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Oral premalignant

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https://www.readbyqxmd.com/read/29148069/long-term-oral-exposure-to-safe-dose-of-bisphenol-a-in-association-with-high-fat-diet-stimulate-the-prostatic-lesions-in-a-rodent-model-for-prostate-cancer
#1
Camila H Facina, Silvana G P Campos, Bianca F Gonçalves, Rejane M Góes, Patricia S L Vilamaior, Sebastião R Taboga
BACKGROUND: Studies have shown that exposure to environmental chemicals known as endocrine disruptors can cause permanent changes in genital organs, such as the prostate. Among these environmental chemicals stands out bisphenol A (BPA). Another factor associated with prostate changes is the consumption of a high-fat diet. Although the relationship between the consumption of a high-fat diet and an increased risk of prostate cancer is well established, the mechanisms that lead to the establishment of this disease are not completely understood, nor the simultaneous action of BPA and high-fat diet...
November 17, 2017: Prostate
https://www.readbyqxmd.com/read/29139244/raman-exfoliative-cytology-for-oral-precancer-diagnosis
#2
Aditi Sahu, Poonam Gera, Venkatesh Pai, Abhishek Dubey, Gunjan Tyagi, Mandavi Waghmare, Sandeep Pagare, Manoj Mahimkar, C Murali Krishna
Oral premalignant lesions (OPLs) such as leukoplakia, erythroplakia, and oral submucous fibrosis, often precede oral cancer. Screening and management of these premalignant conditions can improve prognosis. Raman spectroscopy has previously demonstrated potential in the diagnosis of oral premalignant conditions (in vivo), detected viral infection, and identified cancer in both oral and cervical exfoliated cells (ex vivo). The potential of Raman exfoliative cytology (REC) in identifying premalignant conditions was investigated...
November 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29138137/the-next-frontier-head-and-neck-cancer-immunoprevention
#3
J Silvio Gutkind, Jack D Bui
Restoring T cell-mediated antitumor immunity by targeting immune checkpoint inhibitors in head and neck squamous cell carcinoma (HNSCC) results in immunomodulation and durable remissions. However, the overall response rate to these immunotherapies in HNSCC is only approximately 20%. This raises the possibility that immunologic intervention earlier in the HNSCC continuum, such as in oral premalignant lesions (OPL) could elicit an increased therapeutic response. New experimental studies suggest that immune therapies can be used for HNSCC prevention rather than therapy...
November 14, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/29135982/sting-expression-and-response-to-treatment-with-sting-ligands-in-premalignant-and-malignant-disease
#4
Jason R Baird, Zipeng Feng, Hong D Xiao, David Friedman, Ben Cottam, Bernard A Fox, Gwen Kramer, Rom S Leidner, R Bryan Bell, Kristina H Young, Marka R Crittenden, Michael J Gough
Human papilloma virus positive (HPV+) tumors represent a large proportion of anal, vulvar, vaginal, cervical and head and neck squamous carcinomas (HNSCC) and late stage invasive disease is thought to originate from a premalignant state. Cyclic dinucleotides that activate STimulator of INterferon Genes (STING) have been shown to cause rapid regression of a range of advanced tumors. We aimed to investigate STING ligands as a novel treatment for papilloma. We tested therapies in a spontaneous mouse model of papilloma of the face and anogenital region that histologically resembles human HPV-associated papilloma...
2017: PloS One
https://www.readbyqxmd.com/read/29126494/adjunctive-diagnostic-techniques-for-oral-and-oropharyngeal-cancer-discovery
#5
REVIEW
Michaell A Huber
The most important prognostic factor in predicting the outcome of oral and oropharyngeal cancer (OPC) is the stage at which it is diagnosed. Only 30% of patients are diagnosed with early-stage disease. The oral health care provider performs an important role in early diagnosis of oral cancer. The conventional oral examination consists of a visual and tactile assessment of accessible oral, and head and neck structures. Any suspicious or equivocal lesion should be reevaluated within 4 weeks. Evidence supporting the use of adjunctive devices to improve the ability to screen for and identify OPCs and oral premalignant lesions remains low...
January 2018: Dental Clinics of North America
https://www.readbyqxmd.com/read/29123408/the-matrix-metalloproteinase-and-insulin-like-growth-factor-system-in-oral-cancer-a-prospective-clinical-study
#6
Eik Schiegnitz, Peer W Kämmerer, Holger Schön, Christoph Gülle, Manfred Berres, Keyvan Sagheb, Bilal Al-Nawas
Aim: The absence of reliable single serum biomarkers for oral premalignant lesion (OPL) and oral squamous cell carcinoma (OSCC) limits early diagnosis, monitoring of advanced disease, and prediction of prognosis. Methods: In this prospective study, serum levels of matrix metalloproteinase (MMP)-2, MMP-3, MMP-13, insulin-like growth factor (IGF)-1, and IGF-binding protein (IGFBP)-3 were measured in 81 untreated OSCC patients, 49 healthy subjects, and 75 individuals with OPLs, and correlated with clinicopathological parameters...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29109745/evaluation-of-myofibroblasts-in-oral-submucous-fibrosis-and-oral-squamous-cell-carcinoma-the-pathogenesis-and-correlation
#7
Piyush Gandhi, Umesh Chandra Prasad
Background: Oral submucous fibrosis (OSMF) is a chronic debilitating disease of the oral cavity having premalignant potential and unclear pathogenesis. Recently, myofibroblast has been postulated to play an important role in its pathogenesis and in the process of carcinogenesis. The purpose of this study was to evaluate and compare the presence of myofibroblasts in normal mucosa, different grades of OSMF, and oral squamous cell carcinoma (OSCC). Materials and Methods: The present in vitro cross-sectional descriptive study sample consisted of three groups, including 40 OSCCs, 40 OSMF, and 10 sections of normal oral epithelium taken as control group...
September 2017: Dental Research Journal
https://www.readbyqxmd.com/read/29097794/oral-leukoplakia-and-proliferative-verrucous-leukoplakia-a-review-for-dental-practitioners
#8
K Staines, H Rogers
Objectives To provide an overview of the current thinking in terms of the diagnosis and management of oral leukoplakia and proliferative verrucous leukoplakia as relevant to general dental practitioners.Data sources, data selection, data extraction, data synthesis We searched the MEDLINE Ovid, EMBASE databases and the Cochrane Library, (1990 to 16 April 2017), restricting our search to English language with the following key words: leukoplakia, white patch, proliferative verrucous leukoplakia, precancerous lesion, premalignant lesions, potentially malignant oral conditions and potentially malignant oral disorders...
December 2017: British Dental Journal
https://www.readbyqxmd.com/read/29079347/the-diagnostic-value-of-the-native-fluorescence-visualization-device-for-early-detection-of-premalignant-malignant-lesions-of-the-oral-cavity
#9
Maryam Amirchaghmaghi, Nooshin Mohtasham, Zahra Delavarian, Mohammad Taghi Shakeri, Masoud Hatami, Pegah Mosannen Mozafari
PURPOSE: The present study aimed to determine the diagnostic value of a native fluorescence visualization device in the identification of oral malignant/dysplastic lesions. METHODS: This study involved 45 patients who had oral lesions that were suspected to be malignant, potentially malignant, or benign. The patients visited the Oral Medicine Department of the Mashhad Dental School. The sensitivity, specificity, positive and negative predictive values, and likelihood ratio of this device were determined...
October 24, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29073177/hypomethylated-fgf3-is-a-potential-biomarker-for-early-detection-of-oral-cancer-in-mice-treated-with-the-tobacco-carcinogen-dibenzo-def-p-chrysene
#10
Yuan-Wan Sun, Kun-Ming Chen, Yuka Imamura Kawasawa, Anna C Salzberg, Timothy K Cooper, Carla Caruso, Cesar Aliaga, Junjia Zhu, Krishne Gowda, Shantu Amin, Karam El-Bayoumy
Genetic and epigenetic alterations observed at end stage OSCC formation could be considered as a consequence of cancer development and thus changes in normal or premalignant tissues which had been exposed to oral carcinogens such as Dibenzo[def,p]chrysene (DBP) may better serve as predictive biomarkers of disease development. Many types of DNA damage can induce epigenetic changes which can occur early and in the absence of evident morphological abnormalities. Therefore we used ERRBS to generate genome-scale, single-base resolution DNA methylomes from histologically normal oral tissues of mice treated with DBP under experimental conditions known to induce maximum DNA damage which is essential for the development of OSCC induced by DBP in mice...
2017: PloS One
https://www.readbyqxmd.com/read/29039225/toxicological-impact-of-waterpipe-smoking-and-flavorings-in-the-oral-cavity-and-respiratory-system
#11
Fawad Javed, Shatha Subhi ALHarthi, Munerah Saleh BinShabaib, Sangeeta Gajendra, Georgios E Romanos, Irfan Rahman
Waterpipe smoking (WS), an emerging trend has major health concerns. It is prevalent worldwide as a recreational activity both indoors and outdoors. The aim of this review was to assess the impact of waterpipe smoke on the oral and respiratory system (oral cavity and pulmonary tissues). A number of studies have shown that periodontal health status is compromised in waterpipe smokers when compared with nonsmokers. Some studies have associated WS with oral premalignant and malignant lesions; however, due to the poor quality of these studies, the presented outcomes should be interpreted with caution...
August 2017: Inhalation Toxicology
https://www.readbyqxmd.com/read/29034442/correlation-between-tissue-expression-of-microrna-137-and-cd8-in-oral-lichen-planus
#12
Sana Maher Hasan Aghbari, Abdelrahman Ibrahim Abushouk, Olfat Gamil Shakir, Shaimaa Omar Zayed, Attia Attia
OBJECTIVES: Oral lichen planus (OLP) is a chronic, inflammatory condition, classified by the World Health Organization as a premalignant lesion. We performed this study to evaluate the correlation between microRNA-137 (miR-137) and CD8 oral tissue expression in OLP patients. MATERIALS AND METHODS: Twenty OLP patients [classified into three groups: (a) papular, reticular, or plaque; (b) atrophic; and (c) erosive] and 20 healthy controls were subjected to biopsy of the oral mucosa...
October 15, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29018057/pd-1-blockade-prevents-the-development-and-progression-of-carcinogen-induced-oral-premalignant-lesions
#13
Jin Wang, Tongxin Xie, Bingbing Wang, William N William, John V Heymach, Adel K El-Naggar, Jeffrey N Myers, Carlos Caulin
Oral squamous cell carcinoma (OSCC) is preceded by progressive oral premalignant lesions (OPL). Therefore, therapeutic strategies that prevent malignant progression of OPLs are expected to reduce the incidence of OSCC development. Immune checkpoint inhibitors that target the interaction of programmed death receptor 1 (PD-1) on T cells with the PD-1 ligand PD-L1 on cancer cells have been shown to extend the survival of patients with advanced OSCC. Here, we used the 4-nitroquinoline-1-oxide (4-NQO) mouse model of oral carcinogenesis to test the hypothesis that PD-1 blockade may control the progression of OPLs...
October 10, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28966966/toluidine-blue-staining-in-identification-of-a-biopsy-site-in-potentially-malignant-lesions-a-case-control-study
#14
Mayank Kumar Parakh, R C Jagat Reddy, Prabhu Subramani
OBJECTIVE: Oral cancer is a significant threat to public health all over the world, especially in Southeast Asia. At the present time, screening of oral cancer, its premalignant stages as well as its early detection, is still largely based on visual examination of the mouth. Visual examination is highly subjective and hence lacks the specificity and sensitivity. The objective of this study was to determine the usefulness of toluidine blue in marking a biopsy site in potentially malignant disorders...
October 2017: Asia-Pacific Journal of Oncology Nursing
https://www.readbyqxmd.com/read/28953155/bilateral-submental-flap-an-innovative-modification
#15
Kiran Gadre, Pushkar Gadre, Divya Singh, Anushri Shetty, Ankit Malu
Early management of premalignant lesions like oral submucous fibrosis cannot be underestimated in context of prevention and control of oral malignancies. Soft tissue reconstruction of the oral cavity and face is a complex undertaking. Several flaps local and distant as well as microvascular are available, each with their pros and cons. Microvascular free flaps lay a considerable burden on resources, expertise, increased operating time, and logistics. Simple and technically reproducible alternatives are needed to tackle these issues, more so in developing countries like ours...
November 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28947884/expression-of-vitamin-d-receptor-and-vitamin-d-status-in-patients-with-oral-neoplasms-and-effect-of-vitamin-d-supplementation-on-quality-of-life-in-advanced-cancer-treatment
#16
Akshay Anand, Suyash Singh, Abhinav A Sonkar, Nuzhat Husain, Kul Ranjan Singh, Sudhir Singh, Jitendra K Kushwaha
AIM OF THE STUDY: Vitamin D receptor (VDR) expression and serum vitamin D scores in oral premalignant lesions and oral cancer have not been widely analyzed. The role of vitamin D supplementation in advanced oral cancer for improving quality of life (QOL) is also a matter of research. MATERIAL AND METHODS: Vitamin D receptor expression and vitamin D scores were analyzed in normal oral mucosa (n = 95), leukoplakia (n = 23) and oral cancer (n = 87). 45 patients with advanced oral cancer subjected to chemoradiation were evaluated for the effect of vitamin D supplementation on most observable QOL parameters such as oral mucositis, swallowing performance and overall QOL...
2017: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/28932035/epigenetics-in-oral-squamous-cell-carcinoma
#17
REVIEW
K N Hema, T Smitha, H S Sheethal, S Angeline Mirnalini
Oral squamous cell carcinoma (OSCC) is the most common type of oral neoplasm, accounting for over 90% of all oral malignancies and 38% of head and neck tumors. Worldwide, OSCC is the eighth most common human cancer, with more than 500,000 new cases being diagnosed every year with a fairly onerous prognosis, encouraging further research on factors that might modify disease outcome. Genetic and/or environmental risk factors associated with the development of oral cancer have been sufficiently understood (smoking, alcohol, betel, diet, living habits, etc...
May 2017: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/28932032/mast-cells-and-angiogenesis-in-malignant-and-premalignant-oral-lesions-an-immunohistochemical-study
#18
Daisy Laishram, Kavita Rao, H S Uma Devi, N S Priya, T Smitha, H S Sheethal
INTRODUCTION AND OBJECTIVES: Angiogenesis is a complex event facilitated by angiogenic factors released from neoplastic and host immune cells. Among host immune cells, mast cells (MCs) may have greater significance in tumor progression through angiogenesis. The objectives of the study were to evaluate and correlate mast cell density (MCD) and microvessel density (MVD) in normal gingival tissue, leukoplakia with and without dysplasia and oral squamous cell carcinoma (OSCC) cases. MATERIALS AND METHODS: Among eighty selected cases, twenty were of normal gingiva, twenty each of leukoplakia without and with dysplasia and twenty of OSCC...
May 2017: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/28921845/detection-and-delineation-of-squamous-neoplasia-with-hyperspectral-imaging-in-a-mouse-model-of-tongue-carcinogenesis
#19
Guolan Lu, Dongsheng Wang, Xulei Qin, Susan Muller, Xu Wang, Amy Y Chen, Zhuo Georgia Chen, Baowei Fei
yperspectral imaging (HSI) holds the potential for the noninvasive detection of cancers. Oral cancers are often diagnosed at a late stage when treatment is less effective and the mortality and morbidity rates are high. Early detection of oral cancer is, therefore, crucial in order to improve the clinical outcomes. To investigate the potential of HSI as a non-invasive diagnostic tool, an animal study was designed to acquire hyperspectral images of in vivo and ex vivo mouse tongues from a chemically induced tongue carcinogenesis model...
September 17, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28918177/photodynamic-therapy-in-oral-potentially-malignant-disorders-critical-literature-review-of-existing-protocols
#20
REVIEW
Jéssica Araújo Figueira, Vanessa Cristina Veltrini
INTRODUCTION: Oral cancer is a serious public health issue. Apart from its high rate of prevalence, incidence and mortality, it can often result in more complex and expensive treatment when diagnosed late. Potentially malignant disorders (PMDs) can precede oral cancer, and are usually treated by surgical excision. However, in many cases patients are elderly and multiple interventions may be required. Photodynamic therapy (PDT) is a simple alternative, which has been successfully used in the treatment of oral PMDs...
September 13, 2017: Photodiagnosis and Photodynamic Therapy
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