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https://www.readbyqxmd.com/read/29907662/expression-of-atresia-biomarkers-in-granulosa-cells-after-ovarian-stimulation-in-heifers
#1
David A Landry, Lia Rossi-Perazza, Simon Lafontaine, Marc-Andre Sirard
The use of younger gamete donors in dairy cattle genetic selection programs significantly accelerates genetic gains by decreasing the interval between generations. Ovarian stimulation and the practice of follicle-stimulating hormone (FSH) withdrawal, also known as coasting, are intensively used in pre-pubertal heifers without detrimental effects on subsequent reproductive performance but generally with lower embryo yields. However, recent data from embryo transfer programs showed similar embryo yields in younger and sexually mature animals but with a significant difference in the coasting period...
June 15, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29907333/superstimulation-with-ecg-prior-to-ovum-pick-up-improves-follicular-development-and-fertilization-rate-of-cattle-oocytes
#2
Bibiana Noal Ribas, Daniele Missio, Isac Junior Roman, Normélio Alves Neto, Izaias Claro, Daniela Dos Santos Brum, Fabio Gallas Leivas
This study aimed to evaluate the effect of equine chorionic gonadotrophin (eCG) stimulation prior to ovum pick-up (OPU) on follicular development, number and quality of recovered oocytes, fertilization rate, and early embryo development in vitro. There were four OPU sessions (cross over) conducted on 16 Braford cows to evaluate the effect of various eCG doses. The timing of the wave of ovarian follicular development was synchronized, and three days after, the respective eCG dose was administrated (0, 200, 400, or 800 IU)...
June 9, 2018: Animal Reproduction Science
https://www.readbyqxmd.com/read/29906662/hormonal-stimulation-in-4-to-7-months-old-nelore-bos-taurus-indicus-females-improved-ovarian-follicular-responses-but-not-the-in-vitro-embryo-production
#3
Thaís Abritta Zacarias, Taynan Stonoga Kawamoto, João Ricardo Scaliante Júnior, Ana Luiza Silva Guimarães, Maurício Machaim Franco, Ricardo Alamino Figueiredo
The inclusion of pre-pubertal bovine females in reproductive management could allow in vitro embryo production and reduce generation interval, thereby causing faster genetic gain of the herd. However, oocytes of pre-pubertal females have lower competence, blastocyst production, and pregnancy rates than those collected from pubertal animals. This study aimed to evaluate the effect of an induced hormonal stimulation on the serum concentrations of Anti-Mullerian hormone (AMH) and FSH, ovarian responses, ovum pick up (OPU), and in vitro produced embryos (IVP) from oocytes obtained from four-to seven-months old Nelore female cattle...
May 31, 2018: Theriogenology
https://www.readbyqxmd.com/read/29904943/fgf9-induced-ovarian-cancer-cell-invasion-involves-vegf-a-vegfr2-augmentation-by-virtue-of-ets1-upregulation-and-metabolic-reprogramming
#4
Rahul Bhattacharya, Susri Ray Chaudhuri, Sib S Roy
Ovarian cancer (OC) renders its lethality to enhanced metastasis and late detection. A plethora of growth factors including Vascular Endothelial Growth Factor (VEGF) and Fibroblast Growth Factor (FGF) stimulated signaling pathways regulate the invasive/metastatic behavior of ovarian tumors contributing to its aggressiveness. Autocrine VEGF-functioning by virtue of upregulated VEGFR2 contributes to the invasiveness of OC cells by modulating the MMPs. Studies have highlighted the interaction between FGF and VEGF signaling pathways during angiogenesis...
June 15, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29902617/the-possible-ameliorative-effect-of-olea-europaea-l-oil-against-deltamethrin-induced-oxidative-stress-and-alterations-of-serum-concentrations-of-thyroid-and-reproductive-hormones-in-adult-female-rats
#5
Fatiha Mekircha, Samira Chebab, Rosita Gabbianelli, Essaid Leghouchi
This study aimed to verify whether Olea europaea L. (olive) oil (OEO) exerted a protective effect against oxidative stress induced by deltamethrin (DM) and alterations of pituitary, thyroid and gonadal hormones in adult female rats. DM (0,00256 g/kg body weight),OEO (0,6 g/kg body weight) and DM with OEO were administered to rats orally for 28 days. Volatile compounds present in olive oil were analysed by GC-MS. Estradiol (E2 ), Thyroxine (T4),Thyroid Stimulating Hormone (TSH), Triiodothyronine (T3), Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH), Progesterone (Pg) were measured in serum using Chemiluminescent Microparticle Immunoassay (CMIA)...
June 11, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29901199/fibroblast-growth-factor-18-promotes-the-growth-migration-and-invasion-of-mda%C3%A2-mb%C3%A2-231-cells
#6
Ziyi Yu, Longquan Lou, Yi Zhao
Fibroblast growth factor 18 (FGF18) increases cell motility and invasion in colon tumors, and is linked with ovarian and lung tumors. Furthermore, the increased expression of FGF18 mRNA and protein has been associated with poor overall survival in cancer patients. However, its function has not been investigated in breast cancer. In the present study, we demonstrated that FGF18 promoted cell growth and metastasis in vitro and stimulated tumor growth in xenograft models in vivo. FGF18 mediated the proliferation of MDA‑MB‑231 cells via the ERK/c‑Myc signaling pathway and induced epithelial‑to‑mesenchymal transition (EMT) factors to promote cancer migration and invasion...
June 7, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29899696/identification-of-steroidogenic-components-derived-from-gardenia-jasminoides-ellis-potentially-useful-for-treating-postmenopausal-syndrome
#7
Xueyu Wang, Guo-Cai Wang, Jianhui Rong, Shi Wei Wang, Tzi Bun Ng, Yan Bo Zhang, Kai Fai Lee, Lin Zheng, Hei-Kiu Wong, Ken Kin Lam Yung, Stephen Cho Wing Sze
Estrogen-stimulating principles have been demonstrated to relieve postmenopausal syndrome effectively. Gardenia jasminoides Ellis (GJE) is an herbal medicine possessing multiple pharmacological effects on human health with low toxicity. However, the therapeutic effects of GJE on the management of postmenopausal syndrome and its mechanism of action have not been fully elucidated. In this study, network pharmacology-based approaches were employed to examine steroidogenesis under the influence of GJE. In addition, the possibility of toxicity of GJE was ruled out and four probable active compounds were predicted...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29894213/low-glycosylated-forms-of-both-fsh-and-lh-play-major-roles-in-the-natural-ovarian-stimulation
#8
Leif Wide, Karin Eriksson
BACKGROUND: The natural ovarian stimulation is mediated by four gonadotrophin glycoforms: FSHtri with three, FSHtetra with four, LHdi with two, and LHtri with three N-glycans. The aim of the study was to determine the serum concentrations of the four glycoforms and their contents of anionic monosaccharides (AMS), i.e. sialic acid (SA) and sulfonated N-acetylgalactosamine (SU) residues throughout the menstrual cycle. METHODS: Serum samples were collected from 78 healthy women with regular menstrual cycles...
June 12, 2018: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/29893313/comparing-surgical-outcome-and-ovarian-reserve-after-laparoscopic-hysterectomy-between-two-methods-of-with-and-without-prophylactic-bilateral-salpingectomy-a-randomized-controlled-trial
#9
Zahra Asgari, Afsaneh Tehranian, Safoura Rouholamin, Reihaneh Hosseini, Mahdi Sepidarkish, Mahroo Rezainejad
Background: This study aimed to compare the surgical outcome and ovarian reserve in premenopausal women undergoing laparoscopic hysterectomy (without oophorectomy) for benign cause between two methods of with and without prophylactic bilateral salpingectomy. Materials and Methods: In a prospective randomized clinical trial, 62 premenopausal women with benign indication underwent a laparoscopic hysterectomy. Patients were then randomized to undergo hysterectomy with bilateral salpingectomy (Group 1; n = 15) or without bilateral salpingectomy (Group 2; n = 15)...
April 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29892263/vitamin-d-receptor-taqi-polymorphism-is-associated-with-reduced-follicle-number-in-women-utilizing-assisted-reproductive-technologies
#10
Mila W Reginatto, Bartira M Pizarro, Roberto A Antunes, Ana C A Mancebo, Luísa Hoffmann, Pâmela Fernandes, Patrícia Areas, Maria I Chiamolera, Rosane Silva, Maria do Carmo Borges de Souza, Enrrico Bloise, Tânia M Ortiga-Carvalho
Purpose: Calcitriol, or 1,25-hydroxycholecalciferol, is the active form of vitamin D. It binds and activates vitamin D receptor (VDR). Infertility and defective folliculogenesis have been observed in female vdr- knockout mice; however, whether VDR polymorphisms affect human ovarian responses to controlled ovarian stimulation (COS) remains unclear. We hypothesized that VDR polymorphisms are associated with infertility and COS responses. Thus, we evaluated the association between the TaqI, BsmI , and FokI VDR polymorphisms and ovarian responses in women undergoing COS...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29892142/ovarian-hyperstimulation-syndrome-a-narrative-review-of-its-pathophysiology-risk-factors-prevention-classification-and-management
#11
REVIEW
Bahia Namavar Jahromi, Mohammad Ebrahim Parsanezhad, Zahra Shomali, Pardis Bakhshai, Mahshid Alborzi, Najmeh Moin Vaziri, Zahra Anvar
Ovarian hyperstimulation syndrome (OHSS) is a serious complication of ovulation induction that usually occurs after gonadotropin stimulation, followed by human chorionic gonadotropin administration, for infertility treatment. The existing knowledge about the pathophysiology, risk factors, and primary and secondary methods for the prevention of OHSS is reviewed in this manuscript. The clinical manifestations and characteristics of mild, moderate, severe, and critical forms of the syndrome are defined. The methods of handling affected cases as outpatient or in-hospital management methods as well as indications for hospitalization are summarized in this review...
May 2018: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29891489/intratumoral-delivery-of-an-adenoviral-vector-carrying-the-socs-1-gene-enhances-t-cell-mediated-anti-tumor-immunity-by-suppressing-pd-l1
#12
Satoshi Nakagawa, Satoshi Serada, Reisa Kakubari, Kosuke Hiramatsu, Takahito Sugase, Shinya Matsuzaki, Satoko Matsuzaki, Yutaka Ueda, Kiyoshi Yoshino, Tomoharu Ohkawara, Minoru Fujimoto, Tadamitsu Kishimoto, Tadashi Kimura, Tetsuji Naka
Ovarian cancer (OvCa) is the leading cause of gynecological cancer-related deaths and novel therapeutic strategies are required. Programmed cell death 1 and programmed cell death ligand 1 (PD-L1), which are key mediators of host immune tolerance, are associated with OvCa progression. Recent evidence indicates the importance of IFN-γ-induced PD-L1 for immune tolerance in OvCa. This study aimed to reveal the therapeutic potential of suppressor of cytokine signaling 1 (SOCS-1), an endogenous inhibitor of the janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling pathway, for the treatment of OvCa...
June 11, 2018: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29890865/impact-of-stimulation-duration-and-gonadotropin-type-on-the-incidence-of-premature-progesterone-elevation-a-retrospective-analysis-of-the-ensure-data
#13
Barbara Lawrenz, Jianmin Long, Dominic Stoop, Irine Missou, Human Fatemi
Elevated progesterone levels on the day of trigger negatively impact the outcome of assisted reproductive technique (ART) treatment and forced ovarian stimulation might be a cause of progesterone elevation during ovarian stimulation. To analyze the impact of forced and prolonged stimulation on the progesterone elevation, this data analysis from the Ensure study compared hormonal stimulation with corifollitropin alpha (CFA)-only with CFA plus recombinant (rec) follicle-stimulating hormone (FSH) after day 8 (CFA-plus group) of ovarian stimulation...
June 12, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29889977/ovulation-induction-in-polycystic-ovary-syndrome
#14
Tom Tanbo, Jan Mellembakken, Sverre Bjercke, Eva Ring, Thomas Åbyholm, Peter Fedorcsak
The objective of this narrative review is to suggest a rational order of treatment choices in anovulatory women with polycystic ovary syndrome (PCOS), for whom a multitude of treatment options exist. In obese/overweight PCOS patients the importance of weight reduction should be stressed. Inositol, a dietary supplement with a documented effect on ovulation and without side effects in the doses recommended, may be suggested. Additional first line medical alternatives include insulin sensitizers, selective estrogen receptor modulators and aromatase inhibitors...
June 11, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29888581/-acupuncture-treatment-of-polycystic-ovarian-syndrome-patients-with-abdominal-obesity-by-regulating-dai-meridian-a-randomized-controlled-clinical-trial
#15
Ling-Yu Shen, Cui-Mei Liang, Wen-Jin Yang, Liang Pan, Hua Li, Hui Hu
OBJECTIVE: To explore the therapeutic effect of acupuncture in the treatment of polycystic ovarian syndrome (PCOS) patients with abdominal obesity by regulating glucose metabolism, insulin resistance, sex hormones, etc. METHODS: Eligible PCOS volunteers were randomly divided into treatment group( n =30) and control group( n =28). The treatment group received acupuncture therapy three times a week combined with diet control and exercise. EA (2 Hz/100 Hz, 4-8 mA) was applied to bilateral Daimai (GB 26)and Tianshu (ST 25) for 20 min/time, and bilateral Daheng (SP 15), Shenshu (BL 23), Ciliao (BL 32), Guilai (ST 29), Zulinqi (GB 41) and Waiguan (SJ 5) were stimulated with filiform needles, with the needles retained for 20 min...
April 25, 2018: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29886500/fertility-preservation-in-endocrine-disorders-during-transition-for-girls
#16
Julie Bénard, Nathalie Sermondade, Michaël Grynberg
Recent advances in fertility preservation (FP) techniques have led to a wide spread of indications. FP should now be discussed not only for young girls having to receive gonadotoxic treatments for cancer, but also for those with genetic or endocrine disorders, as well as benign ovarian diseases at risk of premature ovarian insufficiency. For premenarchal girls, ovarian tissue cryopreservation is still the only available technique. Oocyte cryopreservation after ovarian stimulation could be offered to postmenarchal girls...
2018: Endocrine Development
https://www.readbyqxmd.com/read/29886316/a-pharmacogenetic-approach-to-improve-low-ovarian-response-the-role-of-cag-repeats-length-in-the-androgen-receptor-gene
#17
Belén Lledo, Joaquín Llácer, Jose A Ortiz, Beatriz Martinez, Ruth Morales, Rafael Bernabeu
The AR (androgen receptor) polymorphism is associated with POR risk. Furthermore, the use of androgens in POR remains controversial. Our data could clarify the effectiveness of androgen pretreatment. AR genotyping could help us to identify patients at risk for POR and POR patients that will be benefited of androgen pretreatment. OBJECTIVE: The aim of this project was to investigate if the AR (androgen receptor) polymorphism could be used to identify patients at risk for POR and that will benefit from androgens pretreatment...
June 4, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29885884/impact-of-the-levonorgestrel-releasing-intrauterine-device-on-controlled-ovarian-stimulation-outcomes
#18
Amanda J Adeleye, Lusine Aghajanova, Chia-Ning Kao, Marcelle I Cedars, Mark V Sauer
OBJECTIVE: To report differences in ovarian stimulation outcomes in women using a levonorgestrel-releasing intrauterine device (LNG-IUD). DESIGN: Retrospective cohort study. SETTING: University-based infertility practice. PATIENT(S): Female patients pursuing either social oocyte cryopreservation or oocyte donation. INTERVENTION(S): Chart review of all female patients presenting from January 1, 2012, to June 30, 2017, for social oocyte cryopreservation or oocyte donation...
June 6, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29885573/conversion-to-iui-versus-continuance-with-ivf-in-low-responder-patients-a-systematic-review
#19
REVIEW
Dennis T Fujii, Jodi L Quesnell, Ryan J Heitmann
Poor response to ovarian hyper-stimulation can be difficult to predict prior to stimulation even when factoring in patient age and ovarian reserve testing. When faced with the situation of poor response, patients and providers have the difficult decision to proceed with oocyte retrieval, convert to intrauterine insemination (IUI), or cancel the cycle. Although this is not an uncommon scenario, there is little data available to assist with the counseling of these patients. We performed a systematic review of published studies comparing clinical pregnancy and live births between those patients continuing with in-vitro fertilization (IVF) and those converting to IUI...
June 1, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29881719/hormonal-predictors-of-abnormal-luteal-phases-in-normally-cycling-women
#20
Saman H Abdulla, Thomas P Bouchard, Rene A Leiva, Phil Boyle, Jean Iwaz, René Ecochard
Objective: Explore potential relationships between preovulatory, periovulatory, and luteal-phase characteristics in normally cycling women. Design: Observational study. Setting: Eight European natural family planning clinics. Patient(s): Ninety-nine women contributing 266 menstrual cycles. Intervention(s): The participants collected first morning urine samples that were analyzed for estrone-3 glucuronide (E1G), pregnanediol-3- alpha-glucuronide (PDG), follicle stimulating hormone (FSH), and luteinizing hormone (LH)...
2018: Frontiers in Public Health
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