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heterologous immunity

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https://www.readbyqxmd.com/read/29777415/preparation-of-biologically-active-monomeric-recombinant-zebrafish-danio-rerio-and-rainbow-trout-oncorhynchus-mykiss-recombinant-growth-hormones
#1
Ewa Ocłoń, Gili Solomon, Zvi Hayouka, Arieh Gertler
Fish growth hormones (GHs) play an important role in regulating growth, metabolism, reproduction, osmoregulation, and immunity and have thus garnered attention for their application in aquaculture. Zebrafish GH (zGH) cDNA or rainbow trout GH (rtGH) cDNA was cloned into the pMon3401 vector, expressed in MON105-competent Escherichia coli and purified to homogeneity. Their biological activity was evidenced by their ability to interact with ovine GH receptor extracellular domain and stimulate GH receptor-mediated proliferation in FDC-P1-3B9 cells stably transfected with rabbit GH receptor...
May 18, 2018: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/29770135/mucosal-immunity-and-protective-efficacy-of-intranasal-inactivated-influenza-vaccine-is-improved-by-chitosan-nanoparticle-delivery-in-pigs
#2
Santosh Dhakal, Sankar Renu, Shristi Ghimire, Yashavanth Shaan Lakshmanappa, Bradley T Hogshead, Ninoshkaly Feliciano-Ruiz, Fangjia Lu, Harm HogenEsch, Steven Krakowka, Chang Won Lee, Gourapura J Renukaradhya
Annually, swine influenza A virus (SwIAV) causes severe economic loss to swine industry. Currently used inactivated SwIAV vaccines administered by intramuscular injection provide homologous protection, but limited heterologous protection against constantly evolving field viruses, attributable to the induction of inadequate levels of mucosal IgA and cellular immune responses in the respiratory tract. A novel vaccine delivery platform using mucoadhesive chitosan nanoparticles (CNPs) administered through intranasal (IN) route has the potential to elicit strong mucosal and systemic immune responses in pigs...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29769376/-lactobacillus-mucosal-vaccine-vectors-immune-responses-against-bacterial-and-viral-antigens
#3
REVIEW
Jonathan S LeCureux, Gregg A Dean
Lactic acid bacteria (LAB) have been utilized since the 1990s for therapeutic heterologous gene expression. The ability of LAB to elicit an immune response against expressed foreign antigens has led to their exploration as potential mucosal vaccine candidates. LAB vaccine vectors offer many attractive advantages: simple, noninvasive administration (usually oral or intranasal), the acceptance and stability of genetic modifications, relatively low cost, and the highest level of safety possible. Experimentation using LAB of the genus Lactobacillus has become popular in recent years due to their ability to elicit strong systemic and mucosal immune responses...
June 27, 2018: MSphere
https://www.readbyqxmd.com/read/29769087/replacement-of-feline-foamy-virus-bet-by-feline-immunodeficiency-virus-vif-yields-replicative-virus-with-novel-vaccine-candidate-potential
#4
Carmen Ledesma-Feliciano, Sarah Hagen, Ryan Troyer, Xin Zheng, Esther Musselman, Dragana Slavkovic Lukic, Ann-Mareen Franke, Daniel Maeda, Jörg Zielonka, Carsten Münk, Guochao Wei, Sue VandeWoude, Martin Löchelt
BACKGROUND: Hosts are able to restrict viral replication to contain virus spread before adaptive immunity is fully initiated. Many viruses have acquired genes directly counteracting intrinsic restriction mechanisms. This phenomenon has led to a co-evolutionary signature for both the virus and host which often provides a barrier against interspecies transmission events. Through different mechanisms of action, but with similar consequences, spumaviral feline foamy virus (FFV) Bet and lentiviral feline immunodeficiency virus (FIV) Vif counteract feline APOBEC3 (feA3) restriction factors that lead to hypermutation and degradation of retroviral DNA genomes...
May 16, 2018: Retrovirology
https://www.readbyqxmd.com/read/29760700/bacillus-calmette-gu%C3%A3-rin-induced-trained-immunity-is-not-protective-for-experimental-influenza-a-anhui-1-2013-h7n9-infection-in-mice
#5
Charlotte L C J de Bree, Renoud J Marijnissen, Junda M Kel, Sietske K Rosendahl Huber, Peter Aaby, Christine Stabell Benn, Marcel V W Wijnands, Dimitri A Diavatopoulos, Reinout van Crevel, Leo A B Joosten, Mihai G Netea, John Dulos
Avian influenza A of the subtype H7N9 has been responsible for almost 1,600 confirmed human infections and more than 600 deaths since its first outbreak in 2013. Although sustained human-to-human transmission has not been reported yet, further adaptations to humans in the viral genome could potentially lead to an influenza pandemic, which may have severe consequences due to the absence of pre-existent immunity to this strain at population level. Currently there is no influenza A (H7N9) vaccine available. Therefore, in case of a pandemic outbreak, alternative preventive approaches are needed, ideally even independent of the type of influenza virus outbreak...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29759379/simultaneous-surface-display-and-cargo-loading-of-encapsulin-nanocompartments-and-their-use-for-rational-vaccine-design
#6
Priscillia Lagoutte, Charlotte Mignon, Gustavo Stadthagen, Supanee Potisopon, Stéphanie Donnat, Jan Mast, Adrien Lugari, Bettina Werle
In the past decades protein nanoparticles have successfully been used for vaccine applications. Their particulate nature and dense repetitive subunit organization makes them perfect carriers for antigen surface display and confers high immunogenicity. Nanoparticles have emerged as excellent candidates for vectorization of biological and immunostimulating molecules. Nanoparticles and biomolecular nanostructures such as ferritins or virus like particles have been used as diagnostic and therapeutic delivery systems, in vaccine development, as nanoreactors, etc...
May 11, 2018: Vaccine
https://www.readbyqxmd.com/read/29758054/effect-of-fusion-protein-cleavage-site-sequence-on-generation-of-a-genotype-vii-newcastle-disease-virus-vaccine
#7
Vinoth K Manoharan, Berin P Varghese, Anandan Paldurai, Siba K Samal
Newcastle disease (ND) causes severe economic loss to poultry industry worldwide. Frequent outbreaks of ND in commercial chickens vaccinated with live vaccines suggest a need to develop improved vaccines that are genetically matched against circulating Newcastle disease virus (NDV) strains. In this study, the fusion protein cleavage site (FPCS) sequence of NDV strain Banjarmasin/010 (Banj), a genotype VII NDV, was individually modified using primer mutagenesis to those of avian paramyxovirus (APMV) serotypes 2, 7 and 8 and compared with the recombinant Banjarmasin (rBanj) with avirulent NDV LaSota cleavage site (rBanj-LaSota)...
2018: PloS One
https://www.readbyqxmd.com/read/29755458/flexible-signaling-of-myeloid-c-type-lectin-receptors-in-immunity-and-inflammation
#8
REVIEW
Carlos Del Fresno, Salvador Iborra, Paula Saz-Leal, María Martínez-López, David Sancho
Myeloid C-type lectin receptors (CLRs) are important sensors of self and non-self that work in concert with other pattern recognition receptors (PRRs). CLRs have been previously classified based on their signaling motifs as activating or inhibitory receptors. However, specific features of the ligand binding process may result in distinct signaling through a single motif, resulting in the triggering of non-canonical pathways. In addition, CLR ligands are frequently exposed in complex structures that simultaneously bind different CLRs and other PRRs, which lead to integration of heterologous signaling among diverse receptors...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29742421/modular-study-of-the-type-iii-effector-repertoire-in-pseudomonas-syringae-pv-tomato-dc3000-reveals-a-matrix-of-effector-interplay-in-pathogenesis
#9
Hai-Lei Wei, Wei Zhang, Alan Collmer
The bacterial pathogen Pseudomonas syringae pv. tomato DC3000 suppresses the two-tiered innate immune system of Nicotiana benthamiana and other plants by injecting a complex repertoire of type III secretion effector (T3E) proteins. Effectorless polymutant DC3000D36E was used with a modularized system for native delivery of the 29 DC3000 T3Es singly and in pairs. Assays of the performance of this T3E library in N. benthamiana leaves revealed a matrix of T3E interplay, with six T3Es eliciting death and eight others variously suppressing the death activity of the six...
May 8, 2018: Cell Reports
https://www.readbyqxmd.com/read/29739720/heterologous-prime-boost-vaccination-with-adenoviral-vector-and-protein-nanoparticles-induces-both-th1-and-th2-responses-against-middle-east-respiratory-syndrome-coronavirus
#10
Seo-Yeon Jung, Kyung Won Kang, Eun-Young Lee, Dong-Won Seo, Hong-Lim Kim, Hak Kim, TaeWoo Kwon, Hye-Lim Park, Hun Kim, Sang-Myeong Lee, Jae-Hwan Nam
The Middle East respiratory syndrome coronavirus (MERS-CoV) is a highly pathogenic and zoonotic virus with a fatality rate in humans of over 35%. Although several vaccine candidates have been developed, there is still no clinically available vaccine for MERS-CoV. In this study, we developed two types of MERS-CoV vaccines: a recombinant adenovirus serotype 5 encoding the MERS-CoV spike gene (Ad5/MERS) and spike protein nanoparticles formulated with aluminum (alum) adjuvant. Next, we tested a heterologous prime-boost vaccine strategy, which compared priming with Ad5/MERS and boosting with spike protein nanoparticles and vice versa, with homologous prime-boost vaccination comprising priming and boosting with either spike protein nanoparticles or Ad5/MERS...
May 5, 2018: Vaccine
https://www.readbyqxmd.com/read/29739716/the-immunogenicity-and-protection-effect-of-an-inactivated-coxsackievirus-a6-a10-and-a16-vaccine-against-hand-foot-and-mouth-disease
#11
Heeji Lim, Hyun Ju In, Jung-Ah Lee, Jung Sik Yoo, Sang-Won Lee, Gyung Tae Chung, Young Ki Choi, Jae Keun Chung, Sun Ju Cho, June-Woo Lee
Coxsackievirus belongs to the Enterovirus genus of the Picornaviridae family and is one of the major pathogens associated with human hand, foot, and mouth disease (HFMD). Historically, outbreaks of HFMD have mainly been caused by enterovirus 71 and coxsackievirus A16. Recently, coxsackieviruses A6 and A10 have been associated with increased occurrences of sporadic HFMD cases and outbreak events globally. In this study, the immunogenicity of coxsackieviruses A6, A10, and A16 (CA6, CA10, and CA16), which were inactivated by formalin or β-propiolactone (BPL) under different conditions, was evaluated as multivalent vaccine candidates...
May 5, 2018: Vaccine
https://www.readbyqxmd.com/read/29735521/the-complement-system-contributes-to-functional-antibody-mediated-responses-induced-by-immunization-with-plasmodium-falciparum-malaria-sporozoites
#12
Marije C Behet, Liriye Kurtovic, Geert-Jan van Gemert, Celine M Haukes, Rianne Siebelink-Stoter, Wouter Graumans, Marga G van de Vegte-Bolmer, Anja Scholzen, Jeroen D Langereis, Dimitri A Diavatopoulos, James G Beeson, Robert W Sauerwein
Long-lasting and sterile homologous protection against malaria can be achieved by exposure of malaria-naive volunteers under chemoprophylaxis to Plasmodium falciparum -infected mosquitoes (CPS-immunization). While CPS-induced antibodies neutralize sporozoite infectivity in vitro and in vivo , antibody-mediated effector mechanisms are still poorly understood. Here, it was investigated whether complement contributes to CPS-induced pre-erythrocytic immunity.Sera collected before and after CPS-immunization in the presence of active or inactive complement were assessed for recognition of homologous NF54 and heterologous NF135...
May 7, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29735483/inability-to-detect-cross-reactive-memory-t-cells-challenges-the-frequency-of-heterologous-immunity-among-common-viruses
#13
Louise C Rowntree, Thi H O Nguyen, Hanim Halim, Anthony W Purcell, Jamie Rossjohn, Stephanie Gras, Tom C Kotsimbos, Nicole A Mifsud
Human memory T cells that cross-react with epitopes from unrelated viruses can potentially modulate immune responses to subsequent infections by a phenomenon termed heterologous immunity. However, it is unclear whether similarities in structure rather than sequence underpin heterologous T cell cross-reactivity. In this study, we aimed to explore the mechanism of heterologous immunity involving immunodominant epitopes derived from common viruses restricted to high-frequency HLA allotypes (HLA-A*02:01, -B*07:02, and -B*08:01)...
May 7, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29735416/corrigendum-to-heterologous-two-dose-vaccination-with-simian-adenovirus-and-poxvirus-vectors-elicits-long-lasting-cellular-immunity-to-influenza-virus-a-in-healthy-adults-ebiomedicine-29-2018-146-154
#14
L Coughlan, S Sridhar, R Payne, M Edmans, A Milicic, N Venkatraman, B Lugonja, L Clifton, C Qi, P M Folegatti, A M Lawrie, R Roberts, H de Graaf, P Sukhtankar, S N Faust, D J M Lewis, T Lambe, A V S Hill, S C Gilbert
No abstract text is available yet for this article.
May 4, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29730007/molecular-cloning-and-functional-characterization-of-cathepsin-b-from-nile-tilapia-oreochromis-niloticus
#15
Fu-Rui Liang, Hui-Shi He, Chu-Wen Zhang, Xiao-Ming Xu, Zhao-Ping Zeng, Jian-Ping Yuan, Yue-Hui Hong, Jiang-Hai Wang
Cathepsin B (CatB) has been widely known for its hydrolytic ability and involvement in the innate immunity. However, the mechanism of CatB from teleosts participating in immunoregulation remains poorly understood; and the sequence of CatB from Nile tilapia (NtCatB) has not been cloned and characterized. In this study, the coding sequence of NtCatB was cloned, and then characterized by bioinformatic analysis and heterologous expression. The deduced amino acid sequence (330-aa) of NtCatB contains the representative features of CatB...
May 3, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29726930/functional-variants-in-tbx2-are-associated-with-a-syndromic-cardiovascular-and-skeletal-developmental-disorder
#16
Ning Liu, Kelly Schoch, Xi Luo, Loren Pena, Venkata Hemanjani Bhavana, Mary K Kukolich, Sarah Stringer, Zöe Powis, Kelly Radtke, Cameron Mroske, Kristen Deak, Marie T McDonald, Allyn McConkie-Rosell, M Louise Markert, Peter G Kranz, Nicholas Stong, Anna C Need, David Bick, Michelle D Amaral, Elizabeth A Worthey, Shawn Levy, Michael F Wangler, Hugo J Bellen, Shashi Vandana, Shinya Yamamoto
The seventeen genes of the T-box family are transcriptional regulators that are involved in all stages of embryonic development, including craniofacial, brain, heart, skeleton and immune system. Malformation syndromes have been linked to many of the T-box genes. For example, haploinsufficiency of TBX1 is responsible for many structural malformations in DiGeorge syndrome caused by a chromosome 22q11.2 deletion. We report four individuals with an overlapping spectrum of craniofacial dysmorphisms, cardiac anomalies, skeletal malformations, immune deficiency, endocrine abnormalities and developmental impairments, reminiscent of DiGeorge syndrome, who are heterozygotes for TBX2 variants...
May 2, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29725025/single-vector-platform-vaccine-protects-against-lethal-respiratory-challenge-with-tier-1-select-agents-of-anthrax-plague-and-tularemia
#17
Qingmei Jia, Richard Bowen, Barbara Jane Dillon, Saša Masleša-Galić, Brennan T Chang, Austin C Kaidi, Marcus A Horwitz
Bacillus anthracis, Yersinia pestis, and Francisella tularensis are the causative agents of Tier 1 Select Agents anthrax, plague, and tularemia, respectively. Currently, there are no licensed vaccines against plague and tularemia and the licensed anthrax vaccine is suboptimal. Here we report F. tularensis LVS ΔcapB (Live Vaccine Strain with a deletion in capB)- and attenuated multi-deletional Listeria monocytogenes (Lm)-vectored vaccines against all three aforementioned pathogens. We show that LVS ΔcapB- and Lm-vectored vaccines express recombinant B...
May 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29723973/comparative-pathogenesis-of-asian-and-african-lineage-zika-virus-in-indian-rhesus-macaque-s-and-development-of-a-non-human-primate-model-suitable-for-the-evaluation-of-new-drugs-and-vaccines
#18
Jonathan O Rayner, Raj Kalkeri, Scott Goebel, Zhaohui Cai, Brian Green, Shuling Lin, Beth Snyder, Kimberly Hagelin, Kevin B Walters, Fusataka Koide
The establishment of a well characterized non-human primate model of Zika virus (ZIKV) infection is critical for the development of medical interventions. In this study, challenging Indian rhesus macaques (IRMs) with ZIKV strains of the Asian lineage resulted in dose-dependent peak viral loads between days 2 and 5 post infection and a robust immune response which protected the animals from homologous and heterologous re-challenge. In contrast, viremia in IRMs challenged with an African lineage strain was below the assay’s lower limit of quantitation, and the immune response was insufficient to protect from re-challenge...
May 1, 2018: Viruses
https://www.readbyqxmd.com/read/29713644/the-therapeutic-effects-after-transplantation-of-whole-layer-olfactory-mucosa-in-rats-with-optic-nerve-injury
#19
Shun Gong, Hai Jin, Danfeng Zhang, Wei Zou, Chunhui Wang, Zhenxing Li, Rongbin Chen, Yan Dong, Lijun Hou
Background: Existing evidence suggests the potential therapy of transplanting olfactory ensheathing cells (OEC) either alone or in combination with neurotrophic factors or other cell types in optic nerve injury (ONI). However, clinical use of autologous OEC in the acute stages of ONI is not possible. On the other hand, acute application of heterologous transplantation may bring the issue of immune rejection. The olfactory mucosa (OM) with OEC in the lamina propria layer is located in the upper region of the nasal cavity and is easy to dissect under nasal endoscopy, which makes it a candidate as autograft material in acute stages of ONI...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29713324/antibodies-reactive-to-commensal-streptococcus-mitis-show-cross-reactivity-with-virulent-streptococcus-pneumoniae-serotypes
#20
Sudhanshu Shekhar, Rabia Khan, Daniela M Ferreira, Elena Mitsi, Esther German, Gro Herredsvela Rørvik, Dag Berild, Karl Schenck, Keehwan Kwon, Fernanda Petersen
Current vaccines against Streptococcus pneumoniae , a bacterial species that afflicts people by causing a wide spectrum of diseases, do not protect against all pneumococcal serotypes. Thus, alternative vaccines to fight pneumococcal infections that target common proteins are under investigation. One promising strategy is to take advantage of immune cross-reactivity between commensal and pathogenic microbes for cross-protection. In this study, we examined the antibody-mediated cross-reactivity between S. pneumoniae and Streptococcus mitis , a commensal species closely related to S...
2018: Frontiers in Immunology
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