keyword
MENU ▼
Read by QxMD icon Read
search

motor cortex inhibitory interneurons

keyword
https://www.readbyqxmd.com/read/28489931/cortical-involvement-in-celiac-disease-before-and-after-long-term-gluten-free-diet-a-transcranial-magnetic-stimulation-study
#1
Manuela Pennisi, Giuseppe Lanza, Mariagiovanna Cantone, Riccardo Ricceri, Raffaele Ferri, Carmela Cinzia D'Agate, Giovanni Pennisi, Vincenzo Di Lazzaro, Rita Bella
OBJECTIVE: Transcranial Magnetic Stimulation in de novo patients with Celiac Disease previously revealed an imbalance in the excitability of cortical facilitatory and inhibitory circuits. After a median period of 16 months of gluten-free diet, a global increase of cortical excitability was reported, suggesting a glutamate-mediated compensation for disease progression. We have now evaluated cross-sectionally the changes of cortical excitability to TMS after a much longer gluten-free diet...
2017: PloS One
https://www.readbyqxmd.com/read/28445715/altered-somatosensory-cortex-neuronal-activity-in-a-rat-model-of-parkinson-s-disease-and-levodopa-induced-dyskinesias
#2
Mesbah Alam, Regina Rumpel, Xingxing Jin, Christof von Wrangel, Sarah K Tschirner, Joachim K Krauss, Claudia Grothe, Andreas Ratzka, Kerstin Schwabe
Several findings support the concept that sensorimotor integration is disturbed in Parkinson's disease (PD) and in levodopa-induced dyskinesias. In this study, we explored the neuronal firing activity of excitatory pyramidal cells and inhibitory interneurons in the forelimb region of the primary somatosensory cortex (S1FL-Ctx), along with its interaction with oscillatory activity of the primary motor cortex (MCtx) in 6-hydroxydopamine lesioned hemiparkinsonian (HP) and levodopa-primed dyskinetic (HP-LID) rats as compared to controls under urethane (1...
April 23, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28348136/driving-human-motor-cortical-oscillations-leads-to-behaviorally-relevant-changes-in-local-gabaa-inhibition-a-tacs-tms-study
#3
Magdalena Nowak, Emily Hinson, Freek van Ede, Alek Pogosyan, Andrea Guerra, Andrew Quinn, Peter Brown, Charlotte J Stagg
Beta and gamma oscillations are the dominant oscillatory activity in the human motor cortex (M1). However, their physiological basis and precise functional significance remain poorly understood. Here, we used transcranial magnetic stimulation (TMS) to examine the physiological basis and behavioral relevance of driving beta and gamma oscillatory activity in the human M1 using transcranial alternating current stimulation (tACS). tACS was applied using a sham-controlled crossover design at individualized intensity for 20 min and TMS was performed at rest (before, during, and after tACS) and during movement preparation (before and after tACS)...
April 26, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28294153/calretinin-and-neuropeptide-y-interneurons-are-differentially-altered-in-the-motor-cortex-of-the-sod1-g93a-mouse-model-of-als
#4
Rosemary M Clark, Catherine A Blizzard, Kaylene M Young, Anna E King, Tracey C Dickson
Increasing evidence indicates an excitatory/inhibitory imbalance may have a critical role in the pathogenesis of amyotrophic lateral sclerosis (ALS). Impaired inhibitory circuitry is consistently reported in the motor cortex of both familial and sporadic patients, closely associated with cortical hyperexcitability and ALS onset. Inhibitory network dysfunction is presumably mediated by intra-cortical inhibitory interneurons, however, the exact cell types responsible are yet to be identified. In this study we demonstrate dynamic changes in the number of calretinin- (CR) and neuropeptide Y-expressing (NPY) interneurons in the motor cortex of the familial hSOD1(G93A) ALS mouse model, suggesting their potential involvement in motor neuron circuitry defects...
March 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28290507/inhibitory-interneuron-circuits-at-cortical-and-spinal-levels-are-associated-with-individual-differences-in-corticomuscular-coherence-during-isometric-voluntary-contraction
#5
Ryosuke Matsuya, Junichi Ushiyama, Junichi Ushiba
Corticomuscular coherence (CMC) is an oscillatory synchronization of 15-35 Hz (β-band) between electroencephalogram (EEG) of the sensorimotor cortex and electromyogram of contracting muscles. Although we reported that the magnitude of CMC varies among individuals, the physiological mechanisms underlying this variation are still unclear. Here, we aimed to investigate the associations between CMC and intracortical inhibition (ICI) in the primary motor cortex (M1)/recurrent inhibition (RI) in the spinal cord, which probably affect oscillatory neural activities...
March 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28118355/optogenetic-stimulation-shifts-the-excitability-of-cerebral-cortex-from-type-i-to-type-ii-oscillation-onset-and-wave-propagation
#6
Stewart Heitmann, Michael Rule, Wilson Truccolo, Bard Ermentrout
Constant optogenetic stimulation targeting both pyramidal cells and inhibitory interneurons has recently been shown to elicit propagating waves of gamma-band (40-80 Hz) oscillations in the local field potential of non-human primate motor cortex. The oscillations emerge with non-zero frequency and small amplitude-the hallmark of a type II excitable medium-yet they also propagate far beyond the stimulation site in the manner of a type I excitable medium. How can neural tissue exhibit both type I and type II excitability? We investigated the apparent contradiction by modeling the cortex as a Wilson-Cowan neural field in which optogenetic stimulation was represented by an external current source...
January 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/27914882/representation-of-the-body-in-the-lateral-striatum-of-the-freely-moving-rat-fast-spiking-interneurons-respond-to-stimulation-of-individual-body-parts
#7
Julianna M Kulik, Anthony P Pawlak, Manraj Kalkat, Kevin R Coffey, Mark O West
Numerous studies have shown that certain types of striatal interneurons play a crucial role in selection and regulation of striatal output. Striatal Fast-Spiking Interneurons (FSIs) are parvalbumin positive, GABAergic interneurons that constitute less than 1% of the total striatal population. It is becoming increasingly evident that these sparsely distributed neurons exert a strong inhibitory effect on Medium Spiny projection Neurons (MSNs). MSNs in lateral striatum receive direct synaptic input from regions of cortex representing discrete body parts, and show phasic increases in activity during touch or movement of specific body parts...
February 15, 2017: Brain Research
https://www.readbyqxmd.com/read/27891079/contribution-of-tms-and-rtms-in-the-understanding-of-the-pathophysiology-and-in-the-treatment-of-dystonia
#8
REVIEW
Pierre Lozeron, Aurélia Poujois, Alexandra Richard, Sana Masmoudi, Elodie Meppiel, France Woimant, Nathalie Kubis
Dystonias represent a heterogeneous group of movement disorders responsible for sustained muscle contraction, abnormal postures, and muscle twists. It can affect focal or segmental body parts or be generalized. Primary dystonia is the most common form of dystonia but it can also be secondary to metabolic or structural dysfunction, the consequence of a drug's side-effect or of genetic origin. The pathophysiology is still not elucidated. Based on lesion studies, dystonia has been regarded as a pure motor dysfunction of the basal ganglia loop...
2016: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/27641070/inhibition-promotes-long-term-potentiation-at-cerebellar-excitatory-synapses
#9
F Binda, K Dorgans, S Reibel, K Sakimura, M Kano, B Poulain, P Isope
The ability of the cerebellar cortex to learn from experience ensures the accuracy of movements and reflex adaptation, processes which require long-term plasticity at granule cell (GC) to Purkinje neuron (PN) excitatory synapses. PNs also receive GABAergic inhibitory inputs via GCs activation of interneurons; despite the involvement of inhibition in motor learning, its role in long-term plasticity is poorly characterized. Here we reveal a functional coupling between ionotropic GABAA receptors and low threshold CaV3 calcium channels in PNs that sustains calcium influx and promotes long-term potentiation (LTP) at GC to PN synapses...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27358449/differential-excitation-of-distally-versus-proximally-targeting-cortical-interneurons-by-unitary-thalamocortical-bursts
#10
Hang Hu, Ariel Agmon
UNLABELLED: Thalamocortical neurons relay sensory and motor information to the neocortex using both single spikes and bursts; bursts prevail during low-vigilance states but also occur during awake behavior. Bursts are suggested to provide an alerting signal to the cortex and enhance stimulus detection, but the synaptic mechanisms underlying these effects are not clear, because the postsynaptic responses of different subtypes of cortical neurons to unitary thalamocortical bursts are mostly unknown...
June 29, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27322194/investigating-default-mode-and-sensorimotor-network-connectivity-in-amyotrophic-lateral-sclerosis
#11
Sneha Chenji, Shankar Jha, Dawon Lee, Matthew Brown, Peter Seres, Dennell Mah, Sanjay Kalra
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative condition characterized by degeneration of upper motor neurons (UMN) arising from the motor cortex in the brain and lower motor neurons (LMN) in the brainstem and spinal cord. Cerebral changes create differences in brain activity captured by functional magnetic resonance imaging (fMRI), including the spontaneous and simultaneous activity occurring between regions known as the resting state networks (RSNs). Progressive neurodegeneration as observed in ALS may lead to a disruption of RSNs which could provide insights into the disease process...
2016: PloS One
https://www.readbyqxmd.com/read/27297027/amelioration-of-oxidative-stress-induced-phenotype-loss-of-parvalbumin-interneurons-might-contribute-to-the-beneficial-effects-of-environmental-enrichment-in-a-rat-model-of-post-traumatic-stress-disorder
#12
Xiao R Sun, Hui Zhang, Hong T Zhao, Mu H Ji, Hui H Li, Jing Wu, Kuan Y Li, Jian J Yang
Post-traumatic stress disorder (PTSD) is a common psychiatric disease following exposure to a severe traumatic event or physiological stress, which is characterized by anxiety- and depression-like behaviors and cognitive impairment. However, the underlying mechanisms remain elusive. Parvalbumin (PV) interneurons that are susceptible to oxidative stress are a subset of inhibitory GABAergic neurons regulating the excitability of pyramidal neurons, while dysfunction of PV interneurons is casually linked to many mental disorders including PTSD...
October 1, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27159237/an-inhibitory-corticostriatal-pathway
#13
Crystal Rock, Hector Zurita, Charles Wilson, Alfonso Junior Apicella
Anatomical and physiological studies have led to the assumption that the dorsal striatum receives exclusively excitatory afferents from the cortex. Here we test the hypothesis that the dorsal striatum receives also GABAergic projections from the cortex. We addressed this fundamental question by taking advantage of optogenetics and directly examining the functional effects of cortical GABAergic inputs to spiny projection neurons (SPNs) of the mouse auditory and motor cortex. We found that the cortex, via corticostriatal somatostatin neurons (CS-SOM), has a direct inhibitory influence on the output of the striatum SPNs...
2016: ELife
https://www.readbyqxmd.com/read/27149853/parvalbumin-expressing-gabaergic-neurons-in-mouse-barrel-cortex-contribute-to-gating-a-goal-directed-sensorimotor-transformation
#14
Shankar Sachidhanandam, B Semihcan Sermet, Carl C H Petersen
Sensory processing in neocortex is primarily driven by glutamatergic excitation, which is counterbalanced by GABAergic inhibition, mediated by a diversity of largely local inhibitory interneurons. Here, we trained mice to lick a reward spout in response to whisker deflection, and we recorded from genetically defined GABAergic inhibitory neurons in layer 2/3 of the primary somatosensory barrel cortex. Parvalbumin-expressing (PV), vasoactive intestinal peptide-expressing (VIP), and somatostatin-expressing (SST) neurons displayed distinct action potential firing dynamics during task performance...
April 13, 2016: Cell Reports
https://www.readbyqxmd.com/read/27131348/deletion-of-ctnnb1-in-inhibitory-circuitry-contributes-to-autism-associated-behavioral-defects
#15
Fengping Dong, Joanna Jiang, Colleen McSweeney, Donghua Zou, Long Liu, Yingwei Mao
Mutations in β-catenin (CTNNB1) have been implicated in cancer and mental disorders. Recently, loss-of-function mutations of CTNNB1 were linked to intellectual disability (ID), and rare mutations were identified in patients with autism spectrum disorder (ASD). As a key regulator of the canonical Wnt pathway, CTNNB1 plays an essential role in neurodevelopment. However, the function of CTNNB1 in specific neuronal subtypes is unclear. To understand how CTNNB1 deficiency contributes to ASD, we generated CTNNB1 conditional knockout (cKO) mice in parvalbumin interneurons...
July 1, 2016: Human Molecular Genetics
https://www.readbyqxmd.com/read/27105708/energy-deficit-in-parvalbumin-neurons-leads-to-circuit-dysfunction-impaired-sensory-gating-and-social-disability
#16
Melis Inan, Mingrui Zhao, Monica Manuszak, Cansu Karakaya, Anjali M Rajadhyaksha, Virginia M Pickel, Theodore H Schwartz, Peter A Goldstein, Giovanni Manfredi
Parvalbumin-expressing, fast spiking interneurons have high-energy demands, which make them particularly susceptible to energy impairment. Recent evidence suggests a link between mitochondrial dysfunction in fast spiking cortical interneurons and neuropsychiatric disorders. However, the effect of mitochondrial dysfunction restricted to parvalbumin interneurons has not been directly addressed in vivo. To investigate the consequences of mitochondrial dysfunction in parvalbumin interneurons in vivo, we generated conditional knockout mice with a progressive decline in oxidative phosphorylation by deleting cox10 gene selectively in parvalbumin neurons (PV-Cox10 CKO)...
September 2016: Neurobiology of Disease
https://www.readbyqxmd.com/read/27072754/differential-susceptibility-of-cortical-and-sub-cortical-inhibitory-neurons-and-astrocytes-in-the-long-term-following-diffuse-traumatic-brain-injury
#17
Simone F Carron, Edwin B Yan, Dasuni S Alwis, Ramesh Rajan
Long-term diffuse traumatic brain injury (dTBI) causes neuronal hyper-excitation in supragranular layers in sensory cortex, likely through reduced inhibition. Other forms of TBI affect inhibitory interneurons in sub-cortical areas but it is unknown if this occurs in cortex, or in any brain area in dTBI. We investigated dTBI effects on inhibitory neurons and astrocytes in somatosensory and motor cortex, and hippocampus, 8 weeks post-TBI. Brains were labelled with antibodies against calbindin (CB), parvalbumin (PV), calretinin (CR) and neuropeptide Y (NPY) and somatatostatin (SOM) and Glial fibrillary acidic protein (GFAP) a marker for astrogliosis during neurodegeneration...
April 12, 2016: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/27013680/effects-of-optogenetic-activation-of-corticothalamic-terminals-in-the-motor-thalamus-of-awake-monkeys
#18
Adriana Galvan, Xing Hu, Yoland Smith, Thomas Wichmann
UNLABELLED: The role of the corticothalamic projection in the ventral motor thalamus remains poorly understood. Therefore, we studied the electrophysiological responses of neurons in the basal ganglia and cerebellar receiving-territories of the motor thalamus (BGMT and CbMT, respectively) using optogenetic activation of corticothalamic projections in awake rhesus macaques. After injections of viral vectors carrying the excitatory opsins ChR2 or C1V1 into the primary motor and premotor cortices of two monkeys, we used optrodes to light activate opsin-expressing neurons in cortex or their terminals in the thalamus while simultaneously recording the extracellular activity of neurons in the vicinity of the stimulation sites...
March 23, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/26999665/corticospinal-and-reticulospinal-contacts-on-cervical-commissural-and-long-descending-propriospinal-neurons-in-the-adult-rat-spinal-cord-evidence-for-powerful-reticulospinal-connections
#19
Emma J Mitchell, Sarah McCallum, Deborah Dewar, David J Maxwell
Descending systems have a crucial role in the selection of motor output patterns by influencing the activity of interneuronal networks in the spinal cord. Commissural interneurons that project to the contralateral grey matter are key components of such networks as they coordinate left-right motor activity of fore and hind-limbs. The aim of this study was to determine if corticospinal (CST) and reticulospinal (RST) neurons make significant numbers of axonal contacts with cervical commissural interneurons. Two classes of commissural neurons were analysed: 1) local commissural interneurons (LCINs) in segments C4-5; 2) long descending propriospinal neurons (LDPNs) projecting from C4 to the rostral lumbar cord...
2016: PloS One
https://www.readbyqxmd.com/read/26918702/time-invariant-feed-forward-inhibition-of-purkinje-cells-in-the-cerebellar-cortex-in-vivo
#20
Antonin Blot, Camille de Solages, Srdjan Ostojic, German Szapiro, Vincent Hakim, Clément Léna
KEY POINTS: We performed extracellular recording of pairs of interneuron-Purkinje cells in vivo. A single interneuron produces a substantial, short-lasting, inhibition of Purkinje cells. Feed-forward inhibition is associated with characteristic asymmetric cross-correlograms. In vivo, Purkinje cell spikes only depend on the most recent synaptic activity. ABSTRACT: Cerebellar molecular layer interneurons are considered to control the firing rate and spike timing of Purkinje cells...
May 15, 2016: Journal of Physiology
keyword
keyword
64342
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"