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https://www.readbyqxmd.com/read/27894026/the-effect-of-road-network-patterns-on-pedestrian-safety-a-zone-based-bayesian-spatial-modeling-approach
#1
Qiang Guo, Pengpeng Xu, Xin Pei, S C Wong, Danya Yao
Pedestrian safety is increasingly recognized as a major public health concern. Extensive safety studies have been conducted to examine the influence of multiple variables on the occurrence of pedestrian-vehicle crashes. However, the explicit relationship between pedestrian safety and road network characteristics remains unknown. This study particularly focused on the role of different road network patterns on the occurrence of crashes involving pedestrians. A global integration index via space syntax was introduced to quantify the topological structures of road networks...
November 25, 2016: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/27883412/prolonged-hospitalization-of-patients-with-hospital-acquired-pneumoniae-in-the-intensive-care-unit-%C3%A2-morbidity-mortality-and-costs-of
#2
Anna Różańska, Marta Wałaszek, Zdzisław Wolak, Małgorzata Bulanda
BACKGROUND: The objective of this study was to determine epidemiological rates of hospital-acquired pneumonia (HAP) in the Polish ICU and direct costs associated with excess length of stay incurred by the hospital. MATERIAL AND METHODS: The studied data concern patients hospitalized in the years 2010–2012 in a 9-bed ICU of a multi-profile hospital in the Małopolskie Province. Centers for Disease Control and Prevention diagnostic criteria were the basis for the development of definitions of infections...
2016: Przegla̧d Epidemiologiczny
https://www.readbyqxmd.com/read/27881187/class-solutions-for-sabr-vmat-for-high-risk-prostate-cancer-with-and-without-elective-nodal-irradiation
#3
Sarah O S Osman, Prakash Jeevanandam, Nithya Kanakavelu, Denise M Irvine, Ciara A Lyons, Suneil Jain, Alan R Hounsell, Conor K McGarry
BACKGROUND: The purpose of this study is to find the optimal planning settings for prostate SABR-VMAT for high-risk prostate cancer patients irradiated to prostate only (PO) or prostate and pelvic lymph nodes (PPLN). METHODS: For 10 patients, plans using 6MV flattened, flattening-filter-free (FFF) 6MV (6 F) and FFF 10MV (10 F) photon beams with full and partial arc arrangements were generated and compared. The prescribed dose was 40Gy to the prostate with 25Gy to the PLN in 5 fractions...
November 24, 2016: Radiation Oncology
https://www.readbyqxmd.com/read/27836106/preoperative-platelet-count-improves-the-prognostic-prediction-of-the-figo-staging-system-for-operable-cervical-cancer-patients
#4
Ru-Ru Zheng, Xiao-Xiu Huang, Chu Jin, Xin-Xin Zhuang, Le-Chi Ye, Fei-Yun Zheng, Feng Lin
BACKGROUND: Increased platelet has been identified as an independent and unfavorable prognostic indicator in various cancers including cervical cancer. In our study, the prognostic value of preoperative platelet count combining with FIGO (International Federation of Gynecology and Obstetrics) stage in patients with operable cervical cancer was investigated. METHODS: A large cohort study including 800 operable cervical cancer patients was conducted from May 2005 to December 2012...
November 8, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27833092/molecular-inotropy-mediated-by-cardiac-mir-based-pde4d-prkar1%C3%AE-phosphoprotein-signaling
#5
Fikru B Bedada, Joshua J Martindale, Erik Arden, Joseph M Metzger
Molecular inotropy refers to cardiac contractility that can be modified to affect overall heart pump performance. Here we show evidence of a new molecular pathway for positive inotropy by a cardiac-restricted microRNA (miR). We report enhanced cardiac myocyte performance by acute titration of cardiac myosin-embedded miR-208a. The observed positive effect was independent of host gene myosin effects with evidence of negative regulation of cAMP-specific 3',5'-cyclic phosphodiesterase 4D (PDE4D) and the regulatory subunit of PKA (PRKAR1α) content culminating in PKA-site dependent phosphorylation of cardiac troponin I (cTnI) and phospholamban (PLN)...
November 11, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27825759/pegylated-polypeptide-lipid-nanocapsules-to-enhance-the-anticancer-efficacy-of-erlotinib-in-non-small-cell-lung-cancer
#6
Jeonghwan Kim, Thiruganesh Ramasamy, Ju Yeon Choi, Ssang Tae Kim, Yu Seok Youn, Han-Gon Choi, Chul Soon Yong, Jong Oh Kim
In this study, a core-shell type polypeptide-based lipid nanocapsule was developed to enhance anticancer efficacy of erlotinib in non-small cell lung cancers. Mean particle size of PEGylated polypeptide-lipid nanocapsules (PLN) for erlotinib (ERL) delivery was ∼200nm with an effective surface charge of -20mV. Protective PEGylated polypeptide layer acted as a molecular fence and effectively controlled the diffusion of erlotinib from the lipid nanocapsule core, whereas pH-responsiveness of poly(L-aspartic acid) accelerated the release of erlotinib in acidic conditions...
November 2, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27811197/phospholamban-inhibition-by-a-single-dose-of-locked-nucleic-acid-antisense-oligonucleotide-improves-cardiac-contractility-in-pressure-overload-induced-systolic-dysfunction-in-mice
#7
Hirofumi Morihara, Tsuyoshi Yamamoto, Harunori Oiwa, Kota Tonegawa, Daisuke Tsuchiyama, Ikki Kawakatsu, Masanori Obana, Makiko Maeda, Tomomi Mohri, Satoshi Obika, Yasushi Fujio, Hiroyuki Nakayama
BACKGROUND: Phospholamban (PLN) inhibition enhances calcium cycling and is a potential novel therapy for heart failure (HF). Antisense oligonucleotides (ASOs) are a promising tool for unmet medical needs. Nonviral vector use of locked nucleic acid (LNA)-modified ASOs (LNA-ASOs), which shows strong binding to target RNAs and is resistant to nuclease, is considered to have a potential for use in novel therapeutics in the next decades. Thus, the efficacy of a single-dose injection of LNA-ASO for cardiac disease needs to be elucidated...
November 2, 2016: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27756051/preparation-of-99m-tc-isosulfan-blue-for-lymph-node-localization-in-rats-99m-tc-isosulfan-blue-for-lymph-node-localization
#8
Derya İlem-Özdemir, Ulkem Yararbas, Baha Zengel, Gökhan Ertan, Makbule Asikoglu
The sentinel lymph node (SLN) is defined as the first regional lymph node to receive lymphatic drainage from a malignant tumor. Therefore, this node is a "sentinel" for second metastatic lymph node stations and for labeling regional tumor spread. For SLN detection, many surgeons preferred a combination of a preoperative injection of radiolabeled colloid and the intraoperative injection of blue dye. Under this combination protocol, nodes are considered to be "sentinel nodes" if they are radioactive and blue...
October 11, 2016: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/27742792/global-phosphoproteomic-profiling-reveals-perturbed-signaling-in-a-mouse-model-of-dilated-cardiomyopathy
#9
Uros Kuzmanov, Hongbo Guo, Diana Buchsbaum, Jake Cosme, Cynthia Abbasi, Ruth Isserlin, Parveen Sharma, Anthony O Gramolini, Andrew Emili
Phospholamban (PLN) plays a central role in Ca(2+) homeostasis in cardiac myocytes through regulation of the sarco(endo)plasmic reticulum Ca(2+)-ATPase 2A (SERCA2A) Ca(2+) pump. An inherited mutation converting arginine residue 9 in PLN to cysteine (R9C) results in dilated cardiomyopathy (DCM) in humans and transgenic mice, but the downstream signaling defects leading to decompensation and heart failure are poorly understood. Here we used precision mass spectrometry to study the global phosphorylation dynamics of 1,887 cardiac phosphoproteins in early affected heart tissue in a transgenic R9C mouse model of DCM compared with wild-type littermates...
October 14, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27723068/costs-of-the-use-of-carbetocin-in-the-prevention-of-uterine-atony-following-delivery-of-the-infant-by-caesarean-section-retrospective-multicenter-study
#10
Maciej Sobkowski, Zbigniew Celewicz, Jarosław Kalinka, Krzysztof Szymanowski, Marcin Serafin, Katarzyna Śmieja, Anna Grzymała-Figura, Kinga Pacocha, Izabela Pieniążek, Jacek Walczak, Agnieszka Żyła, Adam Bierut
OBJECTIVES: The aim of this study was to compare the costs of using carbetocin in the prevention of uterine atony following delivery of the infant by Cesarean section (C-section) under epidural or spinal anesthesia with standard methods of prevention (SMP). MATERIAL AND METHODS: This retrospective multicenter study was based on data from three medical centers. A questionnaire was developed to gather patient records on consumption and costs of resources related to C-section, prevention of uterine atony and postpartum hemorrhage (PPH) treatment...
2016: Ginekologia Polska
https://www.readbyqxmd.com/read/27714842/high-resolution-mr-imaging-of-pelvic-lymph-nodes-at-7-tesla
#11
Bart W J Philips, Ansje S Fortuin, Stephan Orzada, Tom W J Scheenen, Marnix C Maas
PURPOSE: Pelvic lymph node (PLN) metastases are often smaller than 5 mm and difficult to detect. This work presents a method to perform PLN imaging with ultrahigh-field MRI, using spectrally selective excitation to acquire water and lipid-selective imaging at high spatial resolution. METHODS: A 3D water-selective multigradient echo (mGRE) sequence and lipid-selective gradient echo (GRE) sequence were tested in six healthy volunteers on a 7 Tesla (T) MRI system, using time interleaved acquisition of modes (TIAMO) to improve image homogeneity...
October 7, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27713088/comparison-of-three-lymph-node-classifications-for-survival-prediction-in-distant-metastatic-gastric-cancer
#12
Rui Zhou, Jingwen Zhang, Huiying Sun, Yulin Liao, Wangjun Liao
BACKGROUND: The optimal lymph node (LN) classification system for prognostic assessment in distant metastatic gastric cancer (DMGC) patients who undergo LN dissection remains unclear. Therefore, we compared the prognostic performance of positive LN (PLN), LN ratio (LNR), and log odds of positive LNs (LODDS) in DMGC patients. METHODS: A total of 1999 DMGC patients who underwent lymphadenectomy recorded in the Surveillance Epidemiology and End Results database from 2004 to 2012 were reviewed...
November 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/27704235/photoluminescence-and-coordination-behaviour-of-lanthanide-complexes-of-tris-aminomethyl-ethane-5-oxine-in-aqueous-solution
#13
Rifat Akbar, Minati Baral, B K Kanungo
Photophysical properties of a multidentate tripodal ligand, 5,5'-(2-(((8-hydroxyquinolin-5-yl) methylamino)methyl)-2-methylpropane-1,3-diyl) bis (azanediyl)bis (methylene)diquinolin-8-ol, (TAME5OX), with La(3+) and Er(3+) ions have been examined for photonics applications. The change in behavior in electronic spectra of these complexes reveals the use of TAME5OX as a sensitive optical pH based sensor to detect Ln(3+) ions whereas indication of strong green fluorescence allows simultaneous sensing within the visible region in competitive medium...
October 4, 2016: Journal of Fluorescence
https://www.readbyqxmd.com/read/27703301/p-selectin-targeted-dexamethasone-loaded-lipid-nanoemulsions-a-novel-therapy-to-reduce-vascular-inflammation
#14
Viorel Simion, Cristina Ana Constantinescu, Daniela Stan, Mariana Deleanu, Monica Madalina Tucureanu, Elena Butoi, Ileana Manduteanu, Maya Simionescu, Manuela Calin
Inflammation is a common process associated with numerous vascular pathologies. We hypothesized that targeting the inflamed endothelium by coupling a peptide with high affinity for P-selectin to the surface of dexamethasone-loaded lipid nanoemulsions will highly increase their specific binding to activated endothelial cells (EC) and reduce the cell activation. We developed and characterized dexamethasone-loaded lipid nanoemulsions directed towards P-selectin (PLN-Dex) and monitored their anti-inflammatory effects in vitro using cultured EC (EA...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27694496/antibody-binding-to-cd4-induces-rac-gtpase-activation-and-alters-t-cell-migration
#15
Y Maurice Morillon, Elizabeth Chase Lessey-Morillon, Matthew Clark, Rui Zhang, Bo Wang, Keith Burridge, Roland Tisch
The use of nondepleting Abs specific for CD4 and CD8 is an effective strategy to tolerize CD4(+) and CD8(+) T cells in a tissue-specific manner. We reported that coreceptor therapy reverses diabetes in new onset NOD mice. A striking feature of coreceptor-induced remission is the purging of T cells from the pancreatic lymph nodes (PLN) and islets of NOD mice. Evidence indicates that Abs binding to the coreceptors promotes T cell egress from these tissues. The present study examined how coreceptor therapy affects the migration of CD4(+) T cells residing in the PLN of NOD mice...
September 30, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27694219/foxo3a-regulates-bnip3-and-modulates-mitochondrial-calcium-dynamics-and-function-in-cardiac-stress
#16
Antoine Heni Chaanine, Erik Kohlbrenner, Scott I Gamb, Adam J Guenzel, Katherine A Klaus, Ahmed U Fayyaz, K Sreekumaran Nair, Roger J Hajjar, Margaret M Redfield
The Forkhead box O3a (FOXO3a) transcription factor has been shown to regulate glucose metabolism, muscle atrophy and cell death in post-mitotic cells. Its role in regulating mitochondrial and myocardial function is not well studied. Based on previous work, we hypothesized that FOXO3a, through BNIP3, modulates mitochondrial morphology and function in HF. We modulated the FOXO3a-BNIP3 pathway in normal and phenylephrine (PE) stressed adult cardiac myocytes (ACM) in vitro and developed a cardiotropic adeno-associated virus serotype 9 encoding dominant-negative FOXO3a (AAV9...
September 30, 2016: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/27693791/sodium-fluoride-as-a-nucleating-factor-for-mg-actin-polymerization
#17
Olga A Tsaplina, Sofia Yu Khaitlina
Dynamic instability of actin filaments can be inhibited by Pi analogs beryllium fluoride and aluminium fluoride that mimic the intermediate ADP-Pi state and stabilize actin filaments. On the other hand, the phosphoryl transfer enzymes can be activated in the absence of aluminium by magnesium fluoride if magnesium ions and sodium fluoride (NaF) were present in the solution. Whether magnesium fluoride promotes functional activities of actin is not known. Here we show, for the first time, that sodium fluoride strongly accelerates polymerization of highly dynamic Mg-F-actin assembled from the monomers proteolytically cleaved between Gly42 and Val43 within the D-loop with actin-specific protease protealysin (Pln-actin), apparently due to stabilization of nuclei formed at the initial step of actin polymerization...
October 28, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27689127/data-on-the-histological-and-immune-cell-response-in-the-popliteal-lymph-node-in-mice-following-exposure-to-metal-particles-and-ions
#18
Bethany Winans, Brooke E Tvermoes, Kenneth M Unice, Michael Kovochich, Ernest S Fung, Whitney V Christian, Ellen Donovan, Brent L Finley, Ian Kimber, Dennis J Paustenbach
Hip implants containing cobalt-chromium (CoCr) have been used for over 80 years. In patients with metal-on-metal (MoM) hip implants, it has been suggested that wear debris particles may contribute to metal sensitization in some individuals, leading to adverse reactions. This article presents data from a study in which the popliteal lymph node assay (PLNA) was used to assess immune responses in mice treated with chromium-oxide (Cr2O3) particles, metal salts (CoCl2, CrCl3, and NiCl2) or Cr2O3 particles with metal salts ("A preliminary evaluation of immune stimulation following exposure to metal particles and ions using the mouse popliteal lymph node assay" (B...
December 2016: Data in Brief
https://www.readbyqxmd.com/read/27688314/genotype-dependent-and-independent-calcium-signaling-dysregulation-in-human-hypertrophic-cardiomyopathy
#19
Adam S Helms, Francisco J Alvarado, Jaime Yob, Vi T Tang, Francis Pagani, Mark W Russell, Héctor H Valdivia, Sharlene M Day
BACKGROUND: Aberrant calcium signaling may contribute to arrhythmias and adverse remodeling in hypertrophic cardiomyopathy (HCM). Mutations in sarcomere genes may distinctly alter calcium handling pathways. METHODS: We analyzed gene expression, protein levels, and functional assays for calcium regulatory pathways in human HCM surgical samples with (n=25) and without (n=10) sarcomere mutations compared with control hearts (n=8). RESULTS: Gene expression and protein levels for calsequestrin, L-type calcium channel, sodium-calcium exchanger, phospholamban, calcineurin, and calcium/calmodulin-dependent protein kinase type II (CaMKII) were similar in HCM samples compared with controls...
November 29, 2016: Circulation
https://www.readbyqxmd.com/read/27687517/number-of-evaluated-lymph-nodes-and-positive-lymph-nodes-lymph-node-ratio-and-log-odds-evaluation-in-early-stage-pancreatic-ductal-adenocarcinoma-numerology-or-valid-indicators-of-patient-outcome
#20
G Lahat, N Lubezky, F Gerstenhaber, E Nizri, M Gysi, M Rozenek, Y Goichman, I Nachmany, R Nakache, I Wolf, J M Klausner
BACKGROUND: We evaluated the prognostic significance and universal validity of the total number of evaluated lymph nodes (ELN), number of positive lymph nodes (PLN), lymph node ratio (LNR), and log odds of positive lymph nodes (LODDS) in a relatively large and homogenous cohort of surgically treated pancreatic ductal adenocarcinoma (PDAC) patients. METHODS: Prospectively accrued data were retrospectively analyzed for 282 PDAC patients who had pancreaticoduodenectomy (PD) at our institution...
September 29, 2016: World Journal of Surgical Oncology
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