Patrik Szekér, Tamás Bodó, Katalin Klima, Ágota Csóti, Nikoletta Ngo Hanh, József Murányi, Anna Hajdara, Tibor Gábor Szántó, György Panyi, Márton Megyeri, Zalán Péterfi, Sándor Farkas, Norbert Gyöngyösi, Péter Hornyák
Despite significant advances in the development of therapeutic interventions targeting autoimmune diseases and chronic inflammatory conditions, lack of effective treatment still poses a high unmet need. Modulating chronically activated T cells through the blockade of the Kv1.3 potassium channel is a promising therapeutic approach, however, developing selective Kv1.3 inhibitors is still an arduous task. Phage display-based high throughput peptide library screening is a rapid and robust approach to develop promising drug candidates; however, it requires solid-phase immobilization of target proteins with their binding site preserved...
March 11, 2024: Journal of Biological Chemistry