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Ravikant S Ganga, Dipali Gundre, Shivani Bansal, Pankaj M Shirsat, Pooja Prasad, Rajiv S Desai
OBJECTIVES: Conventional oral examination and biopsy are the only reliable methods for the early detection of oral cancer at present. Autofluorescence examination of oral tissues using the VELscope has been suggested as an adjunctive tool for cancer detection and diagnosis. The aim of our study was to evaluate the efficacy of the VELscope in recognizing dysplastic and/or neoplastic changes in oral mucosal lesions that were identified on conventional oral examination. MATERIALS AND METHODS: Two hundred patients with oral mucosal lesions were subjected to conventional oral examination followed by VELscope examination and their autofluorescence characteristics were compared with the histopathological diagnosis...
December 2017: Oral Oncology
Amerigo Giudice, Francesco Bennardo, Selene Barone, Alessandro Antonelli, Michele Mario Figliuzzi, Leonzio Fortunato
PURPOSE: The main limitation of surgical treatment of medication-related osteonecrosis of the jaw (MRONJ) is difficulty in defining resection margins. The aim of this study was to compare the efficacy of the surgeon's experience and autofluorescence-guided bone surgery to delimit resection margins for necrotic bone. MATERIALS AND METHODS: MRONJ requiring surgical treatment was classified according to American Association of Oral and Maxillofacial Surgeons staging...
May 2018: Journal of Oral and Maxillofacial Surgery
Nanami Yamamoto, Koji Kawaguchi, Hisako Fujihara, Mitsuhiko Hasebe, Yuta Kishi, Masaaki Yasukawa, Kenichi Kumagai, Yoshiki Hamada
The autofluorescence visualization method (AVM) uses blue excitation light to assist in the diagnosis of epithelial dysplasia. It detects epithelial dysplasia as a black area, which is known as fluorescence visualization loss (FVL). In this study, we evaluated the detection accuracy for epithelial dysplasia of the tongue using the objective AVM and assessed its possible clinical utility. Seventy-nine tongue specimens clinically suspected to have leukoplakia or squamous cell carcinoma (SCC) were analyzed. First, the AVM was subjectively performed using the Visually Enhanced Lesion scope (VELscope), and the iodine-staining method was then performed...
November 10, 2017: International Journal of Oral Science
Egon Burian, Caterina Schulz, Florian Probst, Benjamin Palla, Matthias Tröltzsch, Fabio Maglitto, Luigi Califano, Michael Ehrenfeld, Sven Otto
OBJECTIVES: Several diagnostic tools have been developed to assess benign and potentially malignant disorders of soft tissues. In this study, we aimed to assess the value of the VELscope(®) (Visually Enhanced Light Scope) imaging device as a technical tool to investigate malignant lesions of the oral cavity. MATERIAL AND METHODS: In this retrospective study we analyzed the photographs of 90 patients who suffered from malignant oral soft tissue lesions or carcinoma in situ (CIS) from 2008 to 2014 in the Clinic of Oral and Maxillofacial Surgery of LMU in Munich...
September 2017: Journal of Cranio-maxillo-facial Surgery
Tze-Ta Huang, Jehn-Shyun Huang, Yen-Yun Wang, Ken-Chung Chen, Tung-Yiu Wong, Yi-Chun Chen, Che-Wei Wu, Leong-Perng Chan, Yi-Chu Lin, Yu-Hsun Kao, Shoko Nioka, Shyng-Shiou F Yuan, Pau-Choo Chung
OBJECTIVES: VELscope® was developed to inspect oral mucosa autofluorescence. However, its accuracy is heavily dependent on the examining physician's experience. This study was aimed toward the development of a novel quantitative analysis of autofluorescence images for oral cancer screening. MATERIALS AND METHODS: Patients with either oral cancer or precancerous lesions and a control group with normal oral mucosa were enrolled in this study. White light images and VELscope® autofluorescence images of the lesions were taken with a digital camera...
May 2017: Oral Oncology
Marco Cicciù, Alan Scott Herford, Gabriele Cervino, Giuseppe Troiano, Floriana Lauritano, Luigi Laino
Oral squamous cell carcinoma is the most common form of malignancy of the oral cavity; its incidence is increasing and late-stage presentation is common. It is usually predated by oral premalignant disorders. For this reason, early diagnosis is fundamental to reduce the malignant transformation of oral premalignant disorders and for increase the survival rate for oral cancer. Scraping the surface of the lesion is useful for having cytological features of the investigated tissue. The features of smears of oral premalignant lesions are the keratinization growth (red, orange, brown), the increased nuclear area and so the nuclear hyperchromatism, the nuclear pleomorphism, and the chromatin clumping...
March 2017: Journal of Craniofacial Surgery
Sven Otto, Oliver Ristow, Christoph Pache, Matthias Troeltzsch, Riham Fliefel, Michael Ehrenfeld, Christoph Pautke
INTRODUCTION: The delineation of the necrotic bone is a crucial step in the surgical treatment of medication-related osteonecrosis of the jaw (MRONJ). Several different approaches have been described including the innovative technique of fluorescence-guided surgery. However, until now there is a lack of data regarding the outcome. Therefore, the aim of the present study is to investigate the long-term success rates of fluorescence-guided surgery in the treatment of MRONJ. PATIENTS AND METHODS: 54 Patients were prospectively assigned for surgical treatment of medication-related osteonecrosis of the jaw using fluorescence-guided surgery...
August 2016: Journal of Cranio-maxillo-facial Surgery
Yuichi Ohnishi, Tomoko Fujii, Yoshihide Ugaki, Hiroki Yasui, Masahiro Watanabe, Suguru Dateoka, Kenji Kakudo
Early detection of precancerous and early cancerous lesions could greatly reduce both the mortality and morbidity of oral cancer. The objective of this study was to analyze a fluorescence visualization (FV) system for the detection of precancerous and early cancerous lesions in rat tongue carcinogenesis and human oral cancerous lesions using for the first time a 4NQO rat model and human tissue. Based on the results from the rat tongue carcinogenesis model, under direct FV, the normal oral mucosa emitted various shades of pale green autofluorescence...
July 2016: Oncology Reports
Enric Jané-Salas, Andrés Blanco-Carrión, Lluís Jover-Armengol, José López-López
The purpose of this study was to determine the accuracy of autofluorescence techniques for diagnosing oral mucosa lesions, using as reference pattern for comparison the visual diagnosis made by a clinical specialist. A pilot study was conducted with 60 patients divided in a control group without mucosal pathology and a study group with known clinical history for mucosal pathology. Both groups were examined by an oral medicine specialist and by a general dentist who used VELscope(r) system, which applies tissue fluorescence visualization to identify oral mucosal abnormalities...
November 2015: Brazilian Dental Journal
R Nagi, Y-B Reddy-Kantharaj, N Rakesh, S Janardhan-Reddy, S Sahu
BACKGROUND: Earlier detection of oral squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMD) is essential for dental professionals to improve patient survival rates. The aim of this systematic review is to to evaluate the effectiveness of devices that utilise the principles of chemiluminescence and tissue autofluorescence as adjuncts in the detection of OSCC and OPMD. MATERIAL AND METHODS: The electronic retrieval systems and databases searched for relevant articles were PubMed [MEDLINE] and Science direct...
July 1, 2016: Medicina Oral, Patología Oral y Cirugía Bucal
Daigo Yoshiga, Masaaki Sasaguri, Kou Matsuo, Sei Yoshida, Masataka Uehara, Manabu Habu, Kazuya Haraguchi, Tatsurou Tanaka, Yasuhiro Morimoto, Izumi Yoshioka, Kazuhiro Tominaga
UNLABELLED: Diffuse chronic sclerosingosteomyelitis (DCSO) is a refractory disease, becausethe etiology and pathogenesis remain poorly understood and to determine the border betweenunhealthy boneandhealthybone is difficult. However, progressive inflammation, clinical symptoms and a high recurrence rate of DCSO were the reasons for surgical treatment. We report a case of a 66-year old woman with DCSO of the right side of mandible who was treated with hemimandibulectomy and simultaneous reconstruction by vascularized free fibula flap...
October 2015: Journal of Clinical and Experimental Dentistry
Kamran Habib Awan, Shankargouda Patil
BACKGROUND: Oral cancer is a serious global issue and early diagnosis of oral cancer is the key in reducing the high mortality rate. Autofluorescence properties of oral mucosa have been gaining interest in the field of early diagnosis of oral premalignant lesions. OBJECTIVE: The aim of the study was to evaluate the clinical usefulness of an autofluorescence based imaging system to detect oral premalignant and malignant lesions. MATERIALS AND METHODS: A systematic review of the English-language literature to evaluate the effectiveness of visually enhanced lesion scope (VELscope) published between 1966 and March, 2014 was undertaken...
September 1, 2015: Journal of Contemporary Dental Practice
Irène Hitz Lindenmüller, Paco Weiss, Michael Volken, Andreas Filippi
In the present study, the VELscope® autofluorescence device was used in addition to the Winkel Tongue Coating Index (WTCI) to evaluate tongue coating; a corresponding index was developed for evaluation with VELscope®. The distinct orange fluorescence of the tongue dorsum caused by autofluorescent bacterially colonized areas motivates halitosis patients to optimize tongue hygiene. The tongue dorsum of 100 volunteers (35 males, 65 females, average age 51 years) was photographed with and without the autofluorescence device...
2015: Swiss Dental Journal
Martin Scheer, Juliana Fuss, Mehmet Ali Derman, Matthias Kreppel, Jörg Neugebauer, Daniel Rothamel, Uta Drebber, Joachim E Zoeller
The survival of patients with oral cancer is decreased by locoregional recurrence after an initial multimodal treatment. In order to identify lesions in the oral cavity for a possible recurrence, clinical evaluation as well as MRI or CT scanning is advised. The evaluation of mucosa lesions is hampered by changes related to radio- and chemotherapy as well as reconstruction with tissue flaps. Several techniques for easier identification of tissue abnormalities in the oral cavity have been advocated as adjuncts in order to facilitate identification...
March 2016: Oral and Maxillofacial Surgery
Dania Sawan, Ammar Mashlah
AIM: The purpose of this study was the early detection of premalignant and malignant oral soft lesions by fluorescent light (VELscope). MATERIALS AND METHODS: A total of 748 patients were evaluated through clinical and fluorescent light analysis of the entire oral cavity. Any lesion that was detected underwent a surgical excision biopsy as the golden standard for the detection of the lesion's histology; then a comparison was made between the results to assure the efficacy of the fluorescent light analysis outcome...
May 2015: Journal of International Society of Preventive & Community Dentistry
Jasdeep Kaur, Reinhilde Jacobs
BACKGROUND: Normal and cancerous tissues have distinct auto-fluorescence properties because of differences in their biophysical and biochemical agents. Scientific evidences related to diagnostic fluorescence imaging for detection of oral precancerous and cancerous lesions are very limited. OBJECTIVES: The aim of this study was to find out potential relationships between serum, salivary and tissue protoporphyrin IX ( PX) levels in subjects with or without oral precancerous and cancerous lesions...
April 2015: Journal of Clinical and Experimental Dentistry
D Yoshiga, M Sasaguri, K Matsuo, S Kokuryou, M Habu, M Oda, M Kodama, H Tsurushima, O Sakaguchi, T Sakurai, J Tanaka, Y Morimoto, I Yoshioka, K Tominaga
UNLABELLED: There is no standard surgical protocol of bisphosphonate-related osteonecrosis of the jaws (BRONJ), because of the impossibility to visualize this feature intraoperatively. The aim of this study was to introduce how to provide preoperative labeling of the viable bone with minocycline bone fluorescence technique (MBFT) by using VELscope® and investigate histopathologically. INTRODUCTION: The American Association of Oral and Maxillofacial Surgeons (AAOMS) and the Japanese Society of Oral and Maxillofacial Surgeons (JSOMS) now recommend a more conservative treatment strategy...
July 2015: Osteoporosis International
Hadeel M Ayoub, Tara L Newcomb, Gayle B McCombs, Marshall Bonnie
PURPOSE: This study compared the effectiveness of the VELscope® Vx versus visual and tactile intraoral examination in detecting oral lesions in an adult, high risk population. METHODS: The pilot study compared the intra oral findings between 2 examination types. The sample was comprised of 30 participants who were addicted to either cigarettes or a dual addiction (cigarettes plus hookah). High risk population was defined as males who were current cigarette smokers or had a dual addiction...
February 2015: Journal of Dental Hygiene: JDH
A Rashid, S Warnakulasuriya
INTRODUCTION: In recent decades, optical techniques utilising the principles of chemiluminescence and tissue autofluorescence have emerged to facilitate the early detection of any oral mucosal changes suspicious of cancer. PURPOSE: To evaluate the effectiveness of devices that utilise the principles of chemiluminescence and tissue autofluorescence as adjuncts in the detection of oral cancer and oral potentially malignant disorders (OPMDs). METHODS: A systematic review of the published literature to evaluate the effectiveness of the ViziLite(®) and ViziLite(®) Plus with toluidine blue, MicroLux™/DL and the VELscope™ as aids in the detection of oral cancer and OPMDs...
May 2015: Journal of Oral Pathology & Medicine
O Ristow, C Pautke
Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a challenging complication of long-term bisphosphonate treatment. Currently, the drawback in the surgical management of BRONJ is the difficulty distinguishing between viable and necrotic bone. Intraoperative bone fluorescence induced by tetracyclines has been shown to be a valuable aid to overcome this problem. In this technical note we report the finding that viable bone is auto-fluorescent using the VELscope Vx fluorescence lamp. Necrotic bone shows an altered fluorescence pattern (pale or no fluorescence)...
November 2014: International Journal of Oral and Maxillofacial Surgery
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