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https://www.readbyqxmd.com/read/28747911/f1-domain-of-the-leishmania-leishmania-donovani-nucleoside-hydrolase-promotes-a-th1-response-in-leishmania-leishmania-infantum-cured-patients-and-in-asymptomatic-individuals-living-in-an-endemic-area-of-leishmaniasis
#1
Eugenia Carrillo, Laura Fernandez, Ana Victoria Ibarra-Meneses, Micheli L B Santos, Dirlei Nico, Paula M de Luca, Cristiane Bani Correa, Roque Pacheco de Almeida, Javier Moreno, Clarisa B Palatnik-de-Sousa
The Leishmania (Leishmania) donovani nucleoside hydrolase NH36 is the main antigen of the Leishmune(®) vaccine and one of the promising candidates for vaccination against visceral leishmaniasis. The antigenicity of the N-terminal (F1), the central (F2), or the C-terminal recombinant domain (F3) of NH36 was evaluated using peripheral blood mononuclear cells (PBMC) from individuals infected with L. (L.) infantum from an endemic area of visceral leishmaniasis of Spain. Both NH36 and F1 domains significantly increased the PBMC proliferation stimulation index of cured patients and infected asymptomatic individuals compared to healthy controls...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28740915/limited-short-term-effect-of-palliative-radiation-therapy-on-quantitative-computed-tomography-derived-bone-mineral-density-in-femora-with-metastases
#2
Florieke Eggermont, Loes C Derikx, Nico Verdonschot, Gerjon Hannink, Robert S J P Kaatee, Esther Tanck, Yvette M van der Linden
PURPOSE: The aim of this study was to determine the effect of single fraction (SF) and multiple fraction (MF) radiation therapy (RT) on bone mineral density (BMD) in patients with cancer and bone metastases in the proximal femur. We studied this effect in the radiation field and within metastatic lesions, and differentiated between lytic, blastic, and mixed lesions. METHODS AND MATERIALS: This prospective cohort study comprised 42 patients with painful bone metastases, including 47 irradiated femora with 52 metastatic lesions in the proximal femur...
January 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/28740868/climate-warming-promotes-species-diversity-but-with-greater-taxonomic-redundancy-in-complex-environments
#3
Madhav P Thakur, David Tilman, Oliver Purschke, Marcel Ciobanu, Jane Cowles, Forest Isbell, Peter D Wragg, Nico Eisenhauer
Climate warming is predicted to alter species interactions, which could potentially lead to extinction events. However, there is an ongoing debate whether the effects of warming on biodiversity may be moderated by biodiversity itself. We tested warming effects on soil nematodes, one of the most diverse and abundant metazoans in terrestrial ecosystems, along a gradient of environmental complexity created by a gradient of plant species richness. Warming increased nematode species diversity in complex (16-species mixtures) plant communities (by ~36%) but decreased it in simple (monocultures) plant communities (by ~39%) compared to ambient temperature...
July 2017: Science Advances
https://www.readbyqxmd.com/read/28739554/46-xy-disorder-of-sex-development-due-to-17-beta-hydroxysteroid-dehydrogenase-type-3-deficiency-in-an-infant-of-greek-origin
#4
Assimina Galli-Tsinopoulou, Anastasios Serbis, Eleni Kotanidou, Eleni Litou, Vaia Dokousli, Konstantina Mouzaki, Pavlos Fanis, Vassos Neocleous, Nicos Skordis
17β-hydroxysteroid dehydrogenase type 3 (17βHSD-3) enzyme catalyzes the conversion of androstenedione (Δ4) to testosterone (T) in the testes of the developing fetus, thus playing a crucial role in the differentiation of the gonads and in establishing the male sex phenotype. Any mutation in the encoding gene (HSD17B3) can lead to a varying degree of undervirilization of the affected male that ranges from completely undervirilized external female genitalia to predominantly male with micropenis and hypospadias...
July 24, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/28738898/silicanin-1-is-a-conserved-diatom-membrane-protein-involved-in-silica-biomineralization
#5
Alexander Kotzsch, Philip Gröger, Damian Pawolski, Paul H H Bomans, Nico A J M Sommerdijk, Michael Schlierf, Nils Kröger
BACKGROUND: Biological mineral formation (biomineralization) proceeds in specialized compartments often bounded by a lipid bilayer membrane. Currently, the role of membranes in biomineralization is hardly understood. RESULTS: Investigating biomineralization of SiO2 (silica) in diatoms we identified Silicanin-1 (Sin1) as a conserved diatom membrane protein present in silica deposition vesicles (SDVs) of Thalassiosira pseudonana. Fluorescence microscopy of GFP-tagged Sin1 enabled, for the first time, to follow the intracellular locations of a biomineralization protein during silica biogenesis in vivo...
July 24, 2017: BMC Biology
https://www.readbyqxmd.com/read/28738362/advances-in-the-diagnosis-of-obstructive-sleep-apnea-drug-induced-sleep-endoscopy
#6
Madeline J L Revesloot, Linda Benoist, Peter van Maanen, Eric J Kezirian, Nico de Vries
Drug-induced sleep endoscopy was introduced in 1991 and has recently evolved into a pivotal instrument for patients in whom obstructive sleep apnea surgery is considered. Here, we discuss the indications, contraindications, technique, anesthesia, scoring systems, validity, and insights of the literature.
2017: Advances in Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28738340/novel-positional-devices-for-the-treatment-of-positional-obstructive-sleep-apnea-and-how-this-relates-to-sleep-surgery
#7
Madeline J L Revesloot, Linda Benoist, Peter van Maanen, Nico de Vries
If untreated, obstructive sleep apnea (OSA) develops as a gradual progressive disease. In the early stage of the disease most patients with OSA are positional. The archetypical patient might progress from simple positional snoring via positional early-stage mild disease to less positional moderate and finally nonpositional severe OSA. At first, the apnea-hypopnea index (AHI) is high only in the supine position, and later is high in all sleeping positions. The phenomenon is reversible. After partial effective treatment, patients with severe OSA can reverse to less severe positional OSA or, in other words, the AHI drops more in the lateral position than in supine position...
2017: Advances in Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28733645/hdac3-is-a-molecular-brake-of-the-metabolic-switch-supporting-white-adipose-tissue-browning
#8
Alessandra Ferrari, Raffaella Longo, Erika Fiorino, Rui Silva, Nico Mitro, Gaia Cermenati, Federica Gilardi, Béatrice Desvergne, Annapaola Andolfo, Cinzia Magagnotti, Donatella Caruso, Emma De Fabiani, Scott W Hiebert, Maurizio Crestani
White adipose tissue (WAT) can undergo a phenotypic switch, known as browning, in response to environmental stimuli such as cold. Post-translational modifications of histones have been shown to regulate cellular energy metabolism, but their role in white adipose tissue physiology remains incompletely understood. Here we show that histone deacetylase 3 (HDAC3) regulates WAT metabolism and function. Selective ablation of Hdac3 in fat switches the metabolic signature of WAT by activating a futile cycle of de novo fatty acid synthesis and β-oxidation that potentiates WAT oxidative capacity and ultimately supports browning...
July 21, 2017: Nature Communications
https://www.readbyqxmd.com/read/28731710/computational-calorimetry-of-pnipam-cononsolvency-in-water-methanol-mixtures
#9
Cahit Dalgicdir, Francisco Rodriguez-Ropero, Nico F A van der Vegt
We revisit the mechanism for cononsolvency of PNIPAM in water/methanol mixtures. Using extensive molecular dynamics simulations we calculate the calorimetric enthalpy of the PNIPAM collapse transition and observe a unique fingerprint of PNIPAM cononsolvency which is analysed in terms of microscopic interactions. We find that polymer hydration is the determining factor for PNIPAM collapse in the cononsolvency regime. In particular, it is shown that methanol frustrates the ability of water to form hydrogen bonds with the amide proton and therefore causes polymer collapse...
July 21, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28731092/a-ni-p-nico-ldh-core-shell-nanorod-decorated-nickel-foam-with-enhanced-areal-specific-capacitance-for-high-performance-supercapacitors
#10
Jiale Xing, Jing Du, Xuan Zhang, Yubo Shao, Ting Zhang, Cailing Xu
Recently, transition metal-based nanomaterials have played a key role in the applications of supercapacitors. In this study, nickel phosphide (Ni-P) was simply combined with NiCo LDH via facile phosphorization of Ni foam and subsequent electrodeposition to form core-shell nanorod arrays on the Ni foam; the Ni-P@NiCo LDH was then directly used for a pseudocapacitive electrode. Owing to the splendid synergistic effect between Ni-P and NiCo LDH nanosheets as well as the hierarchical structure of 1D nanorods, 2D nanosheets, and 3D Ni foam, the hybrid electrode exhibited significantly enhanced electrochemical performances...
July 21, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28728652/accuracy-of-fractional-flow-reserve-measurements-in-clinical-practice-observations-from-a-core-laboratory-analysis
#11
Mitsuaki Matsumura, Nils P Johnson, William F Fearon, Gary S Mintz, Gregg W Stone, Keith G Oldroyd, Bernard De Bruyne, Nico H J Pijls, Akiko Maehara, Allen Jeremias
OBJECTIVES: The aim of this study was to compare site-reported measurements of fractional flow reserve (FFR) with FFR analysis by an independent core laboratory (CL). BACKGROUND: FFR is an index of coronary stenosis severity that has been validated in multiple trials and is widely used in clinical practice. However, the incidence of suboptimal FFR measurements is unknown. METHODS: Patients undergoing FFR assessment within the CONTRAST (Can Contrast Injection Better Approximate FFR Compared to Pure Resting Physiology) study had paired, repeated measurements of multiple physiological metrics per local practice...
July 24, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28725406/root-exudate-cocktails-the-link-between-plant-diversity-and-soil-microorganisms
#12
Katja Steinauer, Antonis Chatzinotas, Nico Eisenhauer
Higher plant diversity is often associated with higher soil microbial biomass and diversity, which is assumed to be partly due to elevated root exudate diversity. However, there is little experimental evidence that diversity of root exudates shapes soil microbial communities. We tested whether higher root exudate diversity enhances soil microbial biomass and diversity in a plant diversity gradient, thereby negating significant plant diversity effects on soil microbial properties. We set up plant monocultures and two- and three-species mixtures in microcosms using functionally dissimilar plants and soil of a grassland biodiversity experiment in Germany...
October 2016: Ecology and Evolution
https://www.readbyqxmd.com/read/28724912/annual-variations-of-monsoon-and-drought-detected-by-gps-a-case-study-in-yunnan-china
#13
Weiping Jiang, Peng Yuan, Hua Chen, Jianqing Cai, Zhao Li, Nengfang Chao, Nico Sneeuw
The Global Positioning System (GPS) records monsoonal precipitable water vapor (PWV) and vertical crustal displacement (VCD) due to hydrological loading, and can thus be applied jointly to diagnose meteorological and hydrological droughts. We have analyzed the PWV and VCD observations during 2007.0-2015.0 at 26 continuous GPS stations located in Yunnan province, China. We also obtained equivalent water height (EWH) derived from the Gravity Recovery And Climate Experiment (GRACE) and precipitation at these stations with the same period...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28719787/in-vivo-performance-of-a-novel-anatomically-shaped-total-meniscal-prosthesis-made-of-polycarbonate-urethane-a-12-month-evaluation-in-goats
#14
Anne C T Vrancken, Gerjon Hannink, Wojciech Madej, Nico Verdonschot, Tony G van Tienen, Pieter Buma
BACKGROUND: Injury or loss of the meniscus generally leads to degenerative osteoarthritic changes in the knee joint. However, the treatment options for symptomatic patients with total meniscectomy are limited. Therefore, we developed a novel, anatomically shaped, total meniscal implant made of polycarbonate urethane. PURPOSE: To evaluate the in vivo performance of this novel total meniscal implant. The assessment particularly focused on the implant's response to long-term physiological loading in a goat model and its chondroprotective capacity in comparison to clinically relevant controls...
July 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28717381/patterns-and-dynamics-of-neutral-lipid-fatty-acids-in-ants-implications-for-ecological-studies
#15
Félix B Rosumek, Adrian Brückner, Nico Blüthgen, Florian Menzel, Michael Heethoff
BACKGROUND: Trophic interactions are a fundamental aspect of ecosystem functioning, but often difficult to observe directly. Several indirect techniques, such as fatty acid analysis, were developed to assess these interactions. Fatty acid profiles may indicate dietary differences, while individual fatty acids can be used as biomarkers. Ants are among the most important terrestrial animal groups, but little is known about their lipid metabolism, and no study so far used fatty acids to study their trophic ecology...
2017: Frontiers in Zoology
https://www.readbyqxmd.com/read/28716132/a-patient-safety-and-professional-perspective-on-non-conveyance-in-ambulance-care-a-systematic-review
#16
REVIEW
Remco H A Ebben, Lilian C M Vloet, Renate F Speijers, Nico W Tönjes, Jorik Loef, Thomas Pelgrim, Margreet Hoogeveen, Sivera A A Berben
BACKGROUND: This systematic review aimed to describe non-conveyance in ambulance care from patient-safety and ambulance professional perspectives. The review specifically focussed at describing (1) ambulance non-conveyance rates, (2) characteristics of non-conveyed patients, (3) follow-up care after non-conveyance, (4) existing guidelines or protocols, and (5) influencing factors during the non-conveyance decision making process. METHODS: We systematically searched MEDLINE, PubMed, CINAHL, EMBASE, and reference lists of included articles, in June 2016...
July 17, 2017: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/28715694/associative-cueing-of-attention-through-implicit-feature-location-binding
#17
Giovanna Girardi, Daniele Nico
In order to assess associative learning between two task-irrelevant features in cueing spatial attention, we devised a task in which participants have to make an identity comparison between two sequential visual stimuli. Unbeknownst to them, location of the second stimulus could be predicted by the colour of the first or a concurrent sound. Albeit unnecessary to perform the identity-matching judgment the predictive features thus provided an arbitrary association favouring the spatial anticipation of the second stimulus...
July 14, 2017: Acta Psychologica
https://www.readbyqxmd.com/read/28712810/conformational-heterogeneity-in-the-activation-mechanism-of-bax
#18
C Ashley Barnes, Pushpa Mishra, James L Baber, Marie-Paule Strub, Nico Tjandra
Bax is known for its pro-apoptotic role within the mitochondrial pathway of apoptosis. However, the mechanism for transitioning Bax from cytosolic to membrane-bound oligomer remains elusive. Previous nuclear magnetic resonance (NMR) and electron paramagnetic resonance (EPR) studies defined monomeric Bax as conformationally homogeneous. Yet it has recently been proposed that monomeric Bax exists in equilibrium with a minor state that is distinctly different from its NMR structure. Here, we revisited the structural analysis of Bax using methods uniquely suited for unveiling "invisible" states of proteins, namely, NMR paramagnetic relaxation enhancements and EPR double electron-electron resonance (DEER)...
July 3, 2017: Structure
https://www.readbyqxmd.com/read/28711589/fixation-strength-of-a-polyetheretherketone-femoral-component-in-total-knee-arthroplasty
#19
Lennert de Ruiter, Dennis Janssen, Adam Briscoe, Nico Verdonschot
INTRODUCTION: Introducing polyetheretherketone (PEEK) polymer as a material for femoral components in total knee arthroplasty (TKA) could potentially lead to a reduction of the cemented fixation strength. A PEEK implant is more likely to deform under high loads, rendering geometrical locking features less effective. Fixation strength may be enhanced by adding more undercuts or specific surface treatments. The aim of this study is to measure the initial fixation strength and investigate the associated failure patterns of three different iterations of PEEK-OPTIMA(®) implants compared with a Cobalt-Chromium (CoCr) component...
July 12, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28708801/bone-and-joint-infections
#20
Jesús Saavedra-Lozano, Oana Falup-Pecurariu, Saul N Faust, Hermann Girschick, Nico Hartwig, Sheldon Kaplan, Mathie Lorrot, Elpis Mantadakis, Heikki Peltola, Pablo Rojo, Theoklis Zaoutis, Anton LeMair
No abstract text is available yet for this article.
August 2017: Pediatric Infectious Disease Journal
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