Alieh Farshbaf, Nooshin Mohtasham, Asma Khorshid Shamshiri, Kamran Khazaeni, Seyed Hamid Aghaee-Bakhtiari, Fatemeh Arab, Mehri Cheshomi, Melika Hassanabadi, Farnaz Mohajertehran
OBJECTIVES: Oral squamous cell carcinoma (OSCC) is the most common type of oral neoplasms that consist of more over 90% of oral cancers. It was demonstrated that erosive atrophic oral lichen planus (OLP) has potential of malignancy transformation into OSCC. The microRNAs are non-coding regulator sequences involved in cancer process. The miR-99a involve in growth, proliferation, migration, invasion, and metastasis of tumor cells. Therefore, we evaluated miR-99a expression in serum of OSCC and erosive atrophic OLP patients in comparison to healthy control individuals to more investigate about level of miR-99a expression in potential premalignant disorder (erosive atrophic OLP) in comparison to malignant transformation form (OSCC)...
February 24, 2024: Journal of Stomatology, Oral and Maxillofacial Surgery