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https://www.readbyqxmd.com/read/28526809/tumor-cell-specific-aim2-regulates-growth-and-invasion-of-cutaneous-squamous-cell-carcinoma
#1
Mehdi Farshchian, Liisa Nissinen, Elina Siljamäki, Pilvi Riihilä, Minna Piipponen, Atte Kivisaari, Markku Kallajoki, Reidar Grénman, Juha Peltonen, Sirkku Peltonen, Koen D Quint, Jan Nico Bouwes Bavinck, Veli-Matti Kähäri
Cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer. Inflammation is a typical feature in cSCC progression. Analysis of the expression of inflammasome components in cSCC cell lines and normal human epidermal keratinocytes revealed upregulation of the expression of AIM2 mRNA and protein in cSCC cells. Elevated levels of AIM2 mRNA were noted in cSCCs in vivo compared with normal skin. Strong and moderate tumor cell specific expression of AIM2 was detected with immunohistochemistry (IHC) in sporadic human cSCCs in vivo, whereas expression of AIM2 was moderate in cSCC in situ (cSCCIS) and low or absent in actinic keratosis (AK) and normal skin...
May 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28522078/a-randomized-controlled-trial-of-positional-therapy-versus-oral-appliance-therapy-for-position-dependent-sleep-apnea
#2
Linda Benoist, Maurits de Ruiter, Jan de Lange, Nico de Vries
OBJECTIVE: To compare the effectiveness of positional therapy (PT) with the sleep position trainer (SPT) to oral appliance therapy (OAT) in patients with mild-to-moderate positional obstructive sleep apnea (POSA). METHODS: Multicenter, prospective, randomized, controlled trial. Patients with mild-to-moderate POSA (apnea-hypopnea index (AHI) ≥5 ≤ 30/hour sleep) were randomized for PT or OAT. Polysomnography was repeated after 3 months. Efficacy, adherence, mean disease alleviation (MDA), quality of life, dropouts and adverse events were evaluated...
June 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28520548/intracoronary-hypothermia-before-reperfusion-to-reduce-reperfusion-injury-in-acute-myocardial-infarction-a-novel-hypothesis-and-technique
#3
Luuk C Otterspoor, Lokien X van Nunen, Marcel van 't Veer, Nils P Johnson, Nico H J Pijls
Because current reperfusion strategies in acute myocardial infarction (AMI) seem to be exhausted in terms of additional mortality benefit, there remains a need for new methods to attenuate reperfusion injury and, thereby, further reduce myocardial infarct size and improve long-term survival. Therapeutic hypothermia (32-35°C) diminishes reperfusion injury and reduces infarct size in a variety of animal models of AMI if provided before reperfusion. In human studies this reduction has not been confirmed so far, most likely because systemic cooling acts slowly, and therefore, the target temperature is not reached in time or at all in a substantial number of patients...
May 18, 2017: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/28515083/self-healing-capacity-of-deep-sea-ecosystems-affected-by-petroleum-hydrocarbons-understanding-microbial-oil-degradation-at-hydrocarbon-seeps-is-key-to-sustainable-bioremediation-protocols
#4
Alberto Scoma, Michail M Yakimov, Daniele Daffonchio, Nico Boon
No abstract text is available yet for this article.
May 17, 2017: EMBO Reports
https://www.readbyqxmd.com/read/28511936/biotechnologies-for-marine-oil-spill-cleanup-indissoluble-ties-with-microorganisms
#5
REVIEW
Francesca Mapelli, Alberto Scoma, Grégoire Michoud, Federico Aulenta, Nico Boon, Sara Borin, Nicolas Kalogerakis, Daniele Daffonchio
The ubiquitous exploitation of petroleum hydrocarbons (HCs) has been accompanied by accidental spills and chronic pollution in marine ecosystems, including the deep ocean. Physicochemical technologies are available for oil spill cleanup, but HCs must ultimately be mineralized by microorganisms. How environmental factors drive the assembly and activity of HC-degrading microbial communities remains unknown, limiting our capacity to integrate microorganism-based cleanup strategies with current physicochemical remediation technologies...
May 13, 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/28509443/hemodynamically-stimulated-and-in-vivo-generated-axially-vascularized-soft-tissue-free-flaps-for-closure-of-complex-defects-evaluation-in-a-small-animal-model
#6
Volker J Schmidt, Johanna O Wietbrock, Nico Leibig, Jochen F Hernekamp, Dominic Henn, Christian A Radu, Ulrich Kneser
The arteriovenous (AV) loop model permits the creation of significant volumes of axially vascularized tissue that represents an alternative to conventional free flaps, circumventing their common limitations. However, such AV-loop-based flaps have never before been examined in standardized animal models with respect to their suitability for reconstruction of critical bone exposing defects. In the course of our preliminary studies, we implemented a novel defect model in rats that provides standardized and critical wound conditions and evaluated whether AV-loop-generated flaps are suitable for free microsurgical transfer and closure of composite defects...
May 16, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28504272/sirt1-carboxyl-domain-is-an-atp-repressible-domain-that-is-transferrable-to-other-proteins
#7
Hyeog Kang, Shinichi Oka, Duck-Yeon Lee, Junhong Park, Angel M Aponte, Young-Sang Jung, Jacob Bitterman, Peiyong Zhai, Yi He, Hamed Kooshapur, Rodolfo Ghirlando, Nico Tjandra, Sean B Lee, Myung K Kim, Junichi Sadoshima, Jay H Chung
Sirt1 is an NAD(+)-dependent protein deacetylase that regulates many physiological functions, including stress resistance, adipogenesis, cell senescence and energy production. Sirt1 can be activated by energy deprivation, but the mechanism is poorly understood. Here, we report that Sirt1 is negatively regulated by ATP, which binds to the C-terminal domain (CTD) of Sirt1. ATP suppresses Sirt1 activity by impairing the CTD's ability to bind to the deacetylase domain as well as its ability to function as the substrate recruitment site...
May 15, 2017: Nature Communications
https://www.readbyqxmd.com/read/28503167/the-impact-of-space-flight-on-survival-and-interaction-of-cupriavidus-metallidurans-ch34-with-basalt-a-volcanic-moon-analog-rock
#8
Bo Byloos, Ilse Coninx, Olivier Van Hoey, Charles Cockell, Natasha Nicholson, Vyacheslav Ilyin, Rob Van Houdt, Nico Boon, Natalie Leys
Microbe-mineral interactions have become of interest for space exploration as microorganisms could be used to biomine from extra-terrestrial material and extract elements useful as micronutrients in life support systems. This research aimed to identify the impact of space flight on the long-term survival of Cupriavidus metallidurans CH34 in mineral water and the interaction with basalt, a lunar-type rock in preparation for the ESA spaceflight experiment, BIOROCK. Therefore, C. metallidurans CH34 cells were suspended in mineral water supplemented with or without crushed basalt and send for 3 months on board the Russian FOTON-M4 capsule...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28500391/anterior-referencing-of-tibial-slope-in-total-knee-arthroplasty-considerably-influences-knee-kinematics-a-musculoskeletal-simulation-study
#9
Marco A Marra, Marta Strzelczak, Petra J C Heesterbeek, Sebastiaan A W van de Groes, Dennis W Janssen, Bart F J M Koopman, Ate B Wymenga, Nico J J Verdonschot
PURPOSE: In total knee arthroplasty (TKA), the posterior tibial slope is not always reconstructed correctly, and the knee ligaments may become too tight in flexion. To release a tight flexion gap, surgeons can increase the posterior tibial slope using two surgical resection techniques: the anterior tibial cortex (ACR) or the centre of tibial plateau (CPR) referencing. It is not known how this choice affects the knee laxity and function during activities of daily living. The aim of this study was to investigate the effect of tibial slope on knee laxity, kinematics and forces during a squatting activity using computer simulation techniques...
May 12, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28499315/-usual-care-for-panic-disorder-with-without-agoraphobia-in-primary-care
#10
Michael Sommer, Thomas S Hiller, Jörg Breitbart, Nico Schneider, Tobias Teismann, Antje Freytag, Jochen Gensichen
Objective To describe therapy as usual (TAU) for panic disorder with/without agoraphobia (PDA) in primary care. Method Written survey of 38 general practitioners (GPs) who provided TAU to 189 patients with PDA as part of an interventional study. Data were analyzed descriptively. Results The most common TAU-interventions were: exploration of psychosocial problems (83 %), recommendation not to avoid anxiety-provoking stimuli (72 %), prescription of SSRIs (62 %). Common reasons for referrals were various psychiatric comorbidities and treatment-refractory anxiety (77 %)...
May 12, 2017: Psychiatrische Praxis
https://www.readbyqxmd.com/read/28495769/draft-genome-sequence-of-bacillus-toyonensis-vu-des13-isolated-from-folsomia-candida-collembola-entomobryidae
#11
Thierry K S Janssens, Tjalf E de Boer, Valeria Agamennone, Niels Zaagman, Nico M van Straalen, Dick Roelofs
We present here the draft genome of Bacillus toyonensis VU-DES13, which was isolated from the midgut of the soil-living springtail Folsomia candida Previous research revealed the presence of gene clusters for the biosynthesis of various secondary metabolites, including β-lactam antibiotics, in the host's genome. The genome data are discussed in the light of the antimicrobial properties against fungi and oomycetes and a high level of β-lactam resistance of the isolate.
May 11, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28494967/visualizing-calcium-flux-in-freely-moving-nematode-embryos
#12
Evan L Ardiel, Abhishek Kumar, Joseph Marbach, Ryan Christensen, Rishi Gupta, William Duncan, Jonathan S Daniels, Nico Stuurman, Daniel Colón-Ramos, Hari Shroff
The lack of physiological recordings from Caenorhabditis elegans embryos stands in stark contrast to the comprehensive anatomical and gene expression datasets already available. Using light-sheet fluorescence microscopy to address the challenges associated with functional imaging at this developmental stage, we recorded calcium dynamics in muscles and neurons and developed analysis strategies to relate activity and movement. In muscles, we found that the initiation of twitching was associated with a spreading calcium wave in a dorsal muscle bundle...
May 9, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28494960/laser-activated-polymeric-microcapsules-for-ultrasound-imaging-and-therapy-in%C3%A2-vitro-feasibility
#13
Guillaume Lajoinie, Tom van Rooij, Ilya Skachkov, Emilie Blazejewski, Gert Veldhuis, Nico de Jong, Klazina Kooiman, Michel Versluis
Polymeric microcapsules with a light-absorbing dye incorporated in their shell can generate vapor microbubbles that can be spatiotemporally controlled by pulsed laser irradiation. These contrast agents of 6-8 μm in diameter can circulate through the vasculature, offering possibilities for ultrasound (molecular) imaging and targeted therapies. Here, we study the impact of such vapor bubbles on human endothelial cells in terms of cell poration and cell viability to establish the imaging and therapeutic windows...
May 9, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28488982/philanthropy-and-beyond-creating-shared-value-to-promote-well-being-for-individuals-in-their-communities
#14
EDITORIAL
Thomas E Kottke, Nico Pronk, Andrew R Zinkel, George J Isham
Health care organizations can magnify the impact of their community service and other philanthropic activities by implementing programs that create shared value. By definition, shared value is created when an initiative generates benefit for the sponsoring organization while also generating societal and community benefit. Because the programs generate benefit for the sponsoring organizations, the magnitude of any particular initiative is limited only by the market for the benefit and not the resources that are available for philanthropy...
2017: Permanente Journal
https://www.readbyqxmd.com/read/28487735/variations-in-the-3-utr-of-the-cyp21a2-gene-in-heterozygous-females-with-hyperandrogenaemia
#15
Vassos Neocleous, Pavlos Fanis, Meropi Toumba, Alexia A P Phedonos, Michalis Picolos, Elena Andreou, Tassos C Kyriakides, George A Tanteles, Christos Shammas, Leonidas A Phylactou, Nicos Skordis
Heterozygosity for CYP21A2 mutations in females is possibly related to increased risk of developing clinical hyperandrogenism. The present study was designed to seek evidence on the phenotype-genotype correlation in female children, adolescents, and women with CYP21A2 mutations and variants in the 3'UTR region of the gene. Sixty-six patients out of the 169 were identified as carriers of CYP21A2 mutations. Higher values of stimulated 17 hydroxyprogesterone (17-OHP) levels were found in the carriers of the p...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28484948/enhanced-recognition-of-memorable-pictures-in-ultra-fast-rsvp
#16
Nico Broers, Mary C Potter, Mark R Nieuwenstein
Long-term recognition memory for some pictures is consistently better than for others (Isola, Xiao, Parikh, Torralba, & Oliva, IEEE Transaction on Pattern Analysis and Machine Intelligence (PAMI), 36(7), 1469-1482, 2014). Here, we investigated whether pictures found to be memorable in a long-term memory test are also perceived more easily when presented in ultra-rapid RSVP. Participants viewed 6 pictures they had never seen before that were presented for 13 to 360 ms per picture in a rapid serial visual presentation (RSVP) sequence...
May 8, 2017: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/28481551/direct-measurement-of-the-surface-energy-of-graphene
#17
Christian D van Engers, Nico E A Cousens, Vitaliy Babenko, Jude Britton, Bruno Zappone, Nicole Grobert, Susan Perkin
Graphene produced by chemical vapor deposition (CVD) is a promising candidate for implementing graphene in a range of technologies. In most device configurations, one side of the graphene is supported by a solid substrate, wheras the other side is in contact with a medium of interest, such as a liquid or other two-dimensional material within a van der Waals stack. In such devices, graphene interacts on both faces via noncovalent interactions and therefore surface energies are key parameters for device fabrication and operation...
May 16, 2017: Nano Letters
https://www.readbyqxmd.com/read/28479334/cdc42-related-genes-are-upregulated-in-helper-t-cells-from-obese-asthmatic-children
#18
Deepa Rastogi, John Nico, Andrew D Johnston, Toni Adrianne M Tobias, Yurydia Jorge, Fernando Macian, John M Greally DMed
BACKGROUND: Pediatric obesity-related asthma is more severe and less responsive to medications than asthma in normal-weight children. Obese asthmatic children have nonatopic TH1-polarized systemic inflammation that correlates with pulmonary function deficits, but the pathways underlying TH1-polarized inflammation are not well understood. OBJECTIVE: We compared the CD4(+) T-cell transcriptome in obese children with asthma with that in normal-weight children with asthma to identify key differentially expressed genes associated with TH1-polarized inflammation...
May 4, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28475554/sustained-viral-suppression-in-hiv-infected-children-on-once-daily-lopinavir-ritonavir-in-clinical-practice
#19
Ivar P E Gondrie, Diane E T Bastiaans, Pieter L A Fraaij, Gertjan J A Driessen, Linda C Van Der Knaap, Eline G Visser, Petronette Van Jaarsveld, Ronald de Groot, Nico G Hartwig, David M Burger, Annemarie M C Van Rossum
BACKGROUND: The use of lopinavir/ritonavir once-daily (LPV/r QD) has not been approved for children. Good short-term clinical, virological and immunological outcomes have been observed in children on LPV/r QD. METHODS: We evaluated the long-term effectiveness of a LPV/r QD containing regimen in HIV-1 infected children in clinical practice. Selected children (aged 0-18 years) with an undetectable HIV-1 RNA viral load (<50 copies/mL) for at least 6 months on a twice-daily (BID) LPV/r-containing regimen switched to LPV/r QD...
May 4, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28475183/reversible-ultralow-voltage-liquid-liquid-electrowetting-without-a-dielectric-layer
#20
Nico E A Cousens, Anthony R J Kucernak
Electrowetting-on-dielectric devices typically have operating voltages of 10-20 V. A reduction in the operating voltage could greatly reduce the energy consumption of these devices. Herein, fully reversible one-electrolyte electrowetting of a droplet on a solid metal surface is reported for the first time. A reversible change of 29° for an 800 mV step is achieved. The effects of surface roughness, electrolyte composition, electrolyte concentration and droplet composition are investigated. It was found that there is a dramatic dependence of the reversibility and hysteresis of the system on these parameters, contrary to theoretical predictions...
May 5, 2017: Faraday Discussions
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