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https://www.readbyqxmd.com/read/28805874/microfluidic-modeling-of-the-biophysical-microenvironment-in-tumor-cell-invasion
#1
Yu Ling Huang, Jeffrey E Segall, Mingming Wu
Tumor cell invasion, whether penetrating through the extracellular matrix (ECM) or crossing a vascular endothelium, is a critical step in the cancer metastatic cascade. Along the way from a primary tumor to a distant metastatic site, tumor cells interact actively with the microenvironment either via biomechanical (e. g. ECM stiffness) or biochemical (e.g. secreted cytokines) signals. Increasingly, it is recognized that the tumor microenvironment (TME) is a critical player in tumor cell invasion. A main challenge for the mechanistic understanding of tumor cell-TME interactions comes from the complexity of the TME, which consists of extracellular matrices, fluid flows, cytokine gradients and other cell types...
August 14, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28805853/the-activity-of-lone-pair-contributing-to-shg-response-in-bismuth-borates-a-combination-investigation-from-experiment-and-dft-calculation
#2
Cong Hu, Miriding Mutailipu, Ying Wang, Fengjiao Guo, Zhihua Yang, Shilie Pan
Second harmonic generation (SHG) response is one of the most essential properties of nonlinear optical (NLO) materials. To achieve relatively strong SHG response, a feasible strategy is to introduce stereochemically active lone pair (SCALP) cations, such as Bi(3+). NLO materials with Bi(3+) usually exhibit a huge difference in SHG response, the inner correlation between the activity of SCALP and SHG response still being unclear owing to the lack of quantization estimation of the intensity of SCALP. Based on the calculation results of density functional theory (DFT), we develop a theoretical method to compute the intensity of the Bi-6s SCALP, which could describe the stereochemical behavior and exert significantly influences on some apparent optical properties, such as SHG response...
August 14, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28801135/pyrrolo-2-1-f-1-2-4-triazines-from-c-nucleosides-to-kinases-and-back-again-the-remarkable-journey-of-a-versatile-nitrogen-heterocycle
#3
REVIEW
Gregory R Ott, David A Favor
Pyrrolo[2,1-f][1,2,4]triazine, a unique NN bond-containing heterocycle with a bridgehead nitrogen, was first synthesized in the late 1970s but did not find utility until more than a decade later in the early 1990s when it was incorporated into C-nucleosides as a novel purine-like mimetic. This heterocycle remained at the fringes of medicinal chemistry until a confluence of events spurred by the explosion of the kinase inhibitor field in the early 2000s and the pressing need for novel, druggable scaffolds to occupy that exciting space led to numerous applications against diverse therapeutic targets...
July 30, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28800353/how-do-users-design-the-case-of-sugar-cane-harvester-machines
#4
Lidiane Regina Narimoto, João Alberto Camarotto
BACKGROUND: Design in use and inventiveness are key concepts in ergonomics. It is well-known that users design but is not explored in the literature how they manage to do that. OBJECTIVE: This paper aims to contribute to the discussion of how users actually design, by showing a research conducted in sugar cane harvesting in Brazil and in Australia. METHODS: Through the methodology of the Ergonomic Work Analysis (EWA), the design modifications made by the harvesting teams were identified as well as their elaboration process...
2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/28799410/-well-i-m-still-the-diva-enabling-people-with-dementia-to-express-their-identity-through-graffiti-arts-innovative-practice
#5
Ben Hicks, Denise Carroll, Shanti Shanker, Angela El-Zeind
This article reports on a pilot study that investigated the use of graffiti arts as a medium for promoting self-expression in people with dementia. Two people with dementia attended a series of workshops with a graffiti artist where they explored their feelings of changing identity following their dementia diagnoses. As part of the workshops, they were encouraged to develop a personal 'tag' or signature to portray their sense of identity and a piece of street art to express 'their message'. These completed artworks were displayed in a public space in Bournemouth, UK...
January 1, 2017: Dementia
https://www.readbyqxmd.com/read/28799207/the-relation-between-cognitive-and-metacognitive-strategic-processing-during-a-science-simulation
#6
Daniel L Dinsmore, Brian P Zoellner
BACKGROUND: This investigation was designed to uncover the relations between students' cognitive and metacognitive strategies used during a complex climate simulation. While cognitive strategy use during science inquiry has been studied, the factors related to this strategy use, such as concurrent metacognition, prior knowledge, and prior interest, have not been investigated in a multidimensional fashion. AIMS: This study addressed current issues in strategy research by examining not only how metacognitive, surface-level, and deep-level strategies influence performance, but also how these strategies related to each other during a contextually relevant science simulation...
August 10, 2017: British Journal of Educational Psychology
https://www.readbyqxmd.com/read/28799135/appendiceal-duplication-a-comprehensive-review-of-published-cases-and-clinical-recommendations
#7
H Nageswaran, U Khan, F Hill, A Maw
BACKGROUND: Duplex appendix is very rare (incidence 0.004%) but has clinical relevance given the frequency of appendicectomies performed. Failure to recognise duplication can result in failure of treatment and medico-legal consequences. A review of published cases was undertaken to identify factors that may help in managing this rare condition. METHODS: All English and non-English publications were identified in PubMed, Embase and Cochrane databases. Patient demographics, intraoperative findings, anatomical details and histopathology were analysed...
August 10, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28798674/adaptive-gaze-strategies-for-locomotion-with-constricted-visual-field
#8
Colas N Authié, Alain Berthoz, José-Alain Sahel, Avinoam B Safran
In retinitis pigmentosa (RP), loss of peripheral visual field accounts for most difficulties encountered in visuo-motor coordination during locomotion. The purpose of this study was to accurately assess the impact of peripheral visual field loss on gaze strategies during locomotion, and identify compensatory mechanisms. Nine RP subjects presenting a central visual field limited to 10-25° in diameter, and nine healthy subjects were asked to walk in one of three directions-straight ahead to a visual target, leftward and rightward through a door frame, with or without obstacle on the way...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28798076/perivascular-spaces-glymphatic-dysfunction-and-small-vessel-disease
#9
REVIEW
Humberto Mestre, Serhii Kostrikov, Rupal I Mehta, Maiken Nedergaard
Cerebral small vessel diseases (SVDs) range broadly in etiology but share remarkably overlapping pathology. Features of SVD including enlarged perivascular spaces (EPVS) and formation of abluminal protein deposits cannot be completely explained by the putative pathophysiology. The recently discovered glymphatic system provides a new perspective to potentially address these gaps. This work provides a comprehensive review of the known factors that regulate glymphatic function and the disease mechanisms underlying glymphatic impairment emphasizing the role that aquaporin-4 (AQP4)-lined perivascular spaces (PVSs), cerebrovascular pulsatility, and metabolite clearance play in normal CNS physiology...
September 1, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28796797/chaotic-itinerancy-within-the-coupled-dynamics-between-a-physical-body-and-neural-oscillator-networks
#10
Jihoon Park, Hiroki Mori, Yuji Okuyama, Minoru Asada
Chaotic itinerancy is a phenomenon in which the state of a nonlinear dynamical system spontaneously explores and attracts certain states in a state space. From this perspective, the diverse behavior of animals and its spontaneous transitions lead to a complex coupled dynamical system, including a physical body and a brain. Herein, a series of simulations using different types of non-linear oscillator networks (i.e., regular, small-world, scale-free, random) with a musculoskeletal model (i.e., a snake-like robot) as a physical body are conducted to understand how the chaotic itinerancy of bodily behavior emerges from the coupled dynamics between the body and the brain...
2017: PloS One
https://www.readbyqxmd.com/read/28796577/foreword-biology-embodiment-desire
#11
Jennifer Terry, Angela Willey
The sexological roots of "lesbian" and the "queer" turn from biologized categories of sexual difference pose an exciting set of questions and tensions for thinking about queer feminism and biological meanings. This issue seeks to open space to explore how we might reconcile assumptions about "female same-sex sexuality" that often accompany "lesbian" with queer and trans-feminist treatments of science, embodiment, and desiring, while at the same time insisting on the importance of an undertheorized dyke legacy for thinking the at-once material and political nature of sexuality...
August 10, 2017: Journal of Lesbian Studies
https://www.readbyqxmd.com/read/28795799/the-tetraarylpyrrolo-3-2-b-pyrroles-from-serendipitous-discovery-to-promising-heterocyclic-optoelectronic-materials
#12
Maciej Krzeszewski, Dorota Gryko, Daniel T Gryko
Progress in organic optoelectronics requires compounds possessing a suitable combination of photophysical and electronic properties. Another key constraint encompasses the availability of feasible, and hopefully scalable, synthetic procedures for preparing the molecular scaffolds of interest. A multicomponent reaction of aromatic aldehydes, aromatic amines, and butane-2,3-dione that was discovered in 2013 gives straightforward access to previously unavailable 1,2,4,5-tetraarylpyrrolo[3,2-b]pyrroles. These dyes are examples of heteropentalenes-a class of 10-π-electron aromatic compounds...
August 10, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28795400/application-of-micro-ftir-mapping-and-sem-to-study-compositional-heterogeneity-of-siltstones-example-from-the-late-devonian-early-mississippian-middle-bakken-member
#13
C Gasaway, M Mastalerz, F Krause, C Clarkson, C Debuhr
This paper explores the applicability of micro-FTIR mapping to study heterogeneity of organic matter-lean siltstones. Closely spaced samples of Late Devonian dolomitic siltstones of the Middle Bakken Member were analysed with micro-FTIR, powder X-ray diffraction, and scanning electron microscopy (SEM) to explore the distribution and chemical properties of organic matter (OM), muscovite/feldspar/clay group, carbonates, and quartz, and their influence on porosity and permeability of these rocks. Our results show that quartz is the dominant component of the samples, and the main mineralogical differences between the samples are reflected in the abundance of carbonate minerals...
August 10, 2017: Journal of Microscopy
https://www.readbyqxmd.com/read/28794954/cationic-supramolecular-hydrogels-for-overcoming-the-skin-barrier-in-drug-delivery
#14
David Limón, Claire Jiménez-Newman, Mafalda Rodrigues, Arántzazu González-Campo, David B Amabilino, Ana C Calpena, Lluïsa Pérez-García
A cationic bis-imidazolium-based amphiphile was used to form thermoreversible nanostructured supramolecular hydrogels incorporating neutral and cationic drugs for the topical treatment of rosacea. The concentration of the gelator and the type and concentration of the drug incorporated were found to be factors that strongly influenced the gelling temperature, gel-formation period, and overall stability and morphology. The incorporation of brimonidine tartrate resulted in the formation of the most homogeneous material of the three drugs explored, whereas the incorporation of betamethasone resulted in a gel with a completely different morphology comprising linked particles...
August 2017: ChemistryOpen
https://www.readbyqxmd.com/read/28794204/chromosome-topology-guides-the-drosophila-dosage-compensation-complex-for-target-gene-activation
#15
Tamás Schauer, Yad Ghavi-Helm, Tom Sexton, Christian Albig, Catherine Regnard, Giacomo Cavalli, Eileen Em Furlong, Peter B Becker
X chromosome dosage compensation in Drosophila requires chromosome-wide coordination of gene activation. The male-specific lethal dosage compensation complex (DCC) identifies and binds to X-chromosomal high-affinity sites (HAS) from which it boosts transcription. A sub-class of HAS, PionX sites, represent first contacts on the X. Here, we explored the chromosomal interactions of representative PionX sites by high-resolution 4C and determined the global chromosome conformation by Hi-C in sex-sorted embryos. Male and female X chromosomes display similar nuclear architecture, concordant with clustered, constitutively active genes...
August 9, 2017: EMBO Reports
https://www.readbyqxmd.com/read/28793227/the-design-space-of-the-embryonic-cell-cycle-oscillator
#16
Henry H Mattingly, Moshe Sheintuch, Stanislav Y Shvartsman
One of the main tasks in the analysis of models of biomolecular networks is to characterize the domain of the parameter space that corresponds to a specific behavior. Given the large number of parameters in most models, this is no trivial task. We use a model of the embryonic cell cycle to illustrate the approaches that can be used to characterize the domain of parameter space corresponding to limit cycle oscillations, a regime that coordinates periodic entry into and exit from mitosis. Our approach relies on geometric construction of bifurcation sets, numerical continuation, and random sampling of parameters...
August 8, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28792941/the-magic-words-using-computers-to-uncover-mental-associations-for-use-in-magic-trick-design
#17
Howard Williams, Peter W McOwan
The use of computational systems to aid in the design of magic tricks has been previously explored. Here further steps are taken in this direction, introducing the use of computer technology as a natural language data sourcing and processing tool for magic trick design purposes. Crowd sourcing of psychological concepts is investigated; further, the role of human associative memory and its exploitation in magical effects is explored. A new trick is developed and evaluated: a physical card trick partially designed by a computational system configured to search for and explore conceptual spaces readily understood by spectators...
2017: PloS One
https://www.readbyqxmd.com/read/28791142/using-deep-learning-to-quantify-the-beauty-of-outdoor-places
#18
Chanuki Illushka Seresinhe, Tobias Preis, Helen Susannah Moat
Beautiful outdoor locations are protected by governments and have recently been shown to be associated with better health. But what makes an outdoor space beautiful? Does a beautiful outdoor location differ from an outdoor location that is simply natural? Here, we explore whether ratings of over 200 000 images of Great Britain from the online game Scenic-Or-Not, combined with hundreds of image features extracted using the Places Convolutional Neural Network, might help us understand what beautiful outdoor spaces are composed of...
July 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28790882/altered-tracer-distribution-and-clearance-in-the-extracellular-space-of-the-substantia-nigra-in-a-rodent-model-of-parkinson-s-disease
#19
Yuan Fang, Yanchao Dong, Tao Zheng, Dan Du, Jiexia Wen, Dawei Gao, Lanxiang Liu
The relationship between extracellular space (ECS) diffusion parameters and brain drug clearance is not well-studied, especially in the context of Parkinson's disease (PD). Therefore, we used a rodent model of PD to explore the distribution and clearance of a magnetic resonance tracer. Forty male Sprague Dawley rats were randomized into four different groups: a PD group, a Madopar group (PD + Madopar treatment), a sham group, and a control group. All rats received an injection of the extracellular tracer gadolinium-diethylene triaminepentacetic acid (Gd-DTPA) directly into the substantia nigra (SN)...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28790095/reduction-en-masse-of-inguinal-hernia-a-review-of-a-rare-and-potential-fatal-complication-following-reduction-of-inguinal-hernia
#20
Ashanga Yatawatta
Reduction en masse is reduction of a hernial sac into the pre-peritoneal space with a loop of bowel remaining incarcerated at the neck of the sac, leading to early strangulation. This is a rare complication, usually encountered with inguinal hernias, with a false reassurance to the patient and the treating physician that complete reduction has been achieved. Unless early intervention is carried out, this condition will typically present with worsening pain and absence of an appreciable hernia bulge at the groin, and intestinal necrosis may be encountered on exploration...
August 7, 2017: BMJ Case Reports
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