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https://www.readbyqxmd.com/read/28440025/identifying-key-genes-in-rheumatoid-arthritis-by-weighted-gene-co-expression-network-analysis
#1
Chunhui Ma, Qi Lv, Songsong Teng, Yinxian Yu, Kerun Niu, Chengqin Yi
PURPOSE: This study aimed to identify rheumatoid arthritis (RA) related genes based on microarray data using the WGCNA (weighted gene co-expression network analysis) method. METHODS: Two gene expression profile datasets GSE55235 (10 RA samples and 10 healthy controls) and GSE77298 (16 RA samples and seven healthy controls) were downloaded from Gene Expression Omnibus database. Characteristic genes were identified using metaDE package. WGCNA was used to find disease-related networks based on gene expression correlation coefficients, and module significance was defined as the average gene significance of all genes used to assess the correlation between the module and RA status...
April 25, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28406633/probing-the-conformationally-excited-states-of-membrane-proteins-via-1-h-detected-mas-solid-state-nmr-spectroscopy
#2
T Gopinath, Sarah E D Nelson, Kailey J Soller, Gianluigi Veglia
Proteins exist in ensembles of conformational states that interconvert on various motional time scales. High-energy states of proteins, often referred to as conformationally excited states, are sparsely populated and have been found to play an essential role in many biological functions. However, detecting these states is quite difficult for conventional structural techniques. Recent progress in solution NMR spectroscopy made it possible to detect conformationally excited states in soluble proteins and characterize them at high resolution...
April 20, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28391545/burden-of-suicide-in-poland-in-2012-how-could-it-be-measured-and-how-big-is-it
#3
Katarzyna Orlewska, Ewa Orlewska
OBJECTIVES: The aim of our study was to estimate the health-related and economic burden of suicide in Poland in 2012 and to demonstrate the effects of using different assumptions on the disease burden estimation. METHODS: Years of life lost (YLL) were calculated by multiplying the number of deaths by the remaining life expectancy. Local expected YLL (LEYLL) and standard expected YLL (SEYLL) were computed using Polish life expectancy tables and WHO standards, respectively...
April 8, 2017: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
https://www.readbyqxmd.com/read/28365402/distinct-fibrosis-pattern-in-desmosomal-and-phospholamban-mutation-carriers-in-hereditary-cardiomyopathies
#4
Shahrzad Sepehrkhouy, Johannes M I H Gho, René van Es, Magdalena Harakalova, Nicolaas de Jonge, Dennis Dooijes, Jasper J van der Smagt, Marc P Buijsrogge, Richard N W Hauer, Roel Goldschmeding, Roel A de Weger, Folkert W Asselbergs, Aryan Vink
BACKGROUND: Desmosomal and phospholamban (PLN) mutations are associated with arrhythmogenic cardiomyopathy. Ultimately, most cardiomyopathy hearts develop significant cardiac fibrosis. OBJECTIVE: To compare the fibrosis patterns of desmosomal and p. Arg14del PLN associated cardiomyopathies with the pattern in hearts with other hereditary cardiomyopathies. METHODS: A mid-ventricular transversal slice was obtained from hearts of 30 patients with a cardiomyopathy with a known underlying mutation, and from 8 controls...
March 29, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28337239/disease-activity-quality-of-life-and-indirect-costs-of-ulcerative-colitis-in-poland
#5
Paweł Kawalec, Ewa Stawowczyk, Małgorzata Mossakowska, Andrzej Pilc
INTRODUCTION: Ulcerative colitis (UC) require expensive, lifelong treatment, which generates huge direct costs and has a significant impact on the quality of life, especially in the active state of the disease. AIM: To assess the indirect costs, health-related quality of life, and clinical characteristics of patients with UC in Poland. Additionally, we investigated the association between activity of UC and productivity loss of patients in a Polish setting. MATERIAL AND METHODS: A questionnaire survey was conducted using the Patient Simple Clinical Colitis Activity Index (P-SCCAI) to assess disease activity, as well as the modified Work Productivity and Activity Impairment Questionnaire to assess productivity loss...
2017: Przegla̜d Gastroenterologiczny
https://www.readbyqxmd.com/read/28280973/determinants-of-curvature-constant-w-of-the-power-duration-relationship-under-normoxia-and-hypoxia-the-effect-of-pre-exercise-alkalosis
#6
Sanjoy K Deb, Lewis A Gough, S Andy Sparks, Lars R McNaughton
PURPOSE: This study investigated the effect of induced alkalosis on the curvature constant (W') of the power-duration relationship under normoxic and hypoxic conditions. METHODS: Eleven trained cyclists (mean ± SD) Age: 32 ± 7.2 years; body mass (bm): 77.0 ± 9.2 kg; VO2peak: 59.2 ± 6.8 ml·kg(-1)·min(-1) completed seven laboratory visits which involved the determination of individual time to peak alkalosis following sodium bicarbonate (NaHCO3) ingestion, an environment specific ramp test (e...
March 9, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28278204/sarcolipin-deletion-exacerbates-soleus-muscle-atrophy-and-weakness-in-phospholamban-overexpressing-mice
#7
Val A Fajardo, Daniel Gamu, Andrew Mitchell, Darin Bloemberg, Eric Bombardier, Paige J Chambers, Catherine Bellissimo, Joe Quadrilatero, A Russell Tupling
Sarcolipin (SLN) and phospholamban (PLN) are two small proteins that regulate the sarco(endo)plasmic reticulum Ca2+-ATPase pumps. In a recent study, we discovered that Pln overexpression (PlnOE) in slow-twitch type I skeletal muscle fibers drastically impaired SERCA function and caused a centronuclear myopathy-like phenotype, severe muscle atrophy and weakness, and an 8 to 9-fold upregulation of SLN protein in the soleus muscles. Here, we sought to determine the physiological role of SLN upregulation, and based on its role as a SERCA inhibitor, we hypothesized that it would represent a maladaptive response that contributes to the SERCA dysfunction and the overall myopathy observed in the PlnOE mice...
2017: PloS One
https://www.readbyqxmd.com/read/28258669/hpv-vaccinations-in-lublin-region-poland
#8
Paweł Kalinowski, Anna Grządziel
INTRODUCTION: Secondary prophylaxis of cervical cancer consisting in cytology screening tests, despite its effectiveness, does not achieve the desired results. For several years, primary prophylaxis has been available in the form of protective vaccinations. At present, two vaccine preparations are available on the market, and studies conducted on these preparations confirm their almost 100% effectiveness in the prevention of types of HPV present in the vaccine. OBJECTIVE: Analysis of the programmes of protective vaccinations against HPV carried out during the period 2008-2013 in the Lublin Region...
February 14, 2017: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/28213757/germinal-centre-frequency-is-decreased-in-pancreatic-lymph-nodes-from-individuals-with-recent-onset-type-1-diabetes
#9
Abby Willcox, Sarah J Richardson, Lucy S K Walker, Sally C Kent, Noel G Morgan, Kathleen M Gillespie
AIMS/HYPOTHESIS: Pancreatic lymph nodes (PLNs) are critical sites for the initial interaction between islet autoantigens and autoreactive lymphocytes, but the histology of PLNs in tissue from individuals with type 1 diabetes has not been analysed in detail. The aim of this study was to examine PLN tissue sections from healthy donors compared with those at risk of, or with recent-onset and longer-duration type 1 diabetes. METHODS: Immunofluorescence staining was used to examine PLN sections from the following donor groups: non-diabetic (n=15), non-diabetic islet autoantibody-positive (n=5), recent-onset (≤1...
February 17, 2017: Diabetologia
https://www.readbyqxmd.com/read/28191564/correlation-of-the-structural-information-obtained-for-europium-chelate-ensembles-from-gas-phase-photoluminescence-and-ion-mobility-spectroscopy-with-density-functional-computations-and-ligand-field-theory
#10
Jean-François Greisch, Jiří Chmela, Michael E Harding, Dirk Wunderlich, Bernhard Schäfer, Mario Ruben, Wim Klopper, Detlef Schooss, Manfred M Kappes
We report a combined investigation of europium(iii)9-oxo-phenalen-1-one (PLN) coordination complexes, [Eu(PLN)4AE](+) with AE = Mg, Ca, and Sr, using gas-phase photoluminescence, trapped ion-mobility spectrometry and density-functional computations. In order to sort out the structural impact of the alkali earth dications on the photoluminescence spectra, the experimental data are compared to the predicted ligand-field splittings as well as to the collision cross-sections for different isomers of [Eu(PLN)4AE](+)...
February 13, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28182833/comparative-effectiveness-of-mycophenolate-mofetil-for-the-treatment-of-childhood-onset-proliferative-lupus-nephritis
#11
Simon Y Tian, Earl D Silverman, Eleanor Pullenayegum, Patrick E Brown, Joseph Beyene, Brian M Feldman
OBJECTIVES: Although childhood-onset proliferative lupus nephritis (cPLN) leads to significant morbidity and mortality, there is no trial evidence to support the treatment effectiveness of any therapy for cPLN. Marginal structural models (MSMs) enable us to estimate treatment effectiveness using observational data while accounting for confounding by indication. METHODS: We used prospectively collected data to examine the effect of mycophenolate mofetil (MMF), compared to the use of other therapies, on the long-term outcome of our cPLN cohort (age at onset of PLN < 18 years)...
February 9, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28161495/should-the-presence-of-metastatic-para-aortic-lymph-nodes-in-locally-advanced-cervical-cancer-lead-to-more-aggressive-treatment-strategies
#12
Virginia Benito, Sonia Carballo, Patricia Silva, Miriam Esparza, Octavio Arencibia, Mario Federico, Miguel Andújar, Marta Mori, Norberto Medina, Amina Lubrano
STUDY OBJECTIVE: To evaluate risk factors in patients with locally advanced cervical cancer (LACC) undergoing pretherapeutic laparoscopic para-aortic lymphadenectomy (LPL) as well as the progression-free and overall survival rates specifically in the subgroup of patients with metastatic para-aortic lymph nodes (PLNs). DESIGN: Retrospective study conducted on demographic data, pathologic and surgical findings, complications, and disease status recorded for LACC patients undergoing LPL during the period 2009 to 2015...
February 1, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28127834/outcomes-of-uterine-cervical-cancer-patients-with-pelvic-lymph-node-metastases-after-radiotherapy-without-boost-irradiation-of-metastases
#13
Eriko Yoshizawa, Keiichiro Koiwai, Hironobu Ina, Ayumu Fukazawa, Katsuya Sakai, Takesumi Ozawa, Hirohide Matsushita, Masumi Kadoya
AIM: The aim of this study was to evaluate the outcomes of uterine cervical cancer patients with pelvic lymph node (PLN) metastases after radiotherapy without boost irradiation of the metastases and to clarify the necessity of the boost irradiation of metastatic lesions. METHODS: Thirty-two patients with uterine cervical cancer metastasizing only to the PLN were treated with definitive radiotherapy without boost irradiation of the metastases between 2008 and 2012 at our institution and were selected for this study...
January 26, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28122728/absence-of-suppressor-of-cytokine-signaling-2-turns-cardiomyocytes-unresponsive-to-lif-dependent-increase-in-ca2-levels
#14
Cibele Rocha-Resende, Itamar Couto Guedes de Jesus, Danilo Roman-Campos, Artur S Miranda, Fabiana Alves, Rodrigo Ribeiro Resende, Jader Dos Santos Cruz, Fabiana Simão Machado, Silvia Guatimosim
Little is known regarding the role of the Suppressor of Cytokine Signaling (SOCS) in the control of cytokine signaling in cardiomyocytes. We investigated the consequences of SOCS2 ablation for Leukemia Inhibitory Factor (LIF)-induced enhancement of intracellular Ca(2+) ([Ca(2+)]i) transient by performing experiments with cardiomyocytes from SOCS2-knockout (ko) mice. Similar levels of SOCS3 transcripts were seen in cardiomyocytes from wild-type and SOCS2-ko, while SOCS1 mRNA was reduced in SOCS2-ko. Immunoprecipitation experiments showed increased SOCS3 association with gp130 receptor in SOCS2-ko myocytes...
January 25, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/28118521/treatment-of-tumor-necrosis-factor-transgenic-mice-with-anti-tumor-necrosis-factor-restores-lymphatic-contractions-repairs-lymphatic-vessels-and-may-increase-monocyte-macrophage-egress
#15
Echoe M Bouta, Igor Kuzin, Karen de Mesy Bentley, Ronald W Wood, Homaira Rahimi, Rui-Cheng Ji, Christopher T Ritchlin, Andrea Bottaro, Lianping Xing, Edward M Schwarz
OBJECTIVE: Recent studies have demonstrated that there is an inverse relationship between lymphatic egress and inflammatory arthritis in affected joints. As a model, tumor necrosis factor (TNF)-transgenic mice develop advanced arthritis following draining lymph node (LN) collapse, and loss of lymphatic contractions downstream of inflamed joints. It is unknown if these lymphatic deficits are reversible. This study was undertaken to test the hypothesis that anti-TNF therapy reduces advanced erosive inflammatory arthritis, associated with restoration of lymphatic contractions, repair of damaged lymphatic vessels, and evidence of increased monocyte egress...
January 24, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28102477/potential-new-mechanisms-of-pro-arrhythmia-in-arrhythmogenic-cardiomyopathy-focus-on-calcium-sensitive-pathways
#16
REVIEW
C J M van Opbergen, M Delmar, T A B van Veen
Arrhythmogenic cardiomyopathy, or its most well-known subform arrhythmogenic right ventricular cardiomyopathy (ARVC), is a cardiac disease mainly characterised by a gradual replacement of the myocardial mass by fibrous and fatty tissue, leading to dilatation of the ventricular wall, arrhythmias and progression towards heart failure. ARVC is commonly regarded as a disease of the intercalated disk in which mutations in desmosomal proteins are an important causative factor. Interestingly, the Dutch founder mutation PLN R14Del has been identified to play an additional, and major, role in ARVC patients within the Netherlands...
March 2017: Netherlands Heart Journal
https://www.readbyqxmd.com/read/28097316/evaluation-of-structural-progression-in-arrhythmogenic-right-ventricular-dysplasia-cardiomyopathy
#17
Thomas P Mast, Cynthia A James, Hugh Calkins, Arco J Teske, Crystal Tichnell, Brittney Murray, Peter Loh, Stuart D Russell, Birgitta K Velthuis, Daniel P Judge, Dennis Dooijes, Ryan J Tedford, Jeroen F van der Heijden, Harikrishna Tandri, Richard N Hauer, Theodore P Abraham, Pieter A Doevendans, Anneline S J M Te Riele, Maarten J Cramer
Importance: Considerable research has described the arrhythmic course of arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C). However, objective data characterizing structural progression, such as ventricular enlargement and cardiac dysfunction, in ARVD/C are relatively scarce. Objectives: To define the extent of structural progression, identify determinants of structural progression, and determine the association between structural progression and electrocardiographic (ECG) changes in patients with ARVD/C...
March 1, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28081340/importance-of-sonographic-paratracheal-lymph-node-evaluationin-early-autoimmune-thyroiditis
#18
Tuğrul Örmeci, Mukaddes Çolakoğulları, İsrafil Orhan, Bayram Ufuk Şakul
BACKGROUND/AIM: To review the sonographic views of paratracheal lymph nodes (PLNs) in the diagnosis and during different stages of autoimmune thyroiditis. MATERIALS AND METHODS: Features of the PLNs (left and right), thyroid sonography, and laboratory data were investigated in 126 cases. Patients were divided into three groups by using thyroid sonographic criteria in the literature (group 1: control, group 2: early-stage/indeterminate, group 3: definite thyroiditis)...
December 20, 2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28047846/su-f-t-534-using-daily-images-to-verify-dosimetric-advantage-of-dual-isocentric-technique-for-high-risk-prostate-cancer-treated-with-pelvic-lymph-node
#19
T Cui, Q Shang, W Li, A Vassil, P Xia
PURPOSE: To evaluate a dual-isocentric technique to compensate for the daily independent movements of prostate and pelvic lymph nodes (PLN) of high-risk prostate cancer patients. METHODS: Three patients, who received 78 Gy to the prostate, 66 Gy to the seminal vesicle (SV), and 50.4 Gy to the PLN in 39 fractions under CT-on-rail (CTOR) imaging guidance, were retrospectively selected. Each patient was planned with volumetric modulated arc therapy (VMAT) techniques using (1) single isocenter with a 6 mm margin except 4 mm posteriorly (6/4 mm), to the prostate-CTV and a uniform 5 mm margin to the PLN-CTV, and (2) two isocenters, located at the centroids of the prostate or the PLN, with a 5/3 mm margin to the prostate-CTV and a 5 mm uniform margin to the PLN-CTV...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047620/th-cd-207a-12-impacts-of-inter-and-intra-fractional-organ-motion-for-high-risk-prostate-cancer-stereotactic-body-radiation-therapy
#20
N Hassan Rezaeian, Y Chi, Y Zhou, Z Tian, S Jiang, R Hannan, X Jia
PURPOSE: We are conducting a clinical trial on stereotactic body radiation therapy (SBRT) for high-risk prostate cancer. Doses to three targets, prostate, intra-prostatic lesion, and pelvic lymph node (PLN) region, are escalated to three different levels via simultaneous integrated boost technique. Inter-/intra-fractional organ motions deteriorate planned dose distribution. This study aims at developing a dose reconstruction system to comprehensively understand the impacts of organ motion in our clinical trial...
June 2016: Medical Physics
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