keyword
https://read.qxmd.com/read/38536496/fighting-pathogenic-yeasts-with-plant-defensins-and-anti-fungal-proteins-from-fungi
#1
REVIEW
Paloma Manzanares, Moisés Giner-Llorca, Jose F Marcos, Sandra Garrigues
Fungal infections represent a significant health risk worldwide. Opportunistic infections caused by yeasts, particularly by Candida spp. and their virulent emerging isolates, have become a major threat to humans, with an increase in fatal cases of infections attributed to the lack of effective anti-yeast therapies and the emergence of fungal resistance to the currently applied drugs. In this regard, the need for novel anti-fungal agents with modes of action different from those currently available is undeniable...
March 27, 2024: Applied Microbiology and Biotechnology
https://read.qxmd.com/read/38530793/effect-of-an-interdisciplinary-inpatient-program-for-patients-with-crps-in-reducing-disease-activity-a-single-center-prospective-cohort-study
#2
JOURNAL ARTICLE
Stephanie Schneider, Maria M Wertli, Anna Henzi, Monika Hebeisen, Florian Brunner
OBJECTIVE: The aim of this study was to evaluate the benefit of inpatient treatment in reducing disease activity in patients with CRPS who have exhausted outpatient options. Furthermore, the study sought to identify patient-related outcome variables that predict a reduction in disease activity. METHODS: The primary outcome was disease severity (CRPS Severity Score, range 0-16 points)). Secondary outcomes included depression, anxiety, physical function, pain interference, fatigue, sleep disturbance, and ability to participate in social roles and activities, all of which were assessed using the Promis-29...
March 26, 2024: Pain Medicine
https://read.qxmd.com/read/38524726/characteristics-of-students-participating-in-collegiate-recovery-programs-and-the-impact-of-covid-19-an-updated-national-longitudinal-study
#3
JOURNAL ARTICLE
Rebecca L Smith, Thomas Bannard, Jessica McDaniel, Fazil Aliev, Austin Brown, Erica Holliday, Noel Vest, Waltrina DeFrantz-Dufor, Danielle M Dick
The goals of the present study were to describe the development of the first national longitudinal study of collegiate recovery programs (CRP) students; provide an updated characterization of CRP students' demographics, past problem severity, and current recovery-related functioning; and examine the perceived impact of COVID-19 on CRP students' recovery. Universities and community colleges with CRPs across the United States and Ontario, Canada, were invited to partner on this project. Launched in fall 2020, three cohorts of participants were recruited...
2024: Addiction Research & Theory
https://read.qxmd.com/read/38514196/unraveling-trends-in-schistosomiasis-deep-learning-insights-into-national-control-programs-in-china
#4
JOURNAL ARTICLE
Qing Su, Cici Xi Chen Bauer, Robert Bergquist, Zhiguo Cao, Fenghua Gao, Yi Hu, Zhijie Zhang
OBJECTIVES: To achieve the ambitious goal of eliminating schistosome infections, the Chinese government has implemented diverse control strategies. This study explored the progress of the 2 most recent national schistosomiasis control programs in an endemic area along the Yangtze River in China. METHODS: We obtained village-level parasitological data from cross-sectional surveys combined with environmental data in Anhui Province, China from 1997 to 2015. A convolutional neural network (CNN) based on a hierarchical integro-difference equation (IDE) framework (i...
March 13, 2024: Epidemiology and Health
https://read.qxmd.com/read/38512600/literature-review-mechanism-indications-and-clinical-efficacy-of-peripheral-nerve-stimulators-in-lower-extremity-pain
#5
REVIEW
Qing Zhao Ruan, Jason Chang, Daniel Pak, Rajesh Supra, Cyrus Yazdi, Linda Kollenburg, Erkan Kurt, David Reece, Alexandra C G Fonseca, Alaa Abd-Elsayed, Christopher L Robinson
PURPOSE OF REVIEW: Lower extremity pain is deemed by Center for Disease Control and Prevention (CDC) to be a significant source of chronic pain in adults. If not appropriately managed, patients are subjected to risks of prolonged musculoskeletal dysfunction, disruption to quality of life, and elevated healthcare expenditures. Peripheral nerve stimulation (PNS) has shown great potential in recent years demonstrating efficacy in multiple diagnoses ranging from acute post-surgical pain to complex regional pain syndrome (CRPS)...
March 21, 2024: Current Pain and Headache Reports
https://read.qxmd.com/read/38510888/sustained-relief-of-complex-regional-pain-syndrome-crps-pain-following-a-60-day-peripheral-nerve-stimulation-a-report-of-three-cases
#6
Genaro J Gutierrez, Claire A Zurn, Nathan D Crosby
Patients who present to pain clinics with complex regional pain syndrome (CRPS) typically have debilitating pain, including hyperalgesia and allodynia, and additional substantial quality-of-life concerns related to the motor and autonomic-related symptoms of CRPS. Present treatments for CRPS such as neuropathic pain medications and sympathetic blocks are often unsatisfactory for managing symptoms. The present cases highlight the use of a 60-day percutaneous peripheral nerve stimulation (PNS) treatment for three patients with CRPS Type I affecting the foot...
February 2024: Curēus
https://read.qxmd.com/read/38505501/contact-heat-evoked-potentials-insights-into-pain-processing-in-crps-type-i
#7
JOURNAL ARTICLE
Florin Allmendinger, Paulina Simonne Scheuren, Iara De Schoenmacker, Florian Brunner, Jan Rosner, Armin Curt, Michèle Hubli
PURPOSE: The pathophysiological mechanisms underlying the development of chronic pain in complex regional pain syndrome (CRPS) are diverse and involve both peripheral and central changes in pain processing, such as sensitization of the nociceptive system. The aim of this study was to objectively distinguish the specific changes occurring at both peripheral and central levels in nociceptive processing in individuals with chronic CRPS type I. PATIENTS AND METHODS: Nineteen individuals with chronic CRPS type I and 16 age- and sex-matched healthy controls (HC) were recruited...
2024: Journal of Pain Research
https://read.qxmd.com/read/38472555/recent-advancements-in-the-role-of-histone-acetylation-dynamics-to-improve-stress-responses-in-plants
#8
REVIEW
Sanjay Kumar Bajpai, Nisha, Shivali Pandita, Anand Bahadur, Praveen C Verma
In eukaryotes, transcriptional regulation is determined by the DNA sequence and is facilitated through sophisticated and complex chromatin alterations and histone remodelling. Recent research has shown that the histone acetylation dynamic, an intermittent and reversible substitution, constitutes a prerequisite for chromatin modification. These changes in chromatin structure modulate genome-wide and specific changes in response to external and internal cues like cell differentiation, development, growth, light temperature, and biotic stresses...
March 12, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38462787/pudendal-nerve-blockade-for-persistent-genital-arousal-disorder-pgad-a-clinical-review-and-case-report
#9
Michael J Gyorfi, Alaa Abd-Elsayed
BACKGROUND: Persistent genital arousal disorder (PGAD) is a condition characterized by unwanted and potentially painful genital sensations or spontaneous orgasms without stimulation. We present a case of a 55-year-old woman with refractory genital arousal disorder that was treated with serial pudendal nerve blocks. CASE: RW is a 55-year-old woman with chronic pelvic pain, pudendal neuralgia, MDD, SI, GAD, CRPS, and persistent genital arousal disorder for 11 years...
March 10, 2024: Pain Practice: the Official Journal of World Institute of Pain
https://read.qxmd.com/read/38437520/harnessing-van-der-waals-crps-4-and-surface-oxides-for-nonmonotonic-preset-field-induced-exchange-bias-in-fe-3-gete-2
#10
JOURNAL ARTICLE
Aravind Puthirath Balan, Aditya Kumar, Tanja Scholz, Zhongchong Lin, Aga Shahee, Shuai Fu, Thibaud Denneulin, Joseph Vas, András Kovács, Rafal E Dunin-Borkowski, Hai I Wang, Jinbo Yang, Bettina Lotsch, Ulrich Nowak, Mathias Kläui
Two-dimensional van der Waals (vdW) heterostructures are an attractive platform for studying exchange bias due to their defect-free and atomically flat interfaces. Chromium thiophosphate (CrPS4 ), an antiferromagnetic material, possesses uncompensated magnetic spins in a single layer, rendering it a promising candidate for exploring exchange bias phenomena. Recent findings have highlighted that naturally oxidized vdW ferromagnetic Fe3 GeTe2 exhibits exchange bias, attributed to the antiferromagnetic coupling of its ultrathin surface oxide layer (O-FGT) with the underlying unoxidized Fe3 GeTe2 ...
March 4, 2024: ACS Nano
https://read.qxmd.com/read/38416112/new-onset-tinnitus-after-dorsal-root-ganglion-stimulator-implantation-a-case-report
#11
JOURNAL ARTICLE
Mark P Pressler, Brian Brenner, Lynn R Kohan, Andrew M Mendelson
Dorsal column (dcSCS) and dorsal root ganglion stimulation (DRG-S) complications are similar, typically related to placement and device failure. We present the first case of tinnitus after DRG-S implantation. The patient presented with complex regional pain syndrome (CRPS) type 2. After previous failed treatments, she had a lumbosacral DRG-S trial, which provided relief; however, she briefly noted ringing in her ears. After permanent implantation, she reported persistent, intolerable left-sided tinnitus. Tinnitus can be modulated by secondary somatosensory inputs to the cochlear nucleus from the dcSCS...
March 1, 2024: A&A Practice
https://read.qxmd.com/read/38408277/aged-females-unilaterally-hypersensitize-lack-descending-inhibition-and-overexpress-alpha1d-adrenergic-receptors-in-a-murine-posttraumatic-chronic-pain-model
#12
JOURNAL ARTICLE
Silke J Hirsch, Alexandra Budig, Sanar Husam, Frank Birklein
Vulnerability to chronic pain is found to depend on age and sex. Most patients with chronic pain are elderly women, especially with posttraumatic pain after bone fracture that prevails beyond the usual recovery period and develops into a complex regional pain syndrome (CRPS). There, a distal bone fracture seems to initiate a pathophysiological process with unknown mechanism. To investigate whether sex, age, and alpha adrenergic receptors also contribute to a CRPS-like phenotype in animals, we performed experiments on tibia-fractured mice...
February 27, 2024: Pain
https://read.qxmd.com/read/38398434/complex-regional-pain-syndrome-after-distal-radius-fracture-case-report-and-mini-literature-review
#13
Michał Świta, Paweł Szymonek, Konrad Talarek, Agnieszka Tomczyk-Warunek, Karolina Turżańska, Agnieszka Posturzyńska, Anna Winiarska-Mieczan
This study explores the impact of the complex regional pain syndrome (CRPS) on the lives and mobility of patients, with a particular focus on its emergence as a late complication of distal radius fractures (DRFs), a common occurrence, especially among an aging population. The absence of a standardized treatment for the CRPS and the challenge of predicting its occurrence make it a complex medical issue. This research aims to shed light on the effects of treating the CRPS through a case study involving a 75-year-old woman with untreated osteoporosis who experienced a Colles fracture after a fall...
February 16, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38397842/nmda-receptors-regulate-oxidative-damage-in-keratinocytes-during-complex-regional-pain-syndrome-in-hacat-cells-and-male-rats
#14
JOURNAL ARTICLE
Bei Wen, He Zhu, Jijun Xu, Li Xu, Yuguang Huang
Complex regional pain syndrome (CRPS), a type of primary chronic pain, occurs following trauma or systemic disease and typically affects the limbs. CRPS-induced pain responses result in vascular, cutaneous, and autonomic nerve alterations, seriously impacting the quality of life of affected individuals. We previously identified the involvement of keratinocyte N -methyl-d-asparagic acid (NMDA) receptor subunit 2 B (NR2B) in both peripheral and central sensitizations in CRPS, although the mechanisms whereby NR2B functions following activation remain unclear...
February 18, 2024: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/38389922/a-comprehensive-review-of-the-literature-on-cd10-its-function-clinical-application-and-prospects
#15
REVIEW
Shudong Wang, Yinghui Xiao, Xingna An, Ling Luo, Kejian Gong, Dehai Yu
CD10, a zinc-dependent metalloprotease found on the cell surface, plays a pivotal role in an array of physiological and pathological processes including cardiovascular regulation, immune function, fetal development, pain response, oncogenesis, and aging. Recognized as a biomarker for hematopoietic and tissue stem cells, CD10 has garnered attention for its prognostic potential in the progression of leukemia and various solid tumors. Recent studies underscore its regulatory significance and therapeutic promise in combating Alzheimer's disease (AD), and it is noted for its protective role in preventing heart failure (HF), obesity, and type-2 diabetes...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38389565/short-versus-regular-periods-of-cast-immobilization-for-distal-radial-fractures-a-systematic-review-and-meta-analysis
#16
REVIEW
Iqbal F Sayudo, Jesica P Sudarman, André Fernandes, Jae Yong Park, Liron Leibovitch, Elcio Machinski, Mohamed O Mahmoud
The current research on the recommended durations for cast immobilization in adults with distal radial fractures (DRFs) lacks a clear consensus or definitive conclusion. The standard practice involves casting immobilization for five to six weeks. The debate revolves around the potential benefits of shorter periods (three to four weeks) without compromising patient outcomes. While previous research has delved into this subject through systematic reviews, our study stands out by conducting a meta-analysis, aiming for a more precise understanding of whether short or regular cast immobilization duration proves more effective for treating DRFs...
February 2024: Curēus
https://read.qxmd.com/read/38384908/pilot-implementation-of-a-co-mentoring-circles-program-for-the-clinical-research-professionals-evidence-for-formative-evaluation-and-logic-model
#17
JOURNAL ARTICLE
July D Nelson, Mendy E Dunn, Yulia A Levites Strekalova
Clinical research professionals (CRPs) are essential contributors to clinical and translational research endeavors, encompassing roles such as research nurses, research coordinators, data managers, and regulatory affairs specialists. This paper reports on the implementation of a novel training program for the CRPs, the Co-mentoring Circles Program, developed by the University of Florida Health Clinical Research Professionals Consortium, and proposes an initial logic model of CRP workforce development informed by the observations, participant feedback, and the established Translational Workforce Logic Model...
2024: Journal of Clinical and Translational Science
https://read.qxmd.com/read/38384291/enhancing-the-clinical-research-workforce-a-collaborative-approach-with-human-resources
#18
JOURNAL ARTICLE
Denise C Snyder, Heather Gaudaur, Mark Marchant, Laura Viera, Andrea McCubbin, William Verble, Angela Mendell, Christine Gilliam
Jobs for clinical research professionals (CRPs) have grown increasingly complex over the past 20+ years. This is due largely to additional administrative burden for investigators, study teams, sponsors, Clinical Research Organizations (CROs), and sites, particularly Academic Medical Centers (AMCs). Furthermore, National Institutes of Health (NIH) has reduced capacity to effectively fund research recognizing this is dependent on the overall congressional budget, which creates greater pressure for clinician scientists to secure external support...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38375686/climate-regulation-processes-are-linked-to-the-functional-composition-of-plant-communities-in-european-forests-shrublands-and-grasslands
#19
JOURNAL ARTICLE
Stephan Kambach, Fabio Attorre, Irena Axmanová, Ariel Bergamini, Idoia Biurrun, Gianmaria Bonari, Maria Laura Carranza, Alessandro Chiarucci, Milan Chytrý, Jürgen Dengler, Emmanuel Garbolino, Valentin Golub, Thomas Hickler, Ute Jandt, Jan Jansen, Borja Jiménez-Alfaro, Dirk Nikolaus Karger, Zdeňka Lososová, Valerijus Rašomavičius, Solvita Rūsiņa, Petra Sieber, Angela Stanisci, Wilfried Thuiller, Erik Welk, Niklaus E Zimmermann, Helge Bruelheide
Terrestrial ecosystems affect climate by reflecting solar irradiation, evaporative cooling, and carbon sequestration. Yet very little is known about how plant traits affect climate regulation processes (CRPs) in different habitat types. Here, we used linear and random forest models to relate the community-weighted mean and variance values of 19 plant traits (summarized into eight trait axes) to the climate-adjusted proportion of reflected solar irradiation, evapotranspiration, and net primary productivity across 36,630 grid cells at the European extent, classified into 10 types of forest, shrubland, and grassland habitats...
February 2024: Global Change Biology
https://read.qxmd.com/read/38371121/a-case-of-a-father-and-son-with-complex-regional-pain-syndrome-type-1-exhibiting-different-resting-state-functional-connectivity-on-functional-mri
#20
Katsuyuki Moriwaki, Atsuo Yoshino, Yumi Ikejiri, Ryuji Nakamura, Yasuo Tsutsumi
Complex regional pain syndrome (CRPS) type 1 is a chronic pain condition whose pathogenesis involves changes in the central and peripheral nervous systems, with potential genetic contributions. Functional magnetic resonance imaging (fMRI) studies report that alterations in resting-state functional connectivity (rsFC) may reflect central nervous system anomalies in CRPS type 1. Herein, we describe the case of a father and son with CRPS type 1 who exhibited different rsFC patterns in fMRI analyses correlating with their individual CRPS phenotypes...
January 2024: Curēus
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