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Goodarz Golmirzaie, Lindsay S Holland, Stephanie E Moser, Mohit Rastogi, Afton L Hassett, Chad M Brummett
BACKGROUND AND OBJECTIVES: We hypothesized that patients with complex regional pain syndrome (CRPS) with a longer time since their inciting event would demonstrate more symptoms of centralized pain. METHODS: We conducted a cross-sectional analysis of 160 patients with CRPS using validated measures of pain, negative mood, and functioning at the time of their new patient evaluation. The 2011 Fibromyalgia Survey Criteria is a validated self-report measure of widespread body pain and comorbid symptoms (eg, trouble thinking, headaches)...
October 11, 2016: Regional Anesthesia and Pain Medicine
Ognjen Visnjevac, Shrif Costandi, Bimal A Patel, Girgis Azer, Priya Agarwal, Robert Bolash, Nagy A Mekhail
BACKGROUND: Complex regional pain syndrome (CRPS) is a painful, debilitating affliction that is often difficult to treat. It has become common international practice to use spinal cord stimulation (SCS) for the treatment of CRPS as other therapies fail to provide adequate relief, quality of life, or improvement in function. This comprehensive outcome-specific systematic review of the use of SCS for CRPS was performed to elucidate the available evidence with focus on clinically relevant patient-specific outcomes...
October 14, 2016: Pain Practice: the Official Journal of World Institute of Pain
Won Soek Chae, Sang Hyun Kim, Sung Hwan Cho, Joon Ho Lee, Mi Sun Lee
The superficial peroneal nerve is vulnerable to damage from ankle sprain injuries and fractures as well as surgery to this region. And it is also one of the most commonly involved nerves in complex regional pain syndrome type II in the foot and ankle region. We report two cases of ultrasound-guided pulsed radiofrequency treatment of superficial peroneal nerve for reduction of allodynia in CRPS patients.
October 2016: Korean Journal of Pain
Gözde Özcan Söylev, Hakan Boya
Complex regional pain syndrome (CRPS) is a painful and disabling disorder that usually affects the extremities. This complication may affect the knee joint after total knee arthroplasty (TKA). We report a unique case of CRPS of the foot and ankle, which was an unusual involvement site for CRPS after TKA.
October 7, 2016: Acta Orthopaedica et Traumatologica Turcica
Jijun Xu, Yuying Tang, Mian Xie, Bihua Bie, Jiang Wu, Hui Yang, Joseph F Foss, Bin Yang, Richard W Rosenquist, Mohamed Naguib
Complex regional pain syndrome type 1 (CRPS-I) remains one of the most clinically challenging neuropathic pain syndromes and its mechanism has not been fully characterized. Cannabinoid receptor 2 (CB2) has emerged as a promising target for treating different neuropathic pain syndromes. In neuropathic pain models, activated microglia expressing CB2 receptors are seen in the spinal cord. Chemokine fractalkine receptor (CX3CR1) plays a substantial role in microglial activation and neuroinflammation. We hypothesized that a CB2 agonist could modulate neuroinflammation and neuropathic pain in an ischemia model of CRPS by regulating CB2 and CX3CR1 signaling...
September 26, 2016: European Journal of Neuroscience
N Kriek, J G Groeneweg, D L Stronks, D de Ridder, F J P M Huygen
BACKGROUND: Conventional tonic spinal cord stimulation (SCS) is an effective treatment for patients with therapy-resistant complex regional pain syndrome (CRPS). Although the therapeutic effect of SCS can diminish over time due to tolerance, pain control can be regained by changing the pulse width and the amplitude and/or by increasing the stimulation frequency. This multicentre, double-blind, randomized and placebo-controlled crossover trial was conducted to investigate whether more effective pain reduction is achieved with different frequencies (trial registration, current controlled trials, ISRCTN 36655259)...
October 7, 2016: European Journal of Pain: EJP
Daniela Viecceli, Mariana Pires Garcia, Laiana Schneider, Ana Paula Alegretti, Cristiano Kohler Silva, André Lucas Ribeiro, Claiton Viegas Brenol, Ricardo Machado Xavier
OBJECTIVES: To correlate the basal expression of complement regulatory proteins (CRPs) CD55, CD59, CD35, and CD46 in B-lymphocytes from the peripheral blood of a cohort of 10 patients with rheumatoid arthritis (RA) initiating treatment with rituximab (RTX) with depletion and time repopulation of such cells. METHODS: Ten patients with RA received two infusions of 1g of RTX with an interval of 14 days. Immunophenotypic analysis for the detection of CD55, CD59, CD35, and CD46 on B-lymphocytes was carried out immediately before the first infusion...
September 17, 2016: Revista Brasileira de Reumatologia
Laura M Muncie, Nathaniel R Ellens, Emeline Tolod-Kemp, Claudio A Feler, John S Winestone
OBJECTIVE This study is a retrospective case series involving C1-2 spinal cord stimulation in patients with complex regional pain syndrome (CRPS) under general endotracheal anesthesia. Currently, C1-2 paddle lead placement is an accepted practice, which provides effective cervical stimulation to ameliorate upper-extremity and sometimes lower-extremity symptoms experienced by patients with CRPS. However, this technique must be performed under general endotracheal anesthesia rather than in an awake or semiconscious state due to intraoperative safety concerns and patient comfort...
September 30, 2016: Journal of Neurosurgery. Spine
Nicolas Winisdoerffer, Marie-Madeleine Leclercq, Aurélie Muller, Myriam Martin, Myriam Pierrat
OBJECTIVE: A rehabilitation program, with successive types of exercises, including limb laterality recognition, imagined movements and mirror therapy, can be conducted in patients with CRPS I1. This graded motor imagery program, developed by Moseley, needs patients' participation, is educative, and improves edema, pain, and functional capacities. We want to investigate whether this program would improve health-related quality of life of patients with CRPS I. MATERIAL/PATIENTS AND METHODS: All patients with upper or lower limb CRPS I are included...
September 2016: Annals of Physical and Rehabilitation Medicine
Laure Christophe, Eric Chabanat, Ludovic Delporte, Patrice Revol, Sophie Jacquin-Courtois, Pierre Volckmann, Yves Rossetti
OBJECTIVE: Complex regional pain syndrome (CRPS) is an invalidating chronic condition subsequent to peripheral lesions, with frequent therapeutic failure. There is growing consensus for a central contribution to CRPS. However, the nature of this central body representation disorder is increasingly debated. Although it has been repeatedly argued that CRPS results in motor neglect of the affected side, visual egocentric reference frame was found to be deviated towards the pain, i.e. neglect of the healthy side...
September 2016: Annals of Physical and Rehabilitation Medicine
W Porter McRoberts, Catalina Apostol, Abdul Haleem
UNLABELLED: Complex regional pain syndrome (CRPS) presents a therapeutic challenge due to its many presentations and multifaceted pathophysiology. There is no approved treatment algorithm and clinical interventions are often applied empirically. In cases of CRPS where symptoms are localized to an extremity, a targeted treatment is indicated. We describe the use of intrathecal bupivacaine monotherapy, delivered through a retrograde catheter, in the treatment of CRPS affecting the lower extremity...
September 2016: Pain Physician
Luis Soliz, James A Young
No abstract text is available yet for this article.
September 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
Michelle Chi, Isaac P Syrop, Jonas M Sokolof
No abstract text is available yet for this article.
September 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
Laure Christophe, Eric Chabanat, Ludovic Delporte, Patrice Revol, Pierre Volckmann, Sophie Jacquin-Courtois, Yves Rossetti
Complex Regional Pain Syndrome (CRPS) is an invalidating chronic condition subsequent to peripheral lesions. There is growing consensus for a central contribution to CRPS. However, the nature of this central body representation disorder is increasingly debated. Although it has been repeatedly argued that CRPS results in motor neglect of the affected side, visual egocentric reference frame was found to be deviated toward the pain, that is, neglect of the healthy side. Accordingly, prism adaptation has been successfully used to normalize this deviation...
2016: Neural Plasticity
Andrea T Borchers, M Eric Gershwin
The management of patients with chronic pain is a nearly daily challenge to rheumatologists, neurologists, orthopedic surgeons, pain specialists and indeed a issue in nearly every clinical practice. Among the myriad of causes of pain are often included a unique syndrome, generally referred to as complex regional pain syndrome type I (CRPS). Unfortunately this CRPS I has become a catch all phase and there are serious questions on whether it exist at all; this has led to an extraordinary number of poorly defined diagnostic criteria...
September 23, 2016: Autoimmunity Reviews
Anoop Kuttikat, Maliha Shaikh, Amin Oomatia, Richard Parker, Nicholas Shenker
OBJECTIVES: Delays in diagnosis occur with Complex Regional Pain Syndrome (CRPS). We define and prospectively demonstrate that novel bedside tests measuring body perception disruption can identify patients with CRPS post-fracture. METHODS: The objectives of our study were to define and validate four bedside tests; to identify the prevalence of positive tests in patients with CRPS and other chronic pain conditions and to assess the clinical utility (Sensitivity; Specificity; Positive Predictive value; Negative Predictive Value) for identifying CRPS within a Fracture cohort...
September 21, 2016: Clinical Journal of Pain
Kun Soo Jang, Hyeun Sung Kim
Complex regional pain syndrome (CRPS) type II is a syndrome that develops after nerve injury. Symptoms may be severe, and vary depending on the degree of sympathetic nerve involvement. As yet, there is no satisfactory treatment. We report the case of a female patient who had an L5 left transverse process fracture and an S2 body fracture, who developed symptoms of CRPS type II in her left lower leg that were aggravated during ambulation in spite of absolute bed rest for one month after the trauma. Several treatments, including bed rest, medication, and numerous nerve blocks were attempted, but the pain persisted...
September 2016: Journal of Korean Neurosurgical Society
Massimo Varenna, Maria Manara, Francesca Rovelli, Francesca Zucchi, Luigi Sinigaglia
OBJECTIVE:  The aim of this study was to assess whether the effectiveness of bisphosphonate infusion in patients with complex regional pain syndrome type I (CRPS-I) is influenced by variables related to patient and/or disease characteristics. METHODS:  This is a retrospective analysis of patients referred in the last five years to our rheumatologic tertiary care center, all fulfilling the Budapest CRPS-I diagnostic criteria and treated with three different bisphosphonate schedules (clodronate, pamidronate, and neridronate)...
September 20, 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
V Speck, T Schlereth, F Birklein, C Maihöfner
BACKGROUND: Although specific psychological disorders in complex regional pain syndrome (CRPS) have not been identified, studies suggest that CRPS patients may have increased rates of traumatic life events. Because these events do not always lead to apparent psychological symptoms, we systematically screened CRPS patients for posttraumatic stress disorder (PTSD) to determine if PTSD could be a risk factor for CRPS. METHODS: Consecutive CRPS patients referred to two university hospital centres (University of Erlangen, UMC Mainz) between December 2011 and April 2013 were prospectively examined using a diagnostic PTSD instrument (Post-traumatic Stress Diagnostic Scale (PDS)...
September 21, 2016: European Journal of Pain: EJP
Martin G Ferrillo
Complex regional pain syndrome (CRPS) is a poorly understood, debilitating disorder characterized by severe chronic pain in an affected limb or region of the body. This case presentation is the first to describe the effectiveness and prolonged duration of the effect of liposome bupivacaine in stellate ganglion block for CRPS.
September 2016: Clinical Case Reports
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