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https://www.readbyqxmd.com/read/29471606/-clinical-approach-to-abdominal-pain-as-functional-origin
#1
REVIEW
Han Seung Ryu, Suck Chei Choi
Abdominal pain is a common symptom that patients refer to a hospital. Organic causes should be differentiated in patients with abdominal pain and treatment should be administered in accordance with the causes. A meticulous history taking and physical examination are highly useful in making a diagnosis, and blood tests, imaging modalities, and endoscopy are useful for confirming diagnosis. However, in many cases, patients have functional disorders with no obvious abnormal findings obtained even if many diagnostic tests are performed...
February 25, 2018: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/29471461/gendered-pathways-to-burnout-results-from-the-salveo-study
#2
Nancy Beauregard, Alain Marchand, Jaunathan Bilodeau, Pierre Durand, Andrée Demers, Victor Y Haines
Aim: Burnout is a pervasive mental health problem in the workforce, with mounting evidence suggesting ties with occupational and safety outcomes such as work injuries, critical events and musculoskeletal disorders. While environmental [work and non-work, work-to-family conflict (WFC)] and individual (personality) pathways to burnout are well documented, little is known about how gender comes to influence such associative patterns. The aim of the study consisted in examining gendered pathways to burnout...
February 19, 2018: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/29471411/mechanisms-underpinning-the-polypharmacy-effects-of-medications-in-psychiatry
#3
Chiara C Bortolasci, Briana Spolding, Edward Callaly, Sheree Martin, Bruna Panizzutti, Srisaiyini Kidnapillai, Timothy Connor, Kyoko Hasebe, Mohammadreza Mohebbi, Olivia M Dean, Sean L McGee, Seetal Dodd, Laura Gray, Michael Berk, Ken Walder
Background: Bipolar disorder (BD) is a mental health condition with progressive social and cognitive function disturbances. Most patients' treatments are based on polypharmacy, but with no biological basis and little is known of the drugs' interactions. The aim of this study was to analyse the effects of lithium, valproate, quetiapine and lamotrigine, and the interactions between them, on markers of inflammation, bioenergetics, mitochondrial function and oxidative stress in neuron-like cells (NT2) and microglial cells...
February 19, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29471396/involvement-of-epigenetic-modifications-of-gabaergic-interneurons-in-basolateral-amygdala-in-anxiety-like-phenotype-of-prenatally-stressed-mice
#4
Chunting Zhu, Min Liang, Yingchun Li, Xuejiao Feng, Juan Hong, Rong Zhou
Background: Prenatal stress is considered a risk factor for anxiety disorder. Downregulation in the expression of GABAergic gene, that is, glutamic acid decarboxylase 67, associated with DNA methyltransferase overexpression in GABAergic neurons has been regarded as a characteristic component of anxiety disorder. Prenatal stress has an adverse effect on the development of the basolateral amygdala, which is a key region in anxiety regulation. The aim of this study is to analyze the possibility of epigenetic alterations of GABAergic neurons in the basolateral amygdala participating in prenatal stress-induced anxiety...
February 20, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29471395/origin-and-composition-of-cell-free-dna-in-spent-medium-from-human-embryo-culture-during-preimplantation-development
#5
M Vera-Rodriguez, A Diez-Juan, J Jimenez-Almazan, S Martinez, R Navarro, V Peinado, A Mercader, M Meseguer, D Blesa, I Moreno, D Valbuena, C Rubio, C Simon
STUDY QUESTION: What is the origin and composition of cell-free DNA in human embryo spent culture media? SUMMARY ANSWER: Cell-free DNA from human embryo spent culture media represents a mix of maternal and embryonic DNA, and the mixture can be more complex for mosaic embryos. WHAT IS KNOWN ALREADY: In 2016, ~300 000 human embryos were chromosomally and/or genetically analyzed using preimplantation genetic testing for aneuploidies (PGT-A) or monogenic disorders (PGT-M) before transfer into the uterus...
February 20, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29471329/effects-of-varenicline-depressive-symptoms-and-region-of-enrollment-on-smoking-cessation-in-depressed-smokers
#6
Neal Doran, Sarah Dubrava, Robert M Anthenelli
Introduction: Despite effective treatments, relapse to smoking remains a vexing global health problem. One predictor of relapse is depressive symptoms. Medications such as varenicline reduce withdrawal-related symptoms of depression, reducing relapse. This study examined whether varenicline moderated the effect of depressive symptoms on relapse, and whether this varied by region of enrollment. Methods: Adult smokers (n=525; 37% male) with past or current, stable major depressive disorder recruited from US (n=255), and European (n=270) sites participated in a randomized, double-blind cessation treatment trial including 12 weeks of varenicline or placebo, with 40-week non-treatment follow-up...
February 17, 2018: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/29471296/ambulatory-assessment-of-borderline-personality-disorder
#7
Timothy J Trull
Ambulatory assessment (AA) is an important tool that promises to minimize retrospective biases while gathering ecologically valid data, including self-reports, physiological or biological data, and observed behavior, for example, from daily life experiences. AA is well suited for studying borderline personality disorder (BPD) because it can measure moods and emotion (as well as dynamic mood processes, mood changes, and mood instability), problematic behaviors (including interpersonal conflicts, addictive behaviors, binge and purge episodes, and motoric activity), and problematic cognitions/expectancies/urges (e...
February 22, 2018: Psychopathology
https://www.readbyqxmd.com/read/29471252/relationship-between-monocytes-to-lymphocytes-ratio-and-axial-spondyloarthritis
#8
Yukai Huang, Weiming Deng, Shaoling Zheng, Fan Feng, Zhixiang Huang, Qidang Huang, Xin Guo, Zhengping Huang, Xuechang Huang, Xia Pan, Tianwang Li
BACKGROUND: Axial spondyloarthritis (axSpA) is a progressive, chronic, inflammatory skeletal disorder affecting the spine and sacroiliac joints. Many studies have shown that neutrophils, lymphocytes, monocytes, platelets, and red blood cells (RBCs) play important roles in the inflammatory process of axSpA. Neutrophils to lymphocytes ratio (NLR) and red blood cell distribution width (RDW) have been reported to be simple and inexpensive markers to indicate the disease activity of axSpA...
February 19, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29471102/high-fructose-diet-induced-metabolic-syndrome-pathophysiological-mechanism-and-treatment-by-traditional-chinese-medicine
#9
REVIEW
Ying Pan, Ling-Dong Kong
Fructose is a natural monosaccharide broadly used in modern society. Over the past few decades, epidemiological studies have demonstrated that high fructose intake is an etiological factor of metabolic syndrome (MetS). This review highlights research advances on fructose-induced MetS, especially the underlying pathophysiological mechanism as well as pharmacotherapy by traditional Chinese medicine (TCM), using the PubMed, Web of science, China National Knowledge Infrastructure, China Science and Technology Journal and Wanfang Data...
February 19, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29471015/biological-profiling-of-plasma-neuropeptide-y-in-relation-to-posttraumatic-stress-symptoms-in-two-combat-cohorts
#10
Alieke Reijnen, Elbert Geuze, Iris Eekhout, Adam X Maihofer, Caroline M Nievergelt, Dewleen G Baker, Eric Vermetten
In order to decrease the risk of developing stress-related disorders after military deployment, biological vulnerability factors should be identified. Neuropeptide Y (NPY) is a peptide neurotransmitter that is associated with modulation of the stress response. Using the data of two longitudinal prospective cohort studies (N = 892 and N = 2427), plasma NPY (pNPY) was assessed as a possible susceptibility biomarker for the development of PTSD symptoms over time. Data collection started prior to deployment and follow-up assessments were completed up to two years after deployment...
February 19, 2018: Biological Psychology
https://www.readbyqxmd.com/read/29470971/use-of-autologous-serum-tears-for-the-treatment-of-ocular-surface-disease-from-patients-with-systemic-autoimmune-diseases
#11
Tayyeba K Ali, Allister Gibbons, Cristián Cartes, Siamak Zarei-Ghanavati, Mohamed Gomaa, Ingrid Gonzalez, Astrid E Gonzalez, Hilal E Ozturk, Carolina Betancurt, Victor L Perez
PURPOSE: To describe the safety and efficacy of autologous serum tears (AST) in managing ocular surface disease resistant to conventional therapy in patients with systemic autoimmune disease(s). DESIGN: Retrospective, interventional case series. METHODS: Records of patients from 2009 to 2015 with systemic autoimmune disease treated with AST (20-50%) for chronic surface disease were analyzed. Standardized measures of subjective dry eye symptoms, objective dry eye staining of the cornea, and slit lamp findings including punctate epithelial erosion (PEE), filamentary keratopathy (FK) and corneal epithelial defects (KED) were compared during first and last visit...
February 19, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29470775/influence-of-body-mass-index-in-anti-m%C3%A3-llerian-hormone-levels-in-951-non-polycystic-ovarian-syndrome-women-followed-at-a-reproductive-medicine-unit
#12
Joana Simões-Pereira, Joaquim Nunes, Ana Aguiar, Sandra Sousa, Cátia Rodrigues, Joaquim Sampaio Matias, Carlos Calhaz-Jorge
PURPOSE: Anti-Müllerian hormone (AMH) is a useful marker of ovarian reserve. Obesity/overweight are increasing and may affect the reproductive health. Previous studies regarding the effect of body mass index (BMI) on AMH levels are discordant. Our main goal was to evaluate the influence of BMI on AMH levels in women without polycystic ovarian syndrome. METHODS: Revision of medical records of 951 women who performed AMH determinations as part of their fertility workup, between 2011 and 2016...
February 22, 2018: Endocrine
https://www.readbyqxmd.com/read/29470721/association-of-ischemic-stroke-with-ankylosing-spondylitis-a-nationwide-longitudinal-cohort-study
#13
Dong Hyun Lee, Yoon Jin Choi, In-Bo Han, Je Beom Hong, Kyung Do Han, Jung Min Choi, Seil Sohn
BACKGROUND: The purpose of this nationwide age- and sex-matched longitudinal follow-up study was to investigate the risk of developing ischemic stroke in ankylosing spondylitis (AS). METHODS: The data in this study, spanning from January 1, 2010 to December 31, 2014, was obtained from a database maintained by the Korean National Health Insurance Service. A total of 12,988 patients with a diagnosis of AS were enrolled. The control group consisted of 64,940 age-sex-stratified matching subjects without AS...
February 22, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29470673/how-much-does-the-treatment-of-each-major-disease-cost-a-decomposition-of-swiss-national-health-accounts
#14
Simon Wieser, Marco Riguzzi, Mark Pletscher, Carola A Huber, Harry Telser, Matthias Schwenkglenks
In most countries, surprisingly little is known on how national healthcare spending is distributed across diseases. Single-disease cost-of-illness studies cover only a few of the diseases affecting a population and in some cases lead to untenably large estimates. The objective of this study was to decompose healthcare spending in 2011, according to Swiss National Health Accounts, into 21 collectively exhaustive and mutually exclusive major disease categories. Diseases were classified following the Global Burden of Disease Study...
February 22, 2018: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
https://www.readbyqxmd.com/read/29470603/cardiac-gated-intravoxel-incoherent-motion-diffusion-weighted-magnetic-resonance-imaging-for-the-investigation-of-intracranial-cerebrospinal-fluid-dynamics-in-the-lateral-ventricle-a-feasibility-study
#15
Eddie Surer, Cristina Rossi, Anton S Becker, Tim Finkenstaedt, Moritz C Wurnig, Antonios Valavanis, Sebastian Winklhofer
PURPOSE: Intravoxel incoherent motion (IVIM) in diffusion-weighted magnetic resonance imaging (DW-MRI) attributes the signal attenuation to the molecular diffusion and to a faster pseudo-diffusion. Purpose of the study was to demonstrate the feasibility of IVIM for the investigation of intracranial cerebrospinal fluid (CSF) dynamics. METHODS: Cardiac-gated DW-MRI images with fifteen b-values (0-1300s/mm2 ) along three orthogonal directions (mediolateral (ML), anteroposterior (AP), and craniocaudal (CC)) were acquired during maximum systole and diastole in 10 healthy volunteers (6 males, mean age 36 ± 15 years)...
February 22, 2018: Neuroradiology
https://www.readbyqxmd.com/read/29470596/mental-health-burden-in-a-national-sample-of-american-indian-and-alaska-native-adults-differences-between-multiple-race-and-single-race-subgroups
#16
Nancy L Asdigian, Ursula Running Bear, Janette Beals, Spero M Manson, Carol E Kaufman
PURPOSE: Research on American Indian and Alaska Native (AIAN) mental health disparities is based largely on either tribal populations or national samples of adults that do not account for multiracial AIANs, even though over 40% of AIANs identify with multiple racial groups. The present investigation extends this research by assessing mental health status in a national sample of multiracial AIAN adults relative to adults who identify exclusively as either AIAN or White. METHODS: 2012 BRFSS data were used to conduct multinomial logistic regression analyses comparing mental health outcomes among respondents who identified as either AIAN and one or more other races (AIAN-MR), AIAN-Single Race (AIAN-SR), or White-SR...
February 22, 2018: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/29470523/a-late-but-fitter-revertant-cell-explains-the-high-frequency-of-revertant-mosaicism-in-epidermolysis-bullosa
#17
Peter C van den Akker, Anna M G Pasmooij, Hans Joenje, Robert M W Hofstra, Gerard J Te Meerman, Marcel F Jonkman
Revertant mosaicism, or "natural gene therapy", is the phenomenon in which germline mutations are corrected by somatic events. In recent years, revertant mosaicism has been identified in all major types of epidermolysis bullosa, the group of heritable blistering disorders caused by mutations in the genes encoding epidermal adhesion proteins. Moreover, revertant mosaicism appears to be present in all patients with a specific subtype of recessive epidermolysis bullosa. We therefore hypothesized that revertant mosaicism should be expected at least in all patients with recessive forms of epidermolysis bullosa...
2018: PloS One
https://www.readbyqxmd.com/read/29470512/association-between-hiv-status-and-depressive-symptoms-among-children-and-adolescents-in-the-southern-highlands-zone-tanzania-a-case-control-study
#18
Abraham Lwidiko, Stephen Matthew Kibusi, Azan Nyundo, Bonaventura C T Mpondo
BACKGROUND: Children and adolescents continue to have HIV/AIDS in southern Saharan Africa. Scaling up of HIV services has significantly improved access to ARV and consequently improved on morbidity and mortality related to HIV/AIDS including opportunistic infection. Despite the above efforts, non-communicable conditions including mental disorders such as depression have been observed to contribute to the burden of disabilities about which little is documented. This study, therefore, aimed to determine the magnitude of depressive symptoms and the associated factors among HIV-infected children and adolescents...
2018: PloS One
https://www.readbyqxmd.com/read/29470464/generation-of-human-brain-region-specific-organoids-using-a-miniaturized-spinning-bioreactor
#19
Xuyu Qian, Fadi Jacob, Mingxi Max Song, Ha Nam Nguyen, Hongjun Song, Guo-Li Ming
Human brain organoids, 3D self-assembled neural tissues derived from pluripotent stem cells, are important tools for studying human brain development and related disorders. Suspension cultures maintained by spinning bioreactors allow for the growth of large organoids despite the lack of vasculature, but commercially available spinning bioreactors are bulky in size and have low throughput. Here, we describe the procedures for building the miniaturized multiwell spinning bioreactor SpinΩ from 3D-printed parts and commercially available hardware...
March 2018: Nature Protocols
https://www.readbyqxmd.com/read/29470291/recurrent-abdominal-pain-in-children-summary-evidence-from-3-systematic-reviews-of-treatment-effectiveness
#20
Rebecca A Abbott, Alice E Martin, Tamsin V Newlove-Delgado, Alison Bethel, Rebecca S Whear, Jo Thompson Coon, Stuart Logan
OBJECTIVES: Between 4% and 25% of school-aged children complain of recurrent abdominal pain (RAP) severe enough to interfere with their daily activities. METHODS: We carried out a systematic review of randomised controlled trials (RCTs) in eleven databases and 2 trials registries from inception to June 2016. An update search was run in November 2017. All screening was performed by 2 independent reviewers. Included studies were appraised using the Cochrane risk of bias tool and the evidence assessed using GRADE...
February 21, 2018: Journal of Pediatric Gastroenterology and Nutrition
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