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https://www.readbyqxmd.com/read/29243847/utility-of-complete-blood-count-parameters-to-detect-premature-ovarian-insufficiency-in-cases-with-oligomenorrhea-amenorrhea
#1
Ilhan Sanverdi, Cetin Kilicci, Ebru Cogendez, Cigdem Abide Yayla, Enis Ozkaya
BACKGROUND: There are very few biomarkers available to diagnose cases with premature ovarian failure. Some complete blood count parameters have been introduced to be diagnostic biomarkers for several disorders associated with inflammatory process. Due to the evidence that indicated chronic inflammatory process to be underlying pathophysiology in premature ovarian insufficiency (POI), we aimed to assess the predictive value of complete blood count parameters for POI diagnosis. METHOD: A total of 96 women diagnosed to have premature ovarian failure were compared with 110 otherwise healthy women in terms of some basal hormone levels and complete blood count parameters...
December 15, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29243796/can-high-levels-of-d-chiro-inositol-in-follicular-fluid-exert-detrimental-effects-on-blastocyst-quality
#2
K Ravanos, G Monastra, T Pavlidou, M Goudakou, N Prapas
OBJECTIVE: It was previously shown that higher concentrations of myo-inositol in human follicular fluid improve oocyte and embryo quality, whereas D-chiro-inositol seems to worsen oocyte quality and ovarian response in polycystic ovary syndrome patients. Our study was the first one aiming to test whether different myo-inositol and D-chiro-inositol concentration in follicular fluids correlate with blastocyst quality in healthy young women. PATIENTS AND METHODS: Eight egg donors and eleven couples undergoing in vitro fertilization, were involved in a prospective observational study...
December 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29243795/the-effect-on-clinical-results-of-adding-recombinant-lh-in-late-phase-of-ovarian-stimulation-of-patients-with-repeated-implantation-failure-a-pilot-study
#3
A Rahman, D Francomano, F Sagnella, F Lisi, C Manna
OBJECTIVE: To evaluate the efficacy of recombinant LH (r-LH) addition in the late phase of ovarian stimulation in patients with repeated implantation failure (RIF). PATIENTS AND METHODS: 66 infertile couples undergoing ICSI treatment due to male factor were allocated to group A (33) and to group B (33). Group A (29 subjects) received recombinant FSH (r-FSH) supplemented by r-LH in the late follicular phase starting the same day of GnRH-antagonist (GnRH-ant) administration, and group B (32 subjects) received r-FSH alone...
December 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29241924/effects-of-growth-hormone-plus-gonadotropins-on-controlled-ovarian-stimulation-in-infertile-women-of-advanced-age-poor-responders-and-previous-in%C3%A2-vitro-fertilization-failure-patients
#4
Yao-Kai Ho, Tsung-Hsien Lee, Chun-I Lee, En-Hui Cheng, Chun-Chia Huang, Lii-Shung Huang, Maw-Sheng Lee
OBJECTIVE: To investigate the effects of growth hormone (GH) cotreatment in ovarian stimulation in infertile women of advanced age, poor responders, and patients with one or more previous IVF treatment failures. MATERIALS AND METHODS: We conducted a retrospective observational study of 436 patients undergoing GH cotreatment in ovarian stimulation. The first arm included 134 infertile women of advanced age. The second arm included 236 patients with one or more IVF previous treatment failures, and the third arm included 66 younger poor responders...
December 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29241919/does-the-freeze-all-policy-allow-for-a-better-outcome-in-assisted-reproductive-techniques-than-the-use-of-fresh-embryo-transfers-a%C3%A2-retrospective-study-on-cumulative-live-birth-rates
#5
Jui-Chun Chang, Ming-Jer Chen, Hwa-Fen Guu, Ya-Fang Chen, Yu-Chiao Yi, Hsiao-Fan Kung, Li-Yu Chen, Min-Min Chou
OBJECTIVE: There are increasing concerns regarding the adverse effects associated with control ovarian hyperstimulation (COH) in both endometrial and uterine environments. With the "segmentation treatment policy" of assisted reproductive techniques (ART), endometrial problems may be obviated through embryo cryopreservation. However, it remains unclear if the "freeze-all policy" offers a better outcome when compared with fresh embryo transfer (ET). To clarify this, we compared the cumulative live birth rates (CLBRs) between these two patient populations...
December 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29237349/administration-of-oral-contraceptives-could-alleviate-age-related-fertility-decline-possibly-by-preventing-ovarian-damage-in-a-mouse-model
#6
Wataru Isono, Osamu Wada-Hiraike, Yumiko Kawamura, Tomoyuki Fujii, Yutaka Osuga, Hiroki Kurihara
Age-related fertility decline is hypothesized to occur mainly by the spontaneous exhaustion and deterioration of the ovarian follicle, and the accumulation of ovarian tissue damage resulting from the ovulation cycle may play roles in the process. In this study, we hypothesized that suppressing ovulation would exert protective effects against age-related fertility decline. To test this hypothesis, we established a mouse model in which oral contraceptives (OCs) were administered daily. Female C57BL/6N mice were administered OCs daily from the age of 2 months to 12 months as an ovulation suppression mouse model...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/29236987/extra-gonadal-actions-of-fsh-a-critical-need-for-novel-genetic-models
#7
T Rajendra Kumar
Follicle-stimulating hormone (FSH) is critical for ovarian folliculogenesis and essential for female fertility. FSH binds to FSH receptors (FSHRs) and regulates estrogen production in ovarian granulosa cells to orchestrate female reproductive physiology. Ovarian senescence that occurs as a function of aging results in loss of estrogen production and this is believed to be the major reason for bone loss in postmenopausal women. Although conflicting, studies in rodents and humans during the last decade provide genetic, pharmacological and physiological evidence that elevated FSH levels that occur in the face of normal or declining estrogen levels directly regulate bone mass and adiposity...
December 11, 2017: Endocrinology
https://www.readbyqxmd.com/read/29233501/does-ovarian-stimulation-regimen-affect-ivf-outcome-a-two-centre-real-world-retrospective-study-using-predominantly-cleavage-stage-single-embryo-transfer
#8
Per-Olof Karlström, Jan Holte, Nermin Hadziosmanovic, Kenny A Rodriguez-Wallberg, Jan I Olofsson
In this study, ovarian stimulation using highly purified human menopausal gonadotrophin (HP-HMG) and recombinant FSH (rFSH) for IVF were compared in two large assisted reproduction technique centres in Sweden. A total of 5902 women underwent 9631 oocyte retrievals leading to 8818 embryo transfers (7720 on day 2): single embryo transfers (74.2%); birth rate per embryo transfer (27.7%); multiple birth rate (5.0%); incidence of severe ovarian hyperstimulation syndrome (0.71%). Compared with ovarian stimulation with rFSH, women who received HP-HMG were older, had higher dosages of gonadotrophins administered, fewer oocytes retrieved and more embryos transferred...
October 20, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29233485/body-fat-affects-mouse-reproduction-ovarian-hormone-release-and-response-to-follicular-stimulating-hormone
#9
Alexander V Sirotkin, Dušan Fabian, Janka Babeľová Kubandová, Radoslava Vlčková, Saleh Alwasel, Abdel Halim Harrath
We investigated the effects of body fat content on mouse fecundity, ovarian hormone release, and their response to follicle stimulation hormone (FSH). 4 types of females were produced: lean (group 1), normal (group 2), slightly fat (group 3), and significantly fat (group 4). The body weights, fat content, fertility rate, embryo number produced, retarded and degenerated embryo percentage, the release of progesterone (P4), testosterone (T), and insulin-like growth factor I (IGF-I) by isolated ovaries cultured with and without FSH (1...
December 7, 2017: Reproductive Biology
https://www.readbyqxmd.com/read/29229882/igf1-stimulates-differentiation-of-primary-follicles-and-their-growth-in-ovarian-explants-of-zebrafish-danio-rerio-cultured-in-vitro
#10
Pancharatna A Katti, Sheetal S Narvekar, Basavaraj B Goundadkar, Prasad A Deshpande
The present study is an attempt to elucidate the involvement of insulin-like growth factor (IGF1) in the differentiation and growth of primary follicles in ovarian explant cultures of zebrafish. Ovaries from adult females were cultured in triplicate sets/treatment group for 15 days at 22° in the laboratory. Culture medium was supplemented with either insulin (1 ng/mL) or IGF1 (1 ng/mL) or insulin + IGF1 (Experiment 1) or 0.1 or 1.0 or 10 ng/mL of IGF1 (Experiment 2). Ovaries cultured in medium alone served as controls and those fixed at the beginning of the culture as initial controls...
December 2017: Journal of Biosciences
https://www.readbyqxmd.com/read/29229435/developmental-and-cytogenetic-assessments-of-preimplantation-embryos-derived-from-in-vivo-or-in-vitro-matured-human-oocytes
#11
Farzaneh Fesahat, Seyed Mehdi Kalantar, Mohammad Hasan Sheikhha, Hojjatollah Saeedi, Fatemeh Montazeri, Razieh Dehghani Firouzabadi, Mohammad Ali Khalili
Aneuploidy is of great relevance to embryo selection, as it represents one of the important causes of implantation failure. Furthermore, immature oocytes, retrieved during gonadotrophin-stimulated IVF cycles, are generally discarded in clinics; whereas, there was no detectable comprehensive evidence on higher rates of aneuploidy based on maturity status on the day of oocyte retrieval. As well, the correlation between embryo morphology on aneuploidy remains unclear. The aim was to evaluate the developmental and genetic integrity of human preimplantation embryos from rescue in-vitro matured MII stage oocytes as well as in vivo matured oocytes...
December 8, 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29228624/platelet-microparticle-mediated-transfer-of-mir-939-to-epithelial-ovarian-cancer-cells-promotes-epithelial-to-mesenchymal-transition
#12
Meiling Tang, Lu Jiang, Yingying Lin, Xiaoli Wu, Kai Wang, Qizhi He, Xipeng Wang, Weiping Li
Epithelial ovarian cancer (EOC) patients frequently suffer from thrombocytosis, which leads to a poor prognosis. However, the mechanism underlying platelet regulation of biological behavior in EOC remains unclear. The associations between clinicopathological characteristics and thrombocytosis in 171 EOC patients were studied, preoperative thrombocytosis was significantly associated with the stage, metastasis scope, level of preoperative CA125 and overall survival. When SKOV3 cells were cocultured with platelet microparticles (PMPs), the expression of molecules associated with epithelial-mesenchymal transition (EMT) was increased...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29228548/macrophage-depletion-through-colony-stimulating-factor-1-receptor-pathway-blockade-overcomes-adaptive-resistance-to-anti-vegf-therapy
#13
Yasmin A Lyons, Sunila Pradeep, Sherry Y Wu, Monika Haemmerle, Jean M Hansen, Michael J Wagner, Alejandro Villar-Prados, Archana S Nagaraja, Robert L Dood, Rebecca A Previs, Wei Hu, Yang Zhao, Duncan H Mak, Zhilan Xiao, Brenda D Melendez, Gregory A Lizee, Imelda Mercado-Uribe, Keith A Baggerly, Patrick Hwu, Jinsong Liu, Willem W Overwijk, Robert L Coleman, Anil K Sood
Anti-angiogenesis therapy has shown clinical benefit in patients with high-grade serous ovarian cancer (HGSC), but adaptive resistance rapidly emerges. Thus, approaches to overcome such resistance are needed. We developed the setting of adaptive resistance to anti-VEGF therapy, and performed a series of in vivo experiments in both immune competent and nude mouse models. Given the pro-angiogenic properties of tumor-associated macrophages (TAMs) and the dominant role of CSF1R in macrophage function, we added CSF1R inhibitors following emergence of adaptive resistance to anti-VEGF antibody...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29227911/inhibin-a-and-inhibin-b-in-cyclic-and-pregnant-mares-and-mares-with-granulosa-theca-cell-tumors-physiological-and-diagnostic-implications
#14
A J Conley, E L Scholtz, G Dujovne, R F Cotterman, E L Legacki, R C Uliani, M A Alvarenga, B A Ball, B Kalra, G V Savjani, A Kumar
Studies in mares have examined serum inhibin concentrations using immuno-assays unable to distinguish dimeric inhibin-A from inhibin-B isoforms. Inhibin-A and inhibin-B immuno-assays were used to investigate concentrations in cyclic mares, young and old (6 vs 19 years old, respectively) mares following hemi-ovariectomy, mares during pregnancy and in mares with confirmed granulosa cell tumors (GCTs). Mares with inter-ovulatory intervals of 26 days had ovulatory peaks of inhibin-A averaging 80 pg/mL with a mid-cycle nadir of 5 pg/mL...
December 7, 2017: Theriogenology
https://www.readbyqxmd.com/read/29224376/regulation-of-follicle-growth-through-hormonal-factors-and-mechanical-cues-mediated-by-hippo-signaling-pathway
#15
Ikko Kawashima, Kazuhiro Kawamura
The ovary is an interesting organ that shows major structural changes within a short period of time during each reproductive cycle. Follicle development is controlled by local paracrine and systemic endocrine factors. Many hormonal and molecular analyses have been conducted to find the mechanisms underlying structural changes in ovaries, However, exact mechanisms still remain to be determined. Recent development of mechanobiology facilitates the understanding on the contribution of physical forces and changes in the mechanical properties of cells and tissues to physiology and pathophysiology...
December 9, 2017: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/29223475/insights-from-clinical-experience-in-treating-ivf-poor-responders
#16
REVIEW
Kelly J Gonda, Alice D Domar, Norbert Gleicher, Richard P Marrs
'Poor responders' is a term used to describe a subpopulation of IVF patients who do not respond well to ovarian stimulation with gonadotrophins. While there is no standard definition of a poor responder, these patients tend to be of advanced maternal age (≥40 years), have a history of poor ovarian response with conventional stimulation protocols, and/or have low ovarian reserve. Despite the heterogeneity of this patient group, there are characteristics and needs common to many poor responders that can be addressed through a holistic approach...
October 24, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29223167/editorial-new-horizons-in-controlled-ovarian-stimulation
#17
EDITORIAL
Gian Mario Tiboni
No abstract text is available yet for this article.
November 10, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/29221621/-fertility-preservation-in-oncology
#18
REVIEW
Laure Chaput, Anne-Sophie Grémeau, Solène Vorilhon, Hanae Pons, Cécile Chabrot, Victoria Grèze, Jean-Luc Pouly, Florence Brugnon
Since the improvement of cancer diagnosis and treatment, survival rates of these patients increase. Gonadal damages are frequent consequences of cancer treatments with different evidence of impaired fertility. In this context, fertility preservation should be proposed to patients exposed to potentially gonadotoxic treatments. Different preservation approaches may be proposed depending on patient age, sex, cancer type and type of treatment. The indications of fertility preservation depend on sexual maturity...
December 5, 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/29217212/ovarian-morphology-by-transabdominal-ultrasound-correlates-with-reproductive-and-metabolic-disturbance-in-adolescents-with-pcos
#19
Beth W Rackow, Heidi Vanden Brink, Lynwood Hammers, Clare A Flannery, Marla E Lujan, Tania S Burgert
PURPOSE: To determine whether ovarian morphology imaged using transabdominal ultrasonography reflects clinical and metabolic features in adolescents with polycystic ovary syndrome (PCOS). METHODS: A retrospective pilot study was conducted in 33 adolescents (12-18 years) with PCOS as defined by hyperandrogenism and irregular cycles. Adolescents underwent the following assessments at a random time during the menstrual cycle: transabdominal ultrasonography, physical examination (height, weight, and systolic and diastolic blood pressure), fasting hormonal tests (free, percent free, and total testosterone, androstenedione, follicle stimulating hormone, luteinizing hormone), and metabolic tests (including an oral glucose tolerance test, fasting and 2-hour insulin and glucose, homeostatic model assessment of insulin resistance, and whole-body insulin sensitivity index)...
December 5, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/29214348/effect-of-laser-assisted-zona-thinning-during-assisted-reproduction-on-pregnancy-outcome-in-women-with-endometriosis-randomized-controlled-trial
#20
Adel Mohamed Nada, Amr El-Noury, Hesham Al-Inany, Mamdouh Bibars, Tamer Taha, Sameh Salama, Fatma Hassan, Eman Zein
OBJECTIVE: To compare the ICSI-ET outcomes in patients with endometriosis with or without laser-assisted zona pellucida thinning. DESIGN: Randomized controlled trial. SETTING: The study was conducted in the Obstetrics & Gynecology Department, Cairo University hospital, and two private IVF centers in Cairo & Beni-Suif from July 2015 to January 2017 upon infertile and known endometriosis patients who planned to do ICSI-ET. INTERVENTIONS: Before randomization, all patients received the same ovarian stimulation preparation, oocyte retrieval procedures, and the same intracytoplasmic sperm injection procedures...
December 6, 2017: Archives of Gynecology and Obstetrics
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