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https://www.readbyqxmd.com/read/28106706/intravitreal-ocriplasmin-in-clinical-practice-predictors-of-success-visual-outcomes-and-complications
#1
Henry L Feng, Daniel B Roth, Aisha Hasan, Howard F Fine, H Matthew Wheatley, Jonathan L Prenner, Sumit P Shah, Kunjal K Modi, William J Feuer
PURPOSE: To investigate predictors of success, visual outcomes, and complications of intravitreal ocriplasmin for the treatment of symptomatic vitreomacular adhesion in a clinical care setting. METHODS: Retrospective chart review of 49 consecutive eyes of 47 patients who received intravitreal ocriplasmin. Spectral domain optical coherence tomography scans were examined for vitreomacular traction (VMT) release, full-thickness macular hole (FTMH) closure, and other changes in retinal anatomy...
January 18, 2017: Retina
https://www.readbyqxmd.com/read/28106687/superficial-parotidectomy-plane-for-debulking-surgery-in-kimura-disease
#2
Rohit Sharma
Kimura disease (KD) is a rare chronic inflammatory disorder of unknown etiology representing as solitary or multiple subcutaneous nodules predominantly in the head and neck region. Common sites of involvement are preauricular region, forehead and scalp. The soft tissue localization is often associated with regional lymphadenopathy and enlargement of the major salivary gland. The authors report a patient with KD involving the right parotid and left temporal region managed successfully at our center using a combination of debulking superficial parotidectomy and medicinal therapy...
January 18, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28105873/loco-regional-morbidity-after-breast-conservation-and-axillary-lymph-node-dissection-for-early-breast-cancer-with-or-without-regional-nodes-radiotherapy-perspectives-in-modern-breast-cancer-treatment-the-skagen-trial-1-is-active
#3
Hanne Melgaard Nielsen, Rasmus Blechingberg Friis, Søren Linnet, Birgitte Vrou Offersen
BACKGROUND: Axillary lymph node dissection (ALND) and adjuvant radiotherapy (RT) in early breast cancer are associated with a risk of morbidity, including lymphedema and impaired shoulder mobility. The aim of this study was to evaluate loco-regional morbidity after breast conserving surgery (BCS), ALND, taxane-based chemotherapy and whole breast irradiation (WBI) with or without regional nodes RT. MATERIAL AND METHODS: Eligible patients had BCS and ALND from 2007 to 2012 followed by adjuvant taxane-based chemotherapy and if indicated, trastuzumab and endocrine treatment...
January 20, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28105607/tailoring-the-mesoscopic-tio2-layer-concomitant-parameters-for-enabling-high-performance-perovskite-solar-cells
#4
Taehyun Hwang, Sangheon Lee, Jinhyun Kim, Jaewon Kim, Chunjoong Kim, Byungha Shin, Byungwoo Park
Architectural control over the mesoporous TiO2 film, a common electron-transport layer for organic-inorganic hybrid perovskite solar cells, is conducted by employing sub-micron sized polystyrene beads as sacrificial template. Such tailored TiO2 layer is shown to induce asymmetric enhancement of light absorption notably in the long-wavelength region with red-shifted absorption onset of perovskite, leading to ~20% increase of photocurrent and ~10% increase of power conversion efficiency. This enhancement is likely to be originated from the enlarged CH3NH3PbI3(Cl) grains residing in the sub-micron pores rather than from the effect of reduced perovskite-TiO2 interfacial area, which is supported from optical bandgap change, haze transmission of incident light, and one-diode model parameters correlated with the internal surface area of microporous TiO2 layers...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28105367/annular-rectal-constriction-caused-by-infiltrating-bladder-cancer-a-case-report
#5
Hisashi Takeuchi, Naoto Tokuyama, Isao Kuroda, Teiichiro Aoyagi
A 69-year-old man was referred to our hospital with chief complaints of urinary incontinence, pollakiuria, thin stools and edema of the left lower extremity. Computed tomography and magnetic resonance imaging revealed bilateral hydronephrosis, thickening of the rectal and posterolateral bladder walls, and enlargement of the left obturator lymph nodes, suggesting metastasis. The carcinoembryonic antigen and carbohydrate antigen 19-9 levels were 5.6 ng/ml and 460.1 U/ml, respectively. A transurethral bladder biopsy revealed grade 2 urothelial carcinoma with glandular differentiation...
December 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28105235/impact-of-chemotherapy-on-eosinophilia-associated-advanced-rectal-cancer-a-case-report-and-review-of-the-literature
#6
Maki Inoue, Jun Kadono, Hiroshi Sugita, Toshihiro Nakazono, Shunsuke Motoi, Iwao Kitazono, Yuko Goto, Yoshihiko Fukukura, Makoto Yoshimitsu, Takaharu Misaka, Yutaka Imoto
The present study reports a case of eosinophilia-associated rectal cancer that was successfully stabilized using chemotherapy, and reviews the mechanisms of eosinophilia and the importance of chemotherapy. A 65-year-old man, who had previously been diagnosed with suspected rectal cancer, presented with the chief complaint of melena. Eosinophilia, abnormal blood coagulation, and elevated carcinoembryonic antigen and carbohydrate antigen 19-9 tumor marker levels were observed, and the patient was subsequently diagnosed with advanced rectal cancer accompanied by multiple lymph node metastases that extended from the para-aortic lymph nodes to the left axillary lymph nodes...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28104949/enlarged-parathyroid-glands-with-variable-sonomorphology-in-a-case-of-tertiary-hyperparathyroidism-sonographic-histopathologic-correlation
#7
Yashant Aswani, Varsha Dhume, Ravi Varma, Shenaz Saifi
The typical sonomorphology of homogeneously hypoechoic texture of an enlarged parathyroid gland (PG) is a reflection of uniform arrangement of the parathormone-producing chief cells. A variable cellular arrangement, hemorrhage, fibrosis, and adipocytes cause heterogeneous appearance. We describe a case of a 32-year-old male, a case of tertiary hyperparathyroidism, with increased serum parathormone levels, hypercalcemia, and enlargement of all four PGs, albeit with differing morphology. The left lower gland had two nodules, namely, superior and inferior...
October 2016: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/28104604/hiv-infection-model-of-chronic-obstructive-pulmonary-disease-in-mice
#8
Patrick Geraghty, Eran Hadas, Boe-Hyun Kim, Abdoulaye J Dabo, David J Volsky, Robert Foronjy
Cigarette smoke usage is prevalent in HIV+ patients and, despite highly active antiretroviral therapy (HAART), these individuals develop an accelerated form of chronic obstructive pulmonary disease (COPD). Studies investigating the mechanisms of COPD development in HIV have been limited by the lack of suitable mouse models. Here we describe a model of HIV induced COPD in wild type mice using EcoHIV, a chimeric HIV capable of establishing chronic infection in immunocompetent mice. A/J mice were infected with EcoHIV and subjected to whole body cigarette smoke exposure...
January 19, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28104572/progressive-heart-disease-in-mucopolysaccharidosis-type-i-mice-may-be-mediated-by-increased-cathepsin-b-activity
#9
Guilherme Baldo, Angela Maria Vicente Tavares, Esteban Gonzalez, Edina Poletto, Fabiana Quoos Mayer, Ursula da Silveira Matte, Roberto Giugliani
Mucopolysaccharidosis type I (MPS I) is a lysosomal disorder characterized by a deficiency of alpha-L-iduronidase and storage of undegraded glycosaminoglycans (GAGs). Clinical findings of the disease include heart failure, and patients often need valve replacement. It has been shown that, later in life, MPS I mice develop those abnormalities, but to date, there have not been studies on the progression and pathogenesis of the disease. Therefore, in the present study, we evaluated heart function in normal and MPS I male mice from 2 to 8 months of age...
January 6, 2017: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/28104251/efficacy-safety-and-pharmacokinetics-of-natalizumab-in-japanese-multiple-sclerosis-patients-a-double-blind-randomized-controlled-trial-and-open-label-pharmacokinetic-study
#10
Takahiko Saida, Jun-Ichi Kira, Shuji Kishida, Takashi Yamamura, Yukiko Sudo, Kazutaka Ogiwara, J T Tibung, Nisha Lucas, Meena Subramanyam
BACKGROUND: Natalizumab, an anti-α4 integrin monoclonal antibody, has demonstrated efficacy in phase 2 and 3 studies of predominantly Caucasian patients with relapsing-remitting multiple sclerosis (RRMS). OBJECTIVE: To evaluate the efficacy, safety, pharmacokinetics (PK), and pharmacodynamics (PD) of natalizumab in Japanese RRMS patients. METHODS: This multicenter, phase 2 study included an open-label PK/PD study in 12 patients (part A) and a double-blind, placebo-controlled, randomized (computer-generated sequence) study in 94 patients (part B)...
January 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28104197/simplified-mitral-valve-repair-in-pediatric-patients-with-connective-tissue-disorders
#11
Luca A Vricella, William A Ravekes, Eloisa Arbustini, Robert D B Jaquiss, Constantine Mavroudis, Harry C Dietz, Marshall L Jacobs, Narutoshi Hibino, Duke E Cameron
BACKGROUND: In pediatric patients with connective tissue disorders (CTDs), early cardiac presentation often involves severe mitral regurgitation (MR) associated with severe bileaflet prolapse and, less frequently, aortic root enlargement. We adopted a simplified repair to address MR and prevent systolic anterior motion (SAM) in this unique group of patients. MATERIALS AND METHODS: Retrospective review of clinical and echocardiographic data of all pediatric patients (age < 18 years) with CTD and MR undergoing simplified repair at 3 institutions (2000-2014)...
February 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28104158/incidence-and-risk-factors-of-persistent-hyperparathyroidism-after-kidney-transplantation
#12
K Nakai, H Fujii, T Ishimura, M Fujisawa, S Nishi
Persistent hyperparathyroidism after kidney transplantation is related to graft function, but pre-transplantation risk factors of persistent hyperparathyroidism have not been evaluated in detail. We enrolled 86 patients who had undergone kidney transplantation between 2008 and 2014. Nine patients showed persistent hyperparathyroidism characterized by the following: 1) serum parathyroid hormone levels >65 pg/mL and serum calcium levels >10.5 mg/dL at 1 year after kidney transplantation; 2) parathyroidectomy after kidney transplantation; and 3) reintroduction of cinacalcet after kidney transplantation...
January 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28103939/physician-migration-at-its-roots-a-study-on-the-emigration-preferences-and-plans-among-medical-students-in-romania
#13
Şoimita Mihaela Suciu, Codruta Alina Popescu, Mugur Daniel Ciumageanu, Anca Dana Buzoianu
BACKGROUND: Migration of healthcare workers is receiving increased attention worldwide. In Europe, the creation of a border-free labor market and its expansion with the EU enlargements of 2004, 2007, and 2013 endowed health professionals with the right to provide services and to relocate to another EU Member State. For the Romanian doctors, the EU-wide recognition of the medical degree obtained in Romania has created new opportunities, while inadequate working conditions and relatively low salaries pushed many of them to search for employment abroad...
January 19, 2017: Human Resources for Health
https://www.readbyqxmd.com/read/28103910/epithelioid-schwannoma-of-the-skin-displaying-unique-histopathological-features-a-teaching-case-giving-rise-to-diagnostic-difficulties-on-a-morphological-examination-of-a-resected-specimen-with-a-brief-literature-review
#14
Sohsuke Yamada, Mari Kirishima, Tsubasa Hiraki, Michiyo Higashi, Kazuhito Hatanaka, Akihide Tanimoto
BACKGROUND: Epithelioid schwannoma as a rare variant poses a challenge to all pathologists, as this uncommon entity is extremely difficult to conclusively diagnose by morphological analyses on a resected sample alone owing to its unique histopathological features. However, few papers have described the detailed clinicopathological characteristics of epithelioid schwannoma. CASE PRESENTATION: A 65-year-old female presented with a history of a flat and slightly elevated firm and tan plaque accompanied by occasional tenderness, measuring 10 × 8 mm, in the right joint of her hand 1 year before resection...
January 19, 2017: Diagnostic Pathology
https://www.readbyqxmd.com/read/28103746/language-based-social-feedback-processing-with-randomized-senders-an-erp-study
#15
Sebastian Schindler, Johanna Kissler
Recently, several event-related potential (ERP) studies investigated the impact of sender attributions on language-based social feedback processing. Results showed very early responses to the social context, while interactions or effects of emotional content started later. However, in these studies, sender attribution was varied across blocks, possibly inducing unspecific, anticipatory effects. Here, who was giving feedback was disclosed simultaneously with the decision itself. Participants' ERPs differentiated between attributed senders starting with the Early Posterior Negativity (EPN)...
January 20, 2017: Social Neuroscience
https://www.readbyqxmd.com/read/28102933/what-if-a-tumor-is-significantly-enlarged-just-before-stereotactic-body-radiation-therapy-a-case-report-and-review-of-the-literature
#16
Hung-Jen Chen, Ji-An Liang, Chih-Yi Chen, Yang-Hao Yu, Chun-Ru Chien
Stereotactic body radiation therapy (SBRT) plays an important role in early stage non-small cell lung cancer. Tumor growth before radiotherapy planning (RTP) or during SBRT has been reported in lung cancer patients; however, little is known of growth during the period in-between (i.e. after RTP but before SBRT). An 83-year-old man referred to our hospital and diagnosed with medically inoperable non-small cell lung cancer was noted to have significant tumor progression on day 1 of cone beam computed tomography just before the planned SBRT delivery...
November 18, 2016: Thoracic Cancer
https://www.readbyqxmd.com/read/28102554/what-are-the-predicting-factors-for-the-therapeutic-effects-of-dutasteride-in-male-patients-with-lower-urinary-tract-symptoms-investigation-using-a-urodynamic-study
#17
Yoshihisa Matsukawa, Masashi Kato, Yasuhito Funahashi, Tsuyoshi Majima, Tokunori Yamamoto, Momokazu Gotoh
AIMS: We investigated predicting factors for the therapeutic effects of dutasteride in patients with lower urinary tract symptoms (LUTS) due to benign prostatic enlargement (BPE) based on a urodynamic study (UDS). METHODS: This was a single-center, prospective study involving 120 male outpatients with LUTS. They received 0.5 mg of dutasteride per day for 12 months. IPSS, OABSS, IPSS-QOL, and UDS were used for assessing subjective and objective symptoms prior to and 12 months after administration...
January 19, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28102408/bottom-up-synthesis-of-nitrogen-doped-porous-carbon-scaffolds-for-lithium-and-sodium-storage
#18
Hongling Lu, Renpeng Chen, Yi Hu, Xiaoqi Wang, Yanrong Wang, Lianbo Ma, Guoyin Zhu, Tao Chen, Zuoxiu Tie, Zhong Jin, Jie Liu
Here we report an effective bottom-up solution-phase process for the preparation of nitrogen-doped porous carbon scaffolds (NPCSs), which can be employed as high-performance anode materials for both lithium-ion batteries (LIBs) and sodium-ion batteries (SIBs). The as-obtained NPCSs show favorable features for electrochemical energy storage such as high specific surface area, appropriate pore size distribution (3.9 nm in average), large pore volume (1.36 cm(3) g(-1)), nanosheet-like morphology, a certain degree of graphitization, enlarged interlayer distance (0...
January 19, 2017: Nanoscale
https://www.readbyqxmd.com/read/28101889/predictors-of-successful-trial-without-catheter-following-acute-urinary-retention-in-benign-prostatic-enlargement-a-single-centre-multivariate-analysis
#19
Ankur Bansal, Aditi Arora
OBJECTIVE: To evaluate the parameters which predict the success or failure of trial without catheter (TWOC) for acute urine retention (AUR). MATERIALS AND METHODS: Medical records of 2 188 patients presenting with first episode of AUR were analyzed. All patients underwent catheterization and were started on α-blocker followed by TWOC. Age, baseline American urological association (AUA) score, prostate volume (PV), residual volume of urine (RV) and intravesical prostatic protrusion (IPP), prostate specific antigen (PSA) were recorded...
January 19, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28101888/editorial-comment-to-predictors-of-successful-trial-without-catheter-following-acute-urinary-retention-in-benign-prostatic-enlargement-a-single-centre-multivariate-analysis-manuscript-id-nau-16-0436-r1
#20
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