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Oral premalignant

Urmila Udayashankar, Vijay Srinivas Guduru, Anuradha Ananthaneni, Sabitha Devi Ramisetty, Puneeth Horatti Kuberappa, Srilekha Namala
AIMS: To determine the cellular and nuclear area of keratinocytes in smears obtained from the oral mucosa of tobacco users, those with oral squamous cell carcinoma (OSCC), and from normal healthy persons and resolve if any significant difference exists in these three groups. MATERIALS AND METHODS: The study group comprised 100 subjects 20 controls, (40 OSCC patients-20 from lesional sites and 20 from nonlesional sites, 20 tobacco smokers and 20 tobacco chewers) in the age group of 25-75 years...
July 2016: Journal of Cytology
Sunil Pazhayanur Venkateswaran, Leviana Ercylina Nathan, Vimi Sunil Mutalik, Noor Hasni Shamsuddin
CONTEXT: Head and neck squamous cell carcinoma (HNSCC) consists of squamous cell carcinomas (SCCs) arising in the upper aerodigestive tract and accounts for 5% of cancers worldwide. In Malaysia, cancers of the nasopharynx, larynx, tongue and oral cavity are among the top twenty most common cancers in men. Argyrophilic nuclear organizer regions (AgNORs) are increased from normal mucosa to premalignant lesions to malignant lesions and have been associated with tumor grade and prognosis of patients...
September 2016: Journal of Oral and Maxillofacial Pathology: JOMFP
Soussan Irani, Alireza Monsef Esfahani, Anahita Ghorbani
BACKGROUNDS: Lichen planus is a chronic systemic disease and oral mucosa is commonly involved. Oral lichen planus (OLP) most commonly affects middle-aged women. The prevalence of the disease ranges between 0.5% and 2.6% in the general population and the range of malignant transformation varies between 0% and 10%. OBJECTIVES: To assess the rate of malignant transformation of OLP samples. MATERIALS AND METHODS: This retrospective study was carried out on 112 medical records of patients with histological diagnosis of OLP who attended the Department of Pathology at the Educational Hospital from 2005 to 2012...
September 2016: Journal of Oral and Maxillofacial Pathology: JOMFP
Amani M Harrandah, Sarah G Fitzpatrick, Molly H Smith, Dunrui Wang, Donald M Cohen, Edward K L Chan
OBJECTIVE: Malignant transformation of oral premalignant lesions is the key process in the progression to oral squamous cell carcinoma (OSCC). Previously, we identified miR-7 and miR-21 as candidate oncogenes and miR-375 and miR-494 as candidate tumor suppressors in OSCC. We aim to evaluate these microRNAs as biomarkers of malignant transformation in oral premalignant lesions. STUDY DESIGN: Formalin-fixed, paraffin-embedded samples from progressive premalignant lesions and paired sequential OSCC tumors at the same site were obtained from same patients (n = 31)...
August 6, 2016: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Sara D Johnson, M Rita I Young
Current treatment options for head and neck squamous cell carcinoma (HNSCC) patients are often ineffective due to tumor-localized and systemic immunosuppression. Using the 4-NQO mouse model of oral carcinogenesis, this study showed that premalignant oral lesion cells produce higher levels of the immune modulator, PGE2, compared to HNSCC cells. Inhibiting prostaglandin production of premalignant lesion cells with the pan-cyclooxygenase inhibitor indomethacin stimulated their induction of spleen cell cytokine production...
2016: Frontiers in Immunology
Ila Pant, S Girish Rao, Paturu Kondaiah
Oral submucous fibrosis (OSF) is potentially premalignant with progressive and irreversible extracellular matrix deposition accompanied by epithelial atrophy and like other fibrotic disorders, is primarily a TGF-β driven disease. OSF is caused by prolonged chewing of areca nut. Our previous studies reported a pivotal role for TGF-β activation and its effects contributing to OSF. However, the mechanism for activation of TGF-β signaling in OSF is still unknown. In this study we demonstrate activation of TGF-β signaling with sub-cytotoxic dose of areca nut in epithelial cells and discovered a key role for pJNK in this process...
October 6, 2016: Scientific Reports
Shu-Lai Lu, Xiang-Min Qi, Gang Dong, Shu-Lan Chen, Da-Wei Guo, Yun-Long Wang, Pi-Shan Yang
Oral lichen planus (OLP) is one of the most common oral mucosa diseases; however, familial OLP is uncommon. The present study reported and analyzed patients with familial OLP (n=18) in eight different Chinese families between January 1, 2012 and December 31, 2013. Parameters analyzed include gender, age at diagnosis, lesion distribution and lesion type. The follow-up period for each patient was a minimum of 1 year. In this survey, 18/88 individuals in the eight families were affected. Females were more frequently affected, and the female to male ratio for familial OLP (2...
October 2016: Experimental and Therapeutic Medicine
Kamran Habib Awan, Shankargouda Patil
Smokeless tobacco (SLT) is associated with many heath hazards including oral cancer. Its use is more common in South Asian countries. The current paper aims to systematically review the South Asian studies to assess the association of SLT and oral cancer. Detailed automated literature searches of PubMed, Medline, EMBASE and ISI Web of Science from January 1980 to July 2015 were conducted using the key words "oral cancer", "oral precancer", "oral premalignant lesions", "oral squamous cell carcinoma", "smokeless tobacco", "betel quid", "areca nut", "Gutkha" in various combinations...
September 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Farzaneh Agha-Hosseini, Nafiseh Sheykhbahaei, Maryam-Sadat SadrZadeh-Afshar
AIM: Many studies have suggested that a lesion originally diagnosed as oral lichen planus (OLP) has different possibilities of undergoing malignant transformation in time, although these findings remain a controversial issue; for example, some studies reported different values of potential malignancy of OLP. INTRODUCTION: World Health Organization (WHO) classifies OLP as a "potentially malignant disorder" with unspecified malignant transformation risk, and suggests that OLP patients should be closely monitored...
2016: Journal of Contemporary Dental Practice
Jenny T Mao, Jane Smoake, Heesung Park, Qing-Yi Lu, Bingye Xue
Grape seed procyanidin extract (GSE) has been reported to exert antineoplastic properties via the inhibition of cyclooxygenase-2 (COX-2)/prostaglandin E2 (PGE2) eicosanoid pathways. In addition, ample data link carcinogenesis to inflammatory events involving other major eicosanoid metabolic pathways, including prostacyclin (PGI2) and 15-Hydroxyeicosatetraenoic acid (15-HETE). We therefore evaluated the effects of GSE on prostacyclin synthase (PTGIS)/PGI2 and 15-lipoxigenase-2 (15-LOX-2)/15-HETE productions by human lung premalignant and malignant cells and correlated the findings with anti-proliferative or pro-apoptotic effects of GSE...
September 22, 2016: Cancer Prevention Research
Tanvi Dosi, Dhaman Gupta, Alka Hazari, Rajan Rajput, Prabhav Chauhan, Anushri S Rajapuri
AIMS AND OBJECTIVES: To study the genotoxic effects of tobacco on the exfoliated buccal epithelial cells in patients with oral precancerous lesions (OPLs) and Patients with tobacco habit but without oral precancerous lesion(habit controls) by using micronucleus assay as well as the quantification and detection of the biomarkers in these premalignant lesions which will be helpful in finding those patients who are at higher risk for malignant transformation. MATERIALS AND METHODS: Forty samples were collected from the right and left side of buccal epithelial cells obtained from 20 individuals, i...
August 2016: Journal of International Society of Preventive & Community Dentistry
Narongrit Juntanong, Pallop Siewchaisakul, Peter Bradshaw, Patravoot Vatanasapt, Sam Li-Sheng Chen, Amy Ming-Fang Yen, Tony Hsiu-Hsi Chen, Supannee Promthet
BACKGROUND: Oral cavity cancer (OCC) is one of the most common cancers worldwide. No studies have reported on the prevalence and epidemiologic risk factors of oral premalignant lesions (OPLs) in Thailand. The purpose of this study was to investigate the prevalence of OPLs and associated factors in Roi Et Province, Thailand. MATERIALS AND METHODS: To investigate the prevalence of OPLs, a cross-sectional descriptive study was conducted in which 2,300 subjects over 40 years of age were recruited and screened for the prevalence of OPLs...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
Roman C Brands, Olga Köhler, Stephan Rauthe, Stefan Hartmann, Harald Ebhardt, Axel Seher, Christian Linz, Alexander C Kübler, Urs D A Müller-Richter
BACKGROUND: Head and neck squamous cell carcinoma (HNSCC) ranks as the sixth most common tumor entity worldwide. Unfortunately, the multimodal treatment consisting of surgery, radiation, and chemotherapy does not show the desired efficacy. The intent of this study was to evaluate the sensitivity and specificity of an oral brush biopsy in combination with glucose transporter (GLUT)-1 staining in identifying premalignant and malignant lesions. METHODS: A total of 72 patients were included in the study, divided into four diagnostic subgroups (24 healthy, 15 carcinoma, 18 leukoplakia, 15 oral lichen planus)...
September 8, 2016: Clinical Oral Investigations
K Başak, Ş Kayipmaz, Hi Köse, N Karadayi
Background: Several studies have suggested a possible role of human papillomavirus and Epstein-Barr virus in the pathogenesis of oral premalignant lesions. This study aimed to investigate the correlation between squamous dysplasia of the tongue and expression of p16 and Ki67 immunohistochemically as well as human papillomavirus genotypes with Real-time polymerase chain reaction (PCR). Methods: Twenty-three tongue biopsies were detected with immunohistochemically for p16, Epstein-Barr virus and Ki67 and Real-time PCR and chromogenic in-situ hybridization for human papillomavirus...
March 10, 2016: West Indian Medical Journal
Lakshmi Krishnan, Karuppiah Karpagaselvi, Jayalakshmi Kumarswamy, U S Sudheendra, K V Santosh, Archana Patil
BACKGROUND AND OBJECTIVES: Management of oral premalignant lesions depends on clinical assessment and grading of oral epithelial dysplasia (OED), which remains one of the most important predictors of malignant potential. Numerous grading systems for OED exists with varying sets of assessing criteria and are largely considered subjective. The present study attempted to assess the inter- and intra-observer variability in three grading systems: Binary system, WHO (2005) and Ljubljana systems...
May 2016: Journal of Oral and Maxillofacial Pathology: JOMFP
G Suganya, Radhika M Bavle, K Paremala, Soumya Makarla, M Sudhakar, V Reshma
CONTEXT: Oral lichen planus (OLP) is a potentially malignant disease with a prevalence rate of 0.5-2.2%. It is a T-cell-mediated autoimmune disease, in which cytotoxic CD8+ T-cells trigger apoptosis of the basal cells of oral epithelium. The reported progression of OLP to oral squamous cell carcinoma (OSCC) ranges from 0.4% to 6.5%. Apoptosis plays a major role in the maintenance of tissue homeostasis. The evasion of apoptosis in the form of dysregulation of inhibitors of apoptosis proteins (IAPs) may lead to malignant transformation...
May 2016: Journal of Oral and Maxillofacial Pathology: JOMFP
Rajan Saini, Nathan V Lee, Kelly Y P Liu, Catherine F Poh
Oral cancer is a global health burden with significantly poor survival, especially when the diagnosis is at its late stage. Despite advances in current treatment modalities, there has been minimal improvement in survival rates over the last five decades. The development of local recurrence, regional failure, and the formation of second primary tumors accounts for this poor outcome. For survivors, cosmetic and functional compromises resulting from treatment are often devastating. These statistics underscore the need for novel approaches in the management of this deadly disease...
September 2, 2016: Cancers
Prashanth Shetty, Shweta Hegde, K S Vinod, Salona Kalra, Prasoon Goyal, Mimansha Patel
INTRODUCTION: A case control study was carried out to evaluate the synergistic effects of habits quantified by habit index and its effect and severity on the clinicopathological features of oral leukoplakia in a cohort of 100 patients visiting Triveni Dental College, Bilaspur, Chhattisgarh, India. MATERIALS AND METHODS: One hundred patients indulging in tobacco-related habits (smoking and smokeless forms) were categorized into two groups: A case/experimental group consisting of 50 patients presenting with oral leukoplakia lesion and a control group consisting of 50 patients with no clinical signs of oral leukoplakia...
2016: Journal of Contemporary Dental Practice
Alireza Akbarzadeh Baghban, Nasim Taghavi, Maryam Shahla
BACKGROUND: Overexpression of vascular endothelial growth factor (VEGF) and cyclooxygenase-2 (COX-2) and increasing mast cell density (MCD) in premalignant and malignant oral lesions have been documented. However, their correlation with clinicopathologic parameters and survival rate in oral squamous cell carcinoma (OSCC) is not completely clear. This study aimed to assess these subjects. METHODS: VEGF, COX-2, and mast cell tryptase expression were examined immunohistochemically in 57 cases of OSCC...
September 1, 2016: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
Maha Ali M Al-Mohaya, Lubna Al-Otaibi, Fahad Al-Harthi, Ebtissam Al Bakr, Misbahul Arfin, Abdulrahman Al-Asmari
BACKGROUND: Oral lichen planus (OLP) is a premalignant mucocutaneous disease in which genetic factors and immune responses play a major role. Cytokines play an important role in the pathogenesis and disease progression of OLP. The aim of this study was to investigate the impact of gene polymorphisms of T helper cell subtype Th1 and Th2 cytokines, interferon-gamma (IFN-γ), interleukin-6 (IL-6) and transforming growth factor (TGF)-β1 on OLP susceptibility in a Saudi cohort. METHODS: Forty two unrelated patients with OLP and 195 healthy controls were genotyped for IFN-γ (874A/T), IL-6 (174G/C) and TGF-β1 (509C/T) polymorphisms...
2016: BMC Oral Health
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