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https://www.readbyqxmd.com/read/29686504/evaluation-of-a-novel-thermo-alkaline-staphylococcus-aureus-lipase-for-application-in-detergent-formulations
#1
Abir Ben Bacha, Alaa Al-Assaf, Nadine M S Moubayed, Islem Abid
An extracellular lipase of a newly isolated S. aureus strain ALA1 (SAL4) was purified from the optimized culture medium. The SAL4 specific activity determined at 60 °C and pH 12 by using olive oil emulsion or TC4, reached 7215 U/mg and 2484 U/mg, respectively. The 38 NH2 -terminal amino acid sequence of the purified enzyme starting with two extra amino acid residues (LK) was similar to known staphylococcal lipase sequences. This novel lipase maintained almost 100% and 75% of its full activity in a pH range of 4...
March 2018: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/29664874/traumatic-brain-injury-and-infectious-encephalopathy-in-children-from-four-resource-limited-settings-in-africa
#2
Ericka L Fink, Amelie von Saint Andre-von Arnim, Rashmi Kumar, Patrick T Wilson, Tigist Bacha, Abenezer Tirsit Aklilu, Tsegazeab Laeke Teklemariam, Shubhada Hooli, Lisine Tuyisenge, Easmon Otupiri, Anthony Fabio, John Gianakas, Patrick M Kochanek, Derek C Angus, Robert C Tasker
OBJECTIVES: To assess the frequency, interventions, and outcomes of children presenting with traumatic brain injury or infectious encephalopathy in low-resource settings. DESIGN: Prospective study. SETTING: Four hospitals in Sub-Saharan Africa. PATIENTS: Children age 1 day to 17 years old evaluated at the hospital with traumatic brain injury or infectious encephalopathy. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: We evaluated the frequency and outcomes of children presenting consecutively over 4 weeks to any hospital department with traumatic brain injury or infectious encephalopathy...
April 16, 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29621622/outcomes-of-the-arterial-switch-operation-in-%C3%A2-2-5kg-neonates
#3
Michael Salna, Paul J Chai, David Kalfa, Yuki Nakamura, Ganga Krishnamurthy, Jan M Quaegebeur, Marc Najjar, Amee Shah, Stephanie Levasseur, Brett R Anderson, Emile A Bacha
OBJECTIVES: While low birth weight is a known risk factor for mortality in congenital heart lesions and may consequently delay surgical repair, outcomes in low weight neonates undergoing the arterial switch operation have not been well described. Our objective was to assess the safety of this procedure in infants weighing ≤2.5kg at the time of surgery. METHODS: We retrospectively analyzed outcomes for all neonates undergoing the arterial switch operation at our institution from 2005 to 2015...
April 2, 2018: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29619139/factors-associated-with-smoking-cessation-success-in-lebanon
#4
Zeina A Bacha, Nelly Layoun, Georges Khayat, Souheil Allit
Objective: The objective is to assess factors associated with the success rate of smoking cessation among Lebanese smokers in a smoking cessation center. Methods: A cross-sectional data study, conducted between March 2014 and March 2016 in an outpatient smoking cessation center with 156 enrolled patients. The patient's nicotine dependence and motivation to quit smoking were evaluated according to the Fagerstrom Test for Nicotine Dependence and Richmond tests respectively...
January 2018: Pharmacy Practice
https://www.readbyqxmd.com/read/29601909/pseudoaneurysm-formation-associated-with-a-modified-blalock-taussig-shunt
#5
Ashish A Ankola, Matthew A Crystal, Emile A Bacha, David Kalfa
No abstract text is available yet for this article.
March 27, 2018: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29588162/aminochrome-decreases-ngf-gdnf-and-induces-neuroinflammation-in-organotypic-midbrain-slice-cultures
#6
Fillipe M de Araújo, Rafael S Ferreira, Cleide S Souza, Cleonice Creusa Dos Santos, Tácio L R S Rodrigues, Juliana Helena C E Silva, Juciano Gasparotto, Daniel Pens Gelain, Ramon S El-Bachá, Maria de Fátima D Costa, José Claudio M Fonseca, Juan Segura-Aguilar, Silvia L Costa, Victor Diogenes A Silva
Recent evidence shows that aminochrome induces glial activation related to neuroinflammation. This dopamine derived molecule induces formation and stabilization of alpha-synuclein oligomers, mitochondria dysfunction, oxidative stress, dysfunction of proteasomal and lysosomal systems, endoplasmic reticulum stress and disruption of the microtubule network, but until now there has been no evidence of effects on production of cytokines and neurotrophic factors, that are mechanisms involved in neuronal loss in Parkinson's disease (PD)...
March 24, 2018: Neurotoxicology
https://www.readbyqxmd.com/read/29582256/probiotic-treatment-reduces-the-autistic-like-excitation-inhibition-imbalance-in-juvenile-hamsters-induced-by-orally-administered-propionic-acid-and-clindamycin
#7
Afaf El-Ansary, Abir Ben Bacha, Geir Bjørklund, Nora Al-Orf, Ramesa Shafi Bhat, Nadine Moubayed, Kawther Abed
Increasing evidence suggests that the gut microbiota plays a key role in the central nervous system (CNS), and alterations of the gut microbiota composition due to environmental factors can contribute to neurodevelopmental disorders. Animal modeling may help to identify drugs that can normalize the altered gut microbiota and thereby ameliorate abnormal brain signaling pathways. The purpose of the present study was to investigate the therapeutic potency of probiotics such as Bifidobacteria and Lactobacilli on glutamate excitotoxicity as a neurotoxic effect induced by clindamycin and propionic acid (PPA) in juvenile hamsters...
March 27, 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29576261/outcomes-and-prognostic-factors-for-postsurgical-pulmonary-vein-stenosis-in-the-current-era
#8
David Kalfa, Emre Belli, Emile Bacha, Virginie Lambert, Duccio di Carlo, Martin Kostolny, Matej Nosal, Jurgen Horer, Jukka Salminen, Jean Rubay, Illya Yemets, Mark Hazekamp, Bohdan Maruszewski, George Sarris, Hakan Berggren, Tjark Ebels, Onur Baser, François Lacour-Gayet
BACKGROUND: The optimal management and prognostic factors of postsurgical pulmonary vein stenosis remain controversial. We sought to determine current postsurgical pulmonary vein stenosis outcomes and prognostic factors in a multicentric study in the current era. METHODS: Seventy-five patients with postsurgical pulmonary vein stenosis who underwent 103 procedures in 14 European/North American centers (2000-2012) were included retrospectively. A specific pulmonary vein stenosis severity score was developed on the basis of the assessment of each pulmonary vein...
February 23, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29560708/perforated-pan-enteric-tuberculosis-intra-operative-recognition-necessity
#9
Z Mzoughi, R Bayar, S Omrani, H Smati, Dhouba Bacha, M T Khalfallah
No abstract text is available yet for this article.
April 2017: Acta Gastro-enterologica Belgica
https://www.readbyqxmd.com/read/29544419/significance-of-intraoperative-revision-during-arterial-switch-operation-in-the-current-era
#10
Yuki Nakamura, David Kalfa, Paul Chai, Anjali Chelliah, Lindsay Freud, Emile Bacha, Jan Quaegebeur
BACKGROUND: Arterial switch operation (ASO) is a relatively safe operation nowadays. We hypothesize that intraoperative revision for coronary malperfusion still plays an important role during ASO in the current era. METHODS: From January 2005 to May 2016, 244 patients underwent ASO. Medical records were reviewed and the details of intraoperative revision were described. Morbidity and mortality were compared in patients with/without intraoperative revision. Factors related to the need for intraoperative revision were analyzed...
March 2018: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/29526358/patients-with-anomalous-aortic-origin-of-the-coronary-artery-remain-at-risk-after-surgical-repair
#11
Shannon N Nees, Jonathan N Flyer, Anjali Chelliah, Jeffrey D Dayton, Lorraine Touchette, David Kalfa, Paul J Chai, Emile A Bacha, Brett R Anderson
OBJECTIVES: Anomalous aortic origin of a coronary artery (AAOCA) from the opposite sinus of Valsalva is a rare cardiac anomaly associated with sudden cardiac death (SCD). Single-center studies describe surgical repair as safe, although medium- and long-term effects on symptoms and risk of SCD remain unknown. We sought to describe outcomes of surgical repair of AAOCA. METHODS: We reviewed institutional records for patients who underwent AAOCA repair, from 2001 to 2016, at 2 affiliated institutions...
February 8, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29518033/anthocyanin-rich-grape-pomace-extract-vitis-vinifera-l-from-wine-industry-affects-mitochondrial-bioenergetics-and-glucose-metabolism-in-human-hepatocarcinoma-hepg2-cells
#12
Nathalia F F de Sales, Leandro Silva da Costa, Talita I A Carneiro, Daniela A Minuzzo, Felipe L Oliveira, Lourdes M C Cabral, Alexandre G Torres, Tatiana El-Bacha
Cancer cells demand high ATP provisions to support proliferation, and targeting of energy metabolism is a good strategy to increase their sensitivity to treatments. In Brazil, wine manufacture is expanding, increasing the amount of pomace that is produced. We determined the phenolic composition and antioxidant properties of a dark skin Grape Pomace Extract and its effects on metabolism and redox state in human hepatocarcinoma HepG2 cells. The material and the methods used represented the industrial process since pomace derived from white wine production and the extract concentrated by pilot plant scale reverse osmosis...
March 8, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29512800/extracapsular-involvement-in-nodal-metastasis-as-a-prognostic-factor-in-colorectal-cancer
#13
Dhouha Bacha, Zeineb Mzoughi, Oussama Belkacem, Salsabil Rejaibi, Ahlem Lahmar, Lassad Gharbi, Saadia Bouraoui
BACKGROUND: Extracapsular extension of nodal metastasis has recently emerged as an important prognostic factor in different malignancies. In colorectal cancer (CRC), only a limited number of studies have been published and its prognostic value has not yet been completely established. AIMS: To assess the incidence of extracapsular invasion (ECI) in lymph node (LN) metastasis in colorectal adenocarcinoma and to investigate the correlation between this parameter and other clinico-pathological factors...
June 2017: La Tunisie Médicale
https://www.readbyqxmd.com/read/29509216/resected-colorectal-cancer-liver-metastases-prognostic-study-about-110-patients
#14
Zeineb Mzoughi, Achref Djebbi, Ghofrane Talbi, Houcem Smati, Dhouha Bacha, Sana Ben Slama Mallouli, Saadia Bouraoui, Nafa Arfa, Hafedh Mestiri, Lassad Gharbi, Rached Bayar, Mohamed Taher Khalfallah
INTRODUCTION: The prognosis of hepatic metastases in colorectal cancers is constantly being improved at the cost of multidisciplinary care, allowing each patient to have an adapted strategy. The prognostic factors make it possible to recognize patients needing further treatment after resection and closer monitoring. OBJECTIVE: The aim of our study was to conduct a prognostic study to identify factors influencing survival at 5 years for patients operated of colorectal liver metastases...
May 2017: La Tunisie Médicale
https://www.readbyqxmd.com/read/29496742/racial-ethnic-minority-youth-with-recent-onset-type-1-diabetes-have-poor-prognostic-factors
#15
Maria Jose Redondo, Ingrid Libman, Peiyao Cheng, Craig Kollman, Mustafa Tosur, Robin L Gal, Fida Bacha, Georgeanna J Klingensmith, Mark Clements
OBJECTIVE: To compare races/ethnicities for characteristics, at type 1 diabetes diagnosis and during the first 3 years postdiagnosis, known to influence long-term health outcomes. RESEARCH DESIGN AND METHODS: We analyzed 927 Pediatric Diabetes Consortium (PDC) participants <19 years old (631 non-Hispanic white [NHW], 216 Hispanic, and 80 African American [AA]) diagnosed with type 1 diabetes and followed for a median of 3.0 years (interquartile range 2.2-3.6)...
March 1, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29472494/disparities-in-outcomes-and-resource-use-after-hospitalization-for-cardiac-surgery-by-neighborhood-income
#16
Brett R Anderson, Evan S Fieldston, Jane W Newburger, Emile A Bacha, Sherry A Glied
BACKGROUND: Significant disparities exist between patients of different races and with different family incomes; less is understood regarding community-level factors on outcomes. METHODS: In this study, we used linked data from the Pediatric Health Information System database and the US Census Bureau to examine associations between median annual household income by zip code and mortality, length of stay, inpatient standardized costs, and costs per day, over and above the effects of race and payer, first for children undergoing cardiac surgery (2005-2015) and then for all pediatric discharges (2012-2015)...
February 22, 2018: Pediatrics
https://www.readbyqxmd.com/read/29446815/fetoplacental-malformations-and-abnormalities-a-retrospective-analysis-of-398-cases
#17
Sana Ben Slama, Leila Mebazaa, Dhouha Bacha, Saadia Bouraoui, Sabeh Mzabi-Regaya, Ahlem Lahmar
BACKGROUND: The fetoplacental examination is actually very important and sometimes necessary to confirm or correct prenatal diagnosis. AIM: to deduce a list of indications of fetoplacental examination and to determine the type and frequency of malformations found. METHODS: a retrospective study including 398 consecutive fetoplacental examinations, including abortions, stillbirths and children died perinatally. The cases were referred in the department of pathology of the M...
March 2017: La Tunisie Médicale
https://www.readbyqxmd.com/read/29444955/common-and-divergent-features-of-galactose-1-phosphate-and-fructose-1-phosphate-toxicity-in-yeast
#18
Patrick A Gibney, Ariel Schieler, Jonathan C Chen, Jessie M Bacha-Hummel, Maxim Botstein, Matthew Volpe, Sanford J Silverman, Yifan Xu, Bryson D Bennett, Joshua D Rabinowitz, David Botstein
Toxicity resulting from accumulation of sugar-phosphate molecules is an evolutionarily conserved phenomenon, observed in multiple bacterial and eukaryotic systems, including a number of human diseases. However, the molecular mechanisms involved in sugar-phosphate toxicity remain unclear. Using the model eukaryote S. cerevisiae , we developed two systems to accumulate human disease-associated sugar-phosphate species. One system utilizes constitutive expression of galactose permease and galactose kinase to accumulate galactose-1-phosphate, while the other system utilizes constitutive expression of a mammalian ketohexokinase gene to accumulate fructose-1-phosphate...
February 14, 2018: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/29433537/effect-of-mobile-health-on-maternal-health-care-service-utilization-in-eastern-ethiopia-study-protocol-for-a-randomized-controlled-trial
#19
Tilayie Feto Gelano, Nega Assefa, Yadeta Dessie Bacha, Afendi Abdi Mahamed, Kedir Teji Roba, Mitiku Teshome Hambisa
BACKGROUND: Globally, the rapid development of mobile technology has created new ways of addressing public health challenges and shifted the paradigm of health care access and delivery. The primary aim of this study is to examine the effectiveness of Mobile-health on maternal health care service utilization in Eastern Ethiopia. METHODS/DESIGN: Through, a cluster-randomized controlled trial, 640 participants will be selected based on their districts and respective health centers as the unit of randomization...
February 12, 2018: Trials
https://www.readbyqxmd.com/read/29412802/high-fat-diet-stimulates-the-gut-pathogenic-microbiota-and-maintains-hepatic-injury-in-antibiotic-treated-rats
#20
Sooad Al-Daihan, Abir Ben Bacha, Abeer M Al-Dbass, Mona Awad Alonazi, Ramesa Shafi Bhat
The gut and the liver are closely linked to each other, as changes in the gut microbiota can play a significant role in the development of many liver diseases. Gut bacteria respond rapidly to changes in diet and thus can affect the liver through their metabolites. The impact of a high lipid diet on the liver in the presence of an altered gut flora modulated by ampicillin was investigated. The study was performed on 30 male Western albino rats randomly divided into 3 groups: control (phosphate buffered saline treated), group II (ampicillin 50 mg/kg for three weeks to induce microbiota alterations and fed on standard diet) and group III (same dose of ampicillin and fed on a lipid rich diet)...
January 31, 2018: Cellular and Molecular Biology
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