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https://www.readbyqxmd.com/read/28320161/circulating-autoantibodies-against-the-nr2-peptide-of-the-nmda-receptor-are-associated-with-subclinical-brain-damage-in-hypertensive-patients-with-other-pre-existing-conditions-for-vascular-risk
#1
S González-García, A González-Quevedo, Z Hernandez-Diaz, L Alvarez Camino, M Peña-Sanchez, A Cordero-Eiriz, M Brown, J A Gaya, M Betancourt-Losa, I Fernandez-Almirall, M C Menendez-Sainz, R Fernandez-Carriera
Arterial hypertension (HT) and other vascular pre-existing conditions (PEC) generate asymptomatic brain damage which increases the occurrence of stroke and cognitive decline. The aim of this work was to explore if serum antibodies against the NR2 subunit of the NMDA receptor (NR2Ab) could predict subclinical brain damage (SBD) in hypertensive patients with PEC. Forty seven neurologically asymptomatic hypertensive subjects were classified according to the number of PEC (retinopathy, overweight/obesity, diabetes mellitus and dyslipidemia)...
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28319908/the-sociology-of-space-as-a-catalyst-for-innovation-in-the-health-sector
#2
Trust Saidi, Katusha de Villiers, Tania S Douglas
This paper reviews the role of space in facilitating innovation. It draws on the sociology of space in exploring the social practices, institutional forces and material complexity of how people and spaces interact. We assess how space influences the development of innovative solutions to challenges in the health sector. Our aim is to advance an understanding of the social production of space for healthcare innovation. We draw empirical examples from the Innovation Hub at Groote Schuur Hospital in Cape Town to illustrate that innovation does not take place in an institutional vacuum, but requires space that facilitates interaction of different players...
March 9, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28319812/exploring-sequence-space-harnessing-chemical-and-biological-diversity-towards-new-peptide-leads
#3
REVIEW
Richard Obexer, Louise J Walport, Hiroaki Suga
From their early roots in natural products, peptides now represent an expanding class of novel drugs. Their modular structures make them ideal candidates for pooled library screening approaches. Key technologies for library generation and screening, such as SICLOPPS, phage display and mRNA display, give unparalleled access to tight binding peptides. Through combination with genetic code reprogramming and chemical modifications, access to more natural product-like libraries, spanning non-canonical peptide space, is readily achievable...
March 17, 2017: Current Opinion in Chemical Biology
https://www.readbyqxmd.com/read/28319498/fdopa-patterns-in-adrenal-glands-a-pictorial-essay
#4
Aurélie Moreau, Anne Laure Giraudet, David Kryza, Françoise Borson-Chazot, Claire Bournaud-Salinas, Thomas Mognetti, Jean-Christophe Lifante, Patrick Combemale, Francesco Giammarile, Claire Houzard
F-FDOPA is a well-established tool to explore pheochromocytomas. It tends to replace I-MIBG scan in metastatic pheochromocytomas, multiple endocrine neoplasia type 2-related tumors, succinate dehydrogenase [ubiquinone] iron-sulfur subunit-negative tumors, and succinate dehydrogenase[ZERO WIDTH SPACE]-positive lesions. To our knowledge, no study has characterized physiological and pathological adrenal glands with F-FDOPA from a quantitative point of view. We report the features of different normal and pathological adrenal glands with F-FDOPA...
March 17, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28319376/anomalous-protein-protein-interactions-in-multivalent-salt-solution
#5
Coralie Pasquier, Mario Vazdar, Jan Forsman, Pavel Jungwirth, Mikael Lund
The stability of aqueous protein solutions is strongly affected by multivalent ions, which induce ion-ion correlations beyond the scope of classical mean-field theory. Using all-atom Molecular Dynamics (MD) and coarse grained Monte Carlo (MC) simulations, we investigate the interaction between a pair of protein molecules in 3:1 electrolyte solution. In agreement with available experimental findings of "reentrant protein condensation", we observe an anomalous trend in the protein-protein potential of mean force with increasing electrolyte concentration in the order: (i) double-layer repulsion, (ii) ion-ion correlation attraction, (iii) over-charge repulsion, and in excess of 1:1 salt, (iv) non Coulombic attraction...
March 20, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28319369/enhancement-of-the-thermoelectric-properties-of-fega3-type-structures-with-group-6-transition-metals-a-computational-exploration
#6
Benoît Boucher, Rabih Al Rahal Al Orabi, Bruno Fontaine, Yuri Grin, Régis Gautier, Jean-François Halet
The possible existence of group 6 TM3 compounds with T = Cr, Mo, W and M = Ga, In is investigated with the aid of density functional theory calculations. Their most probable crystal structure is expected to be of the FeGa3 type tetragonal space group P42/mnm. All compounds are computed to be semiconductors with a band gap ranging from 0.08 to 0.43 eV, at the modified Becke-Johnson level of theory. The thermoelectric properties are analyzed via calculations based on Boltzmann transport equation under a constant relaxation time approximation...
March 20, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28317338/release-of-calcium-into-the-myofibrillar-space-in-response-to-active-shortening-of-striated-muscle
#7
K A P Edman, C Caputo
AIM: The study was undertaken to explore whether shortening of striated muscle during activity is associated with release of bound Ca(2+) into the myofibrillar space as has previously been proposed in order to explain the depressant effect of active shortening. METHODS: The experiments were carried out on single muscle fibres isolated from the anterior tibialis muscle of Rana temporaria. The fibres were loaded with the calcium sensitive indicator Fluo-3. The fibres, stimulated to produce a partially fused isometric tetanus, were subjected to a shortening ramp or, alternatively, to a stretch ramp during activity while force, fibre length, sarcomere length and the Fluo-3 signal were recorded...
March 19, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28315858/how-does-culture-affect-experiential-training-feedback-in-exported-canadian-health-professional-curricula
#8
Kerry Wilbur, Rasha Mousa Bacha, Somaia Abdelaziz
Objectives: To explore feedback processes of Western-based health professional student training curricula conducted in an Arab clinical teaching setting. Methods: This qualitative study employed document analysis of in-training evaluation reports (ITERs) used by Canadian nursing, pharmacy, respiratory therapy, paramedic, dental hygiene, and pharmacy technician programs established in Qatar. Six experiential training program coordinators were interviewed between February and May 2016 to explore how national cultural differences are perceived to affect feedback processes between students and clinical supervisors...
March 17, 2017: International Journal of Medical Education
https://www.readbyqxmd.com/read/28314206/comparison-of-potassium-and-sodium-binding-in-vivo-and-in-agarose-samples-using-tqtppi-pulse-sequence
#9
Victor D Schepkin, Andreas Neubauer, Armin M Nagel, Thomas F Budinger
Potassium and sodium specific binding in vivo were explored at 21.1T by triple quantum (TQ) magnetic resonance (MR) signals without filtration to achieve high sensitivities and precise quantifications. The pulse sequence used time proportional phase increments (TPPI). During simultaneous phase-time increments, it provided total single quantum (SQ) and TQ MR signals in the second dimension at single and triple quantum frequencies, respectively. The detection of both TQ and SQ signals was performed at identical experimental conditions and the resulting TQ signal equals 60±3% of the SQ signal when all ions experience sufficient time for binding...
March 6, 2017: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/28304134/a-modified-eco-efficiency-framework-and-methodology-for-advancing-the-state-of-practice-of-sustainability-analysis-as-applied-to-green-infrastructure
#10
Santosh R Ghimire, John M Johnston
We propose a modified eco-efficiency (EE) framework and novel sustainability analysis methodology for green infrastructure (GI) practices used in water resource management. GI practices such as rainwater harvesting (RWH), rain gardens, porous pavements, and green roofs are emerging as viable strategies for climate change adaptation. The modified framework includes four economic, 11 environmental, and three social indicators. Using six indicators from the framework, at least one from each dimension of sustainability, we demonstrate the methodology to analyze RWH designs...
March 17, 2017: Integrated Environmental Assessment and Management
https://www.readbyqxmd.com/read/28303951/enhancing-the-sensitivity-of-magnetic-sensors-by-3d-metamaterial-shells
#11
Carles Navau, Rosa Mach-Batlle, Albert Parra, Jordi Prat-Camps, Sergi Laut, Nuria Del-Valle, Alvaro Sanchez
Magnetic sensors are key elements in our interconnected smart society. Their sensitivity becomes essential for many applications in fields such as biomedicine, computer memories, geophysics, or space exploration. Here we present a universal way of increasing the sensitivity of magnetic sensors by surrounding them with a spherical metamaterial shell with specially designed anisotropic magnetic properties. We analytically demonstrate that the magnetic field in the sensing area is enhanced by our metamaterial shell by a known factor that depends on the shell radii ratio...
March 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28303533/urban-health-in-tanzania-questioning-the-urban-advantage
#12
Francis Levira, Gemma Todd
How are health inequalities articulated across urban and rural spaces in Tanzania? This research paper explores the variations, differences, and inequalities, in Tanzania's health outcomes-to question both the idea of an urban advantage in health and the extent of urban-rural inequalities in health. The three research objectives aim to understand: what are the health differences (morbidity and mortality) between Tanzania's urban and rural areas; how are health inequalities articulated within Tanzania's urban and rural areas; and how are health inequalities articulated across age groups for rural-urban Tanzania? By analyzing four national datasets of Tanzania (National Census, Household Budget Survey, Demographic Health Survey, and Health Demographic Surveillance System), this paper reflects on the outcomes of key health indicators across these spaces...
March 16, 2017: Journal of Urban Health: Bulletin of the New York Academy of Medicine
https://www.readbyqxmd.com/read/28303184/the-shifting-phenological-landscape-within-and-between-species-variation-in-leaf-emergence-in-a-mixed-deciduous-woodland
#13
Ella F Cole, Ben C Sheldon
Many organisms rely on synchronizing the timing of their life-history events with those of other trophic levels-known as phenological matching-for survival or successful reproduction. In temperate deciduous forests, the extent of matching with the budburst date of key tree species is of particular relevance for many herbivorous insects and, in turn, insectivorous birds. In order to understand the ecological and evolutionary forces operating in these systems, we require knowledge of the factors influencing leaf emergence of tree communities...
February 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28303070/discrimination-between-spinal-extradural-meningioma-and-both-intra-and-extradural-meningioma-case-report
#14
Kenyu Ito, Shiro Imagama, Kei Ando, Kazuyoshi Kobayashi, Tetsuro Hida, Mikito Tsushima, Akiyuki Matsumoto, Masayoshi Morozumi, Satoshi Tanaka, Yoshihiro Nishida, Naoki Ishiguro
Meningiomas are common spinal tumor and mostly located at intradura. Recurrence rate after surgery for extradural meningioma was higher than intradural meningioma. A patient with intra and extradural spinal meningioma was treated and discussed its features and clinical management. A 41-year-old woman noted numbness of bilateral legs, gait disturbance, and mild bladder disturbance for over the two-month period. Magnetic resonance imaging revealed an epidural mass at T8-9 involving the dura mater from the left side...
February 2017: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28302275/3d-vision-accelerates-laparoscopic-proficiency-and-skills-are-transferable-to-2d-conditions-a-randomized-trial
#15
Stine Maya Dreier Sørensen, Lars Konge, Flemming Bjerrum
BACKGROUND: Laparoscopy is difficult to master, in part because surgeons operate in a three-dimensional (3D) space guided by two-dimensional (2D) images. This trial explores the effect of 3D vision during a laparoscopic training program, and examine whether it is possible to transfer skills acquired with 3D conditions to 2D conditions. METHODS: We designed a randomized controlled trial where residents (n = 34) were randomized to proficiency-based laparoscopic simulator training under either 3D or 2D conditions...
March 9, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28300547/computer-aided-quantification-of-microvascular-networks-application-to-alterations-due-to-pathological-angiogenesis-in-the-hamster
#16
Carlos A Bulant, Pablo J Blanco, Lucas O Müller, Julio Scharfstein, Erik Svensjö
Angiogenesis is both a physiological and a pathological process of great complexity, which is difficult to measure objectively and automatically. The hamster cheek pouch (HCP) prepared for intravital-microscopy (IVM) has been used to characterize microvascular functions in many studies and was chosen to investigate microvascular characteristics observed in normal non-infected hamsters as compared to those HCPs parasitized by Trypanosoma cruzi. Images of HCPs captured at IVM were subjected to computer based measurements of angiogenesis and histamine-induced macromolecular (FITC-dextran) leakage with an image segmentation approach that has the capacity to discriminate between fluorescence emitted by macromolecular tracers inside the vasculature and in the extravascular space...
March 12, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28298117/the-cage-effect-in-systems-of-hard-spheres
#17
W van Megen, H J Schöpe
The cage effect is generally invoked when discussing the delay in the decay of time correlation functions of dense fluids. In an attempt to examine the role of caging more closely, we consider the spread of the displacement distributions of Brownian particles. These distributions are necessarily biased by the presence of neighbouring particles. Accommodation of this bias by those neighbours conserves the displacement distribution locally and presents a collective mechanism for exploring configuration space that is more efficient than the intrinsic Brownian motion...
March 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28297937/complex-dynamics-of-memristive-circuits-analytical-results-and-universal-slow-relaxation
#18
F Caravelli, F L Traversa, M Di Ventra
Networks with memristive elements (resistors with memory) are being explored for a variety of applications ranging from unconventional computing to models of the brain. However, analytical results that highlight the role of the graph connectivity on the memory dynamics are still few, thus limiting our understanding of these important dynamical systems. In this paper, we derive an exact matrix equation of motion that takes into account all the network constraints of a purely memristive circuit, and we employ it to derive analytical results regarding its relaxation properties...
February 2017: Physical Review. E
https://www.readbyqxmd.com/read/28294574/phase-field-boundary-conditions-for-the-voxel-finite-cell-method-surface-free-stress-analysis-of-ct-based-bone-structures
#19
L H Nguyen, S K F Stoter, T Baum, J S Kirschke, M Ruess, Z Yosibash, D Schillinger
The voxel finite cell method employs unfitted finite element meshes and voxel quadrature rules to seamlessly transfer CT data into patient-specific bone discretizations. The method, however, still requires the explicit parametrization of boundary surfaces to impose traction and displacement boundary conditions, which constitutes a potential roadblock to automation. We explore a phase-field based formulation for imposing traction and displacement constraints in a diffuse sense. Its essential component is a diffuse geometry model generated from metastable phase-field solutions of the Allen-Cahn problem that assumes the imaging data as initial condition...
March 11, 2017: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/28294463/information-sharing-with-respite-care-services-for-older-adults-a-qualitative-exploration-of-carers-experiences
#20
Linda C McSwiggan, Judith Marston, Martin Campbell, Timothy B Kelly, Thilo Kroll
Respite services play an important role in supporting older adults and their carers. When an older person is unable to fully represent themselves, provision of respite care relies on effective information-sharing between carers and respite staff. This study aimed to explore, from carers' perspectives, the scope, quality and fit of information-sharing between carers, older people and respite services. An explorative, cross-sectional qualitative study involving a purposive sample of 24 carers, recruited via carer support groups and community groups in voluntary organisations, was undertaken in North East Scotland...
March 10, 2017: Health & Social Care in the Community
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