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Oral premalignant

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https://www.readbyqxmd.com/read/28209005/serum-iron-and-haemoglobin-estimation-in-oral-submucous-fibrosis-and-iron-deficiency-anaemia-a-diagnostic-approach
#1
Divya Bhardwaj, Ajit D Dinkar, Sujata K Satoskar, Sapna Raut Desai
INTRODUCTION: Oral Submucous Fibrosis (OSMF) is a premalignant condition with potential malignant behaviour characterized by juxta-epithelial fibrosis of the oral cavity. In the process of collagen synthesis, iron gets utilized, by the hydroxylation of proline and lysine, leading to decreased serum iron levels. The trace element like iron is receiving much attention in the detection of oral cancer and precancerous condition like OSMF as it was found to be significantly altered in these conditions...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28199027/investigating-the-level-of-salivary-endothelin-1-in-premalignant-and-malignant-lesions
#2
Tahereh Nosratzehi, Sirous Risbaf Fakour, Ebrahim Alijani, Maryam Salehi
PURPOSE: This study aimed to investigate the level of salivary endothelin-1 in premalignant and malignant lesions. MATERIALS AND METHODS: In this study, 75 cases were investigated of which 25 cases were healthy, 25 cases had oral lichen planus (OLP), and 25 cases had oral squamous cell carcinoma (OSCC). In order to collect the saliva samples, the unstimulated spitting was used. The samples were collected between 9 and 12 a.m. They were sent to the lab shortly after being collected and salivary endothelin-1 was recorded for each sample according to the instruction of factory by using enzyme-linked immunosorbent assay and optical density at a wavelength of 450 nm...
February 15, 2017: Special Care in Dentistry
https://www.readbyqxmd.com/read/28198978/high-prevalence-of-human-papillomavirus-hpv-in-oral-mucosal-lesions-of-patients-at-the-ambulatory-of-oral-diagnosis-of-the-federal-university-of-sergipe-northeastern-brazil
#3
Mariana Goveia Melo Ribeiro, Larissa Doddi Marcolino, Bruna Ribeiro de Andrade Ramos, Elaine Alves Miranda, Cleverson Luciano Trento, Sona Jain, Ricardo Queiroz Gurgel, Márcia Guimarães da Silva, Silvio Santana Dolabella
Objective: The aim of this study was to evaluate the frequency of HPV infection and its genotypes in patients with oral lesions at the Ambulatory of Oral Diagnosis of the Federal University of Sergipe, Brazil. Material and Methods: We conducted a molecular study with 21 patients (15 females) aged from two to 83 years with clinically detectable oral lesions. Samples were collected through exfoliation of lesions and HPV-DNA was identified using MY09/11 and GP5+/6+ primers...
January 2017: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/28115253/gold-nanorods-reflectance-discriminate-benign-from-malignant-oral-lesions
#4
Abraham Hirshberg, Irit Allon, Ilya Novikov, Rinat Ankri, Ariel Ashkenazy, Dror Fixler
Nanoparticle-based contrast agents have been used as an imaging tool for selectively detecting cancerous processes. We aimed to evaluate the detection sensitivity of reflection measurements of gold nanorods (GNRs) bio-conjugated to anti-epidermal growth factor receptor (GNRs-EGFR) monoclonal antibodies in discriminating benign from premalignant and malignant human oral lesions. Tissue sections incubated with GNRs-EGFR and the reflectance spectrum was measured using hyperspectral microscopy. Reflectance intensity increased with the progression of the disease, lowest in the control group and increasing as the dysplastic changes increase (p<0...
January 20, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28110942/individualized-five-year-risk-assessment-for-oral-premalignant-lesion-progression-to-cancer
#5
Jason T K Hwang, Ying R Gu, Mi Shen, Ranju Ralhan, Paul G Walfish, Kenneth P H Pritzker, David Mock
OBJECTIVE: The standard of care for premalignant lesion risk assessment is dysplasia grading by histopathology. With significant overlap between dysplasia grades and high inter- and intraobserver variations, histopathology dysplasia grading alone is not a useful prognostic tool. Our aim is to investigate whether a method for quantitatively assessing S100A7, a prognostic biomarker, using image analysis can better predict clinical outcome in cases with oral dysplasia. STUDY DESIGN: Using the Visiopharm image analysis system, we analyzed a cohort of 150 oral biopsy samples to build and test Straticyte, a model for individualized assessment of the 5-year risk of progression of oral precancerous lesions to invasive squamous cell carcinomas...
March 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28071621/assessment-of-the-sociodemographic-characteristics-and-efficacy-of-screening-for-oral-head-and-neck-potential-malignant-lesions-in-apparently-healthy-adults-in-jos-nigeria
#6
A A Adoga, O A Silas, J P Yaro, E T Okwori, A A Iduh, C J Mgbachi
BACKGROUND: The efficacy of screening for oral, head and neck cancers (HNCs) in adequately identifying high-risk groups is controversial. OBJECTIVES: This study aims to review our experience with a free oral, HNC-screening program to determine the sociodemographic characteristics of the participants and the effectiveness of this program to improve future programs. MATERIALS AND METHODS: A prospective cross-sectional survey of participants in a free oral, HNC screening exercise was performed in the years 2009, 2012, and 2013...
April 2016: Indian Journal of Cancer
https://www.readbyqxmd.com/read/28060366/oral-lichenoid-lesions-distinguishing-the-benign-from-the-deadly
#7
Susan Müller
Oral lichen planus is a chronic inflammatory disease of unknown etiology or pathogenesis with varied disease severity that waxes and wanes over a long period of time. Although a common oral mucosal disease, accurate diagnosis is often challenging due to the overlapping clinical and histopathological features of oral lichen planus and other mucosal diseases. Other immune-mediated mucocutaneous diseases can exhibit lichenoid features including mucous membrane pemphigoid, chronic graft-versus-host disease, and discoid lupus erythematosus...
January 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28055109/population-based-screening-program-for-reducing-oral-cancer-mortality-in-2-334-299-taiwanese-cigarette-smokers-and-or-betel-quid-chewers
#8
Shu-Lin Chuang, William Wang-Yu Su, Sam Li-Sheng Chen, Amy Ming-Fang Yen, Cheng-Ping Wang, Jean Ching-Yuan Fann, Sherry Yueh-Hsia Chiu, Yi-Chia Lee, Han-Mo Chiu, Dun-Cheng Chang, Yann-Yuh Jou, Chien-Yuan Wu, Hsiu-Hsi Chen, Mu-Kuan Chen, Shu-Ti Chiou
BACKGROUND: To reduce oral cancer mortality, an organized, population-based screening program for the early detection of oral premalignancy and oral cancer was designed for high-risk individuals with habits of betel quid chewing, cigarette smoking, or both. The objective of this report was to evaluate the long-term effectiveness of this program in reducing the incidence of advanced disease and deaths from oral cancer. METHODS: A nationwide, population-based screening program for oral cancer has been conducted in Taiwan since 2004...
January 5, 2017: Cancer
https://www.readbyqxmd.com/read/28027413/omega-3-a-novel-treatment-agent-in-oral-submucous-fibrosis-a-pilot-study
#9
Milanjeet Kaur Raizada, Digamber M Sable, Asha Chowdhery, Mahesh Shivaji Chavan, Ladu Singh Rajpurohit
BACKGROUND: Oral submucous fibrosis (OSF) is a chronic debilitating disease and a premalignant condition of the oral cavity. It is well known for its impervious nature to medical therapy. Omega 3 polyunsaturated fatty acids have been reported to have anti inflammatory properties. However, its role in OSF is still not known. This preliminary study assessed the efficacy of systemic omega 3 in this disease. METHODS: A randomized single blinded controlled trial was designed and a total of 10 clinically confirmed adult patients of OSF were included in the study...
December 27, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27994410/estimation-of-salivary-sialic-acid-in-oral-premalignancy-and-oral-squamous-cell-carcinoma
#10
Vishakha Chaudhari, G L Pradeep, Nilima Prakash, Aarti M Mahajan
AIMS: Oral cancer is the most life-threatening disease of oral tissues. In societies where the incidence of oral cancer is high, clinically recognizable premalignant lesions are particularly common. Diagnosing oral cancers at an early stage is critical in improving the survival rate and reducing the morbidity associated with the disease. Alterations in the sialic acid levels in cancer patients have stimulated interest in this sugar residue as a possible tumor marker. SETTINGS AND DESIGN: The purpose of this study was to estimate the salivary sialic acid levels in patients with oral premalignancy and squamous cell carcinoma and to correlate it with their grades to develop a cost-effective and noninvasive diagnostic parameter...
October 2016: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/27984435/tissue-fluorescence-imaging-velscope-for-quick-non-invasive-diagnosis-in-oral-pathology
#11
Marco Cicciù, Alan Scott Herford, Gabriele Cervino, Giuseppe Troiano, Floriana Lauritano, Luigi Laino
Oral squamous cell carcinoma is the most common form of malignancy of the oral cavity; its incidence is increasing and late-stage presentation is common. It is usually predated by oral premalignant disorders. For this reason, early diagnosis is fundamental to reduce the malignant transformation of oral premalignant disorders and for increase the survival rate for oral cancer. Scraping the surface of the lesion is useful for having cytological features of the investigated tissue. The features of smears of oral premalignant lesions are the keratinization growth (red, orange, brown), the increased nuclear area and so the nuclear hyperchromatism, the nuclear pleomorphism, and the chromatin clumping...
December 14, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27924796/detection-and-phylogenetic-analysis-of-torque-teno-virus-in-salivary-and-tumor-biopsy-samples-from-head-and-neck-carcinoma-patients
#12
Andrea Hettmann, Anett Demcsák, Ádám Bach, Gábor Decsi, Ágnes Dencs, Dóra Pálinkó, László Rovó, Katalin Nagy, Janos Minarovits, Mária Takács
OBJECTIVES: Because torque teno virus (TTV) has been implicated in tumorigenesis as a cocarcinogen, we studied TTV prevalence in saliva and biopsy samples from head and neck cancer (HNCC) patients, patients with premalignant lesions of oral cancer, and controls. We also wished to determine the TTV genotypes in HNCC patients. METHODS: A seminested polymerase chain reaction (PCR) amplifying the N22 region of the TTV genome, as well as direct sequencing of PCR fragments, was used...
2016: Intervirology
https://www.readbyqxmd.com/read/27914100/transient-immunological-and-clinical-effectiveness-of-treating-mice-bearing-premalignant-oral-lesions-with-pd-1-antibodies
#13
Corinne A Levingston, M Rita I Young
A carcinogen-induced premalignant oral lesion model that progresses to oral cancer was used to examine the impact of blocking PD-1 on cytokine expression and on progression of lesions to cancer. The results of this study show increased production of IL-2 and the inflammatory cytokines IL-6, IL-17 and TNF-α by spleen cells of lesion-bearing mice that were treated with PD-1 antibody for one week compared to cytokine production by spleen cells of lesion-bearing mice treated with control antibody. Production of IFN-γ increased at 3 weeks of PD-1 antibody treatment, although production of the other Th1 and inflammatory mediators declined...
December 3, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27881522/prevalence-of-papillomavirus-in-brazil-a-systematic-review-protocol
#14
Verônica Colpani, Augusto Bacelo Bidinotto, Maicon Falavigna, Silvana Pereira Giozza, Adele Schwartz Benzaken, Cristina Pimenta, Ana Goretti Kalume Maranhão, Carla Magda Allan Santos Domingues, Luciano Serpa Hammes, Eliana M Wendland
INTRODUCTION: Human papillomavirus (HPV) infection is a cause of premalignant and malignant cancer in the lower genital and digestive tracts. In Brazil, there have been no prevalence studies that included a nationwide sample, and the prevalence of HPV has not been determined in many regions. METHODS: We will search the EMBASE, LILACS, MEDLINE, Web of Science and SciELO databases and previously published review articles to identify original research articles assessing HPV prevalence of the perineal (cervical, penile and anal) and oral areas...
November 22, 2016: BMJ Open
https://www.readbyqxmd.com/read/27833864/a-clinical-study-of-oral-mucosal-lesions-in-patients-visiting-a-tertiary-care-centre-in-central-india
#15
Rashmi Goyal, Shalini Jadia, Leena Jain, Chhavi Agarawal
The aim of this study was to find the frequency of various oral mucosal lesions in relation to age, sex, site and associated addiction habits. This retrospective study was done in tertiary care centre including 1280 patients of oral mucosal lesions. Clinical findings and detailed history of their addiction habits with frequency and duration was noted from the existing data. Cytological and histopathological diagnosis of various lesions was recorded to conclude diagnosis. The most common lesion in this study was found to be aphthous ulcers (44...
December 2016: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/27829738/adjunctive-aids-for-the-detection-of-oral-premalignancy
#16
REVIEW
D Charanya, L P Raghupathy, Amjad Fazeela Farzana, R Murugan, R Krishnaraj, G Kalarani
Early detection of cancer greatly decreases the morbidity and mortality rates and thereby increases the 5-year survival rates. In developing countries like India where the disease is highly prevalent focus is mainly on decreasing the mortality rates which can be easily achieved by detection at an asymptomatic stage. Visual examination has been the standard screening method for screening oral cancer through several decades, and it is well known that conventional visual examination is limited to subjective interpretation and cannot be easily achieved in certain anatomical sites...
October 2016: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/27824386/noak-behandling-%C3%A3-kar-risken-f%C3%A3-r-gastrointestinal-bl%C3%A3-dning-kan-avsl%C3%A3-ja-allvarlig-sjukdom-%C3%A2-strukturerad-uppf%C3%A3-ljning-viktig
#17
Anna Haeggström, Dag Risberg, Faris Al-Kahlili, Åsa Gilstring, Ulrika Tullberg, Håkan Wallén
Gastrointestinal bleeding during treatment with non -vitamin K antagonist oral anticoagulants (NOACs) may be caused by malignant lesions Gastrointestinal bleeding due to underlying malignancy may not be uncommon in real life patients on non vitamin K antagonist oral anticoagulants (NOACs) like dabigatran, rivaroxaban or apixaban. We performed a small pilot study in patients referred to endoscopy due to suspected gastrointestinal bleeding. In twenty NOAC-treated patients, we found four cases of manifest malignant colon tumors, one premalignant colon adenoma, and one gastric B-cell lymphoma...
November 7, 2016: Läkartidningen
https://www.readbyqxmd.com/read/27801978/high-resolution-dna-content-analysis-of-microbiopsy-samples-in-oral-lichen-planus
#18
M Pentenero, M Monticone, R Marino, C Aiello, G Marchitto, D Malacarne, W Giaretti, S Gandolfo, P Castagnola
OBJECTIVES: DNA aneuploidy has been reported to be a predictor of poor prognosis in both premalignant and malignant lesions. In oral lichen planus (OLP), this hypothesis remains to be proved. This study aimed to determine the rate of occurrence of DNA aneuploidy in patients with OLP by high-resolution DNA flow cytometry. METHODS: Patients with OLP were consecutively enrolled. Tissue samples were subdivided for formalin fixation and routine histological assessment and for immediate storage at -20°C for later DNA ploidy analysis, which was performed by DAPI staining of the extracted nuclei and excitation with a UV lamp...
November 1, 2016: Oral Diseases
https://www.readbyqxmd.com/read/27794159/expression-of-myofibroblasts-in-oral-squamous-cell-carcinoma-an-immunohistochemical-study
#19
B Vikas Prasad, Gauri S Kakatkar, Preet Jain, Meetu Jain, Maulik Patel, Javed Khan
INTRODUCTION: Oral squamous cell carcinoma (OSCC) is one of the most common types of malignancy affecting the orafacial region and with a high mortality rate. The fact that stroma of the tumor modulates and facilitates the progression and metastasis of the malignancy has been shown in the past studies. The cells of the activated stroma that are responsible for the progression and metastasis of the tumor are the fibroblasts having smooth muscle properties. These myofibroblasts are said to secrete numerous inflammatory mediators and factors which are said to play a crucial role in tumor progression...
October 1, 2016: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/27756983/evaluation-of-cytomorphometric-changes-in-tobacco-users-and-diagnosed-oral-squamous-cell-carcinoma-individuals
#20
Urmila Udayashankar, Vijay Srinivas Guduru, Anuradha Ananthaneni, Sabitha Devi Ramisetty, Puneeth Horatti Kuberappa, Srilekha Namala
AIMS: To determine the cellular and nuclear area of keratinocytes in smears obtained from the oral mucosa of tobacco users, those with oral squamous cell carcinoma (OSCC), and from normal healthy persons and resolve if any significant difference exists in these three groups. MATERIALS AND METHODS: The study group comprised 100 subjects 20 controls, (40 OSCC patients-20 from lesional sites and 20 from nonlesional sites, 20 tobacco smokers and 20 tobacco chewers) in the age group of 25-75 years...
July 2016: Journal of Cytology
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