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https://www.readbyqxmd.com/read/29153978/the-endometria-of-women-with-endometriosis-exhibit-dysfunctional-expression-of-complement-regulatory-proteins-during-the-mid-secretory-phase
#1
Wilder A Palomino, Chandrakant Tayade, Felipe Argandoña, Luigi Devoto, Steven L Young, Bruce A Lessey
The control of complement activation within embryo-endometrium environment is critical for embryo survival. Cell evasion from complement attack requires interaction of complement regulatory proteins (CRPs) with cell adhesion αvβ3 integrin. We aim to compare the expression of CRPs in endometria of women with and without endometriosis and to examine the molecular interaction of decay accelerating factor (DAF) with αvβ3 integrin. Endometrial expression of Membrane cofactor protein (CD46), Decay accelerating factor (DAF), Membrane attack complex inhibitory factor (CD59) and β3 integrin subunit were determined through menstrual cycle by immunohistochemistry...
October 27, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29144596/controlled-radical-polymerization-of-ethylene-using-organotellurium-compounds
#2
Franck D'Agosto, Arne Wolpers, Bastian Ebeling, Yasuyuki Nakamura, Shigeru Yamago, Vincent Monteil
The first successfully controlled radical polymerization (CRP) of ethylene is reported using several organotellurium chain-transfer agents (CTAs) under mild conditions (70 °C, 200 bar of ethylene) within the concept of organotellurium-mediated radical polymerization (TERP). In contrast to preceding works on CRPs of ethylene applying reversible addition-fragmentation chain-transfer (RAFT), the organotellurium-mediated system provided a high livingness and chain-end functionalization of polyethylene chains...
November 16, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29109411/structural-basis-for-receptor-recognition-of-pollen-tube-attraction-peptides
#3
Xiaoxiao Zhang, Weijia Liu, Takuya T Nagae, Hidenori Takeuchi, Heqiao Zhang, Zhifu Han, Tetsuya Higashiyama, Jijie Chai
Transportation of the immobile sperms directed by pollen tubes to the ovule-enclosed female gametophytes is important for plant sexual reproduction. The defensin-like (DEFL) cysteine-rich peptides (CRPs) LUREs play an essential role in pollen tube attraction to the ovule, though their receptors still remain controversial. Here we provide several lines of biochemical evidence showing that the extracellular domain of the leucine-rich repeat receptor kinase (LRR-RK) PRK6 from Arabidopsis thaliana directly interacts with AtLURE1 peptides...
November 6, 2017: Nature Communications
https://www.readbyqxmd.com/read/29107167/does-temperature-elevation-by-sympathetic-neurolysis-improve-pain-in-complex-regional-pain-syndrome-a-retrospective-cohort-study
#4
Sushmitha Dev, Yongjae Yoo, Ho-Jin Lee, Dong-Ho Kim, Yong-Chul Kim, Jee Youn Moon
BACKGROUND: Lumbar sympathetic neurolysis (LSN) is one treatment option for complex regional pain syndrome (CRPS). We examined whether LSN-related temperature changes are associated with clinical outcome; and investigated relationships between the outcome of LSN and clinical variables in patients with CRPS-I. METHODS: We included 95 patients with CRPS-I affecting a single lower extremity, by the Budapest criteria, and who underwent LSN following successful LSBs, in this retrospective study...
October 26, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29091494/abductor-digiti-minimi-flap-for-vascularized-coverage-in-the-surgical-management-of-complex-regional-pain-syndrome-following-carpal-tunnel-release
#5
Kevin Cheung, Melissa A Klausmeyer, Jesse B Jupiter
BACKGROUND: The development of Complex Regional Pain Syndrome (CRPS) represents a potentially devastating complication following carpal tunnel release. In the presence of a suspected incomplete release of the transverse carpal ligament or direct injury to the median nerve, neurolysis as well as nerve coverage to prevent recurrent scar has been shown to be effective. METHODS: Retrospective chart review and telephone interview was conducted for patients who underwent abductor digiti minimi flap coverage and neurolysis of the median nerve for CRPS following carpal tunnel release...
November 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/29081703/factors-associated-with-complex-regional-pain-syndrome-in-surgically-treated-distal-radius-fracture
#6
Joel Ortiz-Romero, Ignacio Bermudez-Soto, Rubén Torres-González, Fernando Espinoza-Choque, Jesús Abraham Zazueta-Hernandez, José Manuel Perez-Atanasio
OBJECTIVE: The aim of this study was to identify factors associated with developing complex regional pain syndrome (CRPS) after surgical treatment for distal radius fracture (DRF). METHODS: This case-control study analyzed patients seen from January 2014 to January 2016. Results: In our sample of 249 patients, 4% developed CRPS. Associated factors were economic compensation via work disability (odds ratio [OR] 14.3), age (OR 9.38), associated fracture (OR 12.94), and level of impact (OR 6...
September 2017: Acta Ortopedica Brasileira
https://www.readbyqxmd.com/read/29064599/spinal-cord-stimulation-in-patients-with-complex-regional-pain-syndrome-a-possible-target-for-immunomodulation
#7
Nadia Kriek, Marco W J Schreurs, J George Groeneweg, Wim A Dik, Gilbert C H Tjiang, Ismail Gültuna, Dirk L Stronks, Frank J P M Huygen
OBJECTIVE: Complex regional pain syndrome (CRPS) is characterized by continued pain disproportional to the inciting event, sensory abnormalities, vasomotor and sudomotor disturbances, and motor and trophic changes. Inflammatory involvement has been demonstrated in past CRPS studies resulting in pain, swelling, and warmth. Currently, it is unknown whether spinal cord stimulation (SCS) has immunomodulatory properties. The aim of this study was to determine whether SCS has immunomodulatory properties in CRPS patients...
October 24, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29057068/case-report-percutaneous-electrical-neural-field-stimulation-in-two-cases-of-sympathetically-mediated-pain
#8
Lynn Fraser, Anna Woodbury
Background: Fibromyalgia and complex regional pain syndrome (CRPS) are both chronic pain syndromes with pathophysiologic mechanisms related to autonomic nervous system dysregulation and central sensitization.  Both syndromes are considered difficult to treat with conventional pain therapies. Case presentations: Here we describe a female veteran with fibromyalgia and a male veteran with CRPS, both of whom failed multiple pharmacologic, physical and psychological therapies for pain, but responded to percutaneous electrical neural field stimulation (PENFS) targeted at the auricular branches of the cranial nerves...
2017: F1000Research
https://www.readbyqxmd.com/read/29052704/patients-experiences-with-communication-and-resolution-programs-after-medical-injury
#9
MULTICENTER STUDY
Jennifer Moore, Marie Bismark, Michelle M Mello
Importance: Dissatisfaction with medical malpractice litigation has stimulated interest by health care organizations in developing alternatives to meet patients' needs after medical injury. In communication-and-resolution programs (CRPs), hospitals and liability insurers communicate with patients about adverse events, use investigation findings to improve patient safety, and offer compensation when substandard care caused harm. Despite increasing interest in this approach, little is known about patients' and family members' experiences with CRPs...
November 1, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/29038061/structural-and-functional-brain-changes-at-early-and-late-stages-of-complex-regional-pain-syndrome
#10
Mahsa Shokouhi, Collin Clarke, Patricia Morley-Forster, Dwight E Moulin, Karen Davis, Keith St Lawrence
Brain plasticity is demonstrated in complex regional pain syndrome (CRPS), although it is unclear how it modulates at different stages of CRPS. The observation that symptoms can progress over time suggests that the pattern of brain changes might also evolve. We measured structural and functional changes as well as sensorimotor integration at early and late stages (ES and LS) of CRPS. Twelve ES patients, sixteen LS patients, and sixteen age- and sex-matched controls were recruited. Gray matter (GM) volume was estimated using voxel-based morphometry...
October 13, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29037934/the-primary-diagnosis-and-the-coexisting-anxiety-disorders-have-no-impact-on-the-additional-surgical-procedure-after-spinal-cord-stimulators-implantation-an-analysis-of-11-029-patients
#11
Koji Tamai, Zorica Buser, Christopher Wang, Permsak Paholpak, Hiroaki Nakamura, Jeffrey C Wang, Patrick C Hsieh
Studies have demonstrated superior outcomes and cost effectiveness of the spinal cord stimulation (SCS) for the treatment of chronic pain syndromes such as failed back surgery syndrome (FBSS) or complex regional pain syndrome (CRPS). However, little is known about the impact of primary diagnosis or mental disorders on the revision rate. This is the Retrospective cohort study to analyze the reintervention rates based on the primary diagnosis or comorbid mental disorder. Data of the annual trends of SCS use, revision and removal rate of SCS and additional surgical rate after removal was collected and analyzed for patients undergoing SCS between 2007 and 2015, within a private insurance billing database...
October 13, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29037309/correlation-between-cellular-expression-of-complement-regulatory-proteins-with-depletion-and-repopulation-of-b-lymphocytes-in-peripheral-blood-of-patients-with-rheumatoid-arthritis-treated-with-rituximab
#12
Daniela Viecceli, Mariana Pires Garcia, Laiana Schneider, Ana Paula Alegretti, Cristiano Kohler Silva, André Lucas Ribeiro, Claiton Viegas Brenol, Ricardo Machado Xavier
OBJECTIVES: To correlate the basal expression of complement regulatory proteins (CRPs) CD55, CD59, CD35, and CD46 in B-lymphocytes from the peripheral blood of a cohort of 10 patients with rheumatoid arthritis (RA) initiating treatment with rituximab (RTX) with depletion and time repopulation of such cells. METHODS: Ten patients with RA received two infusions of 1g of RTX with an interval of 14 days. Immunophenotypic analysis for the detection of CD55, CD59, CD35, and CD46 on B-lymphocytes was carried out immediately before the first infusion...
September 2017: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/29022774/the-management-of-chronic-non-arthritic-scapholunate-dissociation-a-systematic-review
#13
Zafar Naqui, Wee Sim Khor, Anuj Mishra, Vivien Lees, Lindsay Muir
A systematic review was conducted to identify the best management for chronic scapholunate dissociation. EMBASE, MEDLINE, and CENTRAL were searched from 1965-2016. A narrative synthesis was performed. One thousand, one hundred and ninety-one citations were identified, of which 17 had final analysis. In all interventions, the pain score at 2 years reduced from 6.0 to 2.8 with similar effect from capsulodesis and tenodesis techniques. Overall there was an 18% loss of flexion arc. Radial to ulnar arc improved in capsulodesis (+19%; n = 45) and worsened in tenodesis (-6%; n = 45)...
January 1, 2017: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/29020809/fibromyalgia-as-a-predictor-of-complex-regional-pain-syndrome-after-distal-radius-fracture
#14
Marc D Lipman, Daniel E Hess, Brian C Werner, D Nicole Deal
BACKGROUND: Complex regional pain syndrome (CRPS) can be a devastating complication following extremity injury, but risk factors are not well understood. The purpose of this study was to investigate the association between fibromyalgia and the development of CRPS after distal radius fracture. METHODS: The PearlDiver Medicare database was queried using International Classification of Diseases, 9th Revision (ICD-9) and Current Procedural Terminology (CPT) codes for diagnoses and treatments of distal radius fractures...
October 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28973211/low-dose-intravenous-immunoglobulin-treatment-for-long-standing-complex-regional-pain-syndrome-a-randomized-trial
#15
RANDOMIZED CONTROLLED TRIAL
Andreas Goebel, Jatinder Bisla, Roy Carganillo, Bernhard Frank, Rima Gupta, Joanna Kelly, Candy McCabe, Caroline Murphy, Nick Padfield, Ceri Phillips, Mark Sanders, Mick Serpell, Nick Shenker, Karim Shoukrey, Lynne Wyatt, Gareth Ambler
Background: Two small trials suggest that low-dose intravenous immunoglobulin (IVIg) may improve the symptoms of complex regional pain syndrome (CRPS), a rare posttraumatic pain condition. Objective: To confirm the efficacy of low-dose IVIg compared with placebo in reducing pain during a 6-week period in adult patients who had CRPS from 1 to 5 years. Design: 1:1 parallel, randomized, placebo-controlled, multicenter trial for 6 weeks, with an optional 6-week open extension...
October 3, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28971481/transcranial-magnetic-stimulation-studies-in-complex-regional-pain-syndrome-type-i-a-review
#16
REVIEW
R Nardone, F Brigo, Y Höller, L Sebastianelli, V Versace, L Saltuari, P Lochner, E Trinka
The sensory and motor cortical representation corresponding to the affected limb is altered in patients with complex regional pain syndrome (CRPS). Transcranial magnetic stimulation (TMS) represents a useful non-invasive approach for studying cortical physiology. If delivered repetitively, TMS can also modulate cortical excitability and induce long-lasting neuroplastic changes. In this review, we performed a systematic search of all studies using TMS to explore cortical excitability/plasticity and repetitive TMS (rTMS) for the treatment of CRPS...
October 3, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28961359/prevalence-and-cost-analysis-of-complex-regional-pain-syndrome-crps-a-role-for-neuromodulation
#17
Aladine A Elsamadicy, Siyun Yang, Amanda R Sergesketter, Bilal Ashraf, Lefko Charalambous, Hanna Kemeny, Tiffany Ejikeme, Xinru Ren, Promila Pagadala, Beth Parente, Jichun Xie, Shivanand P Lad
OBJECTIVE: The diagnosis and treatment of complex regional pain syndrome (CRPS) is challenging and there is a paucity of data describing its overall cost burden and quantifying its impact on the US healthcare system. The aim of this study was to assess the prevalence and healthcare utilization costs associated with CRPS. MATERIALS AND METHODS: A retrospective longitudinal study was performed using the Truven MarketScan® database to identify patients with a new indexed diagnosis of CRPS (Type I, II, or both) from 2001 to 2012...
September 29, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28960653/the-efficacy-and-safety-of-dorsal-root-ganglion-stimulation-as-a-treatment-for-neuropathic-pain-a-literature-review
#18
REVIEW
Conrad Harrison, Sarah Epton, Stana Bojanic, Alexander L Green, James J FitzGerald
OBJECTIVE: Dorsal root ganglion stimulation (DRGS) received its first regulatory approval (CE marking in Europe) in late 2011, and so its use is now almost six years old. Several thousand patients have already been treated, and a landmark trial in lower limb complex regional pain syndrome (CRPS) and causalgia has recently been published. METHODS: In this review we have summarized the literature to date on the use of DRGS in the treatment of neuropathic pain. RESULTS: The results so far are encouraging, with reports of successful use in treating a wide range of indications including postsurgical pain, CRPS, and phantom pain...
September 28, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28953620/different-patterns-in-mental-rotation-of-facial-expressions-in-complex-regional-pain-syndrome-patients
#19
Won Joon Lee, Soo-Hee Choi, Joon Hwan Jang, Jee Youn Moon, Yong Chul Kim, EunChung Noh, Jung Eun Shin, HyunSoon Shin, Do-Hyung Kang
Although facial pain expressions are considered to be the most visible pain behaviors, it is known that the association between pain intensity and facial pain expression is weak for chronic pain. The authors hypothesized that the facial pain expressiveness was altered in chronic pain and investigated it with a mental rotation task using various facial expression, which seems to be associated with actual facial movements. As a task stimulus, 4 types of facial expression stimuli consisted of upper (tightening of eye and furrowed brows) and lower (raising upper lip) pain-specific facial expressions, and upper (eyeball deviation) and lower (tongue protrusion) facial movements not using facial muscles were used...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28947243/hand-lesion-after-arthroscopic-rotator-cuff-repair-association-with-complex-regional-pain-syndrome
#20
Ryo Tanesue, Masafumi Gotoh, Yasuhiro Mitsui, Hidehiro Nakamura, Hirokazu Honda, Hiroki Ohzono, Hisao Shimokobe, Tsuyoshi Tokunaga, Takaki Imai, Takahiro Okawa, Naoto Shiba
BACKGROUND: It is known that complex regional pain syndrome (CRPS) occurs after arthroscopic rotator cuff repair (ARCR); however, few studies have investigated this complication. Therefore, the purpose of the present study was to evaluate CRPS after ARCR. METHODS: A total of 182 patients who underwent ARCR were enrolled in this study. The average age of patients was 62.8 ± 10.0 years, with an average follow-up period of 21.5 ± 38.1 months. CRPS criteria outlined by the Ministry of Health, Labor, and Welfare study team for CRPS in Japan (MHLWJ) and International Association for the Study of Pain (IASP 2005) were utilized for diagnosis...
September 22, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
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