seventy-one cognitively healthy women (32-69years old) underwent a structural Magnetic Resonance Imaging (sMRI) scan to measure the volumes of total gray matter, cerebrocortical gray matter, and subcortical gray matter...
February 8, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29440208/meta-analysis-of-self-reported-health-symptoms-in-1990-1991-gulf-war-and-gulf-war-era-veterans
#3
Alexis L Maule, Patricia A Janulewicz, Kimberly A Sullivan, Maxine H Krengel, Megan K Yee, Michael McClean, Roberta F White
OBJECTIVES: Across diverse groups of Gulf War (GW) veterans, reports of musculoskeletal pain, cognitive dysfunction, unexplained fatigue, chronic diarrhoea, rashes and respiratory problems are common. GW illness is a condition resulting from GW service in veterans who report a combination of these symptoms. This study integrated the GW literature using meta-analytical methods to characterise the most frequently reported symptoms occurring among veterans who deployed to the 1990-1991 GW and to better understand the magnitude of ill health among GW-deployed veterans compared with non-deployed GW-era veterans...
February 13, 2018: BMJ Open
https://www.readbyqxmd.com/read/29424024/impulse-oscillometry-measurement-of-distal-airways-obstruction-in-depleted-uranium-exposed-gulf-war-veterans
#4
Stella E Hines, Ashley H Barnes, Clayton Brown, Patricia Gucer, Marc S Oliver, Joanna M Gaitens, Marian Condon, Melissa McDiarmid
INTRODUCTION: A cohort of Gulf War I veterans who sustained exposure to depleted uranium undergoes biennial surveillance for potential uranium-related health effects. We performed impulse oscillometry and hypothesized that veterans with higher uranium body burdens would have more obstructive abnormalities than those with lower burdens. METHODS: We compared pulmonary function of veterans in high versus low urine uranium groups by evaluating spirometry and oscillometry values...
February 9, 2018: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/29416828/asymmetrically-enlarged-parietal-foramina-in-a-rare-case-of-goldenhar-syndrome-with-a-possible-etiopathogenesis
#5
Lika'a Fasih Y Al-Kzayer, Shamil Naji Sarsam, Nagham Younus Alhur, Tingting Liu, Yozo Nakazawa
Goldenhar´s syndrome (GS) also known as oculo-auriculo-vertebral spectrum (OAVS) is a relatively rare condition. GS is of multifactorial etiology that includes environmental and/or genetic factors, in addition to teratogens that disturb the blastogenesis. A 5-year-old girl from Saudi Arabia, was a member of dizygotic twins conceived by assisted reproductive technology (ART), and born with features of GS. She had asymmetrical face, cleft lip and palate, right microphthalmia and microtia. Radiological imaging showed right maxillary and mandibular bone hypoplasia, asymmetrically enlarged parietal foramina, a persistent midline occipital foramen, abnormal bone arising from occipital bone, extending along tentorium cerebelli, and a lipoma at the right tentorium cerebelli...
January 5, 2018: Oncotarget
https://www.readbyqxmd.com/read/29370011/health-status-of-gulf-war-and-era-veterans-serving-in-the-us-military-in-2000
#6
Ben Porter, Kyna Long, Rudolph P Rull, Erin K Dursa
OBJECTIVE: This research describes Gulf War and era veterans enrolled in the Millennium Cohort Study, who were sampled from US military personnel serving in 2000, and compares Health characteristics of this sample to a Department of Veterans' Affairs study sampled from the complete population. METHODS: Demographics characteristics of this sample were described. Self-reported health characteristics were compared between the two studies. RESULTS: Gulf War and era veterans in the Millennium Cohort were generally healthier than in the VA study; they had fewer medical conditions and mental health disorders and better self-reported health...
January 24, 2018: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29369940/a-case-study-of-the-ncrp-156-wound-model-of-embedded-du-using-data-from-urine-uranium-concentrations-of-wounded-veterans
#7
Michael T Walkingstick, Eric S Krage, Richard R Brey
Depleted uranium (DU) munitions were initially used by the United States (U.S.) military during the first Persian Gulf War in 1991 in order to penetrate heavily armored vehicles. However, as a result of friendly fire, several U.S. military personnel received intakes from DU munitions. One of the ongoing concerns for these wounded veterans is the potential long-term exposure received from DU embedded fragments. The United States Army Institute of Public Health (AIPH) is the first laboratory that analyzes the urine bioassays from Army Soldiers that are injured with DU fragments...
March 2018: Health Physics
https://www.readbyqxmd.com/read/29277710/anxiety-neuroinflammation-cholinergic-and-gabaergic-abnormalities-are-early-markers-of-gulf-war-illness-in-a-mouse-model-of-the-disease
#8
Isabel Carreras, Nurgul Aytan, Tiffany Mellott, Ji-Kyung Choi, Margaret Lehar, Leah Crabtree, Kimberly Leite-Morris, Bruce G Jenkins, Jan Krzysztof Blusztajn, Alpaslan Dedeoglu
Gulf War Illness (GWI) is a chronic disease that affects the 1991 Gulf War (GW) veterans for which treatment is lacking. It has been hypothesized that drugs used to protect military personnel from chemical attacks and insects during the war: pyridostigmine bromide (PB),N, N-diethyl-m-toluamide (DEET), and permethrin (PER) together with stress may have contributed collectively and synergistically to generate GWI. There is a need to find markers of pathology to be used in pre-clinical trials. For this purpose we employed a previously validated mouse model of GWI evoked by daily exposure to PB (1...
December 22, 2017: Brain Research
https://www.readbyqxmd.com/read/29239837/advancing-the-role-of-neuroimmunity-and-genetic-susceptibility-in-gulf-war-illness
#9
James P O'Callaghan, Lindsay T Michalovicz, Julie V Miller, Kimberly A Kelly
No abstract text is available yet for this article.
November 22, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29230306/cultural-shift-in-mental-illness-a-comparison-of-stress-responses-in-world-war-i-and-the-vietnam-war
#10
Rasjid Skinner, Paul M Kaplick
Objectives: Post-traumatic stress disorder is an established diagnostic category. In particular, over the past 20 years, there has been an interest in culture as a fundamental factor in post-traumatic stress disorder symptom manifestation. However, only a very limited portion of this literature studies the historical variability of post-traumatic stress within a particular culture. Design: Therefore, this study examines whether stress responses to violence associated with armed conflicts have been a culturally stable reaction in Western troops...
December 2017: JRSM Open
https://www.readbyqxmd.com/read/29173457/blast-injury-prevalence-in-skeletal-remains-are-there-differences-between-bosnian-war-samples-and-documented-combat-related-deaths
#11
Marie Christine Dussault, Ian Hanson, Martin J Smith
Court cases at the International Criminal Tribunal for the Former Yugoslavia (ICTY) have seen questions raised about the recognition and causes of blast-related trauma and the relationship to human rights abuses or combat. During trials, defence teams argued that trauma was combat related and prosecutors argued that trauma was related to executions. We compared a sample of 81 cases (males between 18 and 75) from a Bosnian mass grave investigation linked to the Kravica warehouse killings to published combat-related blast injury data from World War One, Vietnam, Northern Ireland, the first Gulf War, Operation Iraqi Freedom and Afghanistan...
November 2017: Science & Justice: Journal of the Forensic Science Society
https://www.readbyqxmd.com/read/29172967/a-comprehensive-analysis-of-italian-web-pages-mentioning-squalene-based-influenza-vaccine-adjuvants-reveals-a-high-prevalence-of-misinformation
#12
Donatella Panatto, Daniela Amicizia, Lucia Arata, Piero Luigi Lai, Roberto Gasparini
Squalene-based adjuvants have been included in influenza vaccines since 1997. Despite several advantages of adjuvanted seasonal and pandemic influenza vaccines, laypeople's perception of such formulations may be hesitant or even negative under certain circumstances. Moreover, in Italian, the term "squalene" has the same root as such common words as "shark" (squalo), "squalid" and "squalidness" that tend to have negative connotations. This study aimed to quantitatively and qualitatively analyze a representative sample of Italian web pages mentioning squalene-based adjuvants used in influenza vaccines...
November 27, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29137891/human-leukocyte-antigen-hla-and-gulf-war-illness-gwi-hla-drb1-13-02-spares-subcortical-atrophy-in-gulf-war-veterans
#13
Lisa M James, Peka Christova, Brian E Engdahl, Scott M Lewis, Adam F Carpenter, Apostolos P Georgopoulos
BACKGROUND: Gulf War Illness (GWI) is a multisystem disorder that has affected a substantial number of veterans who served in the 1990-91 Gulf War. The brain is prominently affected, as manifested by the presence of neurological, cognitive and mood symptoms. We reported previously on the protective role of six Human Leukocyte Antigen (HLA) alleles in GWI (Georgopoulos et al., 2016) and their association with regional brain function (James et al., 2016). More recently, we reported on the presence of subcortical brain atrophy in GWI (Christova et al...
November 9, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29127316/exercise-induced-changes-in-cerebrospinal-fluid-mirnas-in-gulf-war-illness-chronic-fatigue-syndrome-and-sedentary-control-subjects
#14
James N Baraniuk, Narayan Shivapurkar
Gulf War Illness (GWI) and Chronic Fatigue Syndrome (CFS) have similar profiles of pain, fatigue, cognitive dysfunction and exertional exhaustion. Post-exertional malaise suggests exercise alters central nervous system functions. Lumbar punctures were performed in GWI, CFS and control subjects after (i) overnight rest (nonexercise) or (ii) submaximal bicycle exercise. Exercise induced postural tachycardia in one third of GWI subjects (Stress Test Activated Reversible Tachycardia, START). The remainder were Stress Test Originated Phantom Perception (STOPP) subjects...
November 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29126934/neuropsychological-functioning-in-military-pesticide-applicators-from-the-gulf-war-effects-on-information-processing-speed-attention-and-visual-memory
#15
Kimberly Sullivan, Maxine Krengel, William Bradford, Callie Stone, Terri Ann Thompson, Timothy Heeren, Roberta F White
1991 Gulf War (GW) veterans continue to experience debilitating cognitive and mood problems more than two decades following their return from deployment. Suspected causes for these cognitive complaints include additive and/or synergistic effects of the varying combinations of exposures to chemicals in theater, including pesticides and pyridostigmine bromide (PB) pills. This study was undertaken to address one of the key recommendations of the US Department of Defense Environmental Exposure Report on Pesticides, which was to conduct an epidemiological study to further evaluate the role of neurotoxicant exposures in the expression of central nervous system symptoms reported by GW veterans...
November 7, 2017: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/29090894/extension-of-the-presumptive-period-for-compensation-for-gulf-war-veterans-final-rule
#16
(no author information available yet)
The Department of Veterans Affairs (VA) is issuing this final rule to affirm its adjudication regulations regarding compensation for disabilities resulting from undiagnosed illnesses suffered by veterans who served in the Persian Gulf War. This amendment is necessary to extend the period during which disabilities associated with undiagnosed illnesses and medically unexplained chronic multi-symptom illnesses must become manifest in order for a Veteran to be eligible for compensation. The intended effect of this amendment is to provide consistency in VA adjudication policy, preserve certain rights afforded to Persian Gulf War (GW) veterans, and ensure fairness for current and future GW veterans...
October 24, 2017: Federal Register
https://www.readbyqxmd.com/read/29063394/multivariate-curve-resolution-of-organic-pollution-patterns-in-mangrove-forest-sediment-from-qeshm-island-and-khamir-port-persian-gulf-iran
#17
Mahsa Dadashi, Sanaz Ghaffari, Alireza Riyahi Bakhtiari, Roma Tauler
Straight-chain alkanes (n-alkanes) have been proposed as biomarkers to assess petroleum pollution sources in marine environments. In this work, three sampling sites were selected along Iranian-protected mangrove forests in the Persian Gulf. Sample sites were chosen to represent different compositions and sources of n-alkanes in surface sediments (0-5 cm) from different locations in the Khamir Port, in the middle part of the Gulf, and in the Qeshm Island. Samples were analyzed by gas chromatography-mass spectrometry (GC-MS), and the obtained n-alkanes concentrations were analyzed by principal component analysis (PCA) and multivariate curve resolution alternating least squares (MCR-ALS) to deduce their possible sources and distribution patterns...
October 23, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29044021/-asia-syndrome-breast-implant-and-still-s-disease
#18
Cristhian Armenteros, Andrea Odzak, Florencia Arcondo, Marcela De Dios Soler, Tatiana Sinigier, Marcelo Zylberman
Connective tissue diseases associated with silicone breast implants have been widely discussed. In the last decade, siliconosis has been included in the autoimmune/inflammatory syndrome induced by adjuvants (ASIA) next to Gulf War syndrome, macrophage myofascitis and postvaccination phenomena. The ASIA syndrome may appear as lupus, rheumatoid arthritis, or more rarely, as adult Still's disease. We discuss the case of a patient with prolonged fever and clinical criteria for ASIA and Still's disease. The prostheses were resected and pathology showed absence of breast implant associated anaplastic lymphoma ALK (-)...
2017: Medicina
https://www.readbyqxmd.com/read/29036219/correction-role-of-mitochondrial-dna-damage-and-dysfunction-in-veterans-with-gulf-war-illness
#19
Yang Chen, Joel N Meyer, Helene Z Hill, Gudrun Lange, Michael R Condon, Jacquelyn C Klein, Duncan Ndirangu, Michael J Falvo
[This corrects the article DOI: 10.1371/journal.pone.0184832.].
2017: PloS One
https://www.readbyqxmd.com/read/29034324/a-review-of-epidemiologic-studies-of-the-health-of-gulf-war-women-veterans
#20
Steven S Coughlin, Maxine Krengel, Kimberly Sullivan, Penny F Pierce, Vahé Heboyan, Lt Col Candy Wilson
INTRODUCTION: In the 25 years since the 1990-1991 Gulf War (GW), studies have evaluated Gulf War Illness (GWI), sometimes referred to as medically unexplained multi symptom illness, and other medical and neurological conditions in women GW veterans. MATERIALS AND METHODS: In this article, we review epidemiologic studies of the health of women who served in the 1990-1991 GW based upon bibliographic searches in PubMed and CINAHL with relevant search terms through September 2015...
2017: Journal of Environment and Health Sciences
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