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https://www.readbyqxmd.com/read/25371841/autoimmune-gastrointestinal-paralysis-failure-of-conventional-treatment-without-immunomodulation
#1
Craig Weinkauf, Sean McPhillips, Robert Krouse, Ira Levine
The treatment of the rare enteric nervous system (ENS) manifestations of paraneoplastic syndromes, which are most frequently associated with small cell lung cancer (SCLC), is poorly understood and described. Patients with neuroendocrine-derived tumors can develop B-cell reactivity towards the tumor with cross-reactivity for neurons located in the submucosal and myenteric ganglia of the ENS. The ensuing autoimmune neuritis causes aperistalsis and severe gastrointestinal (GI) dysfunction. Immune-directed therapy is not the standard of care but may be paramount for patient recovery...
2014: Case Reports in Surgery
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