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https://www.readbyqxmd.com/read/28938404/the-transcriptome-of-estrogen-independent-mammary-growth-in-female-mice-reveals-that-not-all-mammary-glands-are-created-equally
#1
Grace E Berryhill, Danielle G Lemay, Josephine F Trott, Lucila Aimo, Adam L Lock, Russell C Hovey
Allometric growth of ducts in the mammary glands (MG) is widely-held to be estrogen (E)-dependent. We previously discovered that the dietary fatty acid trans-10, cis-12 conjugated linoleic acid (CLA) stimulates E-independent allometric growth and TEB formation in ovariectomized mice. Given the similar phenotype induced by E and CLA, we investigated the shared and/or divergent mechanisms underlying these changes. We confirmed MG growth induced by CLA is temporally distinct from that elicited by E, then used RNA-Sequencing to compare the transcriptome of the MG during similar proliferative and morphological states...
July 27, 2017: Endocrinology
https://www.readbyqxmd.com/read/28938336/arterial-stiffness-induced-by-carotid-calcification-leads-to-cerebral-gliosis-mediated-by-oxidative-stress
#2
Nataliya Sadekova, M Florencia Iulita, Diane Vallerand, Gervais Muhire, Mohamed Bourmoum, Audrey Claing, Hélène Girouard
BACKGROUND: Arterial stiffness is a risk factor for cognitive decline and dementia. However, its precise effects on the brain remain unexplored. Using a mouse model of carotid stiffness, we investigated its effect on glial activation and oxidative stress. METHODS: Arterial stiffness was induced by the application of calcium chloride to the adventitial region of the right carotid. Superoxide anion production, NADPH activity and levels, as well as glial activation were examined with immunohistochemical and biochemical approaches, 2-week postcalcification...
September 21, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28934943/identification-of-new-corynebacterium-pseudotuberculosis-antigens-by-immunoscreening-of-gene-expression-library
#3
Cleber Eduardo Galvão, Stenio Perdigão Fragoso, Carina Elisei de Oliveira, Odinéia Forner, Renata Ribeiro Bastos Pereira, Cleber Oliveira Soares, Grácia Maria Soares Rosinha
BACKGROUND: Caseous lymphadenitis (CLA) is a disease that affects sheep, goats and occasionally humans. The etiologic agent is the Corynebacterium pseudotuberculosis bacillus. The objective of this study was to build a gene expression library from C. pseudotuberculosis and use immunoscreening to identify genes that encode potential antigenic proteins for the development of DNA and subunit vaccines against CLA. RESULTS: A wild strain of C. pseudotuberculosis was used for extraction and partial digestion of genomic DNA...
September 21, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28912492/epicutaneous-allergen-application-preferentially-boosts-specific-t-cell-responses-in-sensitized-patients
#4
Raffaela Campana, Katharina Moritz, Angela Neubauer, Hans Huber, Rainer Henning, Tess M Brodie, Alexandra Kaider, Federica Sallusto, Stefan Wöhrl, Rudolf Valenta
The effects of epicutaneous allergen administration on systemic immune responses in allergic and non-allergic individuals has not been investigated with defined allergen molecules. We studied the effects of epicutaneous administration of rBet v 1 and rBet v 1 fragments on systemic immune responses in allergic and non-allergic subjects. We conducted a clinical trial in which rBet v 1 and two hypoallergenic rBet v 1 fragments were applied epicutaneously by atopy patch testing (APT) to 15 birch pollen (bp) allergic patients suffering from atopic dermatitis, 5 bp-allergic patients suffering from rhinoconjunctivitis only, 5 patients with respiratory allergy without bp allergy and 5 non-allergic individuals...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28891292/ruminal-biohydrogenation-kinetics-of-defatted-flaxseed-and-sunflower-is-affected-by-heat-treatment
#5
Saman Lashkari, Lone Hymøller, Soren Krogh Jensen
The effect of heat treatment on biohydrogenation of linoleic acid (LA) and linolenic acid (LNA) and formation of stearic acid (SA), cis-9, trans-11 conjugated LA (CLA), trans-10, cis-12 CLA and trans vaccenic acid (VA) was studied in in vitro incubations with diluted rumen fluid as inoculum and partly defatted flaxseed (DF) and partly defatted sunflower (DS) as test feeds. Feeds were heated in a laboratory oven at 110 °C for 0 (unheated), 45 or 90 min. Michaelis-Menten kinetics was applied for quantifying biohydrogenation rate...
September 11, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28889933/bacterial-conjugated-linoleic-acid-production-and-their-applications
#6
REVIEW
Bo Yang, He Gao, Catherine Stanton, R Paul Ross, Hao Zhang, Yong Q Chen, Haiqin Chen, Wei Chen
Conjugated linoleic acid (CLA) has been shown to exert various potential physiological properties including anti-carcinogenic, anti-obesity, anti-cardiovascular and anti-diabetic activities, and consequently has been considered as a promising food supplement. Bacterial biosynthesis of CLA is an attractive approach for commercial production due to its high isomer-selectivity and convenient purification process. Many bacterial species have been reported to convert free linoleic acid (LA) to CLA, hitherto only the precise CLA-producing mechanisms in Propionibacterium acnes and Lactobacillus plantarum have been illustrated completely, prompting the development of recombinant technology used in CLA production...
September 7, 2017: Progress in Lipid Research
https://www.readbyqxmd.com/read/28880869/differences-in-chemical-constituents-of-artemisia-annua-l-from-different-geographical-regions-in-china
#7
Xiaobo Zhang, Yuping Zhao, Lanping Guo, Zhidong Qiu, Luqi Huang, Xiaobo Qu
BACKGROUND: Daodi-herb is a part of Chinese culture, which has been naturally selected by traditional Chinese medicine clinical practice for many years. Sweet wormwood herb is a kind of Daodi-herb, and comes from Artemisia annua L. Artemisinin is a kind of effective antimalarial drug being extracted from A. annua. Because of artemisinin, Sweet wormwood herb earns a reputation. Based on the Pharmacopoeia of the People's Republic of China (PPRC), Sweet wormwood herb can be used to resolve summerheat-heat, and prevent malaria...
2017: PloS One
https://www.readbyqxmd.com/read/28873643/influence-of-seasonal-variation-and-ultra-high-temperature-processing-on-lipid-profile-and-fat-globule-structure-of-swedish-cow-milk
#8
Jing Lu, Jana Pickova, José L Vázquez-Gutiérrez, Maud Langton
To investigate the effects of seasonal variations and processing on cow milk fat, raw milk collected in six individual months and corresponding ultra high temperature (UHT) milk were analyzed. Similar seasonal variations in lipid classes and fatty acid composition were found in raw and UHT milk. Under commercial processing, lipid content was standardized to approximately 1.5% in UHT milk. Decreased diameter of fat droplets (around 1µm) and thinner globule membranes were observed, as revealed using confocal laser scanning microscopy (CLSM)...
January 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28843683/effect-of-substituting-soybean-meal-and-canola-cake-with-dried-distillers-grains-with-solubles-at-2-dietary-crude-protein-levels-on-feed-intake-milk-production-and-milk-quality-in-dairy-cows
#9
C Gaillard, M T Sørensen, M Vestergaard, M R Weisbjerg, A Basar, M K Larsen, H Martinussen, U Kidmose, J Sehested
Dried distillers grain with solubles (DDGS) is an alternative source of feed protein for dairy cows. Previous studies found that DDGS, based on grains other than corn, can substitute for soybean meal and canola cake as a dietary protein source without reducing milk production or quality. As societal concerns exist, and in many areas strict regulation, regarding nitrogen excretion from dairy cows, the dairy industry has focused on reducing dietary protein level and nitrogen excretion. In the present study, we investigated the use of DDGS as a protein source, at a marginally low dietary crude protein (CP) levels, in a grass-clover and corn silage-based ration...
August 23, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28833935/characterization-of-the-triple-component-linoleic-acid-isomerase-in-lactobacillus-plantarum-zs2058-by-genetic-manipulation
#10
Bo Yang, Hui Qi, Zhennan Gu, Zhang Hao, Wei Chen, Haiqin Chen, Yong Q Chen
AIM: To assess the mechanism for CLA production in Lactobacillus plantarum ZS2058. METHODS AND RESULTS: Conjugated linoleic acid (CLA) has attracted great interests for decades due to its health-associated benefits including anti-cancer, anti-atherogenic, anti-obesity, and modulation of the immune system. A number of microbial CLA producers were widely reported including lactic acid bacteria. Lb. plantarum ZS2058, an isolate from Chinese traditional fermented food, could convert LA to CLA with various intermediates...
August 18, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28815782/influence-of-conjugated-linoleic-acids-and-vitamin-e-on-milk-fatty-acid-composition-and-concentrations-of-vitamin-a-and-%C3%AE-tocopherol-in-blood-and-milk-of-dairy-cows
#11
S Schäfers, U Meyer, D von Soosten, L Hüther, C Drong, K Eder, E Most, A Tröscher, W Pelletier, A Zeyner, S Dänicke
The objective of this trial was to investigate the influences of conjugated linoleic acid (CLA) and vitamin E (Vit. E) and their interactions on fatty acid composition and vitamins in milk (α-tocopherol, retinol and β-carotene) as well as on α-tocopherol in blood of pluriparous cows from week 6 ante partum until week 10 post-partum (p.p.). We assigned 59 pluriparous German Holstein cows to four treatment groups with the treatment factors CLA and Vit. E at two levels in a 2 × 2 factorial design. Milk fatty acid composition and milk vitamins were analysed on lactation days 7 and 28...
August 16, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28813094/fatty-acid-profile-in-vertical-strata-of-elephant-grass-subjected-to-intermittent-stocking
#12
Kamila M Dias, Daniel Schmitt, Giselle R Rodolfo, Francisco C Deschamps, Guilherme N Camargo, Raphael S Pereira, André F Sbrissia
The milk and meat from animals with a pasture-based diet have higher proportions of CLA and C18:3 and lower omega-6:omega-3 ratios than products from animals with diets based on corn silage and concentrate. However, most of the published studies have evaluated fatty acid profiles in temperate climate grasses and the literature with tropical grasses is scarce. Thus, the aim of this study was to evaluate the morphological and fatty acid compositions in the vertical strata of elephant grass (Pennisetum purpureum Schum...
August 14, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28804001/production-of-trans-and-conjugated-fatty-acids-in-dairy-ruminants-and-their-putative-effects-on-human-health-a-review
#13
REVIEW
Anne Ferlay, Laurence Bernard, Annabelle Meynadier, Corinne Malpuech-Brugère
Consumption of milk and dairy products is important in Western industrialised countries. Fat content is an important constituent contributing to the nutritional quality of milk and dairy products. In order to improve the health of consumers, there is high interest in improving their fatty acid (FA) composition, which depends principally on rumen and mammary metabolism. This paper reviews the lipid metabolism in ruminants, with a particular focus on the production of trans and conjugated linoleic acids (CLA) and conjugated linolenic acids (CLnA) in the rumen...
August 10, 2017: Biochimie
https://www.readbyqxmd.com/read/28795443/effect-of-conjugated-linoleic-acids-and-omega-3-fatty-acids-with-or-without-resistance-training-on-muscle-mass-in-high-fat-diet-fed-middle-aged-mice
#14
Sang-Rok Lee, Andy V Khamoui, Edward Jo, Michael C Zourdos, Lynn B Panton, Michael J Ormsbee, Jeong-Su Kim
This study investigated the effects of 20 weeks of combined conjugated linoleic acid/omega-3 fatty acid (n-3) administration independently or combined with resistance exercise training (RET) muscle in middle-aged mice consuming a high-fat diet (HFD). Nine-month-old C57BL/6 mice were randomly assigned into four experimental groups (H: high-fat diet, HE: H + RET, HCN: H + CLA/n-3, and HECN: H + CLA/n3 + RET). Body composition and functional capacity were assessed at pre- and post-intervention. Muscle tissues were collected at 14 months of age...
August 10, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28789519/absorption-kinetics-of-the-main-conjugated-linoleic-acid-isomers-in-commercial-rich-oil-after-oral-administration-in-rats
#15
Luís M Rodríguez-Alcalá, Irma Ares, Javier Fontecha, María-Rosa Martínez-Larrañaga, Arturo Anadón, María-Aránzazu Martínez
This study aimed to assess the oral absorption and plasma kinetics of two main isomers contained in commercial conjugated linoleic acid (CLA)-rich oil (Tonalin TG-80), rumenic acid (RA), and C18:2 trans-10, cis-12. The isomer plasma disposition after the single oral dose of 3000 mg of Tonalin TG-80/kg, containing 1200 mg/kg of each isomer, was studied in rats. The isomer plasma concentrations were determined by gas chromatography with flame ionization detection. The plasma kinetics showed rapid oral absorption of RA and C18:2 trans-10, cis-12 (t1/2a 0...
September 6, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28780456/synthesis-single-crystal-dna-interaction-spectrophotometric-and-spectroscopic-characterization-of-the-hydrogen-bonded-charge-transfer-complex-of-2-aminopyrimidine-with-%C3%AF-acceptor-chloranilic-acid-at-different-temperature-in-acetonitrile
#16
Zulkarnain, Lal Miyan, Afaq Ahmad, Md Fazle Alam, Hina Younus
The charge transfer (CT) interaction of 2-aminopyrimidine (AP) with chloranilic acid (CLA) as π-acceptor was investigated spectrophotometrically in acetonitrile at different temperatures in the range of 25-50°C. The 1:1 stoichiometry of the synthesized CT complex was detected using straight line method. Benesi-Hildebrand equation was used to determine the association constant (KCT), molar extinction coefficient (ε) and other physical parameters. Various thermodynamics parameters such as enthalpy (ΔH), entropy (ΔS) and free energy (ΔG) were determined using UV-Visible spectrophotometry in acetonitrile at different temperatures...
July 4, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28771065/acrolein-induced-oxidative-stress-and-genotoxicity-in-rats-protective-effects-of-whey-protein-and-conjugated-linoleic-acid
#17
Birsen Aydın, Zülal Atlı Şekeroğlu, Vedat Şekeroğlu
Acrolein (AC), a highly reactive hazardous pollutant, poses serious threats to human health. Whey protein (WP) and conjugated linoleic acid (CLA) have beneficial health implications. We investigated the protective effects of WP and CLA against AC-induced toxicity in rats. The animals were orally gavaged with CLA (200 mg/kg/day), WP (200 mg/kg/day), AC (5 mg/kg/day), CLA + AC (200 + 5 mg/kg/day), and WP + AC (200 + 5 mg/kg/day) six days per week for 30 days. The oral administration of AC significantly induced oxidative stress by increasing thiobarbituric acid reactive substances (TBARS) and protein carbonyls (PCOs) levels and decreasing glutathione (GSH) level in the spleen, thymus, and polymorphonuclear leukocytes (PMNs)...
August 3, 2017: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/28763005/seasonal-variation-in-fat-quality-and-conjugated-linoleic-acid-content-of-dairy-products-from-the-tropics-evidence-of-potential-impact-on-human-health
#18
Juliana Côrtes Nunes, Monalisa Nilza Lole Ramalho da Silva, Daniel Perrone, Alexandre Guedes Torres
Seasonal variation in conjugated linoleic acid (CLA) content and atherogenicity index (AI) of retail dairy products (whole milk, butter, and prato, a soft yellow cheese) from Brazil was investigated. CLA content of dairy products ranged from 0.55 to 1.53 g CLA/100 g fatty acids and was on average 25% higher during the rainy season compared to the dry season. Dairy products from the rainy season also had lower AI levels, indicating a lower risk of causing cardiovascular disease in consumers. This seasonality led to estimated seasonal variations of milk fat quality consumed by the population of southeastern Brazil, meaning 15% and 19% variation in daily intake of CLA and AI values, respectively...
August 1, 2017: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28758263/anti-epileptic-drugs-induce-cutaneous-lymphocyte-associated-antigen-down-regulation-leading-to-potential-human-herpes-virus-7-reactivation-in-clinically-asymptomatic-patients
#19
F Caillot, E Andrieu, E Houivet, S Duvert-Lehembre, S Calbo, B Sabbah, D Maltete, O Martinaud, F Le Goff, P Malekpour, M Berard, S Rogez, P Joly, D Picard, P Musette
Anti-epileptic drugs (AED) are known to cause cutaneous adverse drug-induced reactions. The pathogenesis of these drug-induced reactions remains poorly understood. In our previous multicenter prospective study, we evidenced reactivation of Epstein-Barr Virus (EBV), Human Herpes Virus 6 (HHV-6) and/or Human Herpes Virus 7 (HHV-7) in 76% of Drug Reaction with Eosinophilia and Systemic Symptom (DRESS) patients. As a consequence of this increased viral antigen exposure, EBV-specific CD8+ T lymphocytes that expressed high levels of Cutaneous Lymphocyte-associated Antigen (CLA) homing markers of skin were found both in blood and in involved organs including skin...
July 31, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28752804/one-pot-conjugated-linoleic-acid-production-from-castor-oil-by-rhizopus-oryzae-lipase-and-resting-cells-of-lactobacillus-plantarum
#20
Abid Ali Khaskheli, Farah Naz Talpur, Aysun Cebeci Aydin, Sana Jawaid, Muhammad Ali Surhio, Hassan Imran Afridi
Conjugated linoleic acid (CLA) has attracted as novel type of fatty acids having unusual health-promoting properties such as anticarcinogenic and antiobesitic effects. The present work employed castor oil as substrate for one-pot production of CLA using washed cells of Lactobacillus plantarum (L. plantarum) and lipases as catalysts. Among the screened lipases, the lipase Rhizopus oryzae (ROL) greatly assisted resting cells to produce CLA. Mass spectral analysis of the product showed that two major isomers of CLA were produced in the reaction mixture i...
July 28, 2017: Bioscience, Biotechnology, and Biochemistry
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