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https://www.readbyqxmd.com/read/29933522/deuterium-reinforced-linoleic-acid-lowers-lipid-peroxidation-and-mitigates-cognitive-impairment-in-the-q140-knock-in-mouse-model-of-huntington-s-disease
#1
Asa Hatami, Chunni Zhu, Aroa Relaño-Gines, Chris Elias, Arpine Galstyan, Michael Jun, Ginger Milne, Charles R Cantor, Marie-Francoise Chesselet, Mikhail S Shchepinov
Huntington's disease (HD) is an autosomal dominant neurodegenerative disease which has no effective treatment and is characterized by psychiatric disorders, motor alterations, and dementia, with the cognitive deficits representing a devastating aspect of the disorder. Oxidative stress and elevated levels of lipid peroxidation (LPO) products are found in mouse models and patients with HD, suggesting that strategies to reduce LPO may be beneficial in HD. In contrast to traditional antioxidants, substituting hydrogen with deuterium at bis-allylic sites in polyunsaturated fatty acids (D-PUFA) decreases the rate-limiting initiation step of PUFA autoxidation, a strategy that has shown benefits in other neurodegenerative diseases...
June 22, 2018: FEBS Journal
https://www.readbyqxmd.com/read/29933492/group-communication-treatment-for-individuals-with-ppa-and-their-partners
#2
Aimee Mooney, Naomi Beale, Melanie Fried-Oken
Primary progressive aphasia (PPA) is a neurodegenerative syndrome characterized by insidious language deterioration. This young-onset disorder leaves adults with reduced communication skills for participation in social activities. There is limited evidence regarding group treatment for individuals with PPA, though the principles of chronic aphasia groups can be applied to this clinical population. We developed a PPA group treatment model incorporating compensatory strategies from augmentative and alternative communication (AAC), communication partner training from aphasia rehabilitation, and systematic instruction from dementia management...
July 2018: Seminars in Speech and Language
https://www.readbyqxmd.com/read/29933465/-victims-of-acts-of-violence-during-the-procedure-of-the-victim-reparation-law-characteristics-of-the-affected-acts-perpetrators-and-predictors-for-the-period-until-claim-of-help-provided-by-law
#3
Stefanie Franke, Christine Kalweit, Annelene Frey, Hanna Heddergott, Astrid-Christine Mitschke, Matthias Wehrmeyer, Nina Heinrichs, Christoph Kröger
AIM OF THE STUDY: Coping with psychological trauma plays a central role in victims of acts of violence. The Victim Reparation Law (in German: Opferentschädigungsgesetz, OEG) provides services for the reparation of participation. To further improve the care of the affected persons, the characteristics of the victims were determined in relation to the acts and the perpetrators. METHOD: 312 OEG-files of adult victims were sighted. On the basis of a system of categories, demographic data, trauma specific and health-related characteristics of the victims, relevant characteristics of the perpetrators and the violence, as well as predictors for the time difference between the violent act and the application were determined...
June 22, 2018: Psychotherapie, Psychosomatik, Medizinische Psychologie
https://www.readbyqxmd.com/read/29933432/the-role-of-cognition-on-navigational-skills-of-children-and-adolescents-with-autism-spectrum-disorders
#4
Manon Robillard, Annie Roy-Charland, Sylvie Cazabon
Purpose: This study examined the role of cognition on the navigational process of a speech-generating device (SGD) among individuals with a diagnosis of autism spectrum disorder (ASD). The objective was to investigate the role of various cognitive factors (i.e., cognitive flexibility, sustained attention, categorization, fluid reasoning, and working memory) on the ability to navigate an SGD with dynamic paging and taxonomic grids in individuals with ASD. Method: Twenty individuals aged 5 to 20 years with ASD were assessed using the Leiter International Performance Scale-Revised (Roid & Miller, 1997) and the Automated Working Memory Assessment (Alloway, 2007)...
June 22, 2018: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/29933387/nk-4-exerts-selective-regulatory-effects-on-the-activation-and-function-of-allergy-related-th2-cells
#5
Keizo Kohno, Satomi Koya-Miyata, Akira Harashima, Toshio Ariyasu, Shimpei Ushio
NK-4 is the main component of the antiallergic drug Lumin, which has been in popular usage since the early 1950s. In this study, we examined whether NK-4 exerts a regulatory effect on the activation and effector function of Th2 cells. NK-4 inhibited IL-4 production by anti-CD3ε mAb-stimulated BALB/c mouse spleen cells, whereas NK-4 had little effect on IFN-γ production. IL-4 and IL-5 secretion by anti-CD3ε mAb- or antigen-stimulated Th2 cells (D10.G4.1) was abrogated by NK-4 without affecting cell numbers, whereas IFN-γ secretion by activated Th1 cells was unchanged...
2018: PloS One
https://www.readbyqxmd.com/read/29933375/integration-of-resting-state-functional-mri-into-clinical-practice-a-large-single-institution-experience
#6
Eric C Leuthardt, Gloria Guzman, S Kathleen Bandt, Carl Hacker, Ananth K Vellimana, David Limbrick, Mikhail Milchenko, Pamela Lamontagne, Benjamin Speidel, Jarod Roland, Michelle Miller-Thomas, Abraham Z Snyder, Daniel Marcus, Joshua Shimony, Tammie L S Benzinger
Functional magnetic resonance imaging (fMRI) is an important tool for pre-surgical evaluation of eloquent cortex. Classic task-based paradigms require patient participation and individual imaging sequence acquisitions for each functional domain that is being assessed. Resting state fMRI (rs-fMRI), however, enables functional localization without patient participation and can evaluate numerous functional domains with a single imaging session. To date, post-processing of this resting state data has been resource intensive, which limits its widespread application for routine clinical use...
2018: PloS One
https://www.readbyqxmd.com/read/29933245/ethnomedicinal-phytochemical-and-pharmacological-profile-of-a-mangrove-plant-ceriops-decandra-griffdin-hou
#7
Imran Mahmud, Naznin Shahria, Sabina Yeasmin, Asif Iqbal, Emdadul Hasan Mukul, Sudipta Gain, Jamil Ahmad Shilpi, Md Khirul Islam
Ceriops decandra is a mangrove tree species, reputed for its folkloric uses in the treatment of gastrointestinal disorders, infection, snakebites, inflammation, and cancer. Different parts of the plant are rich with various phytoconstituents which include diterpenoids (ceriopsin A-G), triterpenoids (lupeol, α-amyrin, oleanolic acid, ursolic acid), and phenolics (catechin, procyanidins).These phytoconstituents and their derivatives could form a new basis for developing new drugs against various diseases. The objective of the present study is to compile the phytochemical, ethnobotanical, biological, and pharmacological significance of the plant to provide directions for future research to find out therapeutically active lead compounds for developing new drugs against diseases of current interest including diabetes, inflammation, and cancer...
June 22, 2018: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/29933222/high-throughput-lipidomics-characterize-key-lipid-molecules-as-potential-therapeutic-targets-of-kaixinsan-protects-against-alzheimer-s-disease-in-app-ps1-transgenic-mice
#8
Hong-Lei Gao, Ai-Hua Zhang, Jing-Bo Yu, Hui Sun, Ling Kong, Xiang-Qian Wang, Guang-Li Yan, Liang Liu, Xi-Jun Wang
Alzheimer's disease (AD) is still a major problem nowadays. Under the circumstance of many chemical drugs have poor effects on AD, traditional Chinese medicine has become a hot spot for us due to its multi-target and multi-path advantages. To explore the potential therapeutic targets of Kaixinsan (KXS) protects against AD in APP/PS1 transgenic mice model. All mice were divided into three groups: control group, model group and KXS group. Orally given KXS from two month old, and the control and model groups were given the same dose of distilled water...
June 18, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29933209/a-qualitative-examination-and-theoretical-model-of-anxiety-in-adults-with-epilepsy
#9
Amelia J Scott, Louise Sharpe, Zoe Thayer, Laurie A Miller, Toh Wong, Kaitlyn Parratt, Armin Nikpour
OBJECTIVE: There is an elevated prevalence of anxiety disorders among people with epilepsy, and the comorbidity of anxiety in epilepsy is associated with adverse medical and psychosocial outcomes. Despite its importance, little is known about what psychosocial or epilepsy factors may be associated with the development of anxiety. The aim of this qualitative study was to determine what factors may explain why some people with epilepsy develop anxiety disorders and others do not. METHODS: Adults with epilepsy were recruited from an outpatient epilepsy service...
June 19, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29933206/the-pattern-of-pharmacological-treatment-of-bipolar-patients-discharged-from-psychiatric-units-in-poland
#10
Jan Jaracz, Edyta Tetera- Rudnicka, Magdalena Bierejszyk, Kaja Witczyk, Agnieszka Raczyńska, Wojciech Nowak, Anna Pisarczyk, Krzysztof Woźniak, Wojciech Czernaś, Adam Moniakowski, Krystyna Jaracz
BACKGROUND: The concomitant use of two or more mood stabilisers (MS), second-generation antipsychotics (SGA), lamotrigine as well as antidepressants, is frequently reported in the treatment of bipolar patients The aim of this study was to investigate the pattern of pharmacological treatment with special regard to polypharmacy defined as two or more psychiatric drugs taken at the same time in the same patients with bipolar disorder discharged from psychiatric units in Poland. METHOD: Pharmacotherapy of 127 consecutive patients (57 females and 70 males) with an ICD-10 diagnosis of bipolar disorder (BP) at the point of discharge from five psychiatric regional hospitals/units in Poland, was evaluated in 2015/2016 on the basis of medical files...
February 5, 2018: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29933137/efficacy-of-group-psychotherapy-for-geriatric-depression-a-systematic-review
#11
L R Tavares, M R Barbosa
BACKGROUND: Geriatric depression is a common and debilitating psychopathology, but evidence supports the efficacy of psychotherapy in its treatment. Group therapy provides advantages over individual interventions. However, only three systematic reviews have focused specifically on the efficacy of group therapy for geriatric depression. OBJECTIVE: To ascertain the effects of group psychotherapy on geriatric depression in people aged 60 years and older, compared with alternative treatments or no treatment...
June 18, 2018: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29933136/reliability-of-dsm-and-empirically-derived-prototype-diagnosis-for-mood-anxiety-and-personality-disorders
#12
Maayan Nagar, Drew Westen, Ora Nakash
BACKGROUND: Prominent psychiatric diagnostic systems such as the DSM-IV and ICD-10 have shown low reliability in clinical practice. An alternative approach to classification of psychiatric disorders is prototype matching. In the current study, we examined reliability of assessing mood, anxiety and personality disorders using a multi-method multi informant approach. More specifically, we examined diagnosis made by treating clinician and independent expert clinical interviewer, using three different diagnostic systems (DSM symptom count, DSM-IV prototype diagnosis and empirically derived prototype diagnosis)...
June 9, 2018: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29933124/beyond-the-tip-of-the-iceberg-adolescent-weight-development-of-women-and-men-with-features-of-binge-eating-disorder
#13
Linda Mustelin, Jaakko Kaprio, Anna Keski-Rahkonen
OBJECTIVE: Binge eating disorder (BED) is a clinical eating disorder that is strongly and bidirectionally related to overweight and obesity. Little is known about how subclinical features of BED relate to weight development in adolescence and young adulthood. METHOD: Women (n = 2825) and men (n = 2423) from the community-based longitudinal FinnTwin16 cohort participated. Seven eating-related cognitions and behaviors similar to the defining features of BED were extracted from the Eating Disorder Inventory-2 and were assessed at a mean age of 24...
June 14, 2018: Eating Behaviors
https://www.readbyqxmd.com/read/29933105/stable-cellular-models-of-nuclear-receptor-pxr-for-high-throughput-evaluation-of-small-molecules
#14
Seema Negi, Shashi Kala Singh, Sanjay Kumar, Subodh Kumar, Rakesh K Tyagi
Pregnane & Xenobiotic Receptor (PXR) is one of the 48 members of the ligand-modulated transcription factors belonging to nuclear receptor superfamily. Though PXR is now well-established as a 'xenosensor', regulating the central detoxification and drug metabolizing machinery, it has also emerged as a key player in several metabolic disorders. This makes PXR attractive to both, researchers and pharmaceutical industry since clinical success of small drug molecules can be pre-evaluated on PXR platform. At the early stages of drug discovery, cell-based assays are used for high-throughput screening of small molecules...
June 19, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29933047/pharmacologic-inhibition-of-akt-leads-to-cell-death-in-relapsed-multiple-myeloma
#15
In-Sung Song, Yu Jeong Jeong, Seung Hun Jeong, Hyoung Kyu Kim, Nam-Chul Ha, MyungGeun Shin, Kyung Soo Ko, Byoung Doo Rhee, Sungbo Shim, Sung-Wuk Jang, Jin Han
Multiple myeloma (MM) is a neoplastic plasma cell disorder with high disease recurrence rates. Novel therapeutic approaches capable of improving outcomes in patients with MM are urgently required. The AKT signalling plays a critical regulatory role in MM pathophysiology, including survival, proliferation, metabolism, and has emerged as a key therapeutic target. Here, we identified a novel AKT inhibitor, HS1793, and defined its mechanism of action and clinical significance in MM. HS1793 disrupted the interaction between AKT and heat shock protein 90, resulting in protein phosphatase 2A-modulated phosphorylated-AKT (p-AKT) reduction...
June 19, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29933016/potential-therapeutic-applications-of-the-genus-annona-local-and-traditional-uses-and-pharmacology
#16
REVIEW
A M Quílez, M A Fernández-Arche, M D García-Giménez, R De la Puerta
ETHNO-PHARMACOLOGICAL RELEVANCE: Annona species (Annonaceae) have long been used as traditional herbal medicines by native peoples in tropical areas. In different countries they are used against a large variety of illnesses, such as parasitic and infectious diseases, cancer, diabetes, peptic ulcers, and mental disorders. AIM OF THE STUDY: This review aims to achieve a comprehensive understanding of the research conducted so far on the local and traditional uses, pharmacological activities, mechanism of actions of active compounds, toxicity, and possible interactions with other drugs of the Annona species...
June 19, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29932956/broad-spectrum-proteomics-analysis-of-the-inferior-colliculus-following-acute-hydrogen-sulfide-exposure
#17
Dong-Suk Kim, Poojya Anantharam, Andrea Hoffmann, Mitchell L Meade, Nadja Grobe, Jeffery M Gearhart, Elizabeth M Whitley, Belinda Mahama, Wilson K Rumbeiha
Acute exposure to high concentrations of H2 S causes severe brain injury and long-term neurological disorders, but the mechanisms involved are not known. To better understand the cellular and molecular mechanisms involved in acute H2 S-induced neurodegeneration we used a broad-spectrum proteomic analysis approach to identify key molecules and molecular pathways involved in the pathogenesis of acute H2 S-induced neurotoxicity and neurodegeneration. Mice were subjected to acute inhalation exposure of up to750 ppm of H2 S...
June 19, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29932874/an-overview-of-systematic-reviews-on-patient-reported-outcome-measures-used-on-neck-disorders
#18
Pavlos Bobos, Joy C MacDermid, David M Walton, Anita Gross, P Lina Santaguida
Study Design Overview of systematic reviews. Background The evaluation of psychometric properties of neck Patient-Reported Outcome Measures (PROMs) from multiple systematic reviews (SRs) will provide a broader view and may identify potential conflicting or consistent results for their psychometric properties. Objective The purpose of this study was to conduct an overview of SRs and synthesize evidence to establish the current state of knowledge on psychometric properties of PROM's for patients with neck disorders...
June 22, 2018: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/29932862/subchondral-bone-and-the-osteochondral-unit-basic-science-and-clinical-implications-in-sports-medicine
#19
Bryan M Saltzman, Jonathan C Riboh
CONTEXT: Articular cartilage injuries and early osteoarthritis are among the most common conditions seen by sports medicine physicians. Nonetheless, treatment options for articular degeneration are limited once the osteoarthritic cascade has started. Intense research is focused on the use of biologics, cartilage regeneration, and transplantation to help maintain and improve cartilage health. An underappreciated component of joint health is the subchondral bone. EVIDENCE ACQUISITION: A comprehensive, nonsystematic review of the published literature was completed via a PubMed/MEDLINE search of the keywords "subchondral" AND "bone" from database inception through December 1, 2016...
June 1, 2018: Sports Health
https://www.readbyqxmd.com/read/29932847/a-population-based-examination-of-trends-and-disparities-in-medication-treatment-for-opioid-use-disorders-among-medicaid-enrollees
#20
Bradley D Stein, Andrew W Dick, Mark Sorbero, Adam J Gordon, Rachel M Burns, Douglas L Leslie, Rosalie Liccardo Pacula
BACKGROUND: Medication treatment (MT) with methadone and buprenorphine are effective treatments for opioid use disorders, but little information is available regarding the extent to which buprenorphine's approval resulted in more individuals receiving MT nor to what extent receipt of such treatment was equitable across communities. METHODS: To examine changes in MT utilization and the association between MT utilization and county-level indicators of poverty, race/ethnicity, and urbanicity, we used Medicaid claims of non-dually eligible Medicaid enrollees aged 18-64 from 14 states for 2002-2009...
June 22, 2018: Substance Abuse
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