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https://www.readbyqxmd.com/read/28351046/retinal-vein-occlusions
#1
Jost B Jonas, Jordi Monés, Agnès Glacet-Bernard, Gabriel Coscas
Retinal vein occlusions (RVOs) have been defined as retinal vascular disorders characterized by dilatation of retinal veins with retinal and subretinal hemorrhages, macular edema, and a varying degree of retinal ischemia. Retinal angiography, either as fluorescein and indocyanine green (ICG) angiography or in the form of optical coherence tomography (OCT)-based angiography, is essential for the diagnosis and assessment of the prognosis of RVOs. It allows the differentiation of diverse types of RVOs, such as perfused or nonperfused, as well as the detection of different modalities in the natural history of RVOs...
2017: Developments in Ophthalmology
https://www.readbyqxmd.com/read/28351035/resting-state-functional-connectivity-changes-associated-with-visuospatial-cognitive-deficits-in-patients-with-mild-alzheimer-disease
#2
Rakesh Balachandar, Srikala Bharath, John P John, Himanshu Joshi, Shilpa Sadanand, Jitender Saini, Keshav J Kumar, Mathew Varghese
BACKGROUND/AIMS: Alzheimer disease (AD) is a neurodegenerative disorder characterized by progressive disconnection of various brain networks leading to neuropsychological impairment. Pathology in the visual association areas has been documented in presymptomatic AD and therefore we aimed at examining the relationship between brain connectivity and visuospatial (VS) cognitive deficits in early AD. METHODS: Tests for VS working memory, episodic memory and construction were used to classify patients with AD (n = 48) as having severe VS deficits (n = 12, female = 4) or mild deficits (n = 11, female = 4)...
March 29, 2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/28351023/effect-of-door-locking-policy-on-inpatient-treatment-of-substance-use-and-dual-disorders
#3
Regine Steinauer, Christian G Huber, Sylvie Petitjean, Gerhard A Wiesbeck, Kenneth M Dürsteler, Undine E Lang, Christian Seifert, Katja Andreeff, Michael Krausz, Marc Walter, Marc Vogel
OBJECTIVE: Substance use treatment is often performed inside locked wards. We investigate the effects of adopting a policy of open-door treatment for a substance use treatment and dual diagnosis ward. METHODS: This is a prospective open-label study investigating 3-month study periods before opening (P1), immediately after (P2), and 1 year after the first period (P3). Data on committed patients, coercion (seclusion, forced medication, absconding events with subsequent police search), violence, and substance use was collected daily...
March 29, 2017: European Addiction Research
https://www.readbyqxmd.com/read/28351022/reference-values-and-factors-associated-with-musculoskeletal-symptoms-in-healthy-adolescents-and-adults
#4
Jennifer N Baldwin, Marnee J McKay, Niamh Moloney, Claire E Hiller, Elizabeth J Nightingale, Joshua Burns
BACKGROUND: Insufficient attention has been given to individuals who report musculoskeletal symptoms yet experience minimal disability. OBJECTIVES: To examine musculoskeletal symptoms among healthy individuals, and compare demographic, psychological and physical factors between individuals with and without symptoms. DESIGN: Cross-sectional observational study. METHOD: Data were from the 1000 Norms Project which recruited 1000 individuals aged 3-101 years...
March 23, 2017: Musculoskelet Sci Pract
https://www.readbyqxmd.com/read/28351004/temporal-changes-in-the-prevalence-of-disordered-eating-behaviors-among-adolescents-living-in-the-metropolitan-area-of-rio-de-janeiro-brazil
#5
Danilo Dias Santana, Erica Guimarães Barros, Rosana Salles da Costa, Gloria Valeria da Veiga
To investigate temporal changes in the prevalence of disordered eating behaviors among adolescents, and their association with socio demographic factors and overweight. Using probability sampling, two population-based cross-sectional surveys were conducted: one in 2005 (n=511) and the other in 2010 (n=314). The frequency of disordered eating behaviors (binge eating, strict dieting or fasting and compensatory behaviors) was investigated using a self-administered questionnaire. The presence of binge eating increased by 18...
March 21, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28350990/the-putative-drp1-inhibitor-mdivi-1-is-a-reversible-mitochondrial-complex-i-inhibitor-that-modulates-reactive-oxygen-species
#6
Evan A Bordt, Pascaline Clerc, Brian A Roelofs, Andrew J Saladino, László Tretter, Vera Adam-Vizi, Edward Cherok, Ahmed Khalil, Nagendra Yadava, Shealinna X Ge, T Chase Francis, Nolan W Kennedy, Lora K Picton, Tanya Kumar, Sruti Uppuluri, Alexandrea M Miller, Kie Itoh, Mariusz Karbowski, Hiromi Sesaki, R Blake Hill, Brian M Polster
Mitochondrial fission mediated by the GTPase dynamin-related protein 1 (Drp1) is an attractive drug target in numerous maladies that range from heart disease to neurodegenerative disorders. The compound mdivi-1 is widely reported to inhibit Drp1-dependent fission, elongate mitochondria, and mitigate brain injury. Here, we show that mdivi-1 reversibly inhibits mitochondrial complex I-dependent O2 consumption and reverse electron transfer-mediated reactive oxygen species (ROS) production at concentrations (e...
March 27, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28350968/induced-pluripotent-stem-cell-derived-cardiomyocytes-cardiac-applications-opportunities-and-challenges
#7
Adrien Moreau, Mohamed Boutjdir, Mohamed Chahine
Chronic diseases are the primary cause of mortality worldwide, accounting for 67% of deaths. One of the major challenges in developing new treatments is the lack of understanding of the exact underlying biological and molecular mechanisms. Chronic cardiovascular diseases are the single most common cause of death worldwide, and sudden deaths due to cardiac arrhythmias account for approximately 50% of all such cases. Traditional genetic screening for genes involved in cardiac disorders is laborious and frequently fails to detect the mutation that explains or causes the disorder...
March 28, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28350951/novel-osteobiologics-and-biomaterials-in-the-treatment-of-spinal-disorders
#8
Wellington K Hsu, Christina L Goldstein, Mohammed F Shamji, Sam K Cho, Paul M Arnold, Michael G Fehlings, Tom E Mroz
Spinal osteobiologics have evolved substantially in this century after the development of many product categories such as growth factors, allograft, and stem cells. The indications for the use of novel biologics within spine surgery are rapidly expanding as the mechanism of each is elucidated. While the knowledge base of bone morphogenetic protein increases with each subsequent year, the application of new nanotechnology and cell-based strategies are being reported. This review will discuss the most recent data in novel osteobiologics, and where we could use future study...
March 1, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28350949/state-of-the-art-in-degenerative-cervical-myelopathy-an-update-on-current-clinical-evidence
#9
Jefferson R Wilson, Lindsay A Tetreault, Jun Kim, Mohammed F Shamji, James S Harrop, Thomas Mroz, Samuel Cho, Michael G Fehlings
Degenerative cervical myelopathy (DCM) is a common cause of spinal cord dysfunction that confronts clinicians on a daily basis. Research performed over the past few decades has provided improved insight into the diagnosis, evaluation, and treatment of this disorder. We aim to provide clinicians with an update regarding the state of the art in DCM, focusing on more recent research pertaining to pathophysiology, natural history, treatment, consideration of the minimally symptomatic patient, surgical outcome prediction, and outcome measurement...
March 1, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28350850/defective-bone-repair-in-mast-cell-deficient-cpa3cre-mice
#10
Jose Luis Ramirez-GarciaLuna, Daniel Chan, Robert Samberg, Mira Abou-Rjeili, Timothy H Wong, Ailian Li, Thorsten B Feyerabend, Hans-Reimer Rodewald, Janet E Henderson, Paul A Martineau
In the adult skeleton, cells of the immune system interact with those of the skeleton during all phases of bone repair to influence the outcome. Mast cells are immune cells best known for their pathologic role in allergy, and may be involved in chronic inflammatory and fibrotic disorders. Potential roles for mast cells in tissue homeostasis, vascularization and repair remain enigmatic. Previous studies in combined mast cell- and Kit-deficient KitW-sh/W-sh mice (KitW-sh) implicated mast cells in bone repair but KitW-sh mice suffer from additional Kit-dependent hematopoietic and non- hematopoietic deficiencies that could have confounded the outcome...
2017: PloS One
https://www.readbyqxmd.com/read/28350844/isolation-and-characterization-of-alternatively-spliced-variants-of-the-mouse-sigma1-receptor-gene-sigmar1
#11
Ling Pan, David A Pasternak, Jin Xu, Mingming Xu, Zhigang Lu, Gavril W Pasternak, Ying-Xian Pan
The sigma1 receptor acts as a chaperone at the endoplasmic reticulum, associates with multiple proteins in various cellular systems, and involves in a number of diseases, such as addiction, pain, cancer and psychiatric disorders. The sigma1 receptor is encoded by the single copy SIGMAR1 gene. The current study identifies five alternatively spliced variants of the mouse sigma1 receptor gene using a polymerase chain reaction cloning approach. All the splice variants are generated by exon skipping or alternative 3' or 5' splicing, producing the truncated sigma1 receptor...
2017: PloS One
https://www.readbyqxmd.com/read/28350822/asthma-corticosteroid-use-and-schizophrenia-a-nationwide-population-based-study-in-taiwan
#12
Wei-Chen Wang, Mong-Liang Lu, Vincent Chin-Hung Chen, Mei-Hing Ng, Kuo-You Huang, Ming-Hong Hsieh, Meng-Jer Hsieh, Roger S McIntyre, Yena Lee, Charles Tzu-Chi Lee
OBJECTIVE: Asthma and corticosteroid use have been implicated as possible risk factors for schizophrenia. The retrospective cohort study herein aimed to investigate the association between asthma, corticosteroid use, and schizophrenia. METHOD: Longitudinal data (2000 to 2007) from adults with asthma (n = 50,046) and without asthma (n = 50,046) were compared on measures of schizophrenia incidence using Taiwan's National Health Insurance Research Database (NHIRD)...
2017: PloS One
https://www.readbyqxmd.com/read/28350808/differential-recruitment-efficacy-of-patient-derived-amyloidogenic-and-myeloma-light-chain-proteins-by-synthetic-fibrils-a-metric-for-predicting-amyloid-propensity
#13
Emily B Martin, Angela Williams, Craig Wooliver, R Eric Heidel, Sarah Adams, John Dunlap, Marina Ramirez-Alvarado, Luis M Blancas-Mejia, Ronald H Lands, Stephen J Kennel, Jonathan S Wall
BACKGROUND: Monoclonal free light chain (LC) proteins are present in the circulation of patients with immunoproliferative disorders such as light chain (AL) amyloidosis and multiple myeloma (MM). Light chain-associated amyloid is a complex pathology composed of proteinaceous fibrils and extracellular matrix proteins found in all patients with AL and in ~10-30% of patients who presented with MM. Amyloid deposits systemically in multiple organs and tissues leading to dysfunction and ultimately death...
2017: PloS One
https://www.readbyqxmd.com/read/28350795/fine-mapping-of-the-human-leukocyte-antigen-locus-as-a-risk-factor-for-alzheimer-disease-a-case-control-study
#14
Natasha Z R Steele, Jessie S Carr, Luke W Bonham, Ethan G Geier, Vincent Damotte, Zachary A Miller, Rahul S Desikan, Kevin L Boehme, Shubhabrata Mukherjee, Paul K Crane, John S K Kauwe, Joel H Kramer, Bruce L Miller, Giovanni Coppola, Jill A Hollenbach, Yadong Huang, Jennifer S Yokoyama
BACKGROUND: Alzheimer disease (AD) is a progressive disorder that affects cognitive function. There is increasing support for the role of neuroinflammation and aberrant immune regulation in the pathophysiology of AD. The immunoregulatory human leukocyte antigen (HLA) complex has been linked to susceptibility for a number of neurodegenerative diseases, including AD; however, studies to date have failed to consistently identify a risk HLA haplotype for AD. Contributing to this difficulty are the complex genetic organization of the HLA region, differences in sequencing and allelic imputation methods, and diversity across ethnic populations...
March 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28350677/insight-into-the-pathophysiologic-mechanisms-behind-cognitive-dysfunction-in-trigonocephaly
#15
Joris J B van der Vlugt, Jacques J M N van der Meulen, Robert R J Coebergh van den Braak, Christl Vermeij-Keers, Edwin G C Horstman, Steven E R Hovius, Frank C Verhulst, André I Wierdsma, Maarten H Lequin, Jolanda M E Okkerse
BACKGROUND: The relationship between trigonocephaly and cognitive problems might be explained by: secondary mechanical factors related to growth restriction of the skull, and primary structural defects caused by a shared mechanism related to brain developmental disorder(s) and skull malformation. However, because the exact pathophysiology remains unknown, we examined the pathophysiologic mechanisms behind cognitive dysfunction in patients with trigonocephaly, with an aim of providing a model for cognitive dysfunction based on routinely available variables...
April 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28350673/the-effect-of-workers-compensation-on-outcome-measurement-methods-after-upper-extremity-surgery-a-systematic-review-and-meta-analysis
#16
Yuki Fujihara, Melissa J Shauver, Meghan E Lark, Lin Zhong, Kevin C Chung
BACKGROUND: Patients who receive workers' compensation often display worse surgical results, such as prolonged pain or reduced functional ability. The outcomes of surgery can be assessed using a variety of surveys, assessments, and measurements. It is unknown whether the confounding effect differs based on how results are measured. The aim of this study was to determine whether these variations exist. METHODS: A search of full-length articles published between January 1, 1995, and December 31, 2015, was conducted using 3 online databases...
April 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28350624/application-of-scanning-electron-microscopy-with-energy-dispersive-x-ray-spectroscopy-for-analyzing-ocular-surface-particles-on-schirmer-strips
#17
Anuroop Avula, Anat Galor, Patricia Blackwelder, Melissa Carballosa-Gautam, Abigail S Hackam, Bennie Jeng, Naresh Kumar
PURPOSE: To demonstrate the application of scanning electron microscopy with energy-dispersive x-ray spectroscopy (SEM/EDS) for analyzing Schirmer strips for particle concentration, size, morphology, and type distribution. METHODS: A cross-sectional design was used. Patients were prospectively recruited from the Miami Veterans Affairs (VA) Healthcare System eye clinic, and they underwent a complete ocular surface examination. The size, type, and chemical composition of particulate matter on Schirmer strips (from the left eye) were analyzed using SEM/EDS...
March 21, 2017: Cornea
https://www.readbyqxmd.com/read/28350563/predicting-the-mental-health-and-functioning-of-torture-survivors
#18
Suzan J Song, Andrew Subica, Charles Kaplan, Wietse Tol, Joop de Jong
The psychological effects of war represent a growing public health concern as more refugees and asylum seekers migrate across borders. This study investigates whether sociodemographic, premigration and postmigration, and psychosocial factors predict adverse psychiatric symptoms in refugees and asylum seekers exposed to torture (N = 278). Hierarchical linear regressions revealed that female sex, older age, and unstable housing predicted greater severity of anxiety, posttraumatic stress disorder (PTSD), and depression...
March 27, 2017: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/28350551/the-impact-of-a-violent-physical-assault-on-a-registered-nurse-her-healing-journey-and-return-to-work
#19
Holly Graham
Healthcare practitioners are at an increased risk for workplace violence. What happens to a practitioner after a devastating physical assault from a patient in the workplace? This case report describes the impact of a violent assault on a registered nurse and her healing journey and return to the workplace. The Department of Veteran Affairs/Department of Defense "Clinical Practice Guidelines for Posttraumatic Stress Disorder" outline three categories of risk factors that are associated with the development of posttraumatic stress disorder: pretraumatic factors, peritraumatic or trauma-related factors, and posttraumatic factors...
March 28, 2017: Journal of Forensic Nursing
https://www.readbyqxmd.com/read/28350467/relating-chromophoric-and-structural-disorder-in-conjugated-polymers
#20
Lena Simine, Peter J Rossky
The optoelectronic properties of amorphous conjugated polymers are sensitive to the details of the conformational disorder and spectroscopy provides the means for structural characterization of the fragments of the chain which interact with light - "chromophores". A faithful interpretation of spectroscopic conformational signatures, however, presents a theoretical challenge. Here we investigate the relationship between the ground state optical gaps, the properties of the excited states, and the structural features of chromophores of a single molecule poly(3-hexyl)-thiophene (P3HT), using quantum-classical atomistic simulations...
March 28, 2017: Journal of Physical Chemistry Letters
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