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https://www.readbyqxmd.com/read/29352662/distinct-progression-patterns-of-brain-disease-in-infantile-and-juvenile-gangliosidoses-volumetric-quantitative-mri-study
#1
Igor Nestrasil, Alia Ahmed, Josephine M Utz, Kyle Rudser, Chester B Whitley, Jeanine R Jarnes-Utz
BACKGROUND: GM1-gangliosidosis and GM2-gangliosidosis (Tay-Sachs disease and Sandhoff disease) are unrelenting heritable neurodegenerative conditions of lysosomal ganglioside accumulation. Although progressive brain atrophy is characteristic, longitudinal quantification of specific brain structures has not been systematically studied. OBJECTIVES: The goal of this longitudinal study has been to quantify and track brain MRI volume changes, including specific structure volume changes, at different times in disease progression of childhood gangliosidoses, and to explore quantitative brain MRI volumetry (qMRI) as a non-invasive marker of disease progression for future treatment trials...
December 20, 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/29352390/a-spatial-registration-toolbox-for-structural-mr-imaging-of-the-aging-brain
#2
Marco Ganzetti, Quanying Liu, Dante Mantini
During aging the brain undergoes a series of structural changes, in size, shape as well as tissue composition. In particular, cortical atrophy and ventricular enlargement are often present in the brain of elderly individuals. This poses serious challenges in the spatial registration of structural MR images. In this study, we addressed this open issue by proposing an enhanced framework for MR registration and segmentation. Our solution was compared with other approaches based on the tools available in SPM12, a widely used software package...
January 19, 2018: Neuroinformatics
https://www.readbyqxmd.com/read/29352171/a-urine-dependent-human-urothelial-organoid-offers-a-potential-alternative-to-rodent-models-of-infection
#3
Harry Horsley, Dhanuson Dharmasena, James Malone-Lee, Jennifer L Rohn
Murine models describe a defined host/pathogen interaction for urinary tract infection, but human cell studies are scant. Although recent human urothelial organoid models are promising, none demonstrate long-term tolerance to urine, the natural substrate of the tissue and of the uropathogens that live there. We developed a novel human organoid from progenitor cells which demonstrates key structural hallmarks and biomarkers of the urothelium. After three weeks of transwell culture with 100% urine at the apical interface, the organoid stratified into multiple layers...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29352070/review-of-extraocular-muscle-biopsies-and-utility-of-biopsy-in-extraocular-muscle-enlargement
#4
Edwina L Eade, Thomas G Hardy, Penelope A McKelvie, Alan A McNab
AIMS: To review the distribution of pathology in extraocular muscle (EOM) biopsies performed at a tertiary orbital centre, identify clinical and imaging features which are associated with benign or malignant diseases and indicate when biopsy is necessary for EOM enlargement. METHODS: Retrospective case series including 93 patients with EOM enlargement who underwent an EOM biopsy. Clinical, radiological and histopathological information was recorded from the medical records...
January 19, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29352064/gif-transcriptional-co-regulators-control-root-meristem-homeostasis
#5
María Florencia Ercoli, Antonella Ferela, Juan M Debernardi, Ana Paula Perrone, Ramiro E Rodriguez, Javier Fernando Palatnik
In the root meristem, the quiescent center (QC) is surrounded by stem cells, which in turn generate the different cell types of the root. QC cells rarely divide under normal conditions but can replenish damaged stem cells. In the proximal meristem, the daughters of stem cells, which are referred to as transit amplifying cells, undergo additional rounds of cell division prior to differentiation. Here, we describe the functions of GRF-INTERACTING FACTORs (GIFs), including ANGUSTIFOLIA3 (AN3), in Arabidopsis thaliana roots...
January 18, 2018: Plant Cell
https://www.readbyqxmd.com/read/29351853/cardiac-biomarkers-as-sensitive-tools-to-evaluate-the-impact-of-xenobiotics-on-amphibians-the-effects-of-anionic-surfactant-linear-alkylbenzene-sulfonate-las
#6
Monica Jones-Costa, Lilian Franco-Belussi, Felipe Augusto Pinto Vidal, Nathália Penteado Gongora, Luciano Mendes Castanho, Cleoni Dos Santos Carvalho, Elaine Cristina Mathias Silva-Zacarin, Fabio Camargo Abdalla, Iolanda Cristina Silveira Duarte, Classius De Oliveira, Cristiane Ronchi de Oliveira, Raquel Fernanda Salla
Amphibian populations have been experiencing a drastic decline worldwide. Aquatic contaminants are among the main factors responsible for this decline, especially in the aquatic environment. The linear alkylbenzene sulfonate (LAS) is of particular concern, since it represents 84% of the anionic surfactants' trade. In Brazil, the maximal LAS concentration allowed in fresh waters is 0.5mgL-1, but its potential harmful effects in amphibians remain unknown. Therefore, this study aimed to analyze the effects of a sublethal concentration of LAS (0...
January 16, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29351404/type-2-diabetes-impairs-the-ability-of-skeletal-muscle-pericytes-to-augment-postischemic-neovascularization-in-db-db-mice
#7
Katherine L Hayes, Louis M Messina, Lawrence M Schwartz, Jinglian Yan, Amy S Burnside, Sarah Witkowski
Peripheral artery disease is an atherosclerotic occlusive disease that causes limb ischemia and has few effective non-interventional treatments. Stem cell therapy is promising, but concomitant diabetes may limit its effectiveness. We evaluated the therapeutic potential of skeletal muscle pericytes to augment postischemic neovascularization in wild type and type 2 diabetic (T2DM) mice. Wild type C57BL/6J and leptin receptor spontaneous mutation db/db T2DM mice underwent unilateral femoral artery excision to induce limb ischemia...
January 10, 2018: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/29351102/fatal-sickling-triggered-by-massive-foreign-particle-embolism-a-case-report-of-unrecognized-indwelling-venous-catheter-drug-abuse-in-sickle-cell-disease
#8
Christopher A Febres-Aldana, Lydia Hernandez Howard
Sickle cell disease (SCD) manifests itself with vaso-occlusive episodes leading to infarction. Placement of intravascular catheters provides a useful route for management of pain crises as well as other complications. However, catheter misuse is a commonly unrecognized problem, which can have lethal consequences. We present a case of fatal splenic sequestration/hyperhemolysis secondary to foreign body pulmonary and systemic embolization due to intravenous administration of hydromorphone pills in a young woman with SCD...
January 18, 2018: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/29350170/atypical-lower-motor-neuron-disease-with-enlargement-of-nissl-substance-report-of-an-autopsy-case
#9
Masayuki Shintaku, Daita Kaneda, Kiyomitsu Oyanagi
The patient was an 81-year-old woman diagnosed with atypical motor neuron disease who died after a long clinical course (7.5 years without mechanical assistance of ventilation) characterized by lower motor neuron signs and symptoms. Upper motor neuron signs and cognitive impairment were not apparent. Autopsy demonstrated severe neuronal loss in the anterior horn of the spinal cord, and some of the remaining neurons showed enlargement of Nissl substance and apparent thickening of the nuclear envelopes. No Bunina bodies, skein-like inclusions, or structures immunoreactive for phosphorylated transactivation response DNA-binding protein 43 were found...
January 19, 2018: Clinical Neuropathology
https://www.readbyqxmd.com/read/29350092/focus-on-the-target-angiographic-features-of-the-fistulous-point-and-prognosis-of-transvenous-embolization-of-cavernous-sinus-dural-arteriovenous-fistula
#10
Hui Guo, QianKun Yin, Peng Liu, Ning Guan, Xiaochuan Huo, Youxiang Li
Background and purpose Transvenous embolization (TVE) is widely utilized as an effective and safe treatment option for cavernous sinus dural arteriovenous fistula (CS-dAVF); however, detecting the exact location of the fistula is challenging. The present study identified the angiographic features of the fistulous point and evaluated the match with the microcatheter tip and fistulous point. Materials and methods An analysis cohort of 45 consecutive patients with CS-dAVF treated by TVE was analyzed retrospectively...
January 1, 2018: Interventional Neuroradiology
https://www.readbyqxmd.com/read/29349971/-intraosseous-lipoma-retrospective-analysis-of-19-patients
#11
Wen Xue, Zeng-Ping Wang, Xiao-Li Guan, Lin Liu, Yao-Wen Qian
OBJECTIVE: To investigate the diagnostic and therapeutic procedures of intraosseous lipoma. METHODS: From June 1986 to January 2016, 19 patients with intraosseous lipoma were treated including 12 males and 7 females, aged from 24 to 76 years, a predilection aged was from 40 to 50 years in 13 cases. Symptoms presented with pain or swelling in 15 patients, the lesions were found incidentally in 3 patients, another case was bone defect lipoma replacement after curettage of bone cyst for 4 years...
March 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29349803/assessment-of-mitral-annulus-and-mitral-leaflet-in-nonvalvular-atrial-fibrillation-patients-with-various-degrees-of-mitral-regurgitation-real-time-3d-transesophageal-echocardiography
#12
Yongjuan Luo, Yanbo Zhu, Xin Guan, Yunjia Lin
AIM: To study the changes of mitral valve (MV) in patients with nonvalvular atrial fibrillation (NVAF)-related mitral regurgitation (MR) and the relationship between MV parameters and the enlarged left atrium (LA). MATERIALS AND METHODS: A total of 43 patients with NVAF were divided into two groups: (1) the MR1 group with mild MR and (2) the MR2 group with moderate-to-severe MR. Real time 3D transesophageal echocardiography (TEE) was performed to detect the structure of MV...
January 19, 2018: Echocardiography
https://www.readbyqxmd.com/read/29349392/ovarian-hyperstimulation-syndrome-as-a-rare-cause-of-acute-bilateral-limb-and-renal-ischemia
#13
Anita Quintas, Maria Emilia Ferreira, Frederico Bastos Gonçalves, José Aragão de Morais, Joao Albuquerque E Castro, Luís Mota Capitao
Ovarian hyperstimulation syndrome (OHS) is a rare and potentially fatal condition, particularly when it is associated with arterial thromboembolic events. We present a case of acute ischemia of both lower limbs and left kidney due to OHS. The clinical presentation included voluminous ascites, pleural effusion, and significant ovarian enlargement. Subsequently, bilateral severe acute limb ischemia and left kidney segmental infarction were established. Surgical thromboembolectomy and muscle débridement of the lower limbs were necessary, and the patient recovered with partial limitations...
June 2017: Journal of Vascular Surgery Cases and Innovative Techniques
https://www.readbyqxmd.com/read/29349363/a-novel-technique-combining-laparoscopic-and-endovascular-approaches-using-image-fusion-guidance-for-anterior-embolization-of-type-ii-endoleak
#14
M Mujeeb Zubair, Ponraj Chinnadurai, Francis E Loh, Thomas M Loh, Alan B Lumsden, Carlos F Bechara
Type II endoleak (T2E) leading to aneurysm sac enlargement is one of the challenging complications associated with endovascular aneurysm repair. Recent guidelines recommend embolization of T2E associated with aneurysmal sac enlargement. Various percutaneous and endovascular techniques have been reported for embolization of T2E. We report a novel technique for T2E embolization combining laparoscopic and endovascular approaches using preoperative image fusion. We believe our technique provides a more direct access to the lumbar feeding vessels that is typically challenging with transarterial or translumbar embolization techniques...
March 2017: Journal of Vascular Surgery Cases and Innovative Techniques
https://www.readbyqxmd.com/read/29349022/arthroscopic-delivery-of-injectable-bone-graft-for-staged-revision-anterior-cruciate-ligament-reconstruction
#15
Kent T Yamaguchi, Gina M Mosich, Kristofer J Jones
Bone defects caused by femoral and tibial tunnel enlargement can pose a significant technical challenge when planning to perform revision anterior cruciate ligament reconstruction. A number of options have been described for managing osseous deficiencies, including the use of large autograft or allograft bone dowels to provide sufficient tunnel fill and subsequent structural support for revision surgery. These techniques can be time-consuming and technically demanding to ensure proper tunnel fill and press-fit stability of the bone graft...
December 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/29347800/roughness-enhanced-transport-in-a-tilted-ratchet-driven-by-l%C3%A3-vy-noise
#16
Yongge Li, Yong Xu, Jürgen Kurths
The enhanced transport of particles by roughness in a tilted rough ratchet potential subject to a Lévy noise is investigated in this paper. Due to the roughness, the transport process exhibits quite different properties compared to the smooth case. We find that the roughness on the potential wall functions like a ladder to provide the convenience for particles to climb up but hinder them to slide down. The mean first passage time from one well to its right adjacent well and the mean velocity are, respectively, calculated versus the roughness, the external force, and the Lévy stability index...
November 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347553/instabilities-of-convection-patterns-in-a-shear-thinning-fluid-between-plates-of-finite-conductivity
#17
Thomas Varé, Chérif Nouar, Christel Métivier
Rayleigh-Bénard convection in a horizontal layer of a non-Newtonian fluid between slabs of arbitrary thickness and finite thermal conductivity is considered. The first part of the paper deals with the primary bifurcation and the relative stability of convective patterns at threshold. Weakly nonlinear analysis combined with Stuart-Landau equation is used. The competition between squares and rolls, as a function of the shear-thinning degree of the fluid, the slabs' thickness, and the ratio of the thermal conductivity of the slabs to that of the fluid is investigated...
October 2017: Physical Review. E
https://www.readbyqxmd.com/read/29346993/vibrational-resonance-in-an-inhomogeneous-medium-with-periodic-dissipation
#18
T O Roy-Layinde, J A Laoye, O O Popoola, U E Vincent, P V E McClintock
The role of nonlinear dissipation in vibrational resonance (VR) is investigated in an inhomogeneous system characterized by a symmetric and spatially periodic potential and subjected to nonuniform state-dependent damping and a biharmonic driving force. The contributions of the parameters of the high-frequency signal to the system's effective dissipation are examined theoretically in comparison to linearly damped systems, for which the parameter of interest is the effective stiffness in the equation of slow vibration...
September 2017: Physical Review. E
https://www.readbyqxmd.com/read/29346733/synthesis-and-structure-activity-relationship-sar-studies-of-novel-pyrazolopyridine-derivatives-as-inhibitors-of-enterovirus-replication
#19
Yanpeng Xing, Jun Zuo, Paul Krogstad, Michael E Jung
A series of novel pyrazolopyridine compounds have been designed and prepared by a general synthetic route. Their activities against the replication of poliovirus-1, EV-A71, and CV-B3 enteroviruses were evaluated. The comprehensive understanding of the Structure-Activity Relationship was obtained by utilizing the variation of four positions, namely N1, C6, C4 and linker unit. From the screened analogues, the inhibitors with the highest selectivity indices at 50% inhibition of viral replication (SI50) were those with isopropyl at the N1 position and thiophenyl-2-yl unit at C6 position...
January 18, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29346712/synergetic-effects-of-prenatal-and-postnatal-high-sucrose-intake-on-glucose-tolerance-and-hepatic-insulin-resistance-in-rat-offspring
#20
Pengjie Zhang, Di Zhu, Yueming Zhang, Lingjun Li, Xionghui Chen, Wenna Zhang, Ruixiu Shi, Jianying Tao, Bing Han, Zhice Xu
SCOPE: High sucrose intake during pregnancy is linked to type 2 diabetes mellitus and altered insulin resistance. METHODS AND RESULTS: This study attempted to ascertain whether prenatal high sucrose intake (20% sucrose) alleviates the detrimental effects of high postnatal sugar consumption in the offspring, and the molecular mechanisms were investigated using a rat model. High prenatal sucrose exposure increased the body weight of the offspring at 1 to 3 weeks of age...
January 18, 2018: Molecular Nutrition & Food Research
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