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Selma J Lekkerkerker, Marc G Besselink, Olivier R Busch, Joanne Verheij, Marc R Engelbrecht, Erik A Rauws, Paul Fockens, Jeanin E van Hooft
BACKGROUND AND AIMS: Currently, 3 guidelines are available for the management of pancreatic cysts. These guidelines vary in their indication for resection of high-risk cysts. We retrospectively compared the final pathological outcome of surgically removed pancreatic cysts with the indications for resection according to 3 different guidelines. METHODS: Patients who underwent pancreatic resection were extracted from our prospective pancreatic cyst database (2006-present)...
September 29, 2016: Gastrointestinal Endoscopy
Linda N Nilsson, Margaret G Keane, Awad Shamali, Judith Millastre Bocos, Monica Marijinissen van Zanten, Anne Antila, Cristina Verdejo Gil, Marco Del Chiaro, Johanna Laukkarinen
BACKGROUND: The current management of pancreatic mucinous cystic neoplasms (MCN) is defined by the consensus European, International Association of Pancreatology and American College of Gastroenterology guidelines. However, the criterion for surgical resection remains uncertain and differs between these guidelines. Therefore through this systematic review of the existing literature we aimed to better define the natural history and prognosis of these lesions, in order to clarify recommendations for future management...
September 20, 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
Tom K Lin, David M Troendle, Daniel B Wallihan, Bradley Barth, Victor L Fox, Douglas S Fishman, Veronique D Morinville
OBJECTIVES: An increasing number of children are being diagnosed with pancreatitis and other pancreatic abnormalities. Dissemination of the information regarding existing imaging techniques and endoscopic modalities to diagnose and manage pancreatic disorders in children is sorely needed. METHODS: We conducted a review of the medical literature on the use of the following imaging and procedural modalities in pediatric pancreatology: transabdominal ultrasonography (TUS), computed tomography (CT), magnetic resonance imaging (MRI)- magnetic resonance cholangiopancreatography (MRCP), endoscopic ultrasonography (EUS), endoscopic retrograde cholangiopancreatography (ERCP)...
August 6, 2016: Journal of Pediatric Gastroenterology and Nutrition
Fred S Gorelick
No abstract text is available yet for this article.
July 21, 2016: Current Opinion in Gastroenterology
S M Jeurnink, M M Nijs, H A B Prins, J P Greving, P D Siersema
No abstract text is available yet for this article.
April 8, 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
Salvador Navarro
The eponymous are used in Medicine with the end to refer a sign, a syndrome, a disease, a technic, etc. It is a recognition of the medical community at the work of some outstanding medical practitioners which have described some aspects of the clinical practice. Forty-six eponymous related with Pancreatology have been joined in this paper. By this mean I try to pay tribute to personages which, with their engine and ability of observation, developed techniques of treatment or exploration or identified signs or diseases...
April 19, 2016: Gastroenterología y Hepatología
Luis Sabater, Fabio Ausania, Olaf J Bakker, Jaume Boadas, J Enrique Domínguez-Muñoz, Massimo Falconi, Laureano Fernández-Cruz, Luca Frulloni, Víctor González-Sánchez, José Lariño-Noia, Björn Lindkvist, Félix Lluís, Francisco Morera-Ocón, Elena Martín-Pérez, Carlos Marra-López, Ángel Moya-Herraiz, John P Neoptolemos, Isabel Pascual, Ángeles Pérez-Aisa, Raffaele Pezzilli, José M Ramia, Belinda Sánchez, Xavier Molero, Inmaculada Ruiz-Montesinos, Eva C Vaquero, Enrique de-Madaria
OBJECTIVE: To provide evidence-based recommendations for the management of exocrine pancreatic insufficiency (EPI) after pancreatic surgery. BACKGROUND: EPI is a common complication after pancreatic surgery but there is certain confusion about its frequency, optimal methods of diagnosis, and when and how to treat these patients. METHODS: Eighteen multidisciplinary reviewers performed a systematic review on 10 predefined questions following the GRADE methodology...
April 1, 2016: Annals of Surgery
T Helmberger
CLINICAL/METHODICAL ISSUE: Autoimmune pancreatitis (AIP) is a rare disease, the pathophysiological understanding of which has been greatly improved over the last years. The most common form, type 1 AIP belongs to the IgG4-related diseases and must be distinguished from type 2 AIP, which is a much rarer entity associated with chronic inflammatory bowel disease. Clinically, there is an overlap with pancreatic cancer. Imaging and further criteria, such as serological and histological parameters are utilized for a differentiation between both entities in order to select the appropriate therapy and to avoid the small but ultimately unnecessary number of pancreatectomies...
April 2016: Der Radiologe
Austin L Chiang, Linda S Lee
The approach to incidentally noted pancreatic cysts is constantly evolving. While surgical resection is indicated for malignant or higher risk cysts, correctly identifying these highest risk pancreatic cystic lesions remains difficult. Using parameters including cyst size, presence of solid components, and pancreatic duct involvement, the 2012 International Association of Pancreatology (IAP) and the 2015 American Gastroenterological Association (AGA) guidelines have sought to identify the higher risk patients who would benefit from further evaluation using endoscopic ultrasound (EUS)...
January 21, 2016: World Journal of Gastroenterology: WJG
Zhi Ven Fong, Cristina R Ferrone, Keith D Lillemoe, Carlos Fernández-Del Castillo
With the widespread use and advances in radiographic imaging, Intraductal Papillary Mucinous Neoplasms (IPMNs) of the pancreas are identified with increasing frequency. Although many studies have addressed its biology and treatment, true understanding of its natural history continues to elude us. Its malignant potential places careproviders in a clinical dilemma of balancing the morbidity of pancreatectomy against the risk of malignant transformation while under continuous surveillance. Recently, there have been conflicting data published in the literature, generating more uncertainty in the field...
May 2016: Annals of Surgery
Kyoichi Takaori, Claudio Bassi, Andrew Biankin, Thomas B Brunner, Ivana Cataldo, Fiona Campbell, David Cunningham, Massimo Falconi, Adam E Frampton, Junji Furuse, Marc Giovannini, Richard Jackson, Akira Nakamura, William Nealon, John P Neoptolemos, Francisco X Real, Aldo Scarpa, Francesco Sclafani, John A Windsor, Koji Yamaguchi, Christopher Wolfgang, Colin D Johnson
BACKGROUND: Pancreatic cancer is one of the most devastating diseases with an extremely high mortality. Medical organizations and scientific societies have published a number of guidelines to address active treatment of pancreatic cancer. The aim of this consensus review was to identify where there is agreement or disagreement among the existing guidelines and to help define the gaps for future studies. METHODS: A panel of expert pancreatologists gathered at the 46th European Pancreatic Club Meeting combined with the 18th International Association of Pancreatology Meeting and collaborated on critical reviews of eight English language guidelines for the clinical management of pancreatic cancer...
January 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
Fanni Zsoldos, Andrea Párniczky, Dóra Mosztbacher, Anna Tóth, Natália Lásztity, Peter Hegyi
BACKGROUND: There are unexpectedly large differences between the incidences of acute pancreatitis (AP) as indicated by different hospitals. Retrospective studies suggest that the reason behind this is the large differences that exist between the local managements of abdominal pain at emergency units. Unfortunately, no evidence-based medicine (EBM) guidelines are available to give proper instruction concerning the necessity of serum pancreatic enzyme measurement during abdominal pain. SUMMARY: Pain in Early Phase of Pediatric Pancreatitis (PINEAPPLE) is an observational, multinational observational clinical trial to explore the route from the first sign of abdominal pain to the diagnosis of pancreatitis (PINEAPPLE trial)...
2016: Digestion
Andrea Párniczky, Dóra Mosztbacher, Fanni Zsoldos, Anna Tóth, Natália Lásztity, Péter Hegyi
BACKGROUND: Single-centered studies show increased number of acute pancreatitis (AP) in children. Here, the Pediatric Section of the Hungarian Pancreatic Study Group introduces an international observational clinical trial (APPLE) to collect a critical mass of clinical data and biomedical research samples in a uniform prospective manner. SUMMARY: The APPLE-R is for patients under 18 years of age with a history of pancreatitis. The study primarily provides information on possible genetic variants behind the disease and their impact on the prognosis...
2016: Digestion
Jiemin Ma, Sayali A Pendharkar, Gregory O'Grady, John A Windsor, Maxim S Petrov
BACKGROUND: Evidence from animal studies suggests that gastrointestinal motility is impaired in acute pancreatitis. Enteral nutrition, and more specifically nasogastric tube feeding, has emerged as a key treatment modality in patients with acute pancreatitis, but its effect on motility has not been investigated in this setting. The aim was to validate the Gastroparesis Cardinal Symptom Index (GCSI) in patients with acute pancreatitis and determine the effect of nasogastric tube feeding on GCSI...
February 2016: Nutrition in Clinical Practice
Jayakrishna Chintanaboina, Zhaohai Yang, Abraham Mathew
Autoimmune pancreatitis (AIP) is a rare cause of chronic pancreatitis that poses a diagnostic challenge to the clinician in that it mimics pancreatic cancer and presents with painless obstructive jaundice. In this review, we discuss the two types of AIP: type 1, known as lymphoplasmacytic sclerosing pancreatitis and type 2, known as idiopathic duct centric pancreatitis. Type 1 AIP is considered as a pancreatic manifestation of immunoglobulin G4-related disease. The etiopathogenesis of AIP, particularly type 2 AIP, is largely unknown...
September 2015: Southern Medical Journal
Philippe Lévy, Vinciane Rebours
BACKGROUND: Cystic pancreatic lesions are more and more often found. Malignant risk ranges from nil to more than 60%. A precise diagnosis is required to adapt surveillance or therapeutic strategy. METHODS: We tried to identify the most difficult differential diagnoses encountered in a tertiary center of pancreatology and to guide the reader as how to reach the correct strategy and diagnosis in these situations. RESULTS: We identified eight clinically difficult situations: i) chronic pancreatitis versus intraductal papillary mucinous neoplasms, ii) serous versus mucinous cystic neoplasms, iii) serous cystic neoplasms versus branch-duct intraductal papillary mucinous neoplasms, iv) intraductal papillary mucinous neoplasms versus acinar cell cystadenoma, v) (pseudo-) solid serous cystic neoplasm versus neuroendocrine tumor, vi) pancreatic neuroendocrine tumors versus solid pseudopapillary tumors, vii) cystic forms of a solid tumor, and viii) rare pancreatic or peripancreatic cystic lesions...
February 2015: Viszeralmedizin
Piotr Ceranowicz, Jakub Cieszkowski, Zygmunt Warzecha, Beata Kuśnierz-Cabala, Artur Dembiński
This review presents the history of discoveries concerning the pancreas. In antiquity and the Middle Ages knowledge about the anatomy of the pancreas was very limited and its function was completely unknown. Significant progress was first made in the seventeenth and eighteenth centuries. Johann Georg Wirsüng, the prosector of the University of Padua, discovered the main pancreatic duct, and Giovanni Santorini discovered the accessory duct. Regnier de Graaf was the first to perform pancreatic exocrine studies, and Paul Langerhans's 1869 discovery of pancreatic islets was the first step toward recognizing the pancreas as an endocrine gland...
2015: BioMed Research International
B Jais, V Rebours, G Malleo, R Salvia, M Fontana, L Maggino, C Bassi, R Manfredi, R Moran, A M Lennon, A Zaheer, C Wolfgang, R Hruban, G Marchegiani, C Fernández Del Castillo, W Brugge, Y Ha, M H Kim, D Oh, I Hirai, W Kimura, J Y Jang, S W Kim, W Jung, H Kang, S Y Song, C M Kang, W J Lee, S Crippa, M Falconi, I Gomatos, J Neoptolemos, A C Milanetto, C Sperti, C Ricci, R Casadei, M Bissolati, G Balzano, I Frigerio, R Girelli, M Delhaye, B Bernier, H Wang, K T Jang, D H Song, M T Huggett, K W Oppong, L Pererva, K V Kopchak, M Del Chiaro, R Segersvard, L S Lee, D Conwell, A Osvaldt, V Campos, G Aguero Garcete, B Napoleon, I Matsumoto, M Shinzeki, F Bolado, J M Urman Fernandez, M G Keane, S P Pereira, I Araujo Acuna, E C Vaquero, M R Angiolini, A Zerbi, J Tang, R W Leong, A Faccinetto, G Morana, M C Petrone, P G Arcidiacono, J H Moon, H J Choi, R S Gill, D Pavey, M Ouaïssi, B Sastre, M Spandre, C G De Angelis, M A Rios-Vives, M Concepcion-Martin, T Ikeura, K Okazaki, L Frulloni, O Messina, P Lévy
OBJECTIVES: Serous cystic neoplasm (SCN) is a cystic neoplasm of the pancreas whose natural history is poorly known. The purpose of the study was to attempt to describe the natural history of SCN, including the specific mortality. DESIGN: Retrospective multinational study including SCN diagnosed between 1990 and 2014. RESULTS: 2622 patients were included. Seventy-four per cent were women, and median age at diagnosis was 58 years (16-99)...
February 2016: Gut
Y S Vinnik, S S Dunaevskaya, D A Antufrieva
OBJECTIVE: The aim of the study was to evaluate the diagnostic value of specific and nonspecific scoring systems Tolstoy-Krasnogorov score, Ranson, BISAP, Glasgow, MODS 2, APACHE II and CTSI, which used at urgent pancreatology for estimation the severity of acute pancreatitis and status of patient. METHODS: 1550 case reports of patients which had inpatient surgical treatment at Road clinical hospital at the station Krasnoyarsk from 2009 till 2013 were analyzed. Diagnosis of severe acute pancreatitis and its complications were determined based on anamnestic data, physical exami- nation, clinical indexes, ultrasonic examination and computed tomography angiography...
2015: Vestnik Rossiĭskoĭ Akademii Meditsinskikh Nauk
Marco Del Chiaro, Caroline Verbeke
Pancreatic cystic neoplasms (PCNs) are a high prevalence disease. It is estimated that about 20% of the general population is affected by PCNs. Some of those lesions can progress till cancer, while others behave in a benign fashion. In particular intraductal papillary mucinous neoplasms of the pancreas can be considered as the pancreatic analogon to colonic polyps. Treatment of these precursor lesions at an early stage can potentially reduce pancreas cancer mortality and introduce a new "era" of preemptive pancreatic surgery...
May 15, 2015: World Journal of Gastrointestinal Pathophysiology
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