A Boeing, L Mavrommatis, N M Daya, H Zhuge, L Volke, A Kocabas, M Kneifel, M Athamneh, K Krause, N Südkamp, K Döring, C Theiss, A Roos, H Zaehres, A K Güttsches, M Vorgerd
Here we introduce the human induced pluripotent stem cell lines (hiPSCs), HIMRi002-A and HIMRi003-A, generated from cultured dermal fibroblasts of 61-year-old (HIMRi002-A) and 38-year-old (HIMRi003-A) female patients, carrying a known heterozygous pathogenic variant (p.A46T) in the Caveolin 3 (CAV3) gene, via lentiviral expression of OCT4, SOX2, KLF4 and c-MYC. HIMRi002-A and HIMRi003-A display typical embryonic stem cell-like morphology, carry the p.A46T CAV3 gene mutation, express several pluripotent stem cell markers, retain normal karyotype (46, XX) and can differentiate in all three germ layers...
October 4, 2023: Stem Cell Research