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https://www.readbyqxmd.com/read/28526544/interleukin-18-gene-deletion-protects-against-sepsis-induced-cardiac-dysfunction-by-inhibiting-pp2a-activity
#1
Yoshitaka Okuhara, Shunichi Yokoe, Toshihiro Iwasaku, Akiyo Eguchi, Koichi Nishimura, Wen Li, Makiko Oboshi, Yoshiro Naito, Toshiaki Mano, Michio Asahi, Haruki Okamura, Tohru Masuyama, Shinichi Hirotani
BACKGROUND: Interleukin-18 (IL-18) neutralization protects against lipopolysaccharide (LPS)-induced injuries, including myocardial dysfunction. However, the mechanism is yet to be fully elucidated. The aim of the present study was to determine whether IL-18 gene deletion prevents sepsis-induced cardiac dysfunction and to elucidate the potential mechanisms underlying IL-18-mediated cardiotoxicity by LPS. METHODS AND RESULTS: Ten-week-old male wild-type (WT) and IL-18 knockout (IL-18 KO) mice were intraperitoneally administered LPS...
May 4, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28498261/clear-cell-carcinoma-of-the-uterine-cervix-a-clinical-and-pathological-analysis-of-47-patients-without-intrauterine-diethylstilbestrol-exposure
#2
Li Yang, Aiwen Zheng, Xiang Zhang, Xianhua Fang, Wenyong Sun, Yaqing Chen
OBJECTIVES: The aim of this study was to summarize the clinical and pathological characteristics and to conduct prognosis analysis of patients who were diagnosed with clear cell carcinoma of the uterine cervix (CCCUC) and without a history of exposure to diethylstilbestrol. METHODS: We performed a retrospective review of all the patients with CCCUC who were diagnosed and treated at Zhejiang Cancer Hospital between 1998 and 2014. Charts were reviewed for clinical and pathological characteristics, and prognosis analysis was conducted...
June 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28498238/nomogram-predicting-overall-survival-in-operable-cervical-cancer-patients
#3
Ru-Ru Zheng, Xiao-Wan Huang, Wen-Yue Liu, Rong-Rong Lin, Fei-Yun Zheng, Feng Lin
OBJECTIVE: Nomograms are widely used as predictive tools to predict oncological outcomes intuitively and precisely. The aim of our study was to develop a nomogram for predicting overall survival (OS) of patients with early stage cervical cancer. METHODS: In this retrospective study, the clinical, pathological, and hematological data and prognosis of 795 cervical cancer patients were investigated. We identified and incorporated independent significant prognostic factors for OS to develop a nomogram...
June 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28487373/interactions-between-small-ankyrin-1-and-sarcolipin-coordinately-regulate-activity-of-the-sarco-endo-plasmic-reticulum-ca2-atpase-serca1
#4
Patrick F Desmond, Amanda Labuza, Joaquin Muriel, Michele L Markwardt, Allison E Mancini, Mark A Rizzo, Robert J Bloch
SERCA1, the sarco(endo)plasmic reticulum Ca2+-ATPase of skeletal muscle, is essential for muscle relaxation and maintenance of low resting Ca2+ levels in the myoplasm. We recently reported that small ankyrin 1 (sAnk1) interacts with the sarco(endo)plasmic reticulum Ca2+-ATPase in skeletal muscle (SERCA1) to inhibit its activity (1). We also showed that this interaction is mediated at least in part through sAnk1's transmembrane domain in a manner similar to that of sarcolipin (SLN). Earlier studies have shown that SLN and phospholamban (PLN), the other well-studied small SERCA-regulatory proteins, oligomerize either alone or together...
May 9, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28482122/para-aortic-lymphadenectomy-can-be-omitted-in-most-endometrial-cancer-patients-at-risk-of-lymph-node-metastasis
#5
Glauco Baiocchi, Carlos Chaves Faloppa, Henrique Mantoan, Willian Ricardo Camarço, Levon Badiglian-Filho, Lillian Yuri Kumagai, Louise De Brot, Alexandre Andre Balieiro Anastacio da Costa
OBJECTIVES: To determine the predictive factors of para-aortic lymph node (PALN) metastasis in endometrial cancer (EC) and recommend a subgroup of patients who can safely forgo PALN dissection. METHODS: We analyzed a series of 255 patients who were at risk of lymph node metastasis and treated from June 2007 to June 2015. All patients underwent systematic pelvic and para-aortic lymphadenectomy. RESULTS: The median number of pelvic lymph nodes (PLN) and PALNs that were resected was 33 and 15, respectively...
May 8, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28472932/chromosome-microarray-analysis-in-the-investigation-of-children-with-congenital-heart-disease
#6
Xiao-Li Wu, Ru Li, Fang Fu, Min Pan, Jin Han, Xin Yang, Yong-Ling Zhang, Fa-Tao Li, Can Liao
BACKGROUND: Our study was aimed to explore the clinical implication of chromosome microarray analysis (CMA) in genetically etiological diagnosis of children with congenital heart disease (CHD). METHODS: A total of 104 children with CHD with or without multiple congenital anomalies (MCA) or intellectual disabilities/developmental delay (ID/DD) but normal karyotype were investigated using Affymetrix CytoScan HD array. RESULT: Pathogenic copy number variations (PCNVs) were identified in 29 children (27...
May 4, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28466451/multiscale-assessment-of-progress-of-electrification-in-indonesia-based-on-brightness-level-derived-from-nighttime-satellite-imagery
#7
Fatwa Ramdani, Putri Setiani
Availability of electricity can be used as an indicator to proximate parameters related to human well-being. Overall, the electrification process in Indonesia has been accelerating in the past two decades. Unfortunately, monitoring the country's progress on its effort to provide wider access to electricity poses challenges due to inconsistency of data provided by each national bureau, and limited availability of information. This study attempts to provide a reliable measure by employing nighttime satellite imagery to observe and to map the progress of electrification within a duration of 20 years, from 1993 to 2013...
June 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28440025/identifying-key-genes-in-rheumatoid-arthritis-by-weighted-gene-co-expression-network-analysis
#8
Chunhui Ma, Qi Lv, Songsong Teng, Yinxian Yu, Kerun Niu, Chengqin Yi
PURPOSE: This study aimed to identify rheumatoid arthritis (RA) related genes based on microarray data using the WGCNA (weighted gene co-expression network analysis) method. METHODS: Two gene expression profile datasets GSE55235 (10 RA samples and 10 healthy controls) and GSE77298 (16 RA samples and seven healthy controls) were downloaded from Gene Expression Omnibus database. Characteristic genes were identified using metaDE package. WGCNA was used to find disease-related networks based on gene expression correlation coefficients, and module significance was defined as the average gene significance of all genes used to assess the correlation between the module and RA status...
April 25, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28406633/probing-the-conformationally-excited-states-of-membrane-proteins-via-1-h-detected-mas-solid-state-nmr-spectroscopy
#9
T Gopinath, Sarah E D Nelson, Kailey J Soller, Gianluigi Veglia
Proteins exist in ensembles of conformational states that interconvert on various motional time scales. High-energy states of proteins, often referred to as conformationally excited states, are sparsely populated and have been found to play an essential role in many biological functions. However, detecting these states is quite difficult for conventional structural techniques. Recent progress in solution NMR spectroscopy made it possible to detect conformationally excited states in soluble proteins and characterize them at high resolution...
May 4, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28391545/burden-of-suicide-in-poland-in-2012-how-could-it-be-measured-and-how-big-is-it
#10
Katarzyna Orlewska, Ewa Orlewska
OBJECTIVES: The aim of our study was to estimate the health-related and economic burden of suicide in Poland in 2012 and to demonstrate the effects of using different assumptions on the disease burden estimation. METHODS: Years of life lost (YLL) were calculated by multiplying the number of deaths by the remaining life expectancy. Local expected YLL (LEYLL) and standard expected YLL (SEYLL) were computed using Polish life expectancy tables and WHO standards, respectively...
April 8, 2017: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
https://www.readbyqxmd.com/read/28365402/distinct-fibrosis-pattern-in-desmosomal-and-phospholamban-mutation-carriers-in-hereditary-cardiomyopathies
#11
Shahrzad Sepehrkhouy, Johannes M I H Gho, René van Es, Magdalena Harakalova, Nicolaas de Jonge, Dennis Dooijes, Jasper J van der Smagt, Marc P Buijsrogge, Richard N W Hauer, Roel Goldschmeding, Roel A de Weger, Folkert W Asselbergs, Aryan Vink
BACKGROUND: Desmosomal and phospholamban (PLN) mutations are associated with arrhythmogenic cardiomyopathy. Ultimately, most cardiomyopathy hearts develop significant cardiac fibrosis. OBJECTIVE: To compare the fibrosis patterns of desmosomal and p. Arg14del PLN associated cardiomyopathies with the pattern in hearts with other hereditary cardiomyopathies. METHODS: A mid-ventricular transversal slice was obtained from hearts of 30 patients with a cardiomyopathy with a known underlying mutation, and from 8 controls...
March 29, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28337239/disease-activity-quality-of-life-and-indirect-costs-of-ulcerative-colitis-in-poland
#12
Paweł Kawalec, Ewa Stawowczyk, Małgorzata Mossakowska, Andrzej Pilc
INTRODUCTION: Ulcerative colitis (UC) require expensive, lifelong treatment, which generates huge direct costs and has a significant impact on the quality of life, especially in the active state of the disease. AIM: To assess the indirect costs, health-related quality of life, and clinical characteristics of patients with UC in Poland. Additionally, we investigated the association between activity of UC and productivity loss of patients in a Polish setting. MATERIAL AND METHODS: A questionnaire survey was conducted using the Patient Simple Clinical Colitis Activity Index (P-SCCAI) to assess disease activity, as well as the modified Work Productivity and Activity Impairment Questionnaire to assess productivity loss...
2017: Przegla̜d Gastroenterologiczny
https://www.readbyqxmd.com/read/28280973/determinants-of-curvature-constant-w-of-the-power-duration-relationship-under-normoxia-and-hypoxia-the-effect-of-pre-exercise-alkalosis
#13
Sanjoy K Deb, Lewis A Gough, S Andy Sparks, Lars R McNaughton
PURPOSE: This study investigated the effect of induced alkalosis on the curvature constant (W') of the power-duration relationship under normoxic and hypoxic conditions. METHODS: Eleven trained cyclists (mean ± SD) Age: 32 ± 7.2 years; body mass (bm): 77.0 ± 9.2 kg; VO2peak: 59.2 ± 6.8 ml·kg(-1)·min(-1) completed seven laboratory visits which involved the determination of individual time to peak alkalosis following sodium bicarbonate (NaHCO3) ingestion, an environment specific ramp test (e...
May 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28278204/sarcolipin-deletion-exacerbates-soleus-muscle-atrophy-and-weakness-in-phospholamban-overexpressing-mice
#14
Val A Fajardo, Daniel Gamu, Andrew Mitchell, Darin Bloemberg, Eric Bombardier, Paige J Chambers, Catherine Bellissimo, Joe Quadrilatero, A Russell Tupling
Sarcolipin (SLN) and phospholamban (PLN) are two small proteins that regulate the sarco(endo)plasmic reticulum Ca2+-ATPase pumps. In a recent study, we discovered that Pln overexpression (PlnOE) in slow-twitch type I skeletal muscle fibers drastically impaired SERCA function and caused a centronuclear myopathy-like phenotype, severe muscle atrophy and weakness, and an 8 to 9-fold upregulation of SLN protein in the soleus muscles. Here, we sought to determine the physiological role of SLN upregulation, and based on its role as a SERCA inhibitor, we hypothesized that it would represent a maladaptive response that contributes to the SERCA dysfunction and the overall myopathy observed in the PlnOE mice...
2017: PloS One
https://www.readbyqxmd.com/read/28258669/hpv-vaccinations-in-lublin-region-poland
#15
Paweł Kalinowski, Anna Grządziel
INTRODUCTION: Secondary prophylaxis of cervical cancer consisting in cytology screening tests, despite its effectiveness, does not achieve the desired results. For several years, primary prophylaxis has been available in the form of protective vaccinations. At present, two vaccine preparations are available on the market, and studies conducted on these preparations confirm their almost 100% effectiveness in the prevention of types of HPV present in the vaccine. OBJECTIVE: Analysis of the programmes of protective vaccinations against HPV carried out during the period 2008-2013 in the Lublin Region...
February 14, 2017: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/28213757/germinal-centre-frequency-is-decreased-in-pancreatic-lymph-nodes-from-individuals-with-recent-onset-type-1-diabetes
#16
Abby Willcox, Sarah J Richardson, Lucy S K Walker, Sally C Kent, Noel G Morgan, Kathleen M Gillespie
AIMS/HYPOTHESIS: Pancreatic lymph nodes (PLNs) are critical sites for the initial interaction between islet autoantigens and autoreactive lymphocytes, but the histology of PLNs in tissue from individuals with type 1 diabetes has not been analysed in detail. The aim of this study was to examine PLN tissue sections from healthy donors compared with those at risk of, or with recent-onset and longer-duration type 1 diabetes. METHODS: Immunofluorescence staining was used to examine PLN sections from the following donor groups: non-diabetic (n=15), non-diabetic islet autoantibody-positive (n=5), recent-onset (≤1...
February 17, 2017: Diabetologia
https://www.readbyqxmd.com/read/28191564/correlation-of-the-structural-information-obtained-for-europium-chelate-ensembles-from-gas-phase-photoluminescence-and-ion-mobility-spectroscopy-with-density-functional-computations-and-ligand-field-theory
#17
Jean-François Greisch, Jiří Chmela, Michael E Harding, Dirk Wunderlich, Bernhard Schäfer, Mario Ruben, Wim Klopper, Detlef Schooss, Manfred M Kappes
We report a combined investigation of europium(iii)9-oxo-phenalen-1-one (PLN) coordination complexes, [Eu(PLN)4AE](+) with AE = Mg, Ca, and Sr, using gas-phase photoluminescence, trapped ion-mobility spectrometry and density-functional computations. In order to sort out the structural impact of the alkali earth dications on the photoluminescence spectra, the experimental data are compared to the predicted ligand-field splittings as well as to the collision cross-sections for different isomers of [Eu(PLN)4AE](+)...
February 13, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28182833/comparative-effectiveness-of-mycophenolate-mofetil-for-the-treatment-of-childhood-onset-proliferative-lupus-nephritis
#18
Simon Y Tian, Earl D Silverman, Eleanor Pullenayegum, Patrick E Brown, Joseph Beyene, Brian M Feldman
OBJECTIVES: Although childhood-onset proliferative lupus nephritis (cPLN) leads to significant morbidity and mortality, there is no trial evidence to support the treatment effectiveness of any therapy for cPLN. Marginal structural models (MSMs) enable us to estimate treatment effectiveness using observational data while accounting for confounding by indication. METHODS: We used prospectively collected data to examine the effect of mycophenolate mofetil (MMF), compared to the use of other therapies, on the long-term outcome of our cPLN cohort (age at onset of PLN < 18 years)...
February 9, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28161495/should-the-presence-of-metastatic-para-aortic-lymph-nodes-in-locally-advanced-cervical-cancer-lead-to-more-aggressive-treatment-strategies
#19
Virginia Benito, Sonia Carballo, Patricia Silva, Miriam Esparza, Octavio Arencibia, Mario Federico, Miguel Andújar, Marta Mori, Norberto Medina, Amina Lubrano
STUDY OBJECTIVE: To evaluate risk factors in patients with locally advanced cervical cancer (LACC) undergoing pretherapeutic laparoscopic para-aortic lymphadenectomy (LPL) as well as the progression-free and overall survival rates specifically in the subgroup of patients with metastatic para-aortic lymph nodes (PLNs). DESIGN: Retrospective study conducted on demographic data, pathologic and surgical findings, complications, and disease status recorded for LACC patients undergoing LPL during the period 2009 to 2015...
May 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28127834/outcomes-of-uterine-cervical-cancer-patients-with-pelvic-lymph-node-metastases-after-radiotherapy-without-boost-irradiation-of-metastases
#20
Eriko Yoshizawa, Keiichiro Koiwai, Hironobu Ina, Ayumu Fukazawa, Katsuya Sakai, Takesumi Ozawa, Hirohide Matsushita, Masumi Kadoya
AIM: The aim of this study was to evaluate the outcomes of uterine cervical cancer patients with pelvic lymph node (PLN) metastases after radiotherapy without boost irradiation of the metastases and to clarify the necessity of the boost irradiation of metastatic lesions. METHODS: Thirty-two patients with uterine cervical cancer metastasizing only to the PLN were treated with definitive radiotherapy without boost irradiation of the metastases between 2008 and 2012 at our institution and were selected for this study...
January 26, 2017: Journal of Obstetrics and Gynaecology Research
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