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https://www.readbyqxmd.com/read/28072810/high-frequency-spinal-cord-stimulation-for-complex-regional-pain-syndrome-a-case-report
#1
Joseph T Crapanzano, Lisa M Harrison-Bernard, Mark R Jones, Alan D Kaye, Erich O Richter, Mordeci N Potash
Complex regional pain syndrome (CRPS) is a chronic, debilitating, neuropathic pain condition which is often misdiagnosed, difficult to manage, and lacks proven methods for remission. Most available methods provide some relief to a small percentage of patients. Recent FDA approval and superiority of the Nevro Senza 10-kHz high frequency (HF10) spinal cord stimulation (SCS) therapy over traditional low-frequency spinal cord stimulation for treatment of chronic back and leg pain may provide a new interventional therapeutic option for patients suffering from CRPS...
January 2017: Pain Physician
https://www.readbyqxmd.com/read/28072749/ultrasound-guided-pulsed-radiofrequency-treatment-of-the-cervical-sympathetic-chain-for-complex-regional-pain-syndrome-a-retrospective-observational-study
#2
Eung Don Kim, Woo Joo Yoo, Yoo Na Kim, Hue Jung Park
The stellate ganglion is a common target to manage neuropathic pain in the upper extremities. However, the effect duration of a single stellate ganglion block is often temporary. To overcome the short-term effects of a single sympathetic block, pulsed radiofrequency (PRF) can be applied. The aim of the present study was to investigate the efficacy of PRF on the cervical sympathetic chain under ultrasound guidance for complex regional pain syndrome (CRPS).Twelve CRPS patients who underwent PRF on the cervical sympathetic chain were enrolled in this retrospective analysis...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28072713/-11c-r-pk11195-positron-emission-tomography-in-patients-with-complex-regional-pain-syndrome-a-pilot-study
#3
So Yeon Jeon, Seongho Seo, Jae Sung Lee, Soo-Hee Choi, Do-Hyeong Lee, Ye-Ha Jung, Man-Kyu Song, Kyung-Jun Lee, Yong Chul Kim, Hyun Woo Kwon, Hyung-Jun Im, Dong Soo Lee, Gi Jeong Cheon, Do-Hyung Kang
Complex regional pain syndrome (CRPS) is characterized by severe and chronic pain, but the pathophysiology of this disease are not clearly understood. The primary aim of our case-control study was to explore neuroinflammation in patients with CRPS using positron emission tomography (PET), with an 18-kDa translocator protein specific radioligand [C]-(R)-PK11195. [C]-(R)-PK11195 PET scans were acquired for 11 patients with CRPS (30-55 years) and 12 control subjects (30-52 years). Parametric image of distribution volume ratio (DVR) for each participant was generated by applying a relative equilibrium-based graphical analysis...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28062308/spinal-reorganization-after-bone-fracture-in-mice
#4
Silke Hirsch, Alaa Ibrahim, Laura Krämer, Fabiola Escolano-Lozano, Tanja Schlereth, Frank Birklein
: Bone fracture with subsequent immobilization of the injured limb can cause Complex Regional Pain Syndrome (CRPS) in humans. Mechanisms of CRPS are still not completely understood but bone fracture with casting in mice leads to a similar posttraumatic inflammation as seen in humans and might therefore be an analogue to human CRPS. Here we report behavioral and spinal electrophysiological changes in mice that developed swelling of the paw, warming of the skin and pain in the injured limb after bone fracture...
January 3, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28044002/abdominal-wall-type-i-complex-regional-pain-syndrome-treated-effectively-with-peripheral-nerve-field-stimulation-a-case-report
#5
Linqiu Zhou, Henry Chou, Eric Holder
Chronic abdominal wall pain is a well-documented complication of abdominal surgery. However, abdominal wall complex regional pain syndrome (CRPS) is a rare medical condition. We present a case of abdominal wall CRPS and its treatment with peripheral nerve field stimulation (PNfS). A 34-year-old female presented with right periumbilical pain for 2 years. She developed burning, sharp and stabbing pain with allodynia (extremely sensitive to wind and light touch) and erythema or pallor 2 weeks after an exploratory appendectomy...
January 2, 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/28040075/results-of-geriatric-distal-radius-fractures-treated-by-intramedullary-fixation
#6
Steffi S I Falk, Thomas Mittlmeier, Georg Gradl
INTRODUCTION: Distal radius fracture are common injuries but no gold standard for their therapy exists. The aim of this study was to evaluate the quality of fracture care in distal radius fractures using an intramedullary implant (Targon DR interlocking nail). The nail had been developed to minimize the surgical exposure, increase fixation strength, to prevent tendon irritations and to allow for a fast return to activity. PATIENTS AND METHODS: Prospective study reports the result of 43 patients with an age over 70 years (range 70-91 years) treated by closed reduction and intramedullary fixation...
December 2016: Injury
https://www.readbyqxmd.com/read/28033251/multicenter-study-on-the-asymmetry-of-skin-temperature-in-complex-regional-pain-syndrome-an-examination-of-temperature-distribution-and-symptom-duration
#7
Chan Woo Cho, Francis Sahngun Nahm, Eunjoo Choi, Pyung-Bok Lee, In-Ki Jang, Chul Joong Lee, Yong Chul Kim, Sang Chul Lee
According to the International Association for the Study of Pain (IASP) and American Medical Association (AMA), the diagnostic criteria for complex regional pain syndrome (CRPS) require the presence of skin temperature asymmetry. In CRPS, it is generally accepted that the temperature of skin of affected limbs changes from warm to cold; however, in our clinical practice, we have experienced many cases with different thermographic characteristics. Therefore, we conducted a retrospective multicenter study that examined the distribution of skin temperature in patients with CRPS and skin temperature asymmetry versus symptom duration...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28031726/complex-regional-pain-syndrome-medical-and-legal-ramifications-of-clinical-variability-and-experience-and-perspective-of-a-practicing-clinician
#8
R P Lazaro
OBJECTIVE: The aim of this study was to demonstrate the ramifications of clinical variability of complex regional pain syndrome (CRPS) and how they can affect the various aspects of this condition, favorably or unfavorably, for both patients and participating medical and legal professionals. METHODS: Twelve patients diagnosed with CRPS at different times in the past 25 years were followed up, and their signs and symptoms were reviewed for variability. None had preexisting or ongoing medical disorders and prior injury to the peripheral nerves or musculoskeletal tissues...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28030470/dorsal-root-ganglion-stimulation-yielded-higher-treatment-success-rate-for-crps-and-causalgia-at-3-and-12-months-randomized-comparative-trial
#9
Timothy R Deer, Robert M Levy, Jeffrey Kramer, Lawrence Poree, Kasra Amirdelfan, Eric Grigsby, Peter Staats, Allen W Burton, Abram H Burgher, Jon Obray, James Scowcroft, Stan Golovac, Leonardo Kapural, Richard Paicius, Christopher Kim, Jason Pope, Thomas Yearwood, Sam Samuel, W Porter McRoberts, Hazmer Cassim, Mark Netherton, Nathan Miller, Michael Schaufele, Edward Tavel, Timothy Davis, Kristina Davis, Linda Johnson, Nagy Mekhail
Animal and human studies indicate that electrical stimulation of DRG neurons may modulate neuropathic pain signals.ACCURATE, a pivotal, prospective, multi-center, randomized-comparative effectiveness trial, was conducted in 152 subjects diagnosed with complex regional pain syndrome (CRPS) or causalgia in the lower extremities. Subjects received neurostimulation of the DRG or dorsal column (SCS). The primary endpoint was a composite of safety and efficacy at 3 months and subjects were assessed through 12 months for long term outcomes and adverse events...
December 23, 2016: Pain
https://www.readbyqxmd.com/read/28025368/analysis-of-common-single-nucleotide-polymorphisms-in-complex-regional-pain-syndrome-genome-wide-association-study-approach-and-pooled-dna-strategy
#10
Piotr K Janicki, Guillermo M Alexander, Jill Eckert, Marek Postula, Robert J Schwartzman
OBJECTIVE: The objective of this study was to use a genome-wide association (GWAS) approach and pooled DNA strategy to search for new genomic loci associated with complex regional pain syndrome (CRPS). DESIGN: The study cohort consisted of 230 patients with established diagnosis of CRPS. The control group consisted of 230 age- and gender-matched subjects without chronic pain. We tested the association of common single nucleotide polymorphisms (SNPs), genotyped using a high-density microarray platform, with CRPS phenotype...
December 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28025367/phenotypic-variation-in-complex-regional-pain-syndrome-comparison-between-presentation-in-knee-alone-or-in-ankle-foot
#11
Catelijne M van Bussel, Dirk L Stronks, Frank J P M Huygen
OBJECTIVE: To compare the phenotypes of patients with complex regional pain syndrome (CRPS) of the knee to those with CRPS of the ankle/foot. SETTING: A retrospective study. SUBJECTS: Patients with CRPS of the knee and patients with CRPS of the ankle/foot. METHODS: We used electronic patient databases to identify patients with CRPS of the knee and patients with CRPS of the ankle/foot. The following variables were recorded: age, gender, duration of complaints, initial injury, and symptoms and signs...
December 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/27979741/complex-regional-pain-syndrome-type-i-in-children-what-is-new
#12
REVIEW
P Lascombes, C Mamie
Complex regional pain syndrome type I (CRPS-I), although first described by the French surgeon Ambroise Paré as far back as the 16th century, nevertheless remains shrouded in mystery. The most common symptoms are pain in an entire hand or foot, allodynia, functional impairment induced by the pain, local oedema and skin color changes and transient sweating abnormalities. Most cases occur after a minor injury (i.e., a sprain or fracture), although there may be no identifiable triggering event, particularly in children...
December 12, 2016: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/27965017/structure-and-functionalities-of-the-human-c-reactive-protein-compared-to-the-zebrafish-multigene-family-of-c-reactive-like-proteins
#13
REVIEW
Melissa Bello-Perez, Alberto Falco, Regla Medina, Jose Antonio Encinar, Beatriz Novoa, Luis Perez, Amparo Estepa, Julio Coll
Because of the recent discovery of multiple c-reactive protein (crp)-like genes in zebrafish (Danio rerio) with predicted heterogeneous phospholipid-binding amino acid sequences and heterogeneous transcript expression levels in viral survivors and adaptive-deficient mutants, zebrafish constitute an attractive new model for exploring the evolution of these protein's functions, including their possible participation in fish trained immunity. Circulating human CRP belongs to the short pentraxin family of oligomeric proteins that are characteristic of early acute-phase innate responses and is widely used as a clinical inflammation marker...
December 10, 2016: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/27935937/let-s-not-waste-time-using-temporal-information-in-clustered-activity-estimation-with-spatial-adjacency-restrictions-caesar-for-parcellating-fmri-data
#14
Ronald J Janssen, Pasi Jylänki, Marcel A J van Gerven
We have proposed a Bayesian approach for functional parcellation of whole-brain FMRI measurements which we call Clustered Activity Estimation with Spatial Adjacency Restrictions (CAESAR). We use distance-dependent Chinese restaurant processes (dd-CRPs) to define a flexible prior which partitions the voxel measurements into clusters whose number and shapes are unknown a priori. With dd-CRPs we can conveniently implement spatial constraints to ensure that our parcellations remain spatially contiguous and thereby physiologically meaningful...
2016: PloS One
https://www.readbyqxmd.com/read/27919822/astrocyte-contributes-to-pain-development-via-mmp2-jnk1-2-signaling-in-a-mouse-model-of-complex-regional-pain-syndrome
#15
Guogang Tian, Xin Luo, Chaoliang Tang, Xiang Cheng, Sookja Kim Chung, Zhengyuan Xia, Chi Wai Cheung, Qulian Guo
BACKGROUND: The activation of spinal glial cells (astrocyte and microglia) is reported in patient with complex regional pain syndrome (CRPS). However, the roles of spinal glial activities in the pathophysiology of CRPS are unclear. Here, we explored the roles of spinal astrocyte and microglia and the molecular mechanisms underlying CRPS using a mouse model of chronic post-ischemia pain (CPIP). RESULTS: CPIP injury increased the level of glial fibrillary acidic protein (GFAP, reactive astrocyte biomarker), but had no significant impact on ionized calcium binding adaptor molecule 1 (IBA1, reactive microglia biomarker), in the ipsilateral dorsal horn on post-injury day (PID) 3 when the pain threshold started to reduce significantly...
December 2, 2016: Life Sciences
https://www.readbyqxmd.com/read/27906935/long-term-prednisolone-in-post-stroke-complex-regional-pain-syndrome
#16
Jayantee Kalita, Usha Misra, Ajit Kumar, Sanjeev K Bhoi
BACKGROUND: There is no study on the long-term use of prednisolone in post-stroke complex regional pain syndrome-1 (CRPS1). OBJECTIVE: To evaluate the efficacy and safety of long-term low dose prednisolone in post-stroke CRPS-I. STUDY DESIGN: Open-labeled randomized controlled trial. SETTING: Tertiary care teaching institute. METHODS: Seventy-seven out of 396 (19.4%) patients with stroke had CRPS-1 and 58 met the inclusion criteria...
November 2016: Pain Physician
https://www.readbyqxmd.com/read/27890578/adult-complex-regional-pain-syndrome-type-i-a-narrative-review
#17
REVIEW
Martino Bussa, Adriana Mascaro, Lorena Cuffaro, Simona Rinaldi
: Complex regional pain syndrome type I (CRPS I) is a multifactorial painful disorder with a complex pathogenesis. Both peripheral and central mechanisms are involved. Acute CRPS I is considered to be an exaggerated inflammatory disorder; however, over time, because of altered function of the sympathetic nervous system and maladaptive neuroplasticity, CRPS I evolves into a neurological disorder. This review thoroughly describes the pathophysiological aspects of CRPS I and summarizes the potential therapeutic options...
November 23, 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27887906/complex-regional-pain-syndrome-associated-with-hyperattention-rather-than-neglect-for-the-healthy-side-a-comprehensive-case-study
#18
Laure Christophe, Ludovic Delporte, Patrice Revol, Annick DePaepe, Gilles Rode, Sophie Jacquin-Courtois, Yves Rossetti
Complex regional pain syndrome (CRPS) is a dehabilitating chronic condition occurring with peripheral lesions. There is growing consensus for a central contribution to CRPS. Although the nature of this central body representation disorder is increasingly debated, it has been repeatedly argued that CRPS results in motor neglect of the affected side. The present article describes a comprehensive and quantitative case report demonstrating that: (1) not all patients with chronic CRPS exhibit decreased spatial attention for the affected side and (2) patients may actually exhibit a substantial, broad and reliable attentional bias toward the painful side, akin to spatial neglect for the healthy side...
December 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27886631/metagenomics-analysis-reveals-a-new-metallothionein-family-sequence-and-metal-binding-features-of-new-environmental-cysteine-rich-proteins
#19
Antoine Ziller, Rajiv Kumar Yadav, Mercè Capdevila, Mondem Sudhakara Reddy, Laurent Vallon, Roland Marmeisse, Silvia Atrian, Òscar Palacios, Laurence Fraissinet-Tachet
Metallothioneins are cysteine-rich proteins, which function as (i) metal carriers in basal cell metabolism and (ii) protective metal chelators in conditions of metal excess. Metallothioneins have been characterized from different eukaryotic model and cultivable species. Presently, they are categorized in 15 families but evolutionary relationships between these metallothionein families remain unresolved. Several cysteine-rich protein encoding genes that conferred Cd-tolerance in Cd-sensitive yeast mutants have previously been isolated from soil eukaryotic metatranscriptomes...
February 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/27868376/n-terminal-region-of-cysteine-rich-protein-crp-in-carlaviruses-is-involved-in-the-determination-of-symptom-types
#20
Naoko Fujita, Ken Komatsu, Yu Ayukawa, Yuki Matsuo, Masayoshi Hashimoto, Osamu Netsu, Tohru Teraoka, Yasuyuki Yamaji, Shigetou Namba, Tsutomu Arie
Plant viruses in the genus Carlavirus include more than 65 members. Plants infected with carlaviruses exhibit various symptoms including leaf malformation and plant stunting. Cysteine-rich protein (CRP) encoded by carlaviruses has been reported to be a pathogenicity determinant. Carlavirus CRPs contain two motifs in their central part: nuclear localization signal (NLS) and zinc finger motif (ZF). Besides these two conserved motifs, carlavirus CRPs possess highly diverged N-terminal 34 amino acid residues with unknown function...
November 21, 2016: Molecular Plant Pathology
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