Giorgia Mori, Beatrice Silvia Orena, Laurent R Chiarelli, Giulia Degiacomi, Olga Riabova, José Camilla Sammartino, Vadim Makarov, Giovanna Riccardi, Maria Rosalia Pasca
Tuberculosis remains one of the leading causes of death from a single pathogen globally. It is estimated that 1/4 of the world's population harbors latent tuberculosis, but only a 5-10% of patients will develop active disease. During latent infection, Mycobacterium tuberculosis can persist unaffected by drugs for years in a non-replicating state with low metabolic activity. The rate of the successful tuberculosis treatment is curbed by the presence of these non-replicating bacilli that can resuscitate after decades and also by the spread of M...
2020: Frontiers in Microbiology