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https://www.readbyqxmd.com/read/28945025/-dna-marker-assisted-selection-of-medicinal-plants-%C3%A2-breeding-research-of-disease-resistant-cultivars-of-panax-notoginseng
#1
Lin-Lin Dong, Zhong-Jian Chen, Yong Wang, Fu-Gang Wei, Lian-Juan Zhang, Jiang Xu, Guang-Fei Wei, Rui Wang, Juan Yang, Wei-Lin Liu, Xi-Wen Li, Yu-Qi Yu, Shi-Lin Chen
DNA marker-assisted selection of medicinal plants is based on the DNA polymorphism, selects the DNA sequences related to the phenotypes such as high yields, superior quality, stress-resistance and so on according to the technologies of molecular hybridization, polymerase chain reaction and high-throughput sequencing, and assists the breeding of new cultivars. This study bred the first disease-resistant cultivar of notoginseng "Miaoxiang Kangqi 1" using the technology of DNA marker-assisted selection of medicinal plants and systematic breeding...
January 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28944974/granulomatous-enteritis-in-rainbow-trout-oncorhynchus-mykiss-associated-with-soya-bean-meal-regardless-of-water-dissolved-oxygen-level
#2
P Mosberian-Tanha, T Landsverk, C M Press, L T Mydland, J W Schrama, M Øverland
This study investigated morphological changes associated with soya bean meal-induced enteritis (SBMIE) in distal intestine (DI) of rainbow trout (Oncorhynchus mykiss) fed a soya bean meal (SBM)-based diet and exposed to normoxia or hypoxia created by optimal and low water flow rates, respectively. A 28-day adaption period was followed by a 42-day challenge period where 600 fish were subjected to dietary challenge and/or hypoxia. Twelve tanks each containing 50 juvenile trout were assigned randomly in triplicate to each treatment...
September 25, 2017: Journal of Fish Diseases
https://www.readbyqxmd.com/read/28944768/a-large-metastatic-intramammary-lesion-of-an-occult-melanoma
#3
Eleonora Nacchiero, Stefania Stucci, Paolo Annoscia, Michelangelo Vestita, Rossella Elia, Paolo Claudio Marannino
OBJECTIVE: Malignant melanomas presenting with unknown primaries are uncommon. In the majority of cases metastases of occult melanoma were detected in skin or in lymph nodes. Melanoma can rarely occur as a primary or metastatic intramammary tumor. CASE REPORT: We report the case of a 58-year-old Caucasian woman who came to our department with a voluminous mass in her right breast. Histopathological examination found metastasis of epithelioid melanoma with unknown primary lesion...
September 4, 2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/28944539/nanofibrous-scaffolds-with-biomimetic-structure
#4
Shahla Khalili, Saied Nouri Khorasani, Mohammad Razavi, Batol Hashemi Beni, Fariba Heydari, Ali Tamayol
This research studies the effect of using a grid-like pattern as a collector on increasing the pore size of the electrospun gelatin/cellulose acetate/elastin scaffolds. The morphological study showed an enlargement in pore size and a decline in fiber diameter in comparison with the scaffold fabricated using conventional flat sheet collectors. The use of the pattern increased the swelling ratio and degradation rate of the scaffold. Investigating the tensile properties of scaffolds revealed that the patterned collector increased the elongation at break up to 145%...
September 25, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28944125/extensive-pyoderma-gangrenosum-a-challenging-diagnosis-and-literature-review-of-management
#5
Faizan Yasin, Salman Assad, Mehr Zahid, Shuja A Malik
Pyoderma gangrenosum is a very rare, non-infectious leukocytic dermatosis, which is often associated with an underlying systemic disease. It is usually diagnosed based on the apparent clinical findings and by excluding other causes of ulcerative skin diseases. Treatment modality includes the use of systemic steroids and oral steroids. Immunosuppressive agents, such as cyclosporine and mycophenolate mofetil, can also be added if it fails to respond to steroids. We report a case of pyoderma gangrenosum in an 85-year-old female who presented in the inpatient facility with rapidly enlarging necrotic, ulcerative lesions with accompanying fever...
July 18, 2017: Curēus
https://www.readbyqxmd.com/read/28943256/spindle-misorientation-of-cerebral-and-cerebellar-progenitors-is-a-mechanistic-cause-of-megalencephaly
#6
Huaibiao Li, Torsten Kroll, Jürgen Moll, Lucien Frappart, Peter Herrlich, Heike Heuer, Aspasia Ploubidou
Misoriented division of neuroprogenitors, by loss-of-function studies of centrosome or spindle components, has been linked to the developmental brain defects microcephaly and lissencephaly. As these approaches also affect centrosome biogenesis, spindle assembly, or cell-cycle progression, the resulting pathologies cannot be attributed solely to spindle misorientation. To address this issue, we employed a truncation of the spindle-orienting protein RHAMM. This truncation of the RHAMM centrosome-targeting domain does not have an impact on centrosome biogenesis or on spindle assembly in vivo...
September 18, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28943223/-the-mouth-of-patients-with-acromegaly
#7
Christine Cortet-Rudelli
Orofacial changes are frequent in acromegaly. Their evolution is slowly progressive. The lips (everted and thickened), the mandibular morphology (prognathism), the tongue (macroglossia), the soft palate and the uvula (increased and thickened), the parodontis (gingival hyperplasia, paradontitis), the teeth (increased interdental spaces, hypercementosis, increased dental mobility, multiple tooth loss) are concerned. Functional consequences are significant (obstructive sleep apnea syndrome, malocclusion, pain of the oral maxillofacial area, decrease of the quality of life)...
September 21, 2017: La Presse Médicale
https://www.readbyqxmd.com/read/28942415/confusion-and-abdominal-symptoms-following-a-rugby-tackle
#8
Demetris Ioannides, Madeleine Davies, Stefan Kluzek
A 19-year-old man was sent to the emergency department following a pitch-side assessment for suspected concussion, unexplained upper abdominal tenderness and vomiting, following a high-impact tackle during a rugby match. A Focussed Assessment with Sonography for Trauma (FAST) scan performed in the emergency department suggested intra-abdominal free fluid, and subsequent head and abdominal CT imaging showed no intracranial lesion but confirmed a significant haemoperitoneum due to large splenic tear and bleeding...
September 23, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28942406/rapidly-enlarging-lipoma
#9
Timea Kosztyuova, Tang Ngee Shim
Lipoma is a common subcutaneous tumour composed of fat tissue. It may occur as a sporadic solitary lesion or as multiple lesions. They often grow very slowly. They vary between 2 and 10 cm in size. There are rarely any subjective symptoms. Lipomas do not usually require treatment unless they are big enough to be symptomatic. We reported a 75-year-old man with a rapidly enlarging and ulcerated mass on his right upper thigh.
September 23, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28942387/percutaneous-pulmonary-valve-implantation-what-have-we-learned-over-the-years
#10
Younes Boudjemline
Percutaneous pulmonary valve implantation has been widely accepted as an alternative to surgery in selected patients with right ventricular outflow tract (RVOT) dysfunction. This totally new field of our specialty pushed centres to rethink overall strategies on how to treat RVOT dysfunction. In this review, we will focus on challenges related to patient selection, and discuss innovative procedural techniques developed over the years to enlarge the number of candidates for the technique.
September 24, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28942347/a-novel-molecularly-imprinted-electrochemical-sensor-based-on-graphene-quantum-dots-coated-on-hollow-nickel-nanospheres-with-high-sensitivity-and-selectivity-for-the-rapid-determination-of-bisphenol-s
#11
Hanbing Rao, Xun Zhao, Xin Liu, Ji Zhong, Zhaoyi Zhang, Ping Zou, Yuanyuan Jiang, Xianxiang Wang, Yanying Wang
In this paper, a novel molecularly imprinted electrochemical sensor (MIECS) based on a glassy carbon electrode (GCE) modified with graphene quantum dots (GQDs) coated on hollow nickel nanospheres (hNiNS) for the rapid determination of bisphenol S (BPS) was proposed for the first time. HNiNS and GQDs as electrode modifications were used to enlarge the active area and electron-transport ability for amplifying the sensor signal, while molecularly imprinted polymer (MIP) film was electropolymerized by using pyrrole as monomer and BPS as template to detect BPS via cyclic voltammetry (CV)...
September 15, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28942309/benign-bilateral-adenomyoepithelioma-of-the-mammary-gland-in-a-ring-tailed-lemur-lemur-catta
#12
A Suárez-Bonnet, E Rodríguez Grau-Bassas, P Herráez, O Quesada-Canales, S L Priestnall, A Espinosa de Los Monteros
Naturally occurring mammary tumours are uncommon in prosimians. A 20-year-old female ring-tailed lemur (Lemur catta) developed bilateral enlargement of the mammary glands. Surgical removal revealed that both masses were comprised of multiple nodules and cystic areas that entirely replaced the normal glands. Histologically, a benign neoplastic biphasic cellular proliferation, composed of luminal-epithelial and basal-myoepithelial components, was identified. Immunohistochemical analysis for expression of cytokeratin (CK) AE1/AE3, CK7, CK5 + 8, CK14, vimentin, p63 and 14-3-3σ highlighted the biphasic nature of the neoplasm...
August 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/28942303/lymphoma-koala-retrovirus-infection-and-reproductive-chlamydiosis-in-a-koala-phascolarctos-cinereus
#13
J Fabijan, L Woolford, S Lathe, G Simmons, F Hemmatzadeh, D J Trott, N Speight
Koala retrovirus (KoRV) infection, thought to be associated with lymphoid neoplasia, and Chlamydia pecorum-related ocular and urogenital disease are both highly prevalent in eastern Australian koala (Phascolarctos cinereus) populations. However, in South Australian koalas, little is known about KoRV infection and C. pecorum-associated disease. We report the first South Australian case of lymphoma in a KoRV-A-positive female koala also affected by severe reproductive chlamydiosis. The koala was from the Mount Lofty Ranges population and was presented with hindlimb lameness...
August 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/28942292/tularaemia-in-european-brown-hares-lepus-europaeus-and-mountain-hares-lepus-timidus-characterized-by-histopathology-and-immunohistochemistry-organ-lesions-and-suggestions-of-routes-of-infection-and-shedding
#14
G Hestvik, H Uhlhorn, F Södersten, S Åkerström, E Karlsson, E Westergren, D Gavier-Widén
Tularaemia is an emerging zoonotic infectious disease caused by the bacterium Francisella tularensis. In Sweden, hares are considered to be key species in the epidemiology of tularaemia. The aim of this study was to characterize the pathology of natural tularaemia infection in European brown hares (EBHs) (Lepus europaeus) and mountain hares (MHs) (Lepus timidus) in Sweden, in order to better understand the presentation of disease and the routes of infection, body dissemination and shedding of F. tularensis...
August 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/28941855/diagnosis-of-clinically-suspected-and-unsuspected-tubercular-lymphadenopathy-by-cytology-culture-and-smear-microscopy
#15
Vivek Gupta, Arvind Bhake
BACKGROUND: Tubercular lymphadenopathy (TBLN) accounts for 20-40% cases of extrapulmonary tuberculosis. But the common presenting symptoms of tuberculosis like fever, cough, weight loss, fatigue, and night sweats are not always associated with tuberculosis lymphadenopathy, thereby, making its diagnosis difficult. Our aim was to study if Fine Needle Aspiration Cytology (FNAC) combined with Zeihl Neelsen stain and culture for Mycobacterium tuberculosis bacilli could improve the diagnostic accuracy in patients clinically suspected and unsuspected for tubercular lymphadenitis...
October 2017: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/28941583/con4ei-evaluation-of-qsar-models-for-hazard-identification-and-labelling-of-eye-irritating-chemicals
#16
L Geerts, E Adriaens, N Alépée, R Guest, J A Willoughby, H Kandarova, A Drzewiecka, P Fochtman, S Verstraelen, A R Van Rompay
Assessment of ocular irritation is a regulatory requirement in safety evaluation of industrial and consumer products. Although a number of in vitro ocular irritation assays exist, none are capable of fully categorizing chemicals as stand-alone assays. Therefore, the CEFIC-LRI-AIMT6-VITO CON4EI (CONsortium for in vitro Eye Irritation testing strategy) project was developed to assess the reliability of eight in vitro test methods and computational models as well as establishing an optimal tiered-testing strategy...
September 20, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28941552/race-sex-and-risk-factors-in-radiographic-worsening-of-knee-osteoarthritis
#17
Ernest R Vina, Di Ran, Erin L Ashbeck, Charles Ratzlaff, C Kent Kwoh
OBJECTIVES: Characterize radiographic worsening in knee osteoarthritis (KOA) by race and sex over 4 years and evaluate the role of established risk factors in observed race/sex differences. METHODS: Whites (WHs) (694 males and 929 females) and African-Americans (AAs) (92 males and 167 females) at risk for radiographic KOA were eligible. Cox shared frailty models were used to estimate race and sex group differences in radiographic worsening, defined by Kellgren-Lawrence (K-L) and OARSI joint space narrowing (JSN)...
August 31, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28941240/dynamic-changes-in-brain-mesenchymal-perivascular-cells-associate-with-multiple-sclerosis-disease-duration-active-inflammation-and-demyelination
#18
Ellen Iacobaeus, Rachael V Sugars, Anton Törnqvist Andrén, Jessica J Alm, Hong Qian, Janek Frantzen, Jia Newcombe, Kanar Alkass, Henrik Druid, Matteo Bottai, Matias Röyttä, Katarina Le Blanc
Vascular changes, including blood brain barrier destabilization, are common pathological features in multiple sclerosis (MS) lesions. Blood vessels within adult organs are reported to harbor mesenchymal stromal cells (MSCs) with phenotypical and functional characteristics similar to pericytes. We performed an immunohistochemical study of MSCs/pericytes in brain tissue from MS and healthy persons. Post-mortem brain tissue from patients with early progressive MS (EPMS), late stage progressive MS (LPMS), and healthy persons were analyzed for the MSC and pericyte markers CD146, platelet-derived growth factor receptor beta (PDGFRβ), CD73, CD271, alpha-smooth muscle actin, and Ki67...
September 23, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28940828/interface-manipulation-improving-plasmon-coupled-photoelectrochemical-water-splitting-on-%C3%AE-fe2o3-photoanodes
#19
Zhe Xu, Zhongwen Fan, Zhan Shi, Mengyu Li, Jianyong Feng, Lang Pei, Chenguang Zhou, Junkang Zhou, Lingxia Yang, Wenchao Li, Guangzhou Xu, Shicheng Yan, Zhigang Zou
Plasmon resonance effect of metal nanoparticles (NPs) offers a promising route to improve the solar energy conversion efficiency of semiconductors. Here, we found that the hot electrons generated by plasmon resonance effect of Au NPs tend to inject into the surface states instead of the conduction band of Fe2O3 photoanodes, then the severe surface recombination occurs. Such an electron transfer process seems to be independent on external applied potentials, but is sensitive to metal-semiconductor interface properties...
September 21, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28940729/natural-history-of-post-void-residual-urine-volume-over-5-years-in-community-dwelling-older-men-the-concord-health-and-ageing-in-men-project
#20
Naomi Noguchi, Lewis Chan, Robert G Cumming, Fiona M Blyth, David J Handelsman, Louise M Waite, David G Le Couteur, Vasi Naganathan
AIMS: To describe the natural history of post-void residual urine volume (PVR) in community-dwelling older men. METHODS: The Concord Health and Ageing in Men Project involves a representative sample of community-dwelling men aged 70 and older in a defined geographic area of Sydney, Australia. PVR were measured at baseline and 2-year and 5-year follow-up. The measurements were considered valid when the voided volumes were 150 mL and over. Three-hundred twenty-nine men without conditions that are likely to alter PVR (neurological disorders, prostate cancer, and a history of urological treatment) were included in the analyses...
September 20, 2017: Neurourology and Urodynamics
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