Amel Dudakovic, Afton K Limberg, Cole E Bothun, Oliver B Dilger, Banu Bayram, Jacob W Bettencourt, Harold I Salmons, Roman Thaler, Daniel C Karczewski, Aaron R Owen, Varun G Iyer, Ashley N Payne, Mason F Carstens, Andre J van Wijnen, Daniel J Berry, Joaquin Sanchez-Sotelo, Mark E Morrey, Matthew P Abdel
Arthrofibrosis, which causes joint motion restrictions, is a common complication following total knee arthroplasty (TKA). Key features associated with arthrofibrosis include myofibroblast activation, knee stiffness, and excessive scar tissue formation. We previously demonstrated that adiponectin levels are suppressed within the knee tissues of patients affected by arthrofibrosis and showed that AdipoRon, an adiponectin receptor agonist, exhibited anti-fibrotic properties in human mesenchymal stem cells. In this study, the therapeutic potential of AdipoRon was evaluated on TGFβ1-mediated myofibroblast differentiation of primary human knee fibroblasts and in a mouse model of knee stiffness...
December 27, 2023: Journal of Cellular Physiology