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https://www.readbyqxmd.com/read/29141135/the-fatty-acid-composition-of-lamb-liver-muscle-and-adipose-tissues-in-response-to-rumen-protected-conjugated-linoleic-acid-cla-supplementation-is-tissue-dependent
#1
Stefano Schiavon, Matteo Bergamaschi, Erika Pellattiero, Alberto Simonetto, Franco Tagliapietra
The tissue-specific response to rumen-protected conjugated linoleic acid supply (rpCLA) of liver, two muscles and three adipose tissues of heavy lambs was studied. Twenty-four lambs, 8 months old, divided into 4 groups of 6, were fed at libitum on a ration supplemented without or with a mixture of rpCLA. Silica and hydrogenated soybean oil was the rpCLA coating matrix. The lambs were slaughtered at 11 months of age. Tissues were collected and analysed for their FA profiles. The dietary rpCLA supplement had no influence on carcass fatness nor on the fat content of the liver and tissues, and had little influence on the FA profiles of these tissues...
November 15, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29132974/topical-electrophilic-nitro-fatty-acids-potentiate-cutaneous-inflammation
#2
Alicia R Mathers, Cara D Carey, Meaghan E Killeen, Sonia R Salvatore, Laura K Ferris, Bruce A Freeman, Francisco J Schopfer, Louis D Falo
Endogenous electrophilic fatty acids mediate anti-inflammatory responses by modulating metabolic and inflammatory signal transduction and gene expression. Nitro-fatty acids and other electrophilic fatty acids may thus be useful for the prevention and treatment of immune-mediated diseases, including inflammatory skin disorders. In this regard, subcutaneous (SC) injections of nitro oleic acid (OA-NO2), an exemplary nitro-fatty acid, inhibit skin inflammation in a model of allergic contact dermatitis (ACD). Given the nitration of unsaturated fatty acids during metabolic and inflammatory processes and the growing use of fatty acids in topical formulations, we sought to further study the effect of nitro-fatty acids on cutaneous inflammation...
November 10, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29130749/does-maternal-synbiotic-supplementation-affect-conjugated-linoleic-acid-level-in-breast-milk-a-randomized-placebo-controlled-clinical-trial
#3
Leila Nikniaz, Reza Mahdavi, Alireza Ostadrahimi, Zeinab Nikniaz, Soghra Aliasgharzadeh
AIM: As conjugated linoleic acid (CLA)is a potential growth promotor in newborns, the present pilot study aimed at measuring the effect of synbiotic supplementation on breast milk CLA level. MATERIALS AND METHODS: Sixty lactating mothers were randomly allocated to take either synbiotic (n = 31) or placebo (n = 29) for 30 days. Maternal anthropometric indices were measured at the onset and end of the study by standard methods and body mass index was calculated...
November 13, 2017: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/29122042/peroxisome-proliferator-activated-receptor-gamma-ppar%C3%AE-agonist-fails-to-overcome-trans-10-cis-12-conjugated-linoleic-acid-cla-inhibition-of-milk-fat-in-dairy-sheep
#4
E C Sandri, M Camêra, E M Sandri, K J Harvatine, D E De Oliveira
The trans-10, cis-12 conjugated linoleic acid (CLA) causes milk fat depression by downregulating expression of genes and transcription factors involved in lipogenesis and it has been proposed that peroxisome proliferator-activated receptor gamma (PPARγ) can be inhibited by trans-10, cis-12 CLA. The PPARγ is a nuclear receptor activated by natural or synthetic ligands and promotes expression of lipogenic genes and its effect on mammary lipogenesis and the interaction with trans-10, cis-12 CLA in lactating ewes was evaluated using thiazolidinedione (TZD), a chemical PPARγ agonist...
November 10, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29120353/fatty-acid-profiles-of-in-vitro-digested-processed-milk
#5
Michael H Tunick, Diane L Van Hekken
Digestion of milkfat releases some long-chain (18-carbon) fatty acids (FAs) that can provide health benefits to the consumer, yet because they are found in small amounts and can be difficult to identify, there is limited information on the effects that common fluid milk processing may have on the digestibility of these FAs. This study provides FA profiles for raw and combinations of homogenized and/or heat-treated (high and ultra-high temperature pasteurization) milk, before and after in vitro digestion, in order to determine the effects of processing on the digestibility of these healthy fatty acids...
November 9, 2017: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/29114968/trans10-cis12-conjugated-linoleic-acid-increases-triacylglycerol-accumulation-in-goat-mammary-epithelial-cells-in%C3%A2-vitro
#6
Tianying Zhang, Yue Ma, Hui Wang, Juan J Loor, Huifen Xu, Huaiping Shi, Jun Luo
Trans10, cis12 conjugated linoleic acid (t10c12-CLA) is well-established in decreasing milk fat content and causing milk fat depression (MFD) in dairy cattle and goats. However, the detailed mechanisms of its effect are not completely understood. Therefore, we used goat mammary epithelial cells (GMECs) to further study the molecular mechanisms whereby t10c12-CLA regulates milk fat synthesis. The optimal concentration of t10c12-CLA (100 μmol/L) for cell culture was determined through a cell vitality and morphology assay, and evaluation of abundance of apoptosis-related proteins...
November 8, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/29114128/efficacy-of-glutathione-s-transferase-purified-antigen-of-the-gastro-intestinal-nematode-haemonchus-contortus-in-diagnosis-of-sheep-haemonchosis
#7
Omnia M Kandil, Irene S Gamil, Seham H M Hendawy, Fatma Medhat, Ola H El-Habit
Haemonchus contortus is one of the most pathogenic and economically important parasites of sheep. Different H. contortus antigens; crude somatic antigen (CSA), excretory/secretory antigen (ESA), crude larval antigen (CLA), glutathione-S-transferase antigen (GST) and recombinant protein (rhcp 26/23) were prepared and characterized using sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) and western blot. The antigens were immunologically evaluated through indirect enzyme linked immunosorbent assay (ELISA) for diagnosis of haemonchosis in experimentally and naturally infected sheep...
December 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/29108059/chromium-cla-and-ractopamine-for-finishing-pigs
#8
C S Marcolla, D M Holanda, S V Ferreira, G C Rocha, N V L Serão, M S Duarte, M L T Abreu, A Saraiva
This study aimed to evaluate the effects of dietary chromium, CLA, and ractopamine on performance, carcass traits, and pork quality of finishing pigs slaughtered at 115 kg BW. Ninety-six crossbred barrows (initial BW = 70.21 ± 1.98 kg) were randomly assigned to 1 of 6 dietary treatments. There were 8 replicates per treatment (48 pens; 2 pigs/pen). A diet formulated according to the nutritional requirements was used as the control (CON). The other 5 diets were based on the CON and supplemented as follows: 0...
October 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/29103706/alterations-in-ruminal-bacterial-populations-at-induction-and-recovery-from-diet-induced-milk-fat-depression-in-dairy-cows
#9
D W Pitta, N Indugu, B Vecchiarelli, D E Rico, K J Harvatine
Ten ruminally cannulated Holstein cows were used in a crossover design that investigated changes in ruminal bacterial populations in response to induction and recovery from diet-induced milk fat depression (MFD). Further, the effect on the ruminal microbiota of the cows with diet-induced milk fat depression inoculated with rumen contents from non-milk fat-depressed donor cows was evaluated. Milk fat depression was induced during the first 10 d of each period by feeding a low-fiber, high-starch, and high-polyunsaturated fatty acid diet (26...
November 2, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29083474/alopecia-areata-is-characterized-by-expansion-of-circulating-th2-tc2-th22-within-the-skin-homing-and-systemic-t-cell-populations
#10
Tali Czarnowicki, Helen Y He, Huei-Chi Wen, Peter W Hashim, John K Nia, Kunal Malik, Yeriel Estrada, Grace W Kimmel, Mark Taliercio, James G Krueger, Emma Guttman-Yassky
BACKGROUND: Characterizing blood profile of alopecia areata (AA) is not only important for treatment advancements, but also for possibly identifying peripheral biomarkers that will eliminate the need for scalp biopsies. We aimed to compare frequencies of skin homing (CLA(+) ) vs. systemic (CLA(-) ) "polar" CD4(+) and CD8(+) and activated T-cell subsets in AA vs. AD and control blood. METHODS: Flow cytometry was used to measure IFN-γ, IL-13, IL-9, IL-17, and IL-22 cytokines in CD4(+) and CD8(+) T-cells...
October 30, 2017: Allergy
https://www.readbyqxmd.com/read/29054600/microbe-dependent-induction-of-il-9-by-cla-t-cells-in-psoriasis-and-relationship-with-il-17a
#11
Ester Ruiz-Romeu, Marta Ferran, Carmen de Jesús-Gil, Pablo García, Marc Sagristà, J M Casanova, J M Fernández, Anca Chiriac, Péter Hóllo, Antonio Celada, Ramon M Pujol, Luis F Santamaria-Babí
IL-9 is present in psoriatic lesions and produced by lymphocytes. However, it is not known whether this cytokine is induced by relevant pathogenic triggers of psoriasis, such as Streptococcus pyogenes. Here we addressed the production of IL-9 in response to various pathogens in a psoriatic ex vivo model. Extracts of S. pyogenes and C. albicans triggered the production of IL-9 and also IL-17A and IFN-γ. This induction was dependent on the interaction between CLA(+) T-cells and epidermal cells. Neutralization of IL-9 reduced S...
October 17, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29036761/effects-of-conjugated-linoleic-acid-n-3-and-resistance-training-on-muscle-quality-and-expression-of-atrophy-related-ubiquitin-ligases-in-middle-aged-mice-with-high-fat-dietinduced-obesity
#12
Seung-Lyul Oh, Sang-Rok Lee, Jeong-Su Kim
PURPOSE: To investigate the effects of conjugated linoleic acid (CLA)/n-3 supplements and resistance exercise training (RT) for 20 weeks on muscle quality and genes related to protein synthesis/degradation in middle-aged mice with high-fat diet (HFD)-induced obesity. METHODS: Nine-month-old C57BL/6 male mice were randomly assigned to five groups: 1) normal diet (C), 2) high-fat diet (H), 3) H+RT (HRT), 4) H+CLA/n-3 (H-CN), and 5) H+RT+CLA/n-3 (H-RTCN). HFD groups were given a diet containing 60% fat for 20 weeks, and exercised groups underwent progressive RT using weighted ladder climbing...
September 30, 2017: Journal of Exercise Nutrition & Biochemistry
https://www.readbyqxmd.com/read/29031386/impact-of-conjugated-linoleic-acid-administered-to-rats-prior-and-after-carcinogenic-agent-on-arachidonic-and-linoleic-acid-metabolites-in-serum-and-tumors
#13
Małgorzata Jelińska, Agnieszka Białek, Iwona Gielecińska, Hanna Mojska, Andrzej Tokarz
The objective of the study was to assess the influence of conjugated linoleic acid (CLA) daily supplementation prior and after carcinogenic agent on the concentrations of eicosanoids - metabolites of arachidonic acid (15-, 12- or 5-hydroxyeicosatetraenoic acids (15-, 12-, 5-HETE), prostaglandin E2 (PGE2)) and linoleic acid (13- or 9-hydroxyoctadecadienoic acids (13-, 9-HODE)) in rat serum and 7,12-dimethylbenz[a]anthracene (DMBA)-induced tumors. Female rats were randomised into six groups, receiving 1% or 2% Bio-C...
November 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/29027986/effects-of-conjugated-linoleic-acid-supplementation-on-the-expression-profile-of-mirnas-in-porcine-adipose-tissue
#14
Qi Wang, Renli Qi, Hong Liu, Jing Wang, Wenming Huang, Feiyun Yang, Jinxiu Huang
Conjugated linoleic acids (CLAs) play a major role in adipocyte differentiation and lipid metabolism in animals. MicroRNAs (miRNAs) appear to be involved in many biological processes in adipose tissue. However, the specific influence on miRNAs by CLA supplementation in porcine adipose tissue remains unclear. Thus, we continuously added 1.5% CLA to the pig diet from the embryo stage to the finishing period and conducted a high-throughput sequencing approach to analyse the changes in adipose tissue miRNAs. We identified 283 known porcine miRNAs, and 14 miRNAs were differentially expressed in response to CLA treatment...
October 13, 2017: Genes
https://www.readbyqxmd.com/read/29025110/effect-of-continuous-local-anesthetic-in-post-cardiac-surgery-patients-a-systematic-review
#15
Serena S Hong, Maree A Milross, Jennifer A Alison
Objective: The purpose of this review was to determine the effect of CLA infusion post cardiac surgery on pain, time to ambulation, severe adverse events, patient satisfaction, time to extubation, length of stay in the intensive care unit and in the hospital, total narcotic consumption, and pulmonary function. Design: Systematic review with meta-analysis (PROSPERO CRD42014010188). Methods: We searched the following electronic databases: the Cochrane Central Register of Controlled Trials (CENTRAL); MEDLINE; EMBASE; CINAHL; Allied and Complementary Medicine (AMED); and PsycINFO; as well as hand-searching cardiothoracic surgery and anesthetic journals and meeting abstracts...
August 16, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29019657/trans-10-cis-12-conjugated-linoleic-acid-affects-expression-of-lipogenic-genes-in-mammary-glands-of-lactating-dairy-goats
#16
Huaiping Shi, Tianying Zhang, Cong Li, Jianjue Wang, Jiangtao Huang, Zhongyang Li
The molecular mechanisms on milk fat depression (MFD) in response to trans-10,cis-12-conjugated linoleic acid (t10,c12-CLA) supplementation in ruminants were elucidated in this research with dairy goats. A total of 30 2-year-old Xinong Saanen dairy goats [40 ± 5 days in milk (DIM)] at peak lactation stage were assigned to a 3 × 3 Latin square design (14 day treatment period, followed with 14 day washout). Three CLA treatments included (a) control, fed the basal diet only without CLA supplementation; (b) orally supplemented with 8 g/day of lipid-encapsulated CLA (low dose, CLA-1); and (c) orally supplemented with 16 g/day of lipid-encapsulated CLA (high dose, CLA-2)...
October 19, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28992034/the-effect-of-energy-restriction-on-fatty-acid-profiles-of-longissimus-dorsi-and-tissue-adipose-depots-in-sheep
#17
S Z Song, J P Wu, S G Zhao, D P Casper, B He, T Liu, X Lang, X Y Gong, L S Liu
Sheep production systems in northwest China depend mostly on natural grasslands. Seasonal growth and maturity fluctuations can cause periodical restrictions in food quality and quantity. These fluctuations, in turn, result in variability in fat deposition and fatty acid profiles in different fat depots. Consequently, the study objective was to compare fat deposition, intramuscular fat (IMF) percentage and fatty acid profiles of the longissimus dorsi (LD), kidney fat (KF), tail fat (TF), and subcutaneous fat (SF) in lambs under ME restrictions similar to seasonal changes observed in the natural grasslands of northwest China...
September 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28990226/milk-fatty-acid-profile-from-cows-fed-with-mixed-rations-and-different-access-time-to-pastureland-during-early-lactation
#18
J Barca, M Carriquiry, L Olazabal, M Fajardo, P Chilibroste, A Meikle
Milk fatty acid (FA) profiles were determined in Holstein cows (n = 27) fed total mixed rations (TMR) ad libitum (G0) or diet composed by TMR (50% dry matter [DM] offered) plus grazing of pasture with 6 hr of access time to paddock in one session (G1) or 9 hr in two sessions (G2) at 45 days in milk (DIM). Moreover, milk FA was determined at 65 DIM when G0 cows turned out to G1 diet without adaptation period (Post-G0), G1 remained as controls. Milk FA was quantified using gas chromatography and mass spectrometry...
October 8, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28983975/hyperglycaemia-in-transition-dairy-cows-effects-of-lactational-stage-and-conjugated-linoleic-acid-supplementation-on-glucose-metabolism-and-turnover
#19
L Grossen-Rösti, E C Kessler, A Tröscher, R M Bruckmaier, J J Gross
Supplementing conjugated linoleic acid (CLA) is supposed to spare glucose due to the milk fat-depressing effect of the trans-10, cis-12 CLA isomer, and allows repartitioning nutrients despite an energy deficiency in early lactation. However, there is still a lack of knowledge in terms of the dynamic pattern of the glucose turnover in transition dairy cows. We hypothesized that dairy cows supplemented with CLA have an altered rate of glucose turnover and insulin sensitivity during early lactation. We conducted three consecutive hyperglycaemic clamps (HGC) in weeks -2, +2 and +4 relative to parturition in Holstein cows supplemented daily either with 70 g of lipid-encapsulated CLA (6...
October 6, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28983940/outline-of-guidelines-for-the-management-of-vasculitis-and-vascular-disorders-in-japan-2016-revised-edition
#20
Takaharu Ikeda, Fukumi Furukawa, Tamihiro Kawakami, Naoko Ishiguro, Miwa Uzuki, Shoichi Ozaki, Kensei Katsuoka, Takeshi Kono, Seiji Kawana, Masanari Kodera, Takashi Sawai, Yasuyuki Sawada, Mariko Seishima, Akiko Tanikawa, Ko-Ron Chen, Minoru Hasegawa
The proposal by the 1994 International Chapel Hill Consensus Conference on the Nomenclature of Systemic Vasculitides (CHCC1994) and by the CHCC2012 markedly influenced the classification and way of considering cutaneous vasculitis. In the proposal by the CHCC1994, hypersensitivity angiitis was defined as an equivalent pathological condition to microscopic polyangiitis or cutaneous leukocytoclastic angiitis (CLA), and it was not adopted as a disease name. However, CLA which was positioned as a type of small-vessel vasculitis is only a pathological name...
October 6, 2017: Journal of Dermatology
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