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https://www.readbyqxmd.com/read/27906935/long-term-prednisolone-in-post-stroke-complex-regional-pain-syndrome
#1
Jayantee Kalita, Usha Misra, Ajit Kumar, Sanjeev K Bhoi
BACKGROUND: There is no study on the long-term use of prednisolone in post-stroke complex regional pain syndrome-1 (CRPS1). OBJECTIVE: To evaluate the efficacy and safety of long-term low dose prednisolone in post-stroke CRPS-I. STUDY DESIGN: Open-labeled randomized controlled trial. SETTING: Tertiary care teaching institute. METHODS: Seventy-seven out of 396 (19.4%) patients with stroke had CRPS-1 and 58 met the inclusion criteria...
November 2016: Pain Physician
https://www.readbyqxmd.com/read/27890578/adult-complex-regional-pain-syndrome-type-i-a-narrative-review
#2
REVIEW
Martino Bussa, Adriana Mascaro, Lorena Cuffaro, Simona Rinaldi
Complex regional pain syndrome type I (CRPS I) is a multifactorial painful disorder with a complex pathogenesis. Both peripheral and central mechanisms are involved. Acute CRPS I is considered an exaggerated inflammatory disorder but over time, because of altered function of the sympathetic nervous system, and maladaptive neuroplasticity, CRPS I evolves into a neurological disorder. This review thoroughly describes the pathophysiological aspects of CRPS I and summarizes the potential therapeutic options. The mechanisms and targets of the treatment are different in the early and late stages of the disease...
November 23, 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27887906/complex-regional-pain-syndrome-associated-with-hyperattention-rather-than-neglect-for-the-healthy-side-a-comprehensive-case-study
#3
Laure Christophe, Ludovic Delporte, Patrice Revol, Annick DePaepe, Gilles Rode, Sophie Jacquin-Courtois, Yves Rossetti
Complex regional pain syndrome (CRPS) is a dehabilitating chronic condition occurring with peripheral lesions. There is growing consensus for a central contribution to CRPS. Although the nature of this central body representation disorder is increasingly debated, it has been repeatedly argued that CRPS results in motor neglect of the affected side. The present article describes a comprehensive and quantitative case report demonstrating that: (1) not all patients with chronic CRPS exhibit decreased spatial attention for the affected side and (2) patients may actually exhibit a substantial, broad and reliable attentional bias toward the painful side, akin to spatial neglect for the healthy side...
November 22, 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27886631/metagenomics-analysis-reveals-a-new-metallothionein-family-sequence-and-metal-binding-features-of-new-environmental-cysteine-rich-proteins
#4
Antoine Ziller, Rajiv Kumar Yadav, Mercè Capdevila, Mondem Sudhakara Reddy, Laurent Vallon, Roland Marmeisse, Silvia Atrian, Òscar Palacios, Laurence Fraissinet-Tachet
Metallothioneins are cysteine-rich proteins, which function as (i) metal carriers in basal cell metabolism and (ii) protective metal chelators in conditions of metal excess. Metallothioneins have been characterized from different eukaryotic model and cultivable species. Presently, they are categorized in 15 families but evolutionary relationships between these metallothionein families remain unresolved. Several cysteine-rich protein encoding genes that conferred Cd-tolerance in Cd-sensitive yeast mutants have previously been isolated from soil eukaryotic metatranscriptomes...
November 12, 2016: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/27868376/n-terminal-region-of-cysteine-rich-protein-crp-in-carlaviruses-is-involved-in-the-determination-of-symptom-types
#5
Naoko Fujita, Ken Komatsu, Yu Ayukawa, Yuki Matsuo, Masayoshi Hashimoto, Osamu Netsu, Tohru Teraoka, Yasuyuki Yamaji, Shigetou Namba, Tsutomu Arie
Plant viruses in the genus Carlavirus include more than 65 members. Plants infected with carlaviruses exhibit various symptoms including leaf malformation and plant stunting. Cysteine-rich protein (CRP) encoded by carlaviruses has been reported to be a pathogenicity determinant. Carlavirus CRPs contain two motifs in their central part: nuclear localization signal (NLS) and zinc finger motif (ZF). Besides these two conserved motifs, carlavirus CRPs possess highly diverged N-terminal 34 amino acid residues with unknown function...
November 21, 2016: Molecular Plant Pathology
https://www.readbyqxmd.com/read/27867145/human-papillomavirus-vaccines-complex-regional-pain-syndrome-postural-orthostatic-tachycardia-syndrome-and-autonomic-dysfunction-a-review-of-the-regulatory-evidence-from-the-european-medicines-agency
#6
Tom Jefferson, Lars Jørgensen
Recent concerns about a possible association between exposure of young women to human papillomavirus (HPV) vaccines and two "dysautonomic syndromes" (a collection of signs and symptoms thought to be caused by autoimmunity) - complex regional pain syndrome (CRPS) and postural orthostatic tachycardia syndrome (POTS) - led the European Medicines Agency (EMA) to review existing evidence. The review was announced by the EMA on July 13, 2015, and was completed on November 4, 2015.
October 17, 2016: Indian Journal of Medical Ethics
https://www.readbyqxmd.com/read/27866235/arthroscopically-assisted-mini-open-partial-synovectomy-for-the-treatment-of-localized-pigmented-villonodular-synovitis-of-the-knee-a-retrospective-comparative-study-with-long-term-follow-up
#7
Dimitrios Georgiannos, Achilleas Boutsiadis, Filon Agathangelidis, Stergios Papastergiou, Dimitrios Karataglis, Ilias Bisbinas
PURPOSE: The purpose of this study was to present the long-term results of treatment of localized pigmented villonodular synovitis (LPVNS) comparing two operative procedures of excision of the lesion-the arthroscopic and the arthroscopically assisted mini-open. We hypothesized that the latter approach allowed for treatment of LPVNS with acceptable recurrence rates, complication rates and functional outcomes. METHODS: Between 1990 and 2006, 21 patients with LPVNS were treated with partial synovectomy through an arthroscopically-assisted mini open technique (group A), and 23 patients were treated with an arthroscopic excision of the lesion (group B)...
November 19, 2016: International Orthopaedics
https://www.readbyqxmd.com/read/27865682/cardiac-rehabilitation-in-portugal-results-from-the-2013-14-national-survey
#8
Conceição Silveira, Ana Abreu
INTRODUCTION: In recent years, cardiac rehabilitation (CR) programs have evolved from being limited to exercise training to comprehensive secondary prevention programs. Given the solid scientific evidence supporting them, they are given a class I recommendation in the American and European guidelines for various cardiovascular diseases, but they continue to be underused in Portugal. OBJECTIVE: To analyze the situation of CR programs in Portugal in 2013-14 and to assess developments in recent years...
November 16, 2016: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/27858687/update-on-the-effects-of-graded-motor-imagery-and-mirror-therapy-on-complex-regional-pain-syndrome-type-1-a-systematic-review
#9
Guillermo Méndez-Rebolledo, Valeska Gatica-Rojas, Rafael Torres-Cueco, María Albornoz-Verdugo, Eduardo Guzmán-Muñoz
Graded motor imagery (GMI) and mirror therapy (MT) is thought to improve pain in patients with complex regional pain syndrome (CRPS) types 1 and 2. However, the evidence is limited and analysis are not independent between types of CRPS. The purpose of this review was to analyze the effects of GMI and MT on pain in independent groups of patients with CRPS types 1 and 2. Searches for literature published between 1990 and 2016 were conducted in databases. Randomized controlled trials that compared GMI or MT with other treatments for CRPS types 1 and 2 were included...
November 11, 2016: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/27847707/relationship-between-hba1c-and-complex-regional-pain-syndrome-in-stroke-patients-with-type-2-diabetes-mellitus
#10
Jong Ho Choi, Ki Pi Yu, Yong-Soon Yoon, Eun Sil Kim, Ji Hyun Jeon
OBJECTIVE: To investigate the relationship between glycosylated hemoglobin A (HbA1c) and complex regional pain syndrome (CRPS) in stroke patients with type 2 diabetes mellitus (T2DM). METHODS: A retrospective chart review was performed of stroke patients from January 2012 to December 2013. We reviewed 331 patients and included 200 in the analysis. We divided them into CRPS and non-CRPS groups and compared them by age, gender, stroke lesion, cause of stroke, duration of T2DM, HbA1c (%), National Institutes of Health Stroke Scale score, affected shoulder flexor muscle strength, Fugl-Meyer Assessment score, motricity index, Functional Independence Measure, Korean version of Modified Barthel Index, blood glucose level on admission day, duration from stroke onset to HbA1c check, and duration from stroke onset to three-phase bone scan for CRPS diagnosis...
October 2016: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/27847313/abnormal-brain-responses-to-action-observation-in-complex-regional-pain-syndrome
#11
Jaakko Hotta, Jukka Saari, Miika Koskinen, Yevhen Hlushchuk, Nina Forss, Riitta Hari
: Patients with complex regional pain syndrome (CRPS) display various abnormalities in central motor function, and their pain is intensified when they perform or just observe motor actions. Here, we examined the abnormalities of brain responses to action observation in CRPS. We analyzed 3-T functional magnetic resonance images from 13 upper-limb CRPS patients (all females, ages 31-58 years) and 13 healthy, age- and sex-matched control subjects. The functional magnetic resonance imaging data were acquired while the subjects viewed brief videos of hand actions shown in the first-person perspective...
November 12, 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/27807858/challenges-of-implementing-a-communication-and-resolution-program-where-multiple-organizations-must-cooperate
#12
Michelle M Mello, Sarah J Armstrong, Yelena Greenberg, Patricia I McCotter, Thomas H Gallagher
OBJECTIVE: To implement a communication-and-resolution program (CRP) in a setting in which liability insurers and health care facilities must collaborate to resolve incidents involving a facility and separately insured clinicians. STUDY SETTING: Six hospitals and clinics and a liability insurer in Washington State. STUDY DESIGN: Sites designed and implemented CRPs and contributed information about cases and operational challenges over 20 months...
November 3, 2016: Health Services Research
https://www.readbyqxmd.com/read/27805769/basal-ganglia-dysfunction-in-complex-regional-pain-syndrome-a-valid-hypothesis
#13
REVIEW
M Azqueta-Gavaldon, H Schulte-Göcking, C Storz, S Azad, A Reiners, D Borsook, L Becerra, E Kraft
: Complex regional pain syndrome (CRPS) is a poorly understood pain disorder of the limbs. Maladaptive cortical plasticity has been shown to play a major role in its pathophysiological presentation. Recently, there is increasing interest in the role of the basal ganglia (BG), since clinical findings and neuroimaging studies point to possible BG involvement in CRPS. CRPS symptoms are often characterized by movement disorders associated with BG dysfunction. Very frequently, dystonia and tremor are reported and, to a lesser extent, myoclonus...
November 2, 2016: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/27803223/international-consensus-on-the-definition-and-classification-of-fibrosis-of-the-knee-joint
#14
N S Kalson, L A Borthwick, D A Mann, D J Deehan, P Lewis, C Mann, M A Mont, R Morgan-Jones, S Oussedik, F M K Williams, A Toms, J N Argenson, J Bellemans, A Bhave, O Furnes, H Gollwitzer, F S Haddad, S Hofmann, V Krenn
AIMS: The aim of this consensus was to develop a definition of post-operative fibrosis of the knee. PATIENTS AND METHODS: An international panel of experts took part in a formal consensus process composed of a discussion phase and three Delphi rounds. RESULTS: Post-operative fibrosis of the knee was defined as a limited range of movement (ROM) in flexion and/or extension, that is not attributable to an osseous or prosthetic block to movement from malaligned, malpositioned or incorrectly sized components, metal hardware, ligament reconstruction, infection (septic arthritis), pain, chronic regional pain syndrome (CRPS) or other specific causes, but due to soft-tissue fibrosis that was not present pre-operatively...
November 2016: Bone & Joint Journal
https://www.readbyqxmd.com/read/27790609/using-the-benford-s-law-as-a-first-step-to-assess-the-quality-of-the-cancer-registry-data
#15
Emanuele Crocetti, Giorgia Randi
BACKGROUND: Benford's law states that the distribution of the first digit different from 0 [first significant digit (FSD)] in many collections of numbers is not uniform. The aim of this study is to evaluate whether population-based cancer incidence rates follow Benford's law, and if this can be used in their data quality check process. METHODS: We sampled 43 population-based cancer registry populations (CRPs) from the Cancer Incidence in 5 Continents-volume X (CI5-X)...
2016: Frontiers in Public Health
https://www.readbyqxmd.com/read/27785090/5-lidocaine-medicated-plaster-for-the-treatment-of-chronic-peripheral-neuropathic-pain-complex-regional-pain-syndrome-and-other-neuropathic-conditions
#16
Enrique Calderón, María Eloísa Calderón-Seoane, Rafael García-Hernández, Luis Miguel Torres
OBJECTIVES: Chronic neuropathic pain and chronic complex regional pain syndrome (CRPS), in particular, are debilitating and difficult-to-treat conditions that have a strong impact on patient's quality of life. The aim of this study was to evaluate the effectiveness of 5% lidocaine-medicated plaster as add-on therapy in patients with chronic peripheral neuropathic pain conditions, including CRPS. PATIENTS AND METHODS: This was a single-center, prospective, observational study set in a specialized pain unit of a tertiary hospital in Spain...
2016: Journal of Pain Research
https://www.readbyqxmd.com/read/27781981/the-place-of-occupational-therapy-in-rehabilitation-strategies-of-complex-regional-pain-syndrome-comparative-study-of-60-cases
#17
L Rome
The purpose of the study was to assess the value of combining occupational therapy (OT) with physical therapy (PT) for the rehabilitation of complex regional pain syndrome (CRPS) and to measure its effectiveness on activities of daily life. Sixty patients with CRPS type 1 were recruited and interviewed between September 1, 2014 and February 1, 2015. Thirty patients had undergone PT and thirty had undergone PT+OT. They were administered the short-form of the "Assessment of Life Habits" questionnaire (v.3.0 LIFE-H) created in Canada...
October 2016: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/27781266/case-outcomes-in-a-communication-and-resolution-program-in-new-york-hospitals
#18
Michelle M Mello, Yelena Greenberg, Susan K Senecal, Janet S Cohn
OBJECTIVE: To determine case outcomes in a communication-and-resolution program (CRP) implemented to respond to adverse events in general surgery. STUDY SETTING: Five acute-care hospitals in New York City. STUDY DESIGN: Following CRP implementation, hospitals recorded information about each CRP event for 22 months. DATA COLLECTION METHODS: Risk managers prospectively collected data in collaboration with representatives from the hospital's insurer...
October 26, 2016: Health Services Research
https://www.readbyqxmd.com/read/27778413/altering-conventional-to-high-density-spinal-cord-stimulation-an-energy-dose-response-relationship-in-neuropathic-pain-therapy
#19
Frank Wille, Jennifer S Breel, Eric W P Bakker, Markus W Hollmann
OBJECTIVES: To examine whether converting from conventional Spinal Cord Stimulation (SCS) to High Density (HD) SCS reduces neuropathic pain over a period of 12 months in patients with failed SCS therapy. METHODS: Retrospective, open label, single center, consecutive case series of 30 neuropathic pain patients (Failed Back Surgery Syndrome [FBSS], Complex Regional Pain Syndrome [CRPS], and polyneuropathy [NP]). Patients with an initial adequate response to conventional SCS, but in whom pain increased over time, were included (Numeric Rating Scales [NRS] >6)...
October 24, 2016: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/27773721/identification-of-krt16-as-a-target-of-an-autoantibody-response-in-complex-regional-pain-syndrome
#20
Maral Tajerian, Victor Hung, Hamda Khan, Lauren J Lahey, Yuan Sun, Frank Birklein, Heidrun H Krämer, William H Robinson, Wade S Kingery, J David Clark
OBJECTIVE: Using a mouse model of complex regional pain syndrome (CRPS), our goal was to identify autoantigens in the skin of the affected limb. METHODS: A CRPS-like state was induced using the tibia fracture/cast immobilization model. Three weeks after fracture, hindpaw skin was homogenized, run on 2-d gels, and probed by sera from fracture and control mice. Spots of interest were analyzed by liquid chromatography-mass spectroscopy (LC-MS) and the list of targets validated by examining their abundance and subcellular localization...
January 2017: Experimental Neurology
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