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https://www.readbyqxmd.com/read/27913584/nitro-fatty-acid-pharmacokinetics-in-the-adipose-tissue-compartment
#1
Marco Fazzari, Nicholas K H Khoo, Steven R Woodcock, Diane K Jorkasky, Lihua Li, Francisco J Schopfer, Bruce A Freeman
Electrophilic nitro-fatty acids (NO2-FAs) promote adaptive and anti-inflammatory cell signaling responses as a result of an electrophilic character that supports post-translational protein modifications. A unique pharmacokinetic profile is expected for NO2-FAs because of an ability to undergo reversible reactions including Michael additions with biological cysteine-containing proteins and esterification into complex lipids. Herein we report via quantitative whole-body autoradiography analysis of rats gavaged with radiolabeled 10-nitro-[14C]oleic acid, preferential accumulation in adipose tissue over two weeks...
December 2, 2016: Journal of Lipid Research
https://www.readbyqxmd.com/read/27898407/expression-pattern-and-regulatory-role-of-microrna-23a-in-conjugated-linoleic-acids-induced-apoptosis-of-adipocytes
#2
Renli Qi, Qi Wang, Jing Wang, Jinxiu Huang, Shan Jiang, Rong Xiao, Zuohua Liu, Feiyun Yang
BACKGROUND/AIMS: Conjugated linoleic acids (CLAs) are known to induce apoptosis in adipocytes; however, the cellular mechanisms involved remained illdefined. We explored the different apoptotic induction effects of two CLA isomers on adipocytes and then investigated the expression and function of microRNAs (miRNAs) related to the apoptosis. METHODS: TUNEL and FCM assays were used to detect CLAs-induced adipocyte apoptosis. Microarrays were used to compare the differential expression of miRNAs...
November 30, 2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27897090/the-effect-of-commercial-conjugated-linoleic-acid-products-on-experimental-periodontitis-and-diabetes-mellitus-in-wistar-rats
#3
Hatice Balci Yuce, Nihat Akbulut, Seda Ocakli, Omer Kayir, Mahfuz Elmastas
OBJECTIVE: The aim of present study was to determine the effects of conjugated linoleic acid enriched milk on alveolar bone loss, hyperglycaemia, oxidative stress and apoptosis in ligature-induced periodontal disease in diabetic rat model. METHODS: Wistar rats were divided into six experimental groups: 1; non-ligated (NL, n = 6) group, 2; ligature only (LO, n = 6) group, 3; streptozotocin only (STZ, n = 8) group, 4; STZ and ligature (STZ + L, n = 8) group, 5; ligature and conjugated linoleic acid (CLA) (L + CLA, n = 8) group, 6; STZ, ligature and CLA group (STZ + L + CLA, n = 8) group...
November 29, 2016: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/27884102/gene-expression-profile-of-intramuscular-muscle-in-nellore-cattle-with-extreme-values-of-fatty-acid
#4
Mariana P Berton, Larissa F S Fonseca, Daniela F J Gimenez, Bruno L Utembergue, Aline S M Cesar, Luiz L Coutinho, Marcos Vinicius A de Lemos, Carolyn Aboujaoude, Angélica S C Pereira, Rafael M de O Silva, Nedenia B Stafuzza, Fabieli L B Feitosa, Hermenegildo L J Chiaia, Bianca F Olivieri, Elisa Peripolli, Rafael L Tonussi, Daniel M Gordo, Rafael Espigolan, Adrielle M Ferrinho, Lenise F Mueller, Lucia G de Albuquerque, Henrique N de Oliveira, Susan Duckett, Fernando Baldi
BACKGROUND: Fatty acid type in beef can be detrimental to human health and has received considerable attention in recent years. The aim of this study was to identify differentially expressed genes in longissimus thoracis muscle of 48 Nellore young bulls with extreme phenotypes for fatty acid composition of intramuscular fat by RNA-seq technique. RESULTS: Differential expression analyses between animals with extreme phenotype for fatty acid composition showed a total of 13 differentially expressed genes for myristic (C14:0), 35 for palmitic (C16:0), 187 for stearic (C18:0), 371 for oleic (C18:1, cis-9), 24 for conjugated linoleic (C18:2 cis-9, trans11, CLA), 89 for linoleic (C18:2 cis-9,12 n6), and 110 genes for α-linolenic (C18:3 n3) fatty acids...
November 25, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27878911/effect-of-increased-feeding-of-dietary-%C3%AE-linolenic-acid-by-grazing-on-formation-of-the-cis9-trans11-18-2-isoform-of-conjugated-linoleic-acid-in-bovine-milk
#5
Mio Yamaguchi, Taki Naito, Yoshikazu Nagao, Yukihito Kabuyama, Kei Hashimoto, Norihiro Azuma, Isamu Maeda
Feeding systems such as grazing affect the fatty acid profile of bovine milk fat. In addition, milk fat is formed as the product of fatty acid metabolism in cow bodies before being secreted into milk. However, how grazing influences milk fatty acid profile through the metabolism has not been completely characterized. When fatty acid concentrations in Holstein milk were compared between grazing and non-grazing periods, α-linolenic acid was significantly higher in the grazing period than in the non-grazing period...
November 23, 2016: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/27875996/differences-in-the-skeletal-muscle-transcriptome-profile-associated-with-extreme-values-of-fatty-acids-content
#6
Aline S M Cesar, Luciana C A Regitano, Mirele D Poleti, Sónia C S Andrade, Polyana C Tizioto, Priscila S N Oliveira, Andrezza M Felício, Michele L do Nascimento, Amália S Chaves, Dante P D Lanna, Rymer R Tullio, Renata T Nassu, James E Koltes, Eric Fritz-Waters, Gerson B Mourão, Adhemar Zerlotini-Neto, James M Reecy, Luiz L Coutinho
BACKGROUND: Lipids are a class of molecules that play an important role in cellular structure and metabolism in all cell types. In the last few decades, it has been reported that long-chain fatty acids (FAs) are involved in several biological functions from transcriptional regulation to physiological processes. Several fatty acids have been both positively and negatively implicated in different biological processes in skeletal muscle and other tissues. To gain insight into biological processes associated with fatty acid content in skeletal muscle, the aim of the present study was to identify differentially expressed genes (DEGs) and functional pathways related to gene expression regulation associated with FA content in cattle...
November 22, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27872567/vaccination-against-corynebacterium-pseudotuberculosis-infections-controlling-caseous-lymphadenitis-cla-and-oedematousskin-disease
#7
Ihab M Moussa, Mohamed S Ali, Ashgan M Hessain, Saleh A Kabli, Hassan A Hemeg, Salha Abdelkareem Selim
Corynebacterium pseudotuberculosis (C. pseudotuberculosis) is a causative organism of caseous lymphadenitis (CLA) in sheep and acute disease in buffaloes known as oedematous skin disease (OSD). Human affected with the disease show liver abscess and abscess in the internal lymph nodes. The vaccination against CLA up till now occurs by using formalin inactivated whole cells of biovar 1 (sheep strain). Combined vaccine composed of formalin inactivated whole cells of sheep strain and recombinant phospholipase D (rPLD) and another vaccine composed of formalin inactivated whole cells (buffalo origin) and rPLD were prepared in Biotechnology center for services and Researches laboratory at Cairo university and applied for protection against CLA...
November 2016: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/27865506/synthesis-of-the-suspected-trans-11-cis-13-conjugated-linoleic-acid-isomer-in-ruminant-mammary-tissue-by-fads3-catalyzed-%C3%AE-13-desaturation-of-vaccenic-acid
#8
Cyrielle Garcia, Cécile Duby, Daniel Catheline, Pablo G Toral, Laurence Bernard, Philippe Legrand, Vincent Rioux
The octadecadienoic conjugated linoleic acid (CLA) isomer with trans-11 and cis-13 double bonds (trans-11,cis-13 CLA) has been described in ruminant milk. For now, this specific CLA is suspected to derive exclusively from ruminal biohydrogenation of dietary α-linolenic acid. However, in rodents, the fatty acid desaturase 3 (FADS3) gene was recently shown to code for an enzyme able to catalyze the unexpected Δ13-desaturation of vaccenic acid, producing a Δ11,13-CLA with all the structural characteristics of the trans-11,cis-13 isomer, although no commercial standard exists for complete conclusive identification...
November 16, 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/27861978/circulating-cla-t-cells-in-atopic-dermatitis-and-their-possible-role-as-peripheral-biomarkers
#9
REVIEW
Tali Czarnowicki, Luis F Santamaria-Babí, Emma Guttman-Yassky
Cutaneous lymphocyte-associated antigen (CLA(+) ) T-cells are specialized for skin homing and represent the main T-cell population in atopic dermatitis (AD) lesions. CLA(+) is expressed on the surface of circulating CD45RO(+) memory T-cells and most skin infiltrating T-cells. Mechanistic studies and thus treatment advancements are limited by the need of large number of skin biopsies. Circulating CLA(+) T-cells may be a reliable surrogate marker of the inflammatory events occurring in the skin, and thus the evaluation of CLA(+) T-cells in the blood may eliminate the need for skin biopsies...
November 8, 2016: Allergy
https://www.readbyqxmd.com/read/27855311/effect-of-aging-on-regional-neuromuscular-regulation-within-human-rectus-femoris-muscle-during-stair-ascent-and-descent
#10
Kohei Watanabe, Motoki Kouzaki, Toshio Moritani
Our recent studies showed the rectus femoris (RF) muscle is regionally regulated during the level walking and this unique neuromuscular activation pattern is influenced by aging (Watanabe et al., 2014, 2016 J Biomech). We aimed to investigate and compare regional neuromuscular activation patterns along the RF muscle between the young and elderly during the stair walking. Fourteen young men (age: 20.4±1.0years) and 14 elderly men (age: 73.8±5.9years) performed the stair ascent and descent. Fifteen trials of three steps were performed for both stair ascent and descent...
November 10, 2016: Gait & Posture
https://www.readbyqxmd.com/read/27843307/the-effect-of-conjugated-linoleic-acid-supplementation-on-the-nutritional-status-of-copd-patients
#11
Hassan Ghobadi, Somaieh Matin, Ali Nemati, Abbas Naghizadeh-Baghi
BACKGROUND: COPD patients are susceptible to anorexia, reduction of caloric intake, weight loss, and malnutrition. One of the possible mechanisms is the increase of inflammatory markers such as interleukin 1β (IL1β), is highly correlated with anorexia. Considering the anti-inflammatory role of conjugated linoleic acid (CLA), this study aimed to investigate the effect of CLA supplementation on the nutritional status of COPD patients. PATIENTS AND METHODS: In a double-blind clinical trial, 93 COPD patients who volunteered to participate in the study and who filled out a written consent form, were randomly assigned to control or supplementation groups...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27834186/twelve-week-conjugated-linoleic-acid-supplementation-has-no-effects-on-the-selected-markers-of-atherosclerosis-in-obese-and-overweight-women
#12
Monika Dus-Zuchowska, Edyta Madry, Patrycja Krzyzanowska, Paweł Bogdanski, Jaroslaw Walkowiak
BACKGROUND: The antiatherogenic effect of conjugated linoleic acid (CLA) has been demonstrated in animal models. Although there are plenty of in vitro studies that suggest the profitable properties of CLA, the results in humans remain inconsistent. OBJECTIVE: In this study, we assessed the impact of CLA supplementation on the levels of atherosclerosis markers - high-sensitivity C-reactive protein (hs-CRP) and asymmetrical dimethylarginine (ADMA). DESIGN: Seventy-four adult female subjects with body mass index ≥25 kg/m(2) were enrolled in the double-blind, placebo-controlled nutritional intervention...
2016: Food & Nutrition Research
https://www.readbyqxmd.com/read/27830423/trans-fatty-acids-in-colostrum-mature-milk-and-diet-of-lactating-adolescents
#13
Roseli de Souza Santos da Costa, Flavia da Silva Santos, Daniela de Barros Mucci, Tânia Vignuda de Souza, Fátima Lucia de Carvalho Sardinha, Célia Regina Moutinho de Miranda Chaves, Maria das Graças Tavares do Carmo
The purpose of this study was to investigate the trans fatty acids (TFA) content and distribution in colostrum, mature milk, and diet of adolescent mothers, after TFA declaration in food labels became mandatory in Brazil. Participants were healthy adolescents (n 54, 15-19 years, 1-90 days postpartum) practicing exclusive breastfeeding. Milk samples were collected 3 days after delivery (colostrum) and in the third month postpartum (mature milk) by hand expression. The fatty acid composition of the milk samples was determined by gas chromatography...
November 9, 2016: Lipids
https://www.readbyqxmd.com/read/27820928/pulmonary-perfusion-changes-as-assessed-by-contrast-enhanced-dual-energy-computed-tomography-after-endoscopic-lung-volume-reduction-by-coils
#14
Frédéric Lador, Anne-Lise Hachulla, Olivia Hohn, Jérôme Plojoux, Maxime Ronot, Xavier Montet, Paola M Soccal
BACKGROUND: Endoscopic lung volume reduction by coils (LVRC) is a recent treatment approach for severe emphysema. Furthermore, dual-energy computed tomography (DECT) now offers a combined assessment of lung morphology and pulmonary perfusion. OBJECTIVES: The aim of our study was to assess the impact of LVRC on pulmonary perfusion with DECT. METHODS: Seventeen patients (64.8 ± 6.7 years) underwent LVRC. DECT was performed prior to and after LVRC...
2016: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/27815799/cla-has-a-useful-effect-on-bone-markers-in-patients-with-rheumatoid-arthritis
#15
N Aryaeian, F Shahram, M Djalali
: Rheumatoid arthritis is a systemic, chronic disease which may increase the risk of osteoporosis. This study was carried out in order to examine the effect of conjugated linoleic acid (CLA) on bone markers in rheumatoid arthritis disease which is the most common autoimmune disease. The present study is a randomized double-blind clinical trial. Subjects included 52 patients with active rheumatoid arthritis who were divided into two groups. Group I received standard treatment plus 2 daily 1...
November 4, 2016: Lipids
https://www.readbyqxmd.com/read/27812039/a-self-assembling-nanomedicine-of-conjugated-linoleic-acid-paclitaxel-conjugate-cla-ptx-with-higher-drug-loading-and-carrier-free-characteristic
#16
Ting Zhong, Xin Yao, Shuang Zhang, Yang Guo, Xiao-Chuan Duan, Wei Ren, Dan Huang, Yi-Fan Yin, Xuan Zhang
The main objective of this study was to demonstrate the proof-of-principle for the hypothesis that conjugated linoleic acid-paclitaxel conjugate (CLA-PTX), a novel fatty acid modified anti-cancer drug conjugate, could self-assemble forming nanoparticles. The results indicated that a novel self-assembling nanomedicine, CLA-PTX@PEG NPs (about 105 nm), with Cremophor EL (CrEL)-free and organic solvent-free characteristics, was prepared by a simple precipitation method. Being the ratio of CLA-PTX:DSPE-PEG was only 1:0...
November 4, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27804906/ability-of-dairy-cows-to-be-inseminated-according-to-breed-and-genetic-merit-for-production-traits-under-contrasting-pasture-based-feeding-systems
#17
N Bedere, C Disenhaus, V Ducrocq, S Leurent-Colette, L Delaby
Strong genetic selection on production traits is considered to be responsible for the declined ability of dairy cows to ensure reproduction. The present study aimed to quantify the effect of genetic characteristics (breeds and genetic merit for production traits) and feeding systems (FS) on the ability of dairy cows to be inseminated. An experiment was conducted during 9 years on Normande and Holstein cows assigned to contrasted pasture-based FS. Diets were based on maize silage in winter and grazing plus concentrate in spring in the High FS; and on grass silage in winter and grazing with no concentrate during spring in the low FS...
November 2, 2016: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/27803494/preparation-of-conjugated-linoleic-acid-microemulsions-and-their-biodistribution
#18
Kazuaki Kishita, Kayo Ibaraki, Shoko Itakura, Yumi Yamasaki, Naoko Nishikata, Kenji Yamamoto, Masataka Shimizu, Kazuo Nishiyama, Masao Yamasaki
Conjugated linoleic acid (CLA) has several beneficial biological properties. Specifically, trans10, cis12-CLA, one of the CLA isomers, has strong physiologic activity against cancer and obesity. However, compared with cis9, trans11-CLA, a naturally occurring CLA isomer, trans10, cis12-CLA tends to be easily metabolized. Therefore, to make efficient use of its biological properties, it is necessary to overcome the rapid clearance of trans10, cis12-CLA from the blood. Here, we employed premix membrane emulsification to prepare two oil-in-water CLA microemulsions (CLA-ME), 100 nm CLA-ME and 200 nm CLA-ME, and investigated their pharmacokinetics in a mouse model...
2016: Journal of Oleo Science
https://www.readbyqxmd.com/read/27778642/conjugated-linoleic-acid-and-metformin-on-insulin-sensitivity-in-obese-children-randomized-clinical-trial
#19
Nayely Garibay-Nieto, Gloria Queipo-Garcia, Flor Alvarez-Huerta, Mayra Bustos-Esquivel, Erendira Villanueva-Ortega, Fernando Ramirez, Mireya Leon, Estibalitz Laresgoiti-Servitje, Ravindranath Duggirala, Teresa Macias, Sergio Cuevas, Abel Jalife, Miguel Fonseca-Sanchez, Fabiola Serratos, Juan Carlos Lopez-Alvarenga
CONTEXT: Insulin resistance precedes metabolic syndrome abnormalities and may promote cardiovascular disease and type 2 diabetes in children with obesity. Results of lifestyle modification programs have been discouraging, and the use of adjuvant strategies has been necessary. OBJECTIVE: This study aimed to evaluate the effects of metformin and conjugated linoleic acid (CLA) on insulin sensitivity, measured via euglycemic-hyperinsulinemic clamp technique and insulin pathway expression molecules in muscle biopsies of children with obesity...
October 25, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27766206/transcript-profiling-in-the-liver-of-early-lactating-dairy-cows-fed-conjugated-linoleic-acid
#20
Robert Ringseis, Wilhelm Windisch, Klaus Eder
In the present study, transcript profiling was carried out in liver biopsies from high-yielding dairy cows at week 5 of lactation in order to identify genes and pathways regulated by feeding rumen-protected conjugated linoleic acid (CLA) during the transition period. Analysis of a bovine whole genome microarray revealed a total number of 130 annotated differentially expressed genes (DEGs) in the liver between cows of the CLA group and the control group (filter: P < 0.05 and fold change (FC) ≥ 1.3 or ≤- 1...
December 2016: Genomics Data
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